[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT02099734":3,"trial-entities:NCT02099734":153,"trial-summary:NCT02099734":157},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":14,"conditions":16,"keywords":19,"study_type":20,"primary_purpose":14,"phases":21,"enrollment_info":22,"interventions":25,"primary_outcomes":37,"secondary_outcomes":42,"sex":43,"minimum_age":44,"maximum_age":14,"healthy_volunteers":45,"eligibility_criteria":46,"std_ages":57,"locations":60,"central_contacts":144,"overall_officials":147,"references":149,"see_also_links":150},"NCT02099734","14-016","Germ Cell Tumor and Testicular Tumor DNA Registry","RECRUITING","2028-01","2026-02","2026-02-04","2014-01","Memorial Sloan Kettering Cancer Center","OTHER",null,"This study is being done to create a registry to help us learn more about germ cell tumors (GCT) and other testicular tumors. The registry will include people with these tumors and also relatives and unrelated people without these tumors. This study will help us learn more about the prevention, diagnosis, treatment and outcome of these tumors. Studying relatives of patients and people unrelated to patients with GCT and other testicular tumors will help us understand why some people get these tumors and why some people don't.",[17,18],"Germ Cell Tumor","Testicular Tumor",[5],"OBSERVATIONAL",[],{"count":23,"type":24},1000,"ESTIMATED",[26,33],{"type":27,"name":28,"armGroupLabels":29},"BEHAVIORAL","Questionnaires",[30,31,32],"A: suspicion of germ cell tumor and\u002For a testicular mass","B: family members of Group A","C: healthy controls unrelated to Group A or B",{"type":13,"name":34,"description":35,"armGroupLabels":36},"sample of blood or saliva","A sample of blood or saliva will be obtained for DNA extraction. Approximately 2-4 tubes of blood will be collected or one tablespoon of saliva. If a participant has already provided a DNA sample for another MSKCC IRB approved protocol, they may not need to provide an additional sample.",[30,31,32],[38],{"measure":39,"description":40,"timeFrame":41},"creation of a Germ Cell Tumor and testicular tumor registry","We will collect clinical data including diagnosis date, pathology, family history, and risk factors in patients with GCT-TT.","5 years",[],"ALL","18 Years",true,{"inclusion":47,"exclusion":55,"raw_text":56},[48,49,50,48,49,51,48,49,52,53,54],"Must be ≥ 18 years of age AND","Must be an English-speaker AND","Must have a diagnosis or suspicion of germ cell tumor and\u002For a testicular mass","Must be a blood relative of the proband. Family members of probands are eligible. These individuals need not have a diagnosis of GCT-TT, as they will be used for segregation analysis of suspected variants found in the proband.","Must not have a personal history of cancer, with the exception of non-melanoma skin cancer, AND","Must not have a family history of germ cell tumor or testicular tumor AND","Must not be a blood relative of controls enrolled in this study",[],"Inclusion Criteria:\n\nCase Cohort\n\n* Must be ≥ 18 years of age AND\n* Must be an English-speaker AND\n* Must have a diagnosis or suspicion of germ cell tumor and\u002For a testicular mass\n\nFamily Member Cohort\n\n* Must be ≥ 18 years of age AND\n* Must be an English-speaker AND\n* Must be a blood relative of the proband. Family members of probands are eligible. These individuals need not have a diagnosis of GCT-TT, as they will be used for segregation analysis of suspected variants found in the proband.