[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"biomarker:ubiquitin-protein-ligase-e3a":3},{"name":4,"total":5,"recruiting":5,"trials":6},"Ubiquitin-Protein Ligase E3A",7,[7,15,22,28,35,41,47],{"nct_id":8,"title":9,"phases":10,"status":12,"updated_at":13,"content_modified":14},"NCT05127226","HALOS: A Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Multiple Ascending Doses of ION582 in Participants With Angelman Syndrome",[11],"Phase 1\u002FPhase 2","RECRUITING","2026-08-03T01:55:52.940420Z","2026-05-05T02:43:28.177807Z",{"nct_id":16,"title":17,"phases":18,"status":12,"updated_at":20,"content_modified":21},"NCT07157254","A Safety and Efficacy Study of GTX-102 in Subjects With Deletion- or Nondeletion-type Angelman Syndrome (AS)",[19],"Phase 2","2026-08-26T02:15:39.267524Z","2026-05-05T02:43:28.075802Z",{"nct_id":23,"title":24,"phases":25,"status":12,"updated_at":26,"content_modified":27},"NCT07181837","A Phase 1\u002F2 Study of the Safety and Efficacy of MVX-220 in Angelman Syndrome",[11],"2026-08-26T02:18:26.932189Z","2026-04-29T02:57:57.156357Z",{"nct_id":29,"title":30,"phases":31,"status":12,"updated_at":33,"content_modified":34},"NCT06914609","REVEAL: A Phase 3 Study of ION582 in Angelman Syndrome",[32],"Phase 3","2026-08-26T02:17:59.904383Z","2026-04-29T02:57:57.142273Z",{"nct_id":36,"title":37,"phases":38,"status":12,"updated_at":39,"content_modified":40},"NCT07605429","BEACON - Phase III Clinical Study of Rugonersen in Angelman Syndrome.",[32],"2026-08-26T02:18:51.009190Z","2026-07-30T01:46:14.445861Z",{"nct_id":42,"title":43,"phases":44,"status":12,"updated_at":45,"content_modified":46},"NCT07417137","A Natural History Study of Angelman Syndrome",[],"2026-08-26T02:19:23.493898Z","2026-05-13T02:55:06.701341Z",{"nct_id":48,"title":49,"phases":50,"status":12,"updated_at":51,"content_modified":52},"NCT06585605","A Retrospective Survey-based Multicenter Study to Delineate the Molecular and Phenotypic Spectrum of Epilepsy-dyskinesia Syndromes",[],"2026-08-26T02:17:50.500039Z","2026-06-02T11:21:24.705937Z"]