[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT01499394":3,"trial-entities:NCT01499394":519,"trial-summary:NCT01499394":523},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":22,"study_type":28,"primary_purpose":29,"phases":30,"enrollment_info":31,"interventions":34,"primary_outcomes":35,"secondary_outcomes":43,"sex":57,"minimum_age":58,"maximum_age":29,"healthy_volunteers":59,"eligibility_criteria":60,"std_ages":69,"locations":72,"central_contacts":508,"overall_officials":512,"references":517,"see_also_links":518},"NCT01499394","TCBIO-001-0710","Caris Biorepository Research Protocol","The Caris Biorepository Research Protocol","RECRUITING","2035-11","2026-01","2026-01-21","2010-11","Caris Science, Inc.","INDUSTRY",false,"The Biorepository for Caris Life Sciences is designed for the purpose of making quality biospecimens and associated clinical data available for research studies related to advancing precision medicine and improving care for patients.\n\nThe Caris Biorepository is a repository of prospectively collected biological specimens and associated clinical and demographic data gathered from multiple sources to be stored, used and shared for research. Caris Life Sciences will maintain the data and specimens and will control access to and use of the information and specimens by multiple individuals for multiple purposes which may evolve over time.","The Caris Biorepository is an effort toward defining the future of medicine incorporating the discoveries of the genomic era by providing physicians, researchers and scientists access to quality human specimens and data aimed at improving human health and fighting disease. This will be accomplished through acquiring and sharing valuable biospecimen information and clinical outcomes in a collaborative, secure environment. The Caris Biorepository will bridge the gap and correlate human specimens with clinical and specimen data valuable to multiple and varying entities interested in advancing science with precision medicine by targeting disease treatments.\n\nThe objective of this project is to develop and implement a state-of-the-science Biorepository that ensures molecular integrity and clinical relevance of human biospecimens used in research and clinical medicine. The Caris Biorepository will also provide vital biospecimens and data to internal researchers and external research collaborators such as government, academia and industry collaborators for the use of drug development discoveries, clinically relevant research trials, publications and posters, and the implementation of future healthcare policies. This project may also impact characterization of trends in practice patterns and their relation to patient outcomes as well as the economic implications of differing evaluation, treatment and management paradigms.",[19,20,21],"Cancer","Early Detection of Cancer","Minimal Residual Disease",[23,24,25,26,27],"Caris Biorepository","MCED","Early Detection","MRD","Pan-Cancer","OBSERVATIONAL",null,[],{"count":32,"type":33},100000,"ESTIMATED",[],[36,40],{"measure":37,"description":38,"timeFrame":39},"Develop biorepository that ensures molecular integrity and clinical relevance of quality human biospecimens and associated clinical data.","Retention of biospecimen samples with DNA","35 years",{"measure":41,"description":42,"timeFrame":39},"Implement release of specimens from biorepository for testing","Research for the purposes of cancer laboratory diagnostic tests.",[44,47,49,51,53,55],{"measure":45,"description":46,"timeFrame":39},"Laboratory testing","DNA and RNA