[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT00983463":3,"trial-entities:NCT00983463":80,"trial-summary:NCT00983463":84},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":26,"primary_purpose":17,"phases":27,"enrollment_info":28,"interventions":31,"primary_outcomes":32,"secondary_outcomes":38,"sex":39,"minimum_age":40,"maximum_age":41,"healthy_volunteers":15,"eligibility_criteria":42,"std_ages":53,"locations":56,"central_contacts":66,"overall_officials":67,"references":74,"see_also_links":79},"NCT00983463","IRB #090657","Abundance and Distribution of Lipids and Proteins in Nonalcoholic Fatty Liver Disease (NAFLD)","Relative Abundance and Spatial Distribution of Lipids and Proteins in Nonalcoholic Fatty Liver Disease (NAFLD)","ENROLLING_BY_INVITATION","2026-11","2025-12","2025-12-18","2009-10","Vanderbilt University","OTHER",false,"Nonalcoholic fatty liver disease (NAFLD) is the most common type of liver disease in the United States. The incidence of NAFLD is very similar to that of obesity, type 2 diabetes, and the metabolic syndrome. The investigators hypothesize that there may be a relationship between over-nutrition, decreased physical activity and the development of fatty liver. The purpose of this study is to identify the types of fats and proteins, and the quantity of each, that are associated with increased severity of NAFLD.",null,[19],"Nonalcoholic Fatty Liver Disease",[21,22,23,24,25],"Nonalcoholic fatty liver disease (NAFLD)","Nonalcoholic steatohepatitis (NASH)","Obesity","Lipidomics","Proteomics","OBSERVATIONAL",[],{"count":29,"type":30},45,"ESTIMATED",[],[33,36],{"measure":34,"timeFrame":35},"To identify and relatively quantify, using high performance liquid chromatography electrospray ionization mass spectrometry, select lipids and proteins present in human liver biopsies.","2 years",{"measure":37,"timeFrame":35},"To spatially profile, using matrix assisted laser desorption ionization time of flight mass spectrometry, select lipids and proteins present in human liver biopsies.",[],"FEMALE","18 Years","65 Years",{"inclusion":43,"exclusion":47,"raw_text":52},[44,45,46],"18-65 year of age","Undergoing elective abdominal or bariatric surgery","May have normal or elevated ALT\u002FAST levels",[48,49,50,51],"Presence of viral hepatitis","Significant alcohol use","Intercurrent infections","Use of any thiazolidinediones","Inclusion Criteria:\n\n* 18-65 year of age\n* Undergoing elective abdominal or bariatric surgery\n* May have normal or elevated ALT\u002FAST levels\n\nExclusion Criteria:\n\n* Presence of viral hepatitis\n* Significant alcohol use\n* Intercurrent infections\n* Use of any thiazolidinediones",[54,55],"ADULT","OLDER_ADULT",[57],{"facility":58,"city":59,"state":60,"zip":61,"country":62,"geoPoint":63},"Vanderbilt University Medical Center","Nashville","Tennessee","37232","United States",{"lat":64,"lon":65},36.16589,-86.78444,[],[68,71],{"name":69,"affiliation":58,"role":70},"Charles R Flynn, PhD","PRINCIPAL_INVESTIGATOR",{"name":72,"affiliation":58,"role":73},"Najji Abumrad, MD","STUDY_CHAIR",[75],{"pmid":76,"type":77,"citation":78},"26599819","DERIVED","Garcia AE, Kasim N, Tamboli RA, Gonzalez RS, Antoun J, Eckert EA, Marks-Shulman PA, Dunn J, Wattacheril J, Wallen T, Abumrad NN, Flynn CR. Lipoprotein Profiles in Class III Obese Caucasian and African American Women with Nonalcoholic Fatty Liver Disease. PLoS One. 2015 Nov 23;10(11):e0142676. doi: 10.1371\u002Fjournal.pone.0142676. eCollection 2015.",[],{"nct_id":4,"conditions":81,"biomarkers":83},[19,82,23],"Nonalcoholic Steatohepatitis",[],{"nct_id":4,"found":15,"summary":17,"prompt_version":17}]