[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"biomarker:her2-negative":3},{"name":4,"total":5,"recruiting":6,"trials":7},"ERBB2 Gene",239,210,[8,16,23,29,35,41,47,53,59,65,71,78,85,91,96,102,108,114,120,126,131,137,143,149,155,161,167,173,179,186,191,197,203,209,215,220,226,232,238,243,249,255,261,267,273,279,285,291,297,303],{"nct_id":9,"title":10,"phases":11,"status":13,"updated_at":14,"content_modified":15},"NCT07205822","A Study of Dato-DXd in Inoperable or Metastatic Hormone Receptor-positive, HER2 IHC 0 Breast Cancer",[12],"Phase 3","RECRUITING","2026-08-26T02:16:16.169331Z","2026-07-30T01:46:14.435695Z",{"nct_id":17,"title":18,"phases":19,"status":13,"updated_at":21,"content_modified":22},"NCT04230109","Sacituzumab Govitecan In TNBC",[20],"Phase 2","2026-08-26T02:15:00.557154Z","2026-07-19T19:36:05.114205Z",{"nct_id":24,"title":25,"phases":26,"status":13,"updated_at":27,"content_modified":28},"NCT05846789","SOC Chemotherapy +\u002F- Tocilizumab for Triple Negative and ER-low Breast Cancers",[20],"2026-08-26T02:18:45.196599Z","2026-07-05T05:32:16.815779Z",{"nct_id":30,"title":31,"phases":32,"status":13,"updated_at":33,"content_modified":34},"NCT05812807","Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab",[12],"2026-08-26T02:18:51.833592Z","2026-07-05T05:32:16.814326Z",{"nct_id":36,"title":37,"phases":38,"status":13,"updated_at":39,"content_modified":40},"NCT06797635","Study of Patritumab Deruxtecan Plus Pembrolizumab With Other Anticancer Agents in Participants With High-Risk Early-Stage Triple-Negative or Hormone Receptor-Low Positive\u002FHER-2 Negative Breast Cancer (MK-1022-010, HERTHENA-Breast-03)",[20],"2026-08-26T02:18:34.622081Z","2026-07-05T05:32:16.694743Z",{"nct_id":42,"title":43,"phases":44,"status":13,"updated_at":45,"content_modified":46},"NCT06757634","Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)",[12],"2026-08-26T02:15:54.846520Z","2026-07-05T05:32:16.692648Z",{"nct_id":48,"title":49,"phases":50,"status":13,"updated_at":51,"content_modified":52},"NCT07222215","PhII Randomized CAPecitabine + ELAcestrant vs. Capecitabine Alone in ER+ Breast Cancer (CAPELA)",[20],"2026-08-26T02:18:23.582895Z","2026-07-05T05:32:16.667982Z",{"nct_id":54,"title":55,"phases":56,"status":13,"updated_at":57,"content_modified":58},"NCT06841354","A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011\u002FTroFuse-011)",[12],"2026-08-26T02:18:59.761994Z","2026-06-16T05:54:07.924230Z",{"nct_id":60,"title":61,"phases":62,"status":13,"updated_at":63,"content_modified":64},"NCT07631000","A Study of Cadonilimab Combined With Chemotherapy in People With Gastric or Gastroesophageal Junction Cancer",[20],"2026-08-26T02:15:17.167444Z","2026-06-06T00:48:49.540654Z",{"nct_id":66,"title":67,"phases":68,"status":13,"updated_at":69,"content_modified":70},"NCT07492641","BGB-43395 Plus Letrozole Versus CDK4\u002F6i Plus Letrozole for Patients With Advanced or Metastatic HR+\u002FHER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease",[12],"2026-08-26T02:16:08.402952Z","2026-06-04T01:30:07.901883Z",{"nct_id":72,"title":73,"phases":74,"status":13,"updated_at":76,"content_modified":77},"NCT05989828","A2-ESO-1 TCR-Engineered T Cells for Relapsed\u002FRefractory Advanced or Metastatic NY-ESO-1 Overexpression Positive Triple Negative Breast Cancer",[75],"Phase 1","2026-08-26T02:16:21.385056Z","2026-05-29T15:36:40.167133Z",{"nct_id":79,"title":80,"phases":81,"status":13,"updated_at":83,"content_modified":84},"NCT07558733","Sapanisertib and Serabelisib (PIKTOR) in