microarray",{"measure":45,"description":48,"timeFrame":39},"Immunohistochemistry",{"measure":45,"description":50,"timeFrame":39},"Gene and protein expression, proteomics and matabolomics",{"measure":45,"description":52,"timeFrame":39},"Mutation analysis",{"measure":45,"description":54,"timeFrame":39},"Experiemental lab testing for development of new diagnostic technology",{"measure":45,"description":56,"timeFrame":39},"Microvesicle discovery, characterization and validation.","ALL","18 Years",true,{"inclusion":61,"exclusion":64,"raw_text":68},[62,63],"18 years of age or older","Capacity to provide informed consent",[65,66,67],"Due to the complexity of state and federal requirements governing the participation of prisoners in research, prisoners-patients will not be approached for participation in the Caris Biorepository.","Minor subjects will not be included in the Caris Biorepository, as it is possible biospecimens and data may be stored beyond the time limitations of assent and it may be impracticable to re-consent these subjects once they become adults.","Individuals who lack the capacity to give informed consent","Inclusion Criteria:\n\n* 18 years of age or older\n* Capacity to provide informed consent\n\nExclusion Criteria:\n\n* Due to the complexity of state and federal requirements governing the participation of prisoners in research, prisoners-patients will not be approached for participation in the Caris Biorepository.\n* Minor subjects will not be included in the Caris Biorepository, as it is possible biospecimens and data may be stored beyond the time limitations of assent and it may be impracticable to re-consent these subjects once they become adults.\n* Individuals who lack the capacity to give informed consent",[70,71],"ADULT","OLDER_ADULT",[73,87,99,111,122,130,142,153,164,175,186,198,209,220,232,245,257,268,279,291,299,311,322,330,342,354,366,377,389,402,413,425,437,448,461,473,484,496],{"facility":74,"status":8,"city":75,"state":76,"country":77,"contacts":78,"geoPoint":84},"University of South Alabama","Mobile","Alabama","United States",[79],{"name":80,"role":81,"phone":82,"email":83},"Tiffany Fulford","CONTACT","251-445-3276","tnfulford@health.southalabama.edu",{"lat":85,"lon":86},30.69436,-88.04305,{"facility":88,"status":8,"city":89,"state":90,"country":77,"contacts":91,"geoPoint":96},"Southwest Medical Imaging","Scottsdale","Arizona",[92],{"name":93,"role":81,"phone":94,"email":95},"Emily Crampton","480-425-4055","ECrampton@esmil.com",{"lat":97,"lon":98},33.50921,-111.89903,{"facility":100,"status":8,"city":101,"state":102,"country":77,"contacts":103,"geoPoint":108},"St. Bernards Medical Center","Jonesboro","Arkansas",[104],{"name":105,"role":81,"phone":106,"email":107},"Dashae King","870-207-8157","dlking@sbrmc.org",{"lat":109,"lon":110},35.8423,-90.70428,{"facility":112,"status":8,"city":113,"state":102,"country":77,"contacts":114,"geoPoint":119},"CARTI Cancer Center","Little Rock",[115],{"name":116,"role":81,"phone":117,"email":118},"Jesse Byrd","501-561-2205","Jesse.Byrd@Carti.com",{"lat":120,"lon":121},34.74648,-92.28959,{"facility":123,"status":8,"city":113,"state":102,"country":77,"contacts":124,"geoPoint":129},"ObjectiveHealth - ARcare Center for Clinical Research",[125],{"name":126,"role":81,"phone":127,"email":128},"Cynthia Whitcomb","501-214-0372","Cynthia.Whitcomb@objective.health",{"lat":120,"lon":121},{"facility":131,"status":8,"city":132,"state":133,"country":77,"contacts":134,"geoPoint":139},"Lee Memorial Health System","Fort Myers","Florida",[135],{"name":136,"role":81,"phone":137,"email":138},"Juliana Turner","239-343-9660","juliana.turner@leehealth.org",{"lat":140,"lon":141},26.62168,-81.84059,{"facility":143,"status":8,"city":144,"state":133,"country":77,"contacts":145,"geoPoint":150},"Cancer