[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"condition:malignant-glioma":3},{"name":4,"total":5,"recruiting":6,"trials":7,"biomarkers":312,"states":321},"Malignant Glioma",57,47,[8,16,23,30,37,43,49,55,61,67,73,79,85,91,97,103,109,115,121,127,133,139,145,151,158,164,169,175,181,187,193,199,205,211,217,223,229,235,240,246,251,257,263,269,275,281,287,293,300,306],{"nct_id":9,"title":10,"phases":11,"status":13,"updated_at":14,"content_modified":15},"NCT06838676","ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas",[12],"Phase 2","RECRUITING","2026-08-26T02:15:02.712396Z","2026-06-16T05:54:07.925383Z",{"nct_id":17,"title":18,"phases":19,"status":13,"updated_at":21,"content_modified":22},"NCT05768919","Study of Liposomal Curcumin in Combination With RT and TMZ in Patients With Newly Diagnosed High-Grade Gliomas",[20],"Phase 1\u002FPhase 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Pediatric Patients With Malignant Glioma and Other Advanced Solid Tumors",[20],"2026-08-26T02:18:55.570428Z","2026-05-05T02:43:28.849356Z",{"nct_id":50,"title":51,"phases":52,"status":13,"updated_at":53,"content_modified":54},"NCT04655404","A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion",[27],"2026-08-26T02:16:45.157238Z","2026-05-05T02:43:28.502559Z",{"nct_id":56,"title":57,"phases":58,"status":13,"updated_at":59,"content_modified":60},"NCT06072586","A Phase 0\u002F1 Study of BDTX-1535 in Recurrent High-Grade Glioma (rHGG) and Newly Diagnosed Glioblastoma (nGBM) Participants With EGFR Alterations or Fusions",[27],"2026-08-26T02:17:28.381459Z","2026-05-05T02:43:28.284426Z",{"nct_id":62,"title":63,"phases":64,"status":13,"updated_at":65,"content_modified":66},"NCT06428045","STARLITE for Unresectable High-Grade Gliomas",[34],"2026-08-26T02:17:33.002248Z","2026-05-05T02:43:27.244499Z",{"nct_id":68,"title":69,"phases":70,"status":13,"updated_at":71,"content_modified":72},"NCT06666712","Chronic CED of TPT for Recurrent Malignant Glioma",[34],"2026-08-26T02:17:29.353236Z","2026-05-05T02:43:26.959232Z",{"nct_id":74,"title":75,"phases":76,"status":13,"updated_at":77,"content_modified":78},"NCT06829173","Concurrent XRD-0394 With Radiation Therapy for High Grade Gliomas",[27],"2026-08-26T02:17:01.714035Z","2026-05-05T02:43:26.919119Z",{"nct_id":80,"title":81,"phases":82,"status":13,"updated_at":83,"content_modified":84},"NCT03122197","Study of Letrozole in Recurrent Gliomas",[27],"2026-08-26T02:15:30.699880Z","2026-05-05T02:43:26.772535Z",{"nct_id":86,"title":87,"phases":88,"status":13,"updated_at":89,"content_modified":90},"NCT07346144","Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma",[20],"2026-08-26T02:15:18.897219Z","2026-05-05T02:43:26.710503Z",{"nct_id":92,"title":93,"phases":94,"status":13,"updated_at":95,"content_modified":96},"NCT05030298","Preoperative Radiosurgery for the Treatment of High Grade Glioma, NeoGlioma Trial",[34],"2026-08-26T02:16:49.565137Z","2026-05-05T02:43:26.674548Z",{"nct_id":98,"title":99,"phases":100,"status":13,"updated_at":101,"content_modified":102},"NCT06528691","Entrectinib as a Single Agent in Upfront Therapy for Children \u003C3 Years of Age With NTRK1\u002F2\u002F3 or ROS1-FUSED CNS Tumors",[12],"2026-08-26T02:16:46.951087Z","2026-05-05T02:35:31.919545Z",{"nct_id":104,"title":105,"phases":106,"status":13,"updated_at":107,"content_modified":108},"NCT04573140","A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma 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Tumors",[34],"2026-08-26T02:19:28.327680Z","2026-07-05T05:32:16.792431Z",{"nct_id":128,"title":129,"phases":130,"status":13,"updated_at":131,"content_modified":132},"NCT06894979","Testing the Addition of an Anti-Cancer Drug, AZD1390, During Radiation Therapy for Newly Diagnosed High Grade Glioma, Diffuse Midline Glioma, or Diffuse Intrinsic Pontine Glioma",[34],"2026-08-03T00:59:21.983893Z","2026-07-05T05:32:16.705849Z",{"nct_id":134,"title":135,"phases":136,"status":13,"updated_at":137,"content_modified":138},"NCT06305910","CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG\u002FDIPG in