[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT03826693":3,"trial-entities:NCT03826693":101,"trial-summary:NCT03826693":105},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":19,"study_type":22,"primary_purpose":23,"phases":24,"enrollment_info":26,"interventions":29,"primary_outcomes":41,"secondary_outcomes":46,"sex":47,"minimum_age":48,"maximum_age":49,"healthy_volunteers":14,"eligibility_criteria":50,"std_ages":62,"locations":65,"central_contacts":85,"overall_officials":89,"references":93,"see_also_links":94},"NCT03826693","48077","Efficacy of Nitrous Oxide in OCD: Pilot Study","RECRUITING","2027-10","2025-08","2025-08-27","2021-04-17","Stanford University","OTHER",false,"This study investigates whether the commonly used and well-tolerated inhaled anesthetic nitrous oxide can rapidly improve symptoms of OCD.","Obsessive-compulsive disorder (OCD) is a chronic and disabling disorder characterized by recurrent intrusive thoughts and associated compulsive behaviors that is estimated to affect more than 3 million individuals in the US each year.\n\nThis study seeks to explore whether a single inhalation of nitrous oxide gas may bring about rapid symptom relief in OCD.",[18],"Obsessive-Compulsive Disorder",[20,21],"OCD","nitrous oxide","INTERVENTIONAL","TREATMENT",[25],"PHASE2",{"count":27,"type":28},45,"ESTIMATED",[30,36],{"type":31,"name":32,"description":33,"armGroupLabels":34},"DRUG","Nitrous Oxide","OCD participants in this arm will receive 50%oxygen\u002F50% nitrous oxide admixture for 60 minutes.",[35],"Experimental: Nitrous Oxide",{"type":31,"name":37,"description":38,"armGroupLabels":39},"Nitrogen","OCD participants in this arm will receive 50%oxygen\u002F50% nitrogen admixture for 60 minutes.",[40],"Control: Nitrogen",[42],{"measure":43,"description":44,"timeFrame":45},"Improvement in the severity of OCD symptoms as measured by the Yale-Brown Obsessive Compulsive Scale (YBOCS)","Improvement in OCD severity is measured by the YBOCS (Yale Brown Obsessive-Compulsive Scale), a gold standard measure of obsessions and compulsions. For the YBOCS the minimum units are 0 and Maximum units on the total scale are 40. The higher the number on the YBOCS, the more severe the symptoms. Response is defined as at least a 35% reduction on the YBOCS.","1 week",[],"ALL","18 Years","65 Years",{"inclusion":51,"exclusion":57,"raw_text":61},[52,53,54,55,56],"Age 18-65","Primary diagnosis of OCD","Sufficient severity of OCD symptoms","Ability to tolerate a treatment-free period","Capacity to provide informed consent",[58,59,60],"Psychiatric or medical conditions that make participation unsafe","Pregnant or nursing females","Concurrent use of any medications that might increase the risk of participation (e.g. drug interactions)","Inclusion Criteria:\n\n* Age 18-65\n* Primary diagnosis of OCD\n* Sufficient severity of OCD symptoms\n* Ability to tolerate a treatment-free period\n* Capacity to provide informed consent\n\nExclusion Criteria:\n\n* Psychiatric or medical conditions that make participation unsafe\n* Pregnant or nursing females\n* Concurrent use of any medications that might increase the risk of participation (e.g. drug interactions)",[63,64],"ADULT","OLDER_ADULT",[66],{"facility":12,"status":7,"city":67,"state":68,"zip":69,"country":70,"contacts":71,"geoPoint":82},"Stanford","California","94304","United States",[72,77,79],{"name":73,"role":74,"phone":75,"email":76},"Pavithra Makunda, MS","CONTACT","650-723-4095","ocdresearch@stanford.edu",{"name":78,"role":74,"phone":75,"email":76},"Sindu Menon, MBBS",{"name":80,"role":81},"Peter van Roessel, MD, PhD","PRINCIPAL_INVESTIGATOR",{"lat":83,"lon":84},37.42411,-122.16608,[86,88],{"name":87,"role":74,"phone":75,"email":76},"Pavithra Mukunda, MS",{"name":78,"role":74,"phone":75,"email":76},[90],{"name":91,"affiliation":92,"role":81},"Peter J van Roessel, MD, PhD","Stanford Univeristy",[],[95,98],{"label":96,"url":97},"Stanford Medicine Faculty Page","https:\u002F\u002Fmed.stanford.edu\u002Fprofiles\u002Fpeter-van-roessel",{"label":99,"url":100},"Rodriguez Lab Website","https:\u002F\u002Frodriguezlab.stanford.edu",{"nct_id":4,"conditions":102,"biomarkers":104},[103],"Obsessive Compulsive Disorder",[],{"nct_id":4,"found":106,"summary":107,"prompt_version":117},true,{"design":108,"status":109,"heading":110,"summary":111,"follow_up":112,"word_count":113,"commitments":114,"compensation":115,"drugs_mentioned":116},"This is an interventional pilot study, meaning participants receive a specific treatment. It aims to enroll 45 individuals.","completed","Pilot Study of Nitrous Oxide for OCD Symptoms","This study is investigating if inhaled nitrous oxide, also known as laughing gas, can quickly improve symptoms of Obsessive-Compulsive Disorder (OCD). Participants will receive either nitrous oxide mixed with oxygen, or nitrogen mixed with oxygen, for 60 minutes. Researchers will then measure changes in OCD symptoms using a standard scale (YBOCS) after one week. You may be able to join if you are between 18 and 65 years old, have a primary diagnosis of OCD, and your symptoms are severe enough. The study aims to enroll 45 participants, but its current recruitment status is unclear.","Your OCD symptoms will be measured one week after the intervention.",95,"Participants will receive a 60-minute inhalation of either nitrous oxide or nitrogen.","Not stated in the trial record.",[32,37],"v2"]