[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT02763683":3,"trial-entities:NCT02763683":97,"trial-summary:NCT02763683":101},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":19,"study_type":25,"primary_purpose":26,"phases":27,"enrollment_info":28,"interventions":31,"primary_outcomes":38,"secondary_outcomes":43,"sex":44,"minimum_age":45,"maximum_age":26,"healthy_volunteers":46,"eligibility_criteria":47,"std_ages":57,"locations":60,"central_contacts":80,"overall_officials":89,"references":95,"see_also_links":96},"NCT02763683","201512032","Investigations of Dementia in Parkinson Disease","RECRUITING","2030-03","2026-05","2026-05-08","2016-06","Washington University School of Medicine","OTHER",false,"The purpose of this study is to use a brain imaging method called Pittsburgh B (PIB) Positron Emission Tomography (PET) and Vesicular Cholinergic Transport (VAT) PET to determine dementia subtypes in patients with Parkinson disease (PD). The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia.","The purpose of this study is to use a brain imaging method called PIB PET and VAT PET to determine dementia subtypes in patients with Parkinson disease (PD). The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia. The investigators will be including both PD and normal subjects in this study. This a long term study and we are considering including a total of 320 participants in this protocol.",[18],"Parkinsons",[20,21,22,23,24],"Parkinsons Disease","PET Imaging","PIB","VAT","Dementia","OBSERVATIONAL",null,[],{"count":29,"type":30},320,"ESTIMATED",[32],{"type":33,"name":34,"description":35,"armGroupLabels":36},"RADIATION","PiB and VAT","There is no intervention for this study. The PiB and VAT are used during the PET procedures to help to identify any excessive abnormal proteins in the brain.",[37,20],"Healthy Controls",[39],{"measure":40,"description":41,"timeFrame":42},"Investigations of Dementia in Parkinsons Disease","The investigators will perform memory\u002Fthinking testing, Lumbar puncture (LP), Magnetic Resonance Imaging (MRI) and (PET) scans to help to determine the cause(s) of memory and thinking in Parkinson Disease.\n\nThe memory and thinking testing by phone on average at 1.5 years through study completion and then in person on average at 3 years through study completion, this will help monitor if there is any decline in memory and thinking.\n\nThe Lumbar Puncture is done on willing participants on average at 3 years through study completion to assess for any abnormal proteins and correlate these with any changes in memory and thinking.\n\nThe MRI is done on average at 3 years through study completion for any abnormal signs or changes in regards to dementia at 3 years.\n\nThe (PiB) \\& (VAT) PET scans will be performed on average at 3 years through study completion, which will be analyzed to assess for changes in regards to abnormal proteins and signs of dementia.","2030",[],"ALL","50 Years",true,{"inclusion":48,"exclusion":50,"raw_text":56},[49],"PD patients must exhibit three of the following cardinal signs: rest tremor, rigidity, bradykinesia, or postural instability; or two of these features with one of the first three displaying asymmetry.",[51,52,53,54,55],"history of head trauma, major neurological or psychiatric diseases other than Parkinson disease and dementia, e.g. stroke, multiple sclerosis, depression or schizophrenia.","severe systemic diseases.","inability to lie still for 90 minutes.","metallic implants, pacemakers, or any other contraindication to MRI.","refusal to consent to brain donation.","Inclusion Criteria:\n\n* PD patients must exhibit three of the following cardinal signs: rest tremor, rigidity, bradykinesia, or postural instability; or two of these features with one of the first three displaying asymmetry.\n\nExclusion Criteria:\n\n* history of head trauma, major neurological or psychiatric diseases other than Parkinson disease and dementia, e.g. stroke, multiple sclerosis, depression or schizophrenia.\n* severe systemic diseases.\n* inability to lie still for 90 minutes.\n* metallic implants, pacemakers, or any other contraindication to MRI.\n* refusal to consent to brain donation.",[58,59],"ADULT","OLDER_ADULT",[61],{"facility":62,"status":7,"city":63,"state":64,"zip":65,"country":66,"contacts":67,"geoPoint":77},"Washington University in St. Louis","St Louis","Missouri","63110","United States",[68,73],{"name":69,"role":70,"phone":71,"email":72},"Susan Donovan, BSN","CONTACT","314-362-6026","donovan@wustl.edu",{"name":74,"role":70,"phone":75,"email":76},"Kaleigh Oberndorfer","314 362 0420","kaleigh@wustl.edu",{"lat":78,"lon":79},38.62727,-90.19789,[81,85],{"name":82,"role":70,"phone":83,"email":84},"Andrea Slavik, RN, BSN","314 273 8313","andreaslavik@wustl.edu",{"name":86,"role":70,"phone":87,"email":88},"Hailee Domash","314 362 6026","domash@wustl.edu",[90,93],{"name":91,"affiliation":12,"role":92},"Joel S Perlmutter, MD","PRINCIPAL_INVESTIGATOR",{"name":94,"role":92},"MD",[],[],{"nct_id":4,"conditions":98,"biomarkers":100},[24,99],"Parkinson Disease",[],{"nct_id":4,"found":46,"summary":102,"prompt_version":111},{"design":103,"status":104,"heading":6,"summary":105,"follow_up":106,"word_count":107,"commitments":108,"compensation":109,"drugs_mentioned":110},"This is an observational study, meaning researchers will observe participants without providing a specific treatment. It plans to include a total of 320 participants.","completed","This study aims to understand different types of dementia in people with Parkinson's disease (PD). Researchers will use special brain scans called Pittsburgh B (PIB) Positron Emission Tomography (PET) and Vesicular Cholinergic Transport (VAT) PET. These scans help identify abnormal proteins in the brain. The goal is to find out which people with PD are at risk for dementia and what causes it. You may be able to join if you are 50 or older and have certain symptoms of Parkinson's disease, such as tremor or stiffness. The study is hoping to include 320 participants and will measure its main goal in 2030.","The primary endpoint for this study will be measured in 2030.",103,"You would undergo brain imaging procedures using PIB and VAT during PET scans. The study is described as long-term.","Not stated in the trial record.",[],"v2"]