[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT00001645":3,"trial-entities:NCT00001645":96,"trial-summary:NCT00001645":104},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":9,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":23,"study_type":29,"primary_purpose":9,"phases":30,"enrollment_info":31,"interventions":34,"primary_outcomes":35,"secondary_outcomes":40,"sex":41,"minimum_age":42,"maximum_age":9,"healthy_volunteers":43,"eligibility_criteria":44,"std_ages":48,"locations":52,"central_contacts":69,"overall_officials":74,"references":77,"see_also_links":92},"NCT00001645","970096","Evaluation, Treatment and Monitoring of Patients With a Known or Suspected Parasitic Infection","Evaluation, Treatment, and Monitoring of Patients With Known or Suspected Parasitic Infection","RECRUITING",null,"2026-03-11","2026-07-28","1998-10-10","National Institute of Allergy and Infectious Diseases (NIAID)","NIH","The purpose of this study is to evaluate, treat and follow patients with parasitic infections.\n\nPeople with a known or suspected parasitic infection who are at least 1 year old may be enrolled. This study does not involve any experimental treatments.\n\nParticipants will have a physical examination and laboratory tests on blood, stool, or urine. Blood samples may be collected at regular intervals, but no more than 450 ml (15 ounces) of blood will be drawn from adults, and no more than 7 ml (1-1\u002F2 teaspoons) per kg (2.2 pounds) of body weight from children, in any 6-week period. Other tests may include x-rays, electrocardiogram (EKG), or tissue biopsy (surgical removal of a small tissue sample), depending on the individual s condition.\n\nPatients may be offered treatment or may be referred to another study that is more appropriate for the problem. Any treatment provided in this study will be according to standard medical practice for the patient s specific medical problem. Patients responses to treatment will be evaluated at regularly scheduled clinic visits. The length of time between visits and the total duration of the study for a given individual will be determined by the study doctor, based on that person s medical condition.","This study is designed as a prospective study to evaluate and treat patients with parasitic infection. Patients with known or suspected parasitic infection will be enrolled and will be evaluated for the presence of a parasitic infection. Minimal studies scheduled for each visit will include a medical history, physical examination, routine laboratory tests, and specialized diagnostic procedures for possible parasitic infections. Treatment plans will be individualized for each patient's particular condition, and the number and length of additional visits and diagnostic evaluations will vary accordingly. Specific treatment regimens will be in accordance with standard medical practice.",[18,19,20,21,22],"Malaria","Intestinal Worms","GI Protozoa","Echiniococcus","Strongyloides",[24,25,26,27,28],"Helminth Infection","Parasite","Known Parasitic Infection","Suspected Parasitic Infection","Natural History","OBSERVATIONAL",[],{"count":32,"type":33},800,"ESTIMATED",[],[36],{"measure":37,"description":38,"timeFrame":39},"The Laboratory of Parasitic Diseases has been conducting studies of the diagnosis, treatment, and pathogenesis of wide variety of parasitic infections.","Elimination of parasitic infection.","1 year",[],"ALL","3 Years",false,{"inclusion":45,"exclusion":46,"raw_text":47},[],[],"* INCLUSION CRITERIA:\n\nAge 3 or over.\n\nAccess to a primary medical care provider outside of the NIH\n\nClinical evidence suggestive of a parasitic infection\n\nEXCLUSION CRITERIA:\n\nLess than 3 years of age\n\nNo evidence suggestive of a parasitic infection",[49,50,51],"CHILD","ADULT","OLDER_ADULT",[53],{"facility":54,"status":8,"city":55,"state":56,"zip":57,"country":58,"contacts":59,"geoPoint":66},"National Institutes of Health Clinical Center","Bethesda","Maryland","20892","United States",[60],{"name":61,"role":62,"phone":63,"phoneExt":64,"email":65},"For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)","CONTACT","800-411-1222","TTY dial 711","ccopr@nih.gov",{"lat":67,"lon":68},38.98067,-77.10026,[70],{"name":71,"role":62,"phone":72,"email":73},"Thomas B Nutman, M.D.","(301) 496-5399","tnutman@mail.nih.gov",[75],{"name":71,"affiliation":13,"role":76},"PRINCIPAL_INVESTIGATOR",[78,82,85,88],{"pmid":79,"type":80,"citation":81},"27181117","BACKGROUND","Nutman TB. Human infection with Strongyloides stercoralis and other related Strongyloides species. Parasitology. 2017 Mar;144(3):263-273. doi: 10.1017\u002FS0031182016000834. Epub 2016 May 16.",{"pmid":83,"type":80,"citation":84},"26209897","O'Connell EM, Nutman TB. Eosinophilia in Infectious Diseases. Immunol Allergy Clin North Am. 2015 Aug;35(3):493-522. doi: 10.1016\u002Fj.iac.2015.05.003.",{"pmid":86,"type":80,"citation":87},"11389490","Nash TE, Ohl CA, Thomas E, Subramanian G, Keiser P, Moore TA. Treatment of patients with refractory giardiasis. Clin Infect Dis. 2001 Jul 1;33(1):22-8. doi: 10.1086\u002F320886. Epub 2001 May 23.",{"pmid":89,"type":90,"citation":91},"35617367","DERIVED","Corda M, Sciurba J, Blaha J, Mahanty S, Paredes A, Garcia HH, Nash TE, Nutman TB, O'Connell EM. A recombinant monoclonal-based Taenia antigen assay that reflects disease activity in extra-parenchymal neurocysticercosis. PLoS Negl Trop Dis. 2022 May 26;16(5):e0010442. doi: 10.1371\u002Fjournal.pntd.0010442. eCollection 2022 May.",[93],{"label":94,"url":95},"NIH Clinical Center Detailed Web Page","https:\u002F\u002Fclinicalstudies.info.nih.gov\u002Fcgi\u002Fdetail.cgi?A_1997-I-0096.html",{"nct_id":4,"conditions":97,"biomarkers":103},[98,20,99,100,18,101,102],"Echinococcosis","Helminthiasis","Intestinal worm","Parasitic Infection","Strongyloidiasis",[],{"nct_id":4,"found":105,"summary":106,"prompt_version":116},true,{"design":107,"status":108,"heading":109,"summary":110,"follow_up":111,"word_count":112,"commitments":113,"compensation":114,"drugs_mentioned":115},"This is an observational study designed to evaluate and treat patients with parasitic infections. It plans to enroll 800 participants.","completed","Observational Study of Parasitic Infections","This study aims to understand, treat, and monitor people with known or suspected parasitic infections like malaria or intestinal worms. There are no experimental treatments involved. You may be eligible if you are at least 3 years old and have signs of a parasitic infection. The study will involve physical exams, lab tests on blood, stool, or urine, and possibly X-rays or tissue biopsies. The main goal is to evaluate how well the Laboratory of Parasitic Diseases studies the diagnosis, treatment, and development of these infections over one year. The current recruitment status is unclear.","The primary endpoint is measured at 1 year, suggesting follow-up for at least that duration.",95,"You will have medical histories, physical exams, routine lab tests, and specialized diagnostic procedures. Treatment plans and the number of visits will vary based on your condition.","Not stated in the trial record.",[],"v2"]