Children and Young Adults",[34],"2026-08-26T02:16:01.079019Z","2026-05-05T02:43:29.586016Z",{"nct_id":140,"title":141,"phases":142,"status":13,"updated_at":143,"content_modified":144},"NCT05096481","PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma",[12],"2026-08-26T02:16:36.513735Z","2026-05-05T02:43:29.390899Z",{"nct_id":146,"title":147,"phases":148,"status":13,"updated_at":149,"content_modified":150},"NCT05843253","Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant",[12],"2026-08-26T02:19:31.671303Z","2026-05-05T02:43:29.388169Z",{"nct_id":152,"title":153,"phases":154,"status":13,"updated_at":156,"content_modified":157},"NCT03340506","Dabrafenib and\u002For Trametinib Rollover Study",[155],"Phase 4","2026-08-26T02:15:14.574786Z","2026-05-05T02:43:28.738043Z",{"nct_id":159,"title":160,"phases":161,"status":13,"updated_at":162,"content_modified":163},"NCT05099003","A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)",[20],"2026-08-26T02:15:28.524219Z","2026-05-05T02:43:28.532137Z",{"nct_id":165,"title":166,"phases":167,"status":13,"updated_at":107,"content_modified":168},"NCT06264388","DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) in Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma",[12],"2026-05-05T02:43:28.014856Z",{"nct_id":170,"title":171,"phases":172,"status":13,"updated_at":173,"content_modified":174},"NCT06504381","DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma",[20],"2026-08-26T02:18:51.009190Z","2026-05-05T02:43:27.510150Z",{"nct_id":176,"title":177,"phases":178,"status":13,"updated_at":179,"content_modified":180},"NCT07468136","Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas",[20],"2026-08-26T02:15:01.639696Z","2026-05-05T02:43:27.129909Z",{"nct_id":182,"title":183,"phases":184,"status":13,"updated_at":185,"content_modified":186},"NCT06624371","Atovaquone Combined With Radiation in Children With Malignant Brain Tumors",[34],"2026-08-26T02:15:13.282904Z","2026-05-05T02:35:31.758752Z",{"nct_id":188,"title":189,"phases":190,"status":13,"updated_at":191,"content_modified":192},"NCT06712875","MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas",[20],"2026-08-26T02:15:10.362237Z","2026-04-29T02:57:57.125147Z",{"nct_id":194,"title":195,"phases":196,"status":13,"updated_at":197,"content_modified":198},"NCT05278208","Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors",[20],"2026-08-26T02:18:21.216897Z","2026-07-24T01:27:14.928126Z",{"nct_id":200,"title":201,"phases":202,"status":13,"updated_at":203,"content_modified":204},"NCT06161974","Study of Olutasidenib and Temozolomide in HGG",[12],"2026-08-26T02:17:51.502023Z","2026-07-05T05:32:16.747418Z",{"nct_id":206,"title":207,"phases":208,"status":13,"updated_at":209,"content_modified":210},"NCT06639607","PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma\u002FHigh-grade Glioma and Recurrent Diffuse Midline Glioma\u002FHigh-grade Glioma, Medulloblastoma, and Ependymoma",[20],"2026-08-03T00:58:26.564367Z","2026-07-05T05:32:16.689130Z",{"nct_id":212,"title":213,"phases":214,"status":13,"updated_at":215,"content_modified":216},"NCT07017816","A Phase 0\u002F1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies.",[27],"2026-08-26T02:17:32.059863Z","2026-05-05T02:43:27.319544Z",{"nct_id":218,"title":219,"phases":220,"status":13,"updated_at":221,"content_modified":222},"NCT04099797","C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)",[34],"2026-08-26T02:16:22.235886Z","2026-05-05T02:43:27.089113Z",{"nct_id":224,"title":225,"phases":226,"status":13,"updated_at":227,"content_modified":228},"NCT05698524","A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma",[34],"2026-08-26T02:17:20.511551Z","2026-05-05T02:35:31.632941Z",{"nct_id":230,"title":231,"phases":232,"status":13,"updated_at":233,"content_modified":234},"NCT05632562","Multiparametic Metabolic and Hypoxic PET\u002FMRI for Disease Assessment in High Grade Glioma",[27],"2026-08-26T02:17:00.709807Z","2026-05-05T02:43:29.229104Z",{"nct_id":236,"title":237,"phases":238,"status":13,"updated_at":47,"content_modified":239},"NCT07447531","T2 