[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT00338065":3,"trial-entities:NCT00338065":90,"trial-summary:NCT00338065":96},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":19,"study_type":20,"primary_purpose":21,"phases":22,"enrollment_info":24,"interventions":27,"primary_outcomes":41,"secondary_outcomes":46,"sex":47,"minimum_age":48,"maximum_age":49,"healthy_volunteers":50,"eligibility_criteria":51,"std_ages":61,"locations":65,"central_contacts":75,"overall_officials":76,"references":81,"see_also_links":89},"NCT00338065","Vanderbilt IRB# 010436","External Influences Upon Ocular Homeostasis","ENROLLING_BY_INVITATION","2027-12","2025-12","2025-12-29","2006-06","Vanderbilt University Medical Center","OTHER",false,"Our experiments are designed to test the overall hypothesis that position-dependent or water-dependent intra-ocular pressure (IOP) spikes occur in humans, and that these challenge ocular homeostasis.","Glaucoma is the second leading cause of blindness in the United States, yet its pathogenesis is poorly understood. This is an insidious disorder since the loss of peripheral vision which occurs first usually is not noticed by the victim. Approximately 1 million people in the United States have glaucoma, but are not aware of it. Glaucoma is not always associated with elevated intraocular pressures so that vision screenings which measure just intraocular pressure without assessing the optic nerve will also miss these patients with glaucomatous damage. Therefore, patients are often diagnosed only when they have severe irreversible vision loss. Vascular insufficiency or abnormal autoregulation versus mechanical pressure damage has been proposed as a major factor in the development of glaucoma. Presently, therapy is based upon lowering intraocular pressure. If a contributing intermittent pressure elevation factor can be elucidated and characterized, specific treatment modalities may then be developed and their effectiveness can be monitored.",[18],"Intraocular Pressure",[18],"INTERVENTIONAL","BASIC_SCIENCE",[23],"NA",{"count":25,"type":26},200,"ESTIMATED",[28,37],{"type":29,"name":30,"description":31,"armGroupLabels":32},"BEHAVIORAL","Postural change","Intraocular pressures, blood pressures, and retinal thicknesses are measured with postural changes",[33,34,35,36],"Normal subjects","Primary open-angle glaucoma subjects","Subjects with autonomic dysfunction","Subjects with normal-pressure glaucoma",{"type":29,"name":38,"description":39,"armGroupLabels":40},"Water drinking","Intraocular pressures, blood pressures, and retinal thicknesses are measured with water drinking.",[33,34,35,36],[42],{"measure":43,"description":44,"timeFrame":45},"Change in Intraocular Pressure","A change in intraocular pressure is measured after change in posture or drinking water.","Within 1 day",[],"ALL","10 Years","90 Years",true,{"inclusion":52,"exclusion":56,"raw_text":60},[53,54,55,33],"Patients with autonomic dysfunction","Patients with open-angle glaucoma","Patients with normal-pressure glaucoma",[57,58,59],"Medical students","Prisoners","Pregnant women","Inclusion Criteria:\n\n* Patients with autonomic dysfunction\n* Patients with open-angle glaucoma\n* Patients with normal-pressure glaucoma\n* Normal subjects\n\nExclusion criteria:\n\n* Medical students\n* Prisoners\n* Pregnant women",[62,63,64],"CHILD","ADULT","OLDER_ADULT",[66],{"facility":67,"city":68,"state":69,"zip":70,"country":71,"geoPoint":72},"Vanderbilt University","Nashville","Tennessee","37232","United States",{"lat":73,"lon":74},36.16589,-86.78444,[],[77],{"name":78,"affiliation":79,"role":80},"Karen Joos, MD,PhD","Vanderbilt Eye Institute","PRINCIPAL_INVESTIGATOR",[82,86],{"pmid":83,"type":84,"citation":85},"23622564","RESULT","Phillips L, Robertson D, Melson MR, Garland EM, Joos KM. Pediatric ptosis as a sign of treatable autonomic dysfunction. Am J Ophthalmol. 2013 Aug;156(2):370-374.e2. doi: 10.1016\u002Fj.ajo.2013.03.009. Epub 2013 Apr 24.",{"pmid":87,"type":84,"citation":88},"33947782","Shibao CA, Joos K, Phillips JA 3rd, Cogan J, Newman JH, Hamid R, Meiler J, Capra J, Sheehan J, Vetrini F, Yang Y, Black B, Diedrich A, Roberston D, Biaggioni I. Familial Autonomic Ganglionopathy Caused by Rare CHRNA3 Genetic Variants. Neurology. 2021 Jul 13;97(2):e145-e155. doi: 10.1212\u002FWNL.0000000000012143. Epub 2021 May 4.",[],{"nct_id":4,"conditions":91,"biomarkers":95},[92,18,93,94],"Disorder of autonomic nervous system","Low tension glaucoma","Open Angle Glaucoma",[],{"nct_id":4,"found":14,"summary":97,"prompt_version":97},null]