Various Combinations in Patients With HR+\u002FHER2- Advanced\u002FMetastatic Breast Cancer",[82],"Phase 1\u002FPhase 2","2026-08-26T02:17:45.190188Z","2026-05-13T02:55:06.724801Z",{"nct_id":86,"title":87,"phases":88,"status":13,"updated_at":89,"content_modified":90},"NCT05898399","Study of ART6043 in Advanced\u002FMetastatic Solid Tumors Patients (POLKA)",[82],"2026-08-26T02:17:32.059863Z","2026-05-13T02:55:06.392298Z",{"nct_id":92,"title":93,"phases":94,"status":13,"updated_at":51,"content_modified":95},"NCT06347068","Study of Autologous CAR-T Cells Targeting B7-H3 in TNBC iC9-CAR.B7-H3 T Cells",[75],"2026-05-05T02:47:14.272026Z",{"nct_id":97,"title":98,"phases":99,"status":13,"updated_at":100,"content_modified":101},"NCT07311993","Phase 1 Study of CLR 125 in Triple Negative Breast Cancer",[75],"2026-08-26T02:17:05.997056Z","2026-05-05T02:43:29.732695Z",{"nct_id":103,"title":104,"phases":105,"status":13,"updated_at":106,"content_modified":107},"NCT06507618","Pre-Operative Window of ET to Inform RT Decisions (POWER II)",[12],"2026-08-26T02:18:13.438956Z","2026-05-05T02:43:29.726692Z",{"nct_id":109,"title":110,"phases":111,"status":13,"updated_at":112,"content_modified":113},"NCT06042569","Dose-Reduced Docetaxel With Cyclophosphamide for the Treatment of Vulnerable Older Women With Stage I-III HER2 Negative Breast Cancer, the DOROTHY Trial",[20],"2026-08-26T02:19:29.922117Z","2026-05-05T02:43:29.722865Z",{"nct_id":115,"title":116,"phases":117,"status":13,"updated_at":118,"content_modified":119},"NCT06099769","A Study of Enzalutamide, Enzalutamide in Combination With Mifepristone, or Chemotherapy in People With Metastatic Breast Cancer",[20],"2026-08-26T02:17:47.813245Z","2026-05-05T02:43:29.707998Z",{"nct_id":121,"title":122,"phases":123,"status":13,"updated_at":124,"content_modified":125},"NCT06959537","A Phase Ib Study of Novel Combination (New) of Low Dose Oral CyclophoSphamide (s) to Potentiate Axatilimab (A) + Retifanlimab (R) in Treating Metastatic Triple Negative Breast Cancer (TNBC)",[75],"2026-08-26T02:17:55.355429Z","2026-05-05T02:43:29.697183Z",{"nct_id":127,"title":128,"phases":129,"status":13,"updated_at":83,"content_modified":130},"NCT04965064","Trial of Neratinib Plus Capecitabine in Subjects With HER2-Negative Metastatic Breast Cancer With Brain Metastases and Abnormally Active HER2 Signaling",[20],"2026-05-05T02:43:29.668617Z",{"nct_id":132,"title":133,"phases":134,"status":13,"updated_at":135,"content_modified":136},"NCT05508906","Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer",[75],"2026-08-26T02:15:33.331531Z","2026-05-05T02:43:29.666612Z",{"nct_id":138,"title":139,"phases":140,"status":13,"updated_at":141,"content_modified":142},"NCT06238921","Sacituzumab Govitecan and Zimberelimab w\u002FSRS in the Management of Metastatic Triple Negative Breast Cancer With Brain Metastases",[82],"2026-08-26T02:19:00.742020Z","2026-05-05T02:43:29.665620Z",{"nct_id":144,"title":145,"phases":146,"status":13,"updated_at":147,"content_modified":148},"NCT05996107","Study of Ribociclib Administered Concurrently With Postoperative Radiation Therapy in Patients With High-Risk, HR+\u002FHER2- Breast Cancer",[75],"2026-08-26T02:15:01.639696Z","2026-05-05T02:43:29.664904Z",{"nct_id":150,"title":151,"phases":152,"status":13,"updated_at":153,"content_modified":154},"NCT06105684","Phase II Single Arm Trial of Low Dose Capecitabine in Patients With Advanced Breast Cancer",[20],"2026-08-26T02:15:11.740957Z","2026-05-05T02:43:29.663539Z",{"nct_id":156,"title":157,"phases":158,"status":13,"updated_at":159,"content_modified":160},"NCT07227233","Artificial