[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT02417714":3,"trial-entities:NCT02417714":81,"trial-summary:NCT02417714":84},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":25,"primary_purpose":15,"phases":26,"enrollment_info":27,"interventions":30,"primary_outcomes":31,"secondary_outcomes":35,"sex":36,"minimum_age":37,"maximum_age":38,"healthy_volunteers":39,"eligibility_criteria":40,"std_ages":44,"locations":47,"central_contacts":64,"overall_officials":73,"references":76,"see_also_links":77},"NCT02417714","140188","Prospective Evaluation of Next Generation CT Reconstruction (NextGenIR)","Prospective Evaluation of Next Generation CT Reconstruction","RECRUITING","2026-09-22","2025-10-29","2026-08-07","2014-09-08","National Heart, Lung, and Blood Institute (NHLBI)","NIH",null,"Background:\n\n\\- Computed Tomography (CT) is a scan that makes detailed pictures of the body. It uses radiation to do that. In 2011, about 85.3 million CT scans were done in the United States. But there is growing concern about the health effects of radiation. There are new and different ways to make CT pictures that use less radiation. Researchers want to learn whether these new methods create images that are similar to images from a traditional CT.\n\nObjective:\n\n\\- To learn if new CT imaging methods with less radiation make images that are similar to traditional ways.\n\nEligibility:\n\n\\- Adults 18 years of age and older who are scheduled for a CT of the chest, abdomen and pelvis with contrast.\n\nDesign:\n\n* Researchers will review participants medical records to see if they can be in this study.\n* Participants may have blood drawn from an arm vein by a needle stick. The blood will be used to make sure they can be in this study and that it is safe for them to have contrast.\n* During the participants CT scan appointment, one extra scan will be done using low radiation methods.\n* During a CT scan, the participant lies on a table. A large x-ray machine takes pictures of the body.","Computed Tomography uses ionizing radiation to make pictures of the body. Different methods of creating CT pictures have been developed that allow reductions in the amount of radiation. The purpose of this research study is to learn whether these new imaging methods using less radiation to create images are similar to the traditional and current method.",[19],"Healthy Subjects",[21,22,23,24],"Computed Tomography","Radiation Reduction","Iterative Reconstruction","Natural History","OBSERVATIONAL",[],{"count":28,"type":29},215,"ESTIMATED",[],[32],{"measure":33,"timeFrame":34},"Compare with respect to 6 image quality metrics the overall image quality from a research low radiation dose body CT utilizing advanced (model based) iterative reconstruction with a clinical standard radiation dose CT from the same subject.","Baseline (Day 0)",[],"ALL","18 Years","99 Years",false,{"inclusion":41,"exclusion":42,"raw_text":43},[],[],"* INCLUSION CRITERIA:\n\nInclusion Criteria for Body CT:\n\n1. Clinical indication for a chest, abdomen and pelvis CT with contrast\n2. Age equal to or greater than 18 years\n3. Able to understand and willing to sign the Informed Consent Form\n\nInclusion Criteria for Chest CT:\n\n1. Clinical indication for a CT with or without contrast that includes the chest\n2. Age equal to or greater than 18 years\n3. Able to understand and willing to sign the Informed Consent Form\n\nEXCLUSION CRITERIA:\n\nExclusion Criteria for Body CT:\n\n1. Pregnancy\n2. Serum Cr \\> 1.5 mg\u002FdL\n3. Clinical CT scan with more than one contrast imaging phase (for example three phase liver)\n\nExclusion Criteria for Chest CT\n\n1\\. Pregnancy",[45,46],"ADULT","OLDER_ADULT",[48],{"facility":49,"status":8,"city":50,"state":51,"zip":52,"country":53,"contacts":54,"geoPoint":61},"National Institutes of Health Clinical Center","Bethesda","Maryland","20892","United States",[55],{"name":56,"role":57,"phone":58,"phoneExt":59,"email":60},"NIH Clinical Center Office of Patient Recruitment (OPR)","CONTACT","800-411-1222","TTY dial 711","ccopr@nih.gov",{"lat":62,"lon":63},38.98067,-77.10026,[65,69],{"name":66,"role":57,"phone":67,"email":68},"Margaret C Lowery, R.N.","(301) 451-3128","peg.lowery@nih.gov",{"name":70,"role":57,"phone":71,"email":72},"Marcus Y Chen, M.D.","(301) 496-0077","chenmy@mail.nih.gov",[74],{"name":70,"affiliation":13,"role":75},"PRINCIPAL_INVESTIGATOR",[],[78],{"label":79,"url":80},"NIH Clinical Center Detailed Web Page","https:\u002F\u002Fclinicalstudies.info.nih.gov\u002Fcgi\u002Fdetail.cgi?A_2014-H-0188.html",{"nct_id":4,"conditions":82,"biomarkers":83},[19],[],{"nct_id":4,"found":85,"summary":86,"prompt_version":96},true,{"design":87,"status":88,"heading":89,"summary":90,"follow_up":91,"word_count":92,"commitments":93,"compensation":94,"drugs_mentioned":95},"This is an observational study, meaning researchers will observe and compare CT images from 215 participants. It is not specified if it's randomized or blinded.","completed","Evaluating Next Generation CT Reconstruction (NextGenIR)","This study is looking at new ways to create CT (Computed Tomography) scans. CT scans make detailed pictures of your body using radiation. Researchers want to see if these newer methods, which use less radiation, produce images that are just as good as images from traditional CT scans. You might be able to join if you are an adult (18 years or older) and are already scheduled for a CT scan of your chest, abdomen, and pelvis with contrast. The study will compare the quality of images from a low-radiation CT scan using advanced reconstruction methods with images from a standard-dose CT scan.","Image quality will be measured at baseline (Day 0).",103,"You would undergo a research low-radiation body CT scan in addition to your clinically indicated CT scan. Image quality will be measured at baseline (Day 0).","Not stated in the trial record.",[],"v2"]