\n\nControl Cohort\n\n* Must be ≥ 18 years of age AND\n* Must be an English-speaker AND\n* Must not have a personal history of cancer, with the exception of non-melanoma skin cancer, AND\n* Must not have a family history of germ cell tumor or testicular tumor AND\n* Must not be a blood relative of controls enrolled in this study\n\nExclusion Criteria:",[58,59],"ADULT","OLDER_ADULT",[61,74,83,92,105,114,123,135],{"facility":62,"status":7,"city":63,"state":64,"country":65,"contacts":66,"geoPoint":71},"Memorial Sloan Kettering Basking Ridge","Basking Ridge","New Jersey","United States",[67],{"name":68,"role":69,"phone":70},"Darren Feldman, MD","CONTACT","646-422-4491",{"lat":72,"lon":73},40.70621,-74.54932,{"facility":75,"status":7,"city":76,"state":64,"zip":77,"country":65,"contacts":78,"geoPoint":80},"Memorial Sloan Kettering Monmouth","Middletown","07748",[79],{"name":68,"role":69,"phone":70},{"lat":81,"lon":82},40.39428,-74.11709,{"facility":84,"status":7,"city":85,"state":64,"zip":86,"country":65,"contacts":87,"geoPoint":89},"Memorial Sloan Kettering Bergen","Montvale","07645",[88],{"name":68,"role":69,"phone":70},{"lat":90,"lon":91},41.04676,-74.02292,{"facility":93,"status":94,"city":95,"state":96,"zip":97,"country":65,"contacts":98,"geoPoint":102},"Cold Springs Harbor Laboratory (Specimen Analysis)","NOT_YET_RECRUITING","Cold Spring Harbor","New York","11724",[99],{"name":100,"role":69,"phone":101},"Richard McCombie, PhD","516-367-8800",{"lat":103,"lon":104},40.87149,-73.45679,{"facility":106,"status":7,"city":107,"state":96,"zip":108,"country":65,"contacts":109,"geoPoint":111},"Memorial Sloan Kettering Commack","Commack","11725",[110],{"name":68,"role":69,"phone":70},{"lat":112,"lon":113},40.84288,-73.29289,{"facility":115,"status":7,"city":116,"state":96,"zip":117,"country":65,"contacts":118,"geoPoint":120},"Memorial Sloan Kettering Westchester","Harrison","10604",[119],{"name":68,"role":69,"phone":70},{"lat":121,"lon":122},40.96899,-73.71263,{"facility":12,"status":7,"city":96,"state":96,"zip":124,"country":65,"contacts":125,"geoPoint":132},"10065",[126,127,130],{"name":68,"role":69,"phone":70},{"name":128,"role":69,"phone":129},"Joel Sheinfeld, MD","646-422-4311",{"name":68,"role":131},"PRINCIPAL_INVESTIGATOR",{"lat":133,"lon":134},40.71427,-74.00597,{"facility":136,"status":94,"city":137,"state":96,"zip":138,"country":65,"contacts":139,"geoPoint":141},"Memorial Sloan Kettering Nassau","Uniondale","11553",[140],{"name":68,"role":69,"phone":70},{"lat":142,"lon":143},40.70038,-73.59291,[145,146],{"name":68,"role":69,"phone":70},{"name":128,"role":69,"phone":129},[148],{"name":68,"affiliation":12,"role":131},[],[151],{"label":12,"url":152},"http:\u002F\u002Fwww.mskcc.org\u002F",{"nct_id":4,"conditions":154,"biomarkers":156},[17,155],"Testicular Neoplasm",[],{"nct_id":4,"found":45,"summary":158,"prompt_version":167},{"design":159,"status":160,"heading":6,"summary":161,"follow_up":162,"word_count":163,"commitments":164,"compensation":165,"drugs_mentioned":166},"This is an observational study aiming to enroll 1000 participants. It is designed to create a registry of individuals with germ cell tumors, testicular tumors, and their family members.","completed","This study is creating a registry to better understand germ cell tumors (GCT) and other testicular tumors. Researchers will collect questionnaires and a sample of your blood or saliva for DNA analysis. This registry will help us learn more about how to prevent, diagnose, treat, and understand the outcomes of these tumors. We are looking for people aged 18 or older who have been diagnosed with or are suspected of having a germ cell tumor or testicular mass, as well as their English-speaking blood relatives. We also welcome English-speaking individuals who do not have these tumors and are not related to someone who does. The goal is to create this registry over five years, which will help us understand why some people develop these tumors and others do not. The current recruitment status is unclear.","The primary goal is the creation of the registry, measured at 5 years. It is not specified how long individual participants will be followed after providing samples.",135,"You will be asked to complete questionnaires and provide a sample of blood (2-4 tubes) or saliva (one tablespoon) for DNA extraction. If you have already provided a DNA sample for another MSKCC study, you may not need to provide another one.","Not stated in the trial record.",[28],"v2"]