Intelligence and Machine Learning to Guide CDK4\u002F6 Inhibitor Rechallenge in Breast Cancer.",[20],"2026-08-26T02:15:02.712396Z","2026-05-05T02:43:29.537001Z",{"nct_id":162,"title":163,"phases":164,"status":13,"updated_at":165,"content_modified":166},"NCT06361940","Molecular Analyses to Predict Pathways of Endocrine Resistance Following Short Term Neoadjuvant Endocrine Treatment in Patients With Hormone Receptor-Positive HER2-negative Breast Cancer",[20],"2026-08-26T02:16:31.714843Z","2026-05-05T02:43:29.535954Z",{"nct_id":168,"title":169,"phases":170,"status":13,"updated_at":171,"content_modified":172},"NCT06110793","A Study of Lenvatinib, Pembrolizumab, and Fulvestrant in People With Breast Cancer",[82],"2026-08-26T02:16:13.426928Z","2026-05-05T02:43:29.534135Z",{"nct_id":174,"title":175,"phases":176,"status":13,"updated_at":177,"content_modified":178},"NCT07137871","Clinical Trial of Avasopasem in Patients With Metastatic Hormone Receptor Positive Breast Cancer With Progression on a CDK 4\u002F6 Inhibitor and Hormonal Therapy",[75],"2026-08-26T02:16:46.147215Z","2026-05-05T02:43:29.529779Z",{"nct_id":180,"title":181,"phases":182,"status":13,"updated_at":184,"content_modified":185},"NCT06435351","Personalized Dendritic Cell Vaccine Pilot for High Risk TNBC After Neoadjuvant Therapy",[183],"Early Phase 1","2026-08-26T02:15:46.655893Z","2026-05-05T02:43:29.524933Z",{"nct_id":187,"title":188,"phases":189,"status":13,"updated_at":165,"content_modified":190},"NCT05304962","FIH Study of RGT-419B Alone and With Endocrine Therapy in HR-Positive, HER2-Negative Advanced\u002FMetastatic Breast Cancer",[75],"2026-05-05T02:43:29.504873Z",{"nct_id":192,"title":193,"phases":194,"status":13,"updated_at":195,"content_modified":196},"NCT06875128","Evaluation of the Safety and Efficacy of Treatment w\u002FHigh Dose Melphalan Given Directly Into the Liver Followed by Treatment w\u002FApproved Cancer Treatment or Approved Cancer Treatment Alone in Patients w\u002F Metastatic Breast Cancer w\u002FLiver Dominant Disease",[20],"2026-08-26T02:16:42.787115Z","2026-05-05T02:43:29.495901Z",{"nct_id":198,"title":199,"phases":200,"status":13,"updated_at":201,"content_modified":202},"NCT07524855","A Study of HLD-0117 in Patients With Metastatic Breast Cancer",[75],"2026-08-26T02:16:52.995882Z","2026-05-05T02:43:29.411715Z",{"nct_id":204,"title":205,"phases":206,"status":13,"updated_at":207,"content_modified":208},"NCT06176261","DATO-BASE: DATOpotamab-deruxtecan for Breast Cancer Brain metAstaSEs",[20],"2026-08-26T02:15:37.042762Z","2026-05-05T02:43:29.387572Z",{"nct_id":210,"title":211,"phases":212,"status":13,"updated_at":213,"content_modified":214},"NCT07017673","Phase II Trial of Ivonescimab in Combination With Carboplatin + Docetaxel in Patients With Early-Stage Triple Negative Breast Cancer",[20],"2026-08-26T02:17:11.311767Z","2026-05-05T02:43:29.360234Z",{"nct_id":216,"title":217,"phases":218,"status":13,"updated_at":27,"content_modified":219},"NCT05837455","NeoTAILOR: ABiomarker-directed Approach to Guide Neoadjuvant Therapy for Patients With Stage II\u002FIII ER-positive, HER2-negative Breast Cancer",[20],"2026-05-05T02:43:29.334648Z",{"nct_id":221,"title":222,"phases":223,"status":13,"updated_at":224,"content_modified":225},"NCT05187832","A Study of AND019 in Women With ER Positive HER2 Negative Advanced or Metastatic Breast