Care of North Florida","Lake City",[146],{"name":147,"role":81,"phone":148,"email":149},"Natalie Espenship","386-755-1655","Natalie.Espenship@cancercareofnorthflorida.com",{"lat":151,"lon":152},30.18968,-82.63929,{"facility":154,"status":8,"city":155,"state":133,"country":77,"contacts":156,"geoPoint":161},"Advent Health","Orlando",[157],{"name":158,"role":81,"phone":159,"email":160},"Corina Mattix","407-303-1327","Corina.Mattix@AdventHealth.com",{"lat":162,"lon":163},28.53834,-81.37924,{"facility":165,"status":8,"city":166,"state":133,"country":77,"contacts":167,"geoPoint":172},"The University of South Florida","Tampa",[168],{"name":169,"role":81,"phone":170,"email":171},"Brittney Short","727-612-4026","bborresen@tgh.org",{"lat":173,"lon":174},27.94752,-82.45843,{"facility":176,"status":8,"city":177,"state":133,"country":77,"contacts":178,"geoPoint":183},"Cleveland Clinic Florida","Weston",[179],{"name":180,"role":81,"phone":181,"email":182},"Brianna Hammond","954-487-2257","HAMMONB7@ccf.org",{"lat":184,"lon":185},26.10037,-80.39977,{"facility":187,"status":8,"city":188,"state":189,"zip":190,"country":77,"contacts":191,"geoPoint":195},"Phoebe Putney Memorial Hospital","Albany","Georgia","31701",[192],{"name":193,"role":81,"phone":194},"Cathy Shoemaker, OCN CBCN","229-312-0354",{"lat":196,"lon":197},31.57851,-84.15574,{"facility":199,"status":8,"city":200,"state":189,"country":77,"contacts":201,"geoPoint":206},"Emory University","Atlanta",[202],{"name":203,"role":81,"phone":204,"email":205},"Sharon Egbue-Ojirogbe","404-778-8027","cegbueo@emory.edu",{"lat":207,"lon":208},33.749,-84.38798,{"facility":210,"status":8,"city":211,"state":189,"country":77,"contacts":212,"geoPoint":217},"Augusta University Research Institute","Augusta",[213],{"name":214,"role":81,"phone":215,"email":216},"Alexander Ward","706-721-1623","ALWARD@augusta.edu",{"lat":218,"lon":219},33.47097,-81.97484,{"facility":221,"status":8,"city":222,"state":189,"country":77,"contacts":223,"geoPoint":229},"Cancer Center of Middle Georgia","Dublin",[224],{"name":225,"role":81,"phone":226,"phoneExt":227,"email":228},"Audrey Bryan","478-272-8266","321","research@ccmgeorgia.com",{"lat":230,"lon":231},32.54044,-82.90375,{"facility":233,"status":8,"city":234,"state":235,"country":77,"contacts":236,"geoPoint":242},"Hope and Healing Cancer Services","Hinsdale","Illinois",[237],{"name":238,"role":81,"phone":239,"phoneExt":240,"email":241},"Ava Baftirovska","630 560 0121","107","abaftirovska@hopenheal.care",{"lat":243,"lon":244},41.80086,-87.93701,{"facility":246,"status":8,"city":247,"state":248,"country":77,"contacts":249,"geoPoint":254},"CHRISTUS - St. Frances Cabrini Hospital","Alexandria","Louisiana",[250],{"name":251,"role":81,"phone":252,"email":253},"Crystal Dubois","318-528-5137","crystal.dubois2@christushealth.org",{"lat":255,"lon":256},31.31129,-92.44514,{"facility":258,"status":8,"city":259,"state":248,"country":77,"contacts":260,"geoPoint":265},"Tulane University","New Orleans",[261],{"name":262,"role":81,"phone":263,"email":264},"Priya Bhandari","504-988-6053","pbhandari@tulane.edu",{"lat":266,"lon":267},29.95465,-90.07507,{"facility":269,"status":8,"city":270,"state":248,"country":77,"contacts":271,"geoPoint":276},"CHRISTUS - Highland Medical Center","Shreveport",[272],{"name":273,"role":81,"phone":274,"email":275},"Thea Spencer","318-681-6007","thea.spencer@christushealth.org",{"lat":277,"lon":278},32.52515,-93.75018,{"facility":280,"status":8,"city":281,"state":282,"country":77,"contacts":283,"geoPoint":288},"Mercy Medical