Star Magnetic Resonance Imaging and Biomarker Blood Testing to Predict the Change and Progress of Malignant Gliomas",[],"2026-05-05T02:43:27.391703Z",{"nct_id":241,"title":242,"phases":243,"status":13,"updated_at":244,"content_modified":245},"NCT05553041","18F-Fluciclovine PET-MRI in High-grade Glioma",[27],"2026-08-26T02:18:06.247899Z","2026-05-05T02:43:28.962637Z",{"nct_id":247,"title":248,"phases":249,"status":13,"updated_at":83,"content_modified":250},"NCT04485559","Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)",[34],"2026-06-17T19:21:16.686753Z",{"nct_id":252,"title":253,"phases":254,"status":13,"updated_at":255,"content_modified":256},"NCT06470711","Mapping of Electrical Properties in the Brain",[],"2026-08-26T02:17:27.435233Z","2026-05-13T02:55:06.492582Z",{"nct_id":258,"title":259,"phases":260,"status":13,"updated_at":261,"content_modified":262},"NCT06146738","The PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203)",[],"2026-08-26T02:15:15.642947Z","2026-05-13T02:55:06.419460Z",{"nct_id":264,"title":265,"phases":266,"status":13,"updated_at":267,"content_modified":268},"NCT06146725","The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202)",[],"2026-08-26T02:16:33.772093Z","2026-05-13T02:55:06.419270Z",{"nct_id":270,"title":271,"phases":272,"status":13,"updated_at":273,"content_modified":274},"NCT06118723","The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201)",[],"2026-08-26T02:18:02.701182Z","2026-05-13T02:55:06.416320Z",{"nct_id":276,"title":277,"phases":278,"status":13,"updated_at":279,"content_modified":280},"NCT05839379","Targeted Pediatric High-Grade Glioma Therapy",[],"2026-08-26T02:18:20.384845Z","2026-05-13T02:55:06.380433Z",{"nct_id":282,"title":283,"phases":284,"status":13,"updated_at":285,"content_modified":286},"NCT07210632","Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG)",[27],"2026-08-26T02:18:30.351130Z","2026-07-05T05:32:16.660346Z",{"nct_id":288,"title":289,"phases":290,"status":13,"updated_at":291,"content_modified":292},"NCT05717153","Intratumoral Extracellular Metabolic Impact of DFMO and AMXT 1501 in Patients With Diffuse or High Grade Glioma",[27],"2026-08-26T02:17:09.131534Z","2026-05-05T02:43:28.732512Z",{"nct_id":294,"title":295,"phases":296,"status":297,"updated_at":298,"content_modified":299},"NCT06946680","IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Newly Diagnosed and Recurrent Pediatric High-grade Glioma (pHGG) and Newly Diagnosed Diffuse Intrinsic Pontine Glioma (ndDIPG)",[34],"NOT_YET_RECRUITING","2026-08-26T02:17:52.450442Z","2026-05-29T15:36:40.176961Z",{"nct_id":301,"title":302,"phases":303,"status":297,"updated_at":304,"content_modified":305},"NCT07389278","Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG)",[20],"2026-08-26T02:18:12.612955Z","2026-05-05T02:43:28.503578Z",{"nct_id":307,"title":308,"phases":309,"status":297,"updated_at":310,"content_modified":311},"NCT07521657","Efficacy of Mirdametinib Alone or Combination With Radiotherapy for Germline and Sporadic NF1-Altered High-Grade Glioma",[12],"2026-08-26T02:19:25.538428Z","2026-05-05T02:43:27.841887Z",[313,317],{"biomarker":314,"count":315,"slug":316},"Histone H3 Lysine 28",5,"histone-h3-lysine-28",{"biomarker":318,"count":319,"slug":320},"IDH1 wt Allele",4,"idh1-wt-allele",[322,326,330,334,338,341,345,349,352,355,359,362,366,370,374,377,380,383,386,389,392,396],{"state":323,"count":324,"slug":325},"Ohio",16,"ohio",{"state":327,"count":328,"slug":329},"Texas",15,"texas",{"state":331,"count":332,"slug":333},"District of Columbia",14,"district-of-columbia",{"state":335,"count":336,"slug":337},"Florida",13,"florida",{"state":339,"count":336,"slug":340},"Pennsylvania","pennsylvania",{"state":342,"count":343,"slug":344},"Massachusetts",11,"massachusetts",{"state":346,"count":347,"slug":348},"Colorado",10,"colorado",{"state":350,"count":347,"slug":351},"Illinois","illinois",{"state":353,"count":347,"slug":354},"North Carolina","north-carolina",{"state":356,"count":357,"slug":358},"New 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