[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT02432092":3,"trial-entities:NCT02432092":85,"trial-summary:NCT02432092":91},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":24,"study_type":32,"primary_purpose":33,"phases":34,"enrollment_info":35,"interventions":38,"primary_outcomes":39,"secondary_outcomes":43,"sex":44,"minimum_age":33,"maximum_age":33,"healthy_volunteers":14,"eligibility_criteria":45,"std_ages":53,"locations":57,"central_contacts":73,"overall_officials":80,"references":83,"see_also_links":84},"NCT02432092","1403919054","Pediatric Cardiomyopathy Mutation Analysis","RECRUITING","2030-12-31","2026-06","2026-06-22","2014-04","Indiana University","OTHER",false,"The goal of this protocol is to obtain information from individuals with cardiomyopathy and from their families in order to elucidate the molecular genetics of this disorder. This will provide the basis for future genetic counseling as well as contribute to elucidating the biology of normal and abnormal cardiac function.","Cardiomyopathy is a genetically heterogeneous heart muscle disorder that results in ventricular dysfunction. While significant progress has been made in identifying the genetic basis of cardiomyopathy in adults, molecular diagnosis in children has proven more challenging and current algorithms do not incorporate mutation analysis in the clinical protocol. However, recent studies indicate that cardiomyopathy outcomes in children are origin specific, highlighting the importance of precise diagnosis. The goal of this study is to identify the genetic causes of pediatric cardiomyopathy. Rapid, comprehensive and cost-effective detection of genetic causes of cardiomyopathy will aid management and development of novel treatment strategies.",[18,19,20,21,22,23],"Cardiomyopathies","Dilated Cardiomyopathy","Hypertrophic Cardiomyopathy","Restrictive Cardiomyopathy","Arrhythmogenic Right Ventricular Cardiomyopathy","Left Ventricular Non-compaction Cardiomyopathy",[25,26,27,28,29,30,31],"Cardiomegaly","Cardiovascular Diseases","Heart Diseases","Systolic dysfunction","Diastolic dysfunction","Ventricular hypertrophy","Heart failure","OBSERVATIONAL",null,[],{"count":36,"type":37},300,"ESTIMATED",[],[40],{"measure":41,"timeFrame":42},"Elucidate the molecular genetics of cardiomyopathy","7 years",[],"ALL",{"inclusion":46,"exclusion":49,"raw_text":52},[47,48],"Subjects with cardiomyopathy","Family members of subjects with cardiomyopathy",[50,51],"Subjects without cardiomyopathy","Family members of subjects without cardiomyopathy","Inclusion Criteria:\n\n* Subjects with cardiomyopathy\n* Family members of subjects with cardiomyopathy\n\nExclusion Criteria:\n\n* Subjects without cardiomyopathy\n* Family members of subjects without cardiomyopathy",[54,55,56],"CHILD","ADULT","OLDER_ADULT",[58],{"facility":59,"status":7,"city":60,"state":61,"zip":62,"country":63,"contacts":64,"geoPoint":70},"IU School of Medicine","Indianapolis","Indiana","46202","United States",[65],{"name":66,"role":67,"phone":68,"email":69},"Stephanie Ware, MD, PhD","CONTACT","317-278-2807","stware@iu.edu",{"lat":71,"lon":72},39.76838,-86.15804,[74,78],{"name":75,"role":67,"phone":76,"email":77},"Sarah Murphy, MPH","(317) 278-3026","bankssk@iu.edu",{"name":66,"role":67,"phone":79,"email":69},"(317) 278-2807",[81],{"name":66,"affiliation":59,"role":82},"PRINCIPAL_INVESTIGATOR",[],[],{"nct_id":4,"conditions":86,"biomarkers":90},[87,88,19,20,89,21],"Arrhythmogenic Right Ventricular Dysplasia","Cardiomyopathy","Left Ventricular Non-Compaction Syndrome",[],{"nct_id":4,"found":92,"summary":93,"prompt_version":103},true,{"design":94,"status":95,"heading":96,"summary":97,"follow_up":98,"word_count":99,"commitments":100,"compensation":101,"drugs_mentioned":102},"This is an observational study, meaning researchers will gather information without giving any specific treatments. It plans to include up to 300 participants.","completed","Pediatric Cardiomyopathy Genetic Study","This study aims to understand the genetic causes of cardiomyopathy (a disease of the heart muscle) in children. Researchers will collect information from children with cardiomyopathy and their family members to identify the specific genes involved. The goal is to improve genetic counseling, understand how the heart works normally and abnormally, and develop better ways to manage and treat pediatric cardiomyopathy. There are no specific drugs or interventions being tested in this study. The main goal is to identify the genetic causes of cardiomyopathy, which will be measured over seven years. You can join if you have cardiomyopathy or are a family member of someone with cardiomyopathy. The current recruitment status is unclear.","The study aims to understand the molecular genetics of cardiomyopathy, with results measured at 7 years.",113,"Not specified in the trial record.","Not stated in the trial record.",[],"v2"]