Cancer",[75],"2026-08-26T02:15:21.365312Z","2026-05-05T02:43:29.332539Z",{"nct_id":227,"title":228,"phases":229,"status":13,"updated_at":230,"content_modified":231},"NCT05491226","Reinvigorating TNBC Response to Immunotherapy With Combination Myeloid Inhibition and Radiation",[20],"2026-08-26T02:17:04.346841Z","2026-05-05T02:43:29.329083Z",{"nct_id":233,"title":234,"phases":235,"status":13,"updated_at":236,"content_modified":237},"NCT06016738","OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+\u002FHER2- Advanced Breast Cancer",[12],"2026-08-03T02:04:34.624671Z","2026-05-05T02:43:29.327475Z",{"nct_id":239,"title":240,"phases":241,"status":13,"updated_at":63,"content_modified":242},"NCT05900895","Estradiol Plus Olaparib for Breast Cancer (PHOEBE)",[75],"2026-05-05T02:43:29.321608Z",{"nct_id":244,"title":245,"phases":246,"status":13,"updated_at":247,"content_modified":248},"NCT07405801","A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer",[20],"2026-08-26T02:19:21.761002Z","2026-05-05T02:43:29.297943Z",{"nct_id":250,"title":251,"phases":252,"status":13,"updated_at":253,"content_modified":254},"NCT06377852","The CDK4\u002F6 Inhibitor Dosing Knowledge (CDK) Study",[12],"2026-08-26T02:16:59.895916Z","2026-05-05T02:43:29.227274Z",{"nct_id":256,"title":257,"phases":258,"status":13,"updated_at":259,"content_modified":260},"NCT05693766","Gene Signatures to Guide HR+MBC Therapy in a Diverse Cohort",[20],"2026-08-26T02:18:54.586325Z","2026-05-05T02:43:29.223810Z",{"nct_id":262,"title":263,"phases":264,"status":13,"updated_at":265,"content_modified":266},"NCT06525766","Adaptive Therapy With Capecitabine for Treatment of Metastatic ER Positive, HER2 Negative Breast Cancer",[20],"2026-08-26T02:16:39.977107Z","2026-05-05T02:43:29.196793Z",{"nct_id":268,"title":269,"phases":270,"status":13,"updated_at":271,"content_modified":272},"NCT06450873","Turkey Tail Mushroom for Treating Post-Menopausal Women With HER2-Negative ER-Positive Breast Cancer Undergoing Surgery",[20],"2026-08-26T02:17:51.502023Z","2026-05-05T02:43:29.186687Z",{"nct_id":274,"title":275,"phases":276,"status":13,"updated_at":277,"content_modified":278},"NCT07071038","Evaluating the Use of a Medication 'Switch' vs Guideline-directed Interventions for Relieving Side Effects of Aromatase Inhibitors Among Breast Cancer Patients",[20],"2026-08-26T02:15:58.452248Z","2026-05-05T02:43:29.183968Z",{"nct_id":280,"title":281,"phases":282,"status":13,"updated_at":283,"content_modified":284},"NCT03804944","Converting HR+ Breast Cancer Into an Individualized Vaccine",[20],"2026-08-26T02:17:44.240289Z","2026-05-05T02:43:29.133974Z",{"nct_id":286,"title":287,"phases":288,"status":13,"updated_at":289,"content_modified":290},"NCT05379595","A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer",[82],"2026-08-26T02:18:33.598205Z","2026-05-05T02:43:29.076898Z",{"nct_id":292,"title":293,"phases":294,"status":13,"updated_at":295,"content_modified":296},"NCT07287098","A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer",[20],"2026-08-26T02:19:16.454910Z","2026-05-05T02:43:29.072318Z",{"nct_id":298,"title":299,"phases":300,"status":13,"updated_at":301,"content_modified":302},"NCT05505643","Cryoablation vs Lumpectomy in T1 Breast Cancers",[],"2026-08-26T02:15:27.567165Z","2026-05-05T02:43:29.058231Z",{"nct_id":304,"title":305,"phases":306,"status":13,"updated_at":307,"content_modified":308},"NCT06062498","Elacestrant vs Elacestrant Plus a CDK4\u002F6 Inhibitor in Patients With ERpositive\u002FHER2-negative Advanced or Metastatic Breast Cancer",[20],"2026-08-26T02:18:08.005333Z","2026-05-05T02:43:29.019896Z"]