Center","Baltimore","Maryland",[284],{"name":285,"role":81,"phone":286,"email":287},"Rhiannon Kim","410-951-7908","rkim1@mdmercy.com",{"lat":289,"lon":290},39.29038,-76.61219,{"facility":292,"status":8,"city":281,"state":282,"country":77,"contacts":293,"geoPoint":298},"Sinai Hospital of Baltimore",[294],{"name":295,"role":81,"phone":296,"email":297},"Pamela Nickoles","410-601-6120","Pnickole@lifebridgehealth.org",{"lat":289,"lon":290},{"facility":300,"status":8,"city":301,"state":302,"country":77,"contacts":303,"geoPoint":308},"Hattiesburg Clinic","Hattiesburg","Mississippi",[304],{"name":305,"role":81,"phone":306,"email":307},"Gloria Simmons","601-288-2494","Gloria.Simmons@forrestgeneral.com",{"lat":309,"lon":310},31.32712,-89.29034,{"facility":312,"status":8,"city":313,"state":302,"country":77,"contacts":314,"geoPoint":319},"Jackson Oncology Associates","Jackson",[315],{"name":316,"role":81,"phone":317,"email":318},"Teresa Davis","601-974-5547","tdavis@jacksononcology.com",{"lat":320,"lon":321},32.29876,-90.18481,{"facility":323,"status":8,"city":313,"state":302,"country":77,"contacts":324,"geoPoint":329},"University of Mississippi Medical Center",[325],{"name":326,"role":81,"phone":327,"email":328},"Tanya Robinson","601-815-2123","trobinson13@umc.edu",{"lat":320,"lon":321},{"facility":331,"status":8,"city":332,"state":333,"country":77,"contacts":334,"geoPoint":339},"ObjectiveHealth - Premier Health Research","Sparta","New Jersey",[335],{"name":336,"role":81,"phone":337,"email":338},"Lori Walsh","862-294-0418","Lori.Walsh@objective.health",{"lat":340,"lon":341},41.03343,-74.63849,{"facility":343,"status":8,"city":344,"state":345,"country":77,"contacts":346,"geoPoint":351},"CHRISTUS - St. Vincent Regional Cancer Center","Santa Fe","New Mexico",[347],{"name":348,"role":81,"phone":349,"email":350},"MiQuela Gutierrez","505-913-8822","Miquela.Gutierrez@stvin.org",{"lat":352,"lon":353},35.68698,-105.9378,{"facility":355,"status":8,"city":356,"state":357,"country":77,"contacts":358,"geoPoint":363},"St. Lawrence Health System","Potsdam","New York",[359],{"name":360,"role":81,"phone":361,"email":362},"McKenna Boula","315-261-6319","McKenna.Boula@rochesterregional.org",{"lat":364,"lon":365},44.66978,-74.98131,{"facility":367,"status":8,"city":368,"state":357,"country":77,"contacts":369,"geoPoint":374},"National Translational Research Group","Ridge",[370],{"name":371,"role":81,"phone":372,"email":373},"Stella Smaragdas","631-675-5103","ssmaragdas@nycancer.com",{"lat":375,"lon":376},40.89399,-72.89594,{"facility":378,"status":8,"city":379,"state":380,"country":77,"contacts":381,"geoPoint":386},"Altru Health System","Grand Forks","North Dakota",[382],{"name":383,"role":81,"phone":384,"email":385},"Alexis Tatum","701-780-1563","ATATUM@altru.org",{"lat":387,"lon":388},47.92526,-97.03285,{"facility":390,"status":8,"city":391,"state":392,"country":77,"contacts":393,"geoPoint":399},"NEO Urology Associates","Boardman","Ohio",[394],{"name":395,"role":81,"phone":396,"phoneExt":397,"email":398},"Tina Picino","330-729-9214","240","tpicino@neourology.com",{"lat":400,"lon":401},41.02423,-80.66285,{"facility":403,"status":8,"city":404,"state":392,"country":77,"contacts":405,"geoPoint":410},"Great Lakes Medical Research","Cleveland",[406],{"name":407,"role":81,"phone":408,"email":409},"Cortney Vazquez","216-372-0505","cvazquez@thectnx.com",{"lat":411,"lon":412},41.4995,-81.69541,{"facility":414,"status":8,"city":415,"state":416,"country":77,"contacts":417,"geoPoint":422},"Bend Memorial Clinic","Bend","Oregon",[418],{"name":419,"role":81,"phone":420,"email":421},"Madison