[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT04101188":3,"trial-entities:NCT04101188":108,"trial-summary:NCT04101188":112},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":19,"study_type":23,"primary_purpose":24,"phases":25,"enrollment_info":27,"interventions":30,"primary_outcomes":46,"secondary_outcomes":54,"sex":59,"minimum_age":60,"maximum_age":61,"healthy_volunteers":14,"eligibility_criteria":62,"std_ages":80,"locations":82,"central_contacts":97,"overall_officials":103,"references":106,"see_also_links":107},"NCT04101188","1472577","Mechanisms Underlying the Protective Vascular Effects of Dietary Potassium in Humans","RECRUITING","2026-07-31","2026-03","2026-03-04","2020-01-16","University of Delaware","OTHER",true,"Americans continue to consume high amounts of sodium. Potassium is notable for its blood pressure lowering effects but less is known regarding its effect on the vasculature. This investigation seeks to determine the role of dietary potassium on the vasculature in the presence of a high sodium diet in salt-resistant adults.","Significant public health efforts have been made towards salt reduction but most have met with failure. Dietary factors such high sodium\u002Flow potassium diets contribute to the development of cardiovascular diseases (CVDs) such as atherosclerosis and high blood pressure (BP). This is important as CVD is the number one killer in the U.S. While the role of these two nutrients on BP is widely accepted, their impact on the vasculature has received less attention. Endothelial dysfunction, characterized by impaired dilation, is an important non-traditional risk factor for atherosclerosis. Evidence supporting potassium's beneficial role on vascular health remains unclear although it may be more effective in the presence of a high sodium diet. A purported mechanism responsible for sodium-induced vascular dysfunction is overproduction of reactive oxygen species (ROS) resulting in reduced nitric oxide (NO) production\u002Fbioavailability. Additionally, high sodium diets have been shown to stiffen the endothelium. This investigation will evaluate the vascular effects of dietary potassium during a high salt diet including its impact on sodium-induced oxidative stress and endothelial cell stiffness.",[18],"Cardiovascular Risk Factor",[20,21,22],"Dietary Potassium","Dietary Sodium","Vascular Health","INTERVENTIONAL","PREVENTION",[26],"NA",{"count":28,"type":29},90,"ESTIMATED",[31,36,41],{"type":13,"name":32,"description":33,"armGroupLabels":34},"Moderate Potassium\u002FLow Sodium Diet","Consumption of 10 days of a diet moderate in potassium and low in sodium.",[35],"Moderate Potassium\u002FLow Sodium",{"type":13,"name":37,"description":38,"armGroupLabels":39},"Moderate Potassium\u002FHigh Sodium Diet","Consumption of 10 days of a diet moderate in potassium and high in sodium.",[40],"Moderate Potassium\u002FHigh Sodium",{"type":13,"name":42,"description":43,"armGroupLabels":44},"High Potassium\u002FHigh Sodium Diet","Consumption of 10 days of a diet high in potassium and high in sodium.",[45],"High Potassium\u002FHigh Sodium",[47,51],{"measure":48,"description":49,"timeFrame":50},"Conduit artery endothelial-dependent dilation","The change in flow-mediated dilation (FMD) between the 3 diets as assessed by brachial artery FMD","on day 10 of the diet",{"measure":52,"description":53,"timeFrame":50},"Microvascular function","Cutaneous microvascular dilatory response to local heating assessed by laser Doppler flowmetry coupled with intradermal microdialysis",[55],{"measure":56,"description":57,"timeFrame":58},"Ambulatory BP monitoring","assessed by 24-hour ambulatory blood pressure","on day 7 and 10 of diet","ALL","18 Years","45 Years",{"inclusion":63,"exclusion":67,"raw_text":79},[64,65,66],"healthy","normal blood pressure","normal resting ECG",[68,69,70,71,72,73,74,75,76,77,78],"hypertension","history of heart disease","diabetes","kidney disease","obese (BMI ≥30)","significant weight changes in the last 6 months","use of tobacco products","pregnant","on a special diet (gluten free; vegan)","take any medications for the above conditions","endurance trained athletes","Inclusion Criteria:\n\n* healthy\n* normal blood pressure\n* normal resting ECG\n\nExclusion Criteria:\n\n* hypertension\n* history of heart disease\n* diabetes\n* kidney disease\n* obese (BMI ≥30)\n* significant weight changes in the last 6 months\n* use of tobacco products\n* pregnant\n* on a special diet (gluten free; vegan)\n* take any medications for the above conditions\n* endurance trained athletes",[81],"ADULT",[83],{"facility":12,"status":7,"city":84,"state":85,"zip":86,"country":87,"contacts":88,"geoPoint":94},"Newark","Delaware","19716","United States",[89],{"name":90,"role":91,"phone":92,"email":93},"Shannon L Lennon, PHD","CONTACT","302-831-2798","slennon@udel.edu",{"lat":95,"lon":96},39.68372,-75.74966,[98,101],{"name":99,"role":91,"phone":100,"email":93},"Shannon L Lennon, PhD","(302)831-2798",{"name":99,"role":91,"phone":102,"email":93},"3028312798",[104],{"name":99,"affiliation":12,"role":105},"PRINCIPAL_INVESTIGATOR",[],[],{"nct_id":4,"conditions":109,"biomarkers":111},[110],"Healthy",[],{"nct_id":4,"found":14,"summary":113,"prompt_version":123},{"design":114,"status":115,"heading":116,"summary":117,"follow_up":118,"word_count":119,"commitments":120,"compensation":121,"drugs_mentioned":122},"This interventional study plans to enroll 90 healthy participants. It is not specified if the study is randomized or blinded.","completed","Dietary Potassium and Vascular Health Study","This study is looking at how different levels of potassium and sodium in your diet affect your blood vessels. Researchers want to understand if dietary potassium can protect your blood vessels, especially when you eat a high-sodium diet. You would follow one of three diets for 10 days: Moderate Potassium\u002FLow Sodium, Moderate Potassium\u002FHigh Sodium, or High Potassium\u002FHigh Sodium. The study will measure how well your blood vessels expand (conduit artery endothelial-dependent dilation) and how well tiny blood vessels work (microvascular function) after each diet. They are looking for healthy adults between 18 and 45 years old with normal blood pressure and heart readings. The current status of this study is unclear.","Measurements are taken on day 10 of the diet, but no further follow-up is specified.",111,"You would consume specific diets for 10 days. Measurements of your blood vessel function would be taken on day 10 of each diet period.","Not stated in the trial record.",[],"v2"]