[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"biomarker:h3-k27m-variant":3},{"name":4,"total":5,"recruiting":5,"trials":6},"H3 K27M Variant",11,[7,15,22,28,35,42,48,54,60,66,72],{"nct_id":8,"title":9,"phases":10,"status":12,"updated_at":13,"content_modified":14},"NCT05077735","Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Trial",[11],"Phase 2","RECRUITING","2026-08-26T02:14:59.425132Z","2026-07-19T19:36:05.115026Z",{"nct_id":16,"title":17,"phases":18,"status":12,"updated_at":20,"content_modified":21},"NCT04943848","rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG",[19],"Phase 1","2026-08-26T02:16:10.529598Z","2026-05-05T02:43:28.983532Z",{"nct_id":23,"title":24,"phases":25,"status":12,"updated_at":26,"content_modified":27},"NCT07076498","Engineered HSV-1 M032 for the Treatment of Children and Adults With Newly Diagnosed Diffuse Midline Glioma After Standard of Care Radiation",[19],"2026-08-26T02:16:36.513735Z","2026-05-05T02:43:27.816834Z",{"nct_id":29,"title":30,"phases":31,"status":12,"updated_at":33,"content_modified":34},"NCT05580562","ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)",[32],"Phase 3","2026-08-26T02:16:20.336282Z","2026-05-05T02:43:27.610964Z",{"nct_id":36,"title":37,"phases":38,"status":12,"updated_at":40,"content_modified":41},"NCT05099003","A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)",[39],"Phase 1\u002FPhase 2","2026-08-26T02:15:28.524219Z","2026-05-05T02:43:28.532137Z",{"nct_id":43,"title":44,"phases":45,"status":12,"updated_at":46,"content_modified":47},"NCT05009992","Combination Therapy for the Treatment of Diffuse Midline Gliomas",[11],"2026-08-26T02:16:51.982021Z","2026-05-05T02:43:28.301737Z",{"nct_id":49,"title":50,"phases":51,"status":12,"updated_at":52,"content_modified":53},"NCT06624371","Atovaquone Combined With Radiation in Children With Malignant Brain Tumors",[19],"2026-08-26T02:15:13.282904Z","2026-05-05T02:35:31.758752Z",{"nct_id":55,"title":56,"phases":57,"status":12,"updated_at":58,"content_modified":59},"NCT04541082","Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms",[19],"2026-08-26T02:18:37.277498Z","2026-05-05T02:43:29.163334Z",{"nct_id":61,"title":62,"phases":63,"status":12,"updated_at":64,"content_modified":65},"NCT05956821","Treatment of Relapsed\u002FRefractory Intracranial Glioma in Patients Under 22 Years of Age",[39],"2026-08-26T02:19:26.493949Z","2026-05-05T02:43:28.959675Z",{"nct_id":67,"title":68,"phases":69,"status":12,"updated_at":70,"content_modified":71},"NCT04870944","CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma",[39],"2026-08-03T02:31:11.254845Z","2026-05-05T02:43:27.478011Z",{"nct_id":73,"title":74,"phases":75,"status":12,"updated_at":76,"content_modified":77},"NCT03101813","International Diffuse Intrinsic Pontine Glioma (DIPG)\u002FDiffuse Midline Glioma (DMG) Registry and Repository",[],"2026-08-26T02:16:44.178623Z","2026-05-13T02:55:06.107366Z"]