Cox","541-706-5339","mklinskicox@summithealth.com",{"lat":423,"lon":424},44.05817,-121.31531,{"facility":426,"status":8,"city":427,"state":428,"country":77,"contacts":429,"geoPoint":434},"Clinical Biotechnology Research Institute at RSFH","Charleston","South Carolina",[430],{"name":431,"role":81,"phone":432,"email":433},"Aindrea Maddray","843-724-2204","Aindrea.Maddray@rsfh.com",{"lat":435,"lon":436},32.77632,-79.93275,{"facility":438,"status":8,"city":439,"state":428,"country":77,"contacts":440,"geoPoint":445},"Spartanburg Regional Health Services","Spartanburg",[441],{"name":442,"role":81,"phone":443,"email":444},"Kamara Mertz-Rivera","864-560-6104","kmertz-Rivera@gibbscc.org",{"lat":446,"lon":447},34.94957,-81.93205,{"facility":449,"status":8,"city":450,"state":451,"country":77,"contacts":452,"geoPoint":458},"West Cancer Center","Germantown","Tennessee",[453],{"name":454,"role":81,"phone":455,"phoneExt":456,"email":457},"Melissa Smith","901-683-0055","62739","msmith@WESTCLINIC.com",{"lat":459,"lon":460},35.08676,-89.81009,{"facility":462,"status":8,"city":463,"state":464,"country":77,"contacts":465,"geoPoint":470},"ObjectiveHealth - Amarillo Premier Research","Amarillo","Texas",[466],{"name":467,"role":81,"phone":468,"email":469},"Lauren Kuehler","806-641-0256","Lauren.Kuehler@objective.health",{"lat":471,"lon":472},35.222,-101.8313,{"facility":474,"status":8,"city":475,"state":464,"country":77,"contacts":476,"geoPoint":481},"CHRISTUS - St. Michael's Health","Texarkana",[477],{"name":478,"role":81,"phone":479,"email":480},"Kimberly Everett","903-614-6885","kimberly.everett@christushealth.org",{"lat":482,"lon":483},33.42513,-94.04769,{"facility":485,"status":8,"city":427,"state":486,"zip":487,"country":77,"contacts":488,"geoPoint":493},"CAMC Clinical Trials","West Virginia","25304",[489],{"name":490,"role":81,"phone":491,"email":492},"Kristi Sutphin","304-388-9945","kristi.sutphin@CAMC.org",{"lat":494,"lon":495},38.34982,-81.63262,{"facility":497,"status":8,"city":498,"state":499,"country":77,"contacts":500,"geoPoint":505},"Mercy Health","Janesville","Wisconsin",[501],{"name":502,"role":81,"phone":503,"email":504},"Ashli Huppert","608-756-6695","ahuppert@mhemail.org",{"lat":506,"lon":507},42.68279,-89.01872,[509],{"name":510,"role":81,"email":511},"Mary Baker","carisresearch@carisls.com",[513],{"name":514,"affiliation":515,"role":516},"Matthew Oberley, MD","Caris Life Sciences","PRINCIPAL_INVESTIGATOR",[],[],{"nct_id":4,"conditions":520,"biomarkers":522},[521],"Malignant Neoplasm",[],{"nct_id":4,"found":59,"summary":524,"prompt_version":533},{"design":525,"status":526,"heading":6,"summary":527,"follow_up":528,"word_count":529,"commitments":530,"compensation":531,"drugs_mentioned":532},"This is an observational study, meaning researchers will collect information without giving any specific treatments. The study plans to enroll 100,000 participants.","completed","This study is creating a collection of human biological samples (like tissue or blood) and health information, called a biorepository. This collection will help researchers learn more about cancer, how to find it early, and how to treat it. The goal is to make these samples and data available for many research studies over the next 35 years to advance precision medicine (medical care tailored to you) and improve patient care. You can join if you are 18 years or older and can give informed consent (understand and agree to participate). The study is currently collecting samples, but the exact status is unclear.","The biorepository aims to be developed and specimens released for testing over a period of 35 years.",103,"Not specified in the trial record.","Not stated in the trial record.",[],"v2"]