[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT03062748":3,"trial-entities:NCT03062748":77,"trial-summary:NCT03062748":80},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":19,"study_type":20,"primary_purpose":16,"phases":21,"enrollment_info":22,"interventions":25,"primary_outcomes":26,"secondary_outcomes":36,"sex":43,"minimum_age":44,"maximum_age":16,"healthy_volunteers":14,"eligibility_criteria":45,"std_ages":60,"locations":63,"central_contacts":73,"overall_officials":74,"references":75,"see_also_links":76},"NCT03062748","5218","Predicting Cardiometabolic Risk in Mild-to-Moderate Obstructive Sleep Apnea: Inflammation vs. Apnea\u002FHypopnea Index","ENROLLING_BY_INVITATION","2027-12","2026-04","2026-04-23","2017-03-01","Milton S. Hershey Medical Center","OTHER",false,"The purpose of the study is to compare the relative contribution of systemic inflammation vs. Obstructive Sleep Apnea (OSA) severity (as measured by Apnea Hypopnea Index) in predicting cardiovascular and metabolic aberrations associated with mild-to-moderate obstructive sleep apnea.",null,[18],"Obstructive Sleep Apnea",[],"OBSERVATIONAL",[],{"count":23,"type":24},196,"ESTIMATED",[],[27,31,33],{"measure":28,"description":29,"timeFrame":30},"Presence of the metabolic syndrome","At least 3 of the following 5 risk factors must be met in order to have the metabolic syndrome:\n\n1. Elevated waist measurement (≥102 cm for men or ≥89 cm for women)\n2. Elevated triglycerides (≥150 mg\u002FdL or use of medication)\n3. Low HDL cholesterol (\\\u003C50 mg\u002FdL for women or \\\u003C40 mg\u002FdL for men or use of medication)\n4. Elevated blood pressure (≥130 mmHg systolic or ≥ 85 mmHg diastolic or use of medication)\n5. Elevated fasting blood sugar (≥100 mg\u002FdL or use of medication)\n\nSource: https:\u002F\u002Fwww.nhlbi.nih.gov\u002Fhealth\u002Fhealth-topics\u002Ftopics\u002Fms","baseline",{"measure":18,"description":32,"timeFrame":30},"AHI from one night polysomnography",{"measure":34,"description":35,"timeFrame":30},"Markers of systemic inflammation","CRP, IL-6, TNFa",[37,40],{"measure":38,"description":39,"timeFrame":30},"Heart rate variability","from polysomnography",{"measure":41,"description":42,"timeFrame":30},"Subjective measure of sleepiness","Epworth Sleepiness Scale","ALL","18 Years",{"inclusion":46,"exclusion":51,"raw_text":59},[47,48,49,50],"Mild to moderate OSA (5≤ AHI \\\u003C30)","BMI ≤ 45","Age ≥ 18","Men \\& Women",[52,53,54,55,56,57,58],"AHI ≥ 30","BMI \\>45","Current use of steroids or anti-inflammatory medication","Diagnosis of insulin dependent diabetes","Diagnosis of autoimmune disorder","Shiftwork","Current use of CPAP","Inclusion Criteria:\n\n* Mild to moderate OSA (5≤ AHI \\\u003C30)\n* BMI ≤ 45\n* Age ≥ 18\n* Men \\& Women\n\nExclusion Criteria:\n\n* AHI ≥ 30\n* BMI \\>45\n* Current use of steroids or anti-inflammatory medication\n* Diagnosis of insulin dependent diabetes\n* Diagnosis of autoimmune disorder\n* Shiftwork\n* Current use of CPAP",[61,62],"ADULT","OLDER_ADULT",[64],{"facility":65,"city":66,"state":67,"zip":68,"country":69,"geoPoint":70},"Penn State College of Medicine, Penn State Milton S. Hershey Medical Center","Hershey","Pennsylvania","17033","United States",{"lat":71,"lon":72},40.28592,-76.65025,[],[],[],[],{"nct_id":4,"conditions":78,"biomarkers":79},[18],[],{"nct_id":4,"found":14,"summary":16,"prompt_version":16}]