[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT00047996":3,"trial-entities:NCT00047996":82,"trial-summary:NCT00047996":86},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":9,"brief_summary":15,"detailed_description":15,"conditions":16,"keywords":18,"study_type":29,"primary_purpose":9,"phases":30,"enrollment_info":31,"interventions":34,"primary_outcomes":35,"secondary_outcomes":38,"sex":39,"minimum_age":40,"maximum_age":41,"healthy_volunteers":42,"eligibility_criteria":43,"std_ages":47,"locations":50,"central_contacts":68,"overall_officials":69,"references":73,"see_also_links":78},"NCT00047996","030015","Blood Collection for Research Related to Certain Diseases Involving Blood Vessels","Human Specimen Collection to Support Basic and Clinical Research","ENROLLING_BY_INVITATION",null,"2026-07-21","2026-07-30","2002-11-04","National Heart, Lung, and Blood Institute (NHLBI)","NIH","The collection of human specimens from both patients and healthy volunteers is necessary for the development of laboratory assays to further basic and clinical research studies. This protocol defines the purposes for which specimens will be collected and establishes general conditions under which sample collection will be performed.",[17],"Sickle Cell Disease",[19,20,21,22,23,24,25,26,27,28],"DNA","Endothelial Function","Leukocyte Gene Expression","RNA","Natural History","Sickle Cell","Coronary Artery Disease","CAD","Healthy Volunteer","HV","OBSERVATIONAL",[],{"count":32,"type":33},2000,"ESTIMATED",[],[36],{"measure":37},"evaluating the role of nitric oxide, inflammatory mediators, and endothelial function in inflammatory diseases of the vasculature such as sickle cell disease, coronary artery disease, pulmonary vascular or advanced lung disease, malaria, and sep...",[],"ALL","18 Years","100 Years",true,{"inclusion":44,"exclusion":45,"raw_text":46},[],[],"* INCLUSION CRITERIA:\n\nMales or females of age 18 years and older can be included in the study.\n\nEXCLUSION CRITERIA:\n\nIndividuals without sickle cell disease or other chronic anemias who wish to donate blood will be excluded if the hemoglobin is less than 10 g\u002FdL for women or less than 12g\u002FdL for men.\n\nIndividuals with sickle cell disease or other chronic anemias will be excluded from donating blood samples if the hemoglobin is less than 6 g\u002FdL.\n\nA participant s most recent CBC result, obtained in the past 12 months, will be used to determine eligibility.\n\nThere are no exclusion criteria for participants donating urine.",[48,49],"ADULT","OLDER_ADULT",[51,60],{"facility":52,"city":53,"state":54,"zip":55,"country":56,"geoPoint":57},"National Institutes of Health Clinical Center","Bethesda","Maryland","20892","United States",{"lat":58,"lon":59},38.98067,-77.10026,{"facility":61,"city":62,"state":63,"zip":64,"country":56,"geoPoint":65},"INOVA Fairfax Hosptial","Fairfax","Virginia","22042",{"lat":66,"lon":67},38.84622,-77.30637,[],[70],{"name":71,"affiliation":13,"role":72},"Swee Lay Thein, M.D.","PRINCIPAL_INVESTIGATOR",[74],{"pmid":75,"type":76,"citation":77},"33661274","DERIVED","Tumburu L, Ghosh-Choudhary S, Seifuddin FT, Barbu EA, Yang S, Ahmad MM, Wilkins LHW, Tunc I, Sivakumar I, Nichols JS, Dagur PK, Yang S, Almeida LEF, Quezado ZMN, Combs CA, Lindberg E, Bleck CKE, Zhu J, Shet AS, Chung JH, Pirooznia M, Thein SL. Circulating mitochondrial DNA is a proinflammatory DAMP in sickle cell disease. Blood. 2021 Jun 3;137(22):3116-3126. doi: 10.1182\u002Fblood.2020009063.",[79],{"label":80,"url":81},"NIH Clinical Center Detailed Web Page","https:\u002F\u002Fclinicalstudies.info.nih.gov\u002Fcgi\u002Fdetail.cgi?A_2003-H-0015.html",{"nct_id":4,"conditions":83,"biomarkers":85},[84,25,27,17],"Chronic anemia",[],{"nct_id":4,"found":87,"summary":9,"prompt_version":9},false]