[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT04376229":3,"trial-entities:NCT04376229":110,"trial-summary:NCT04376229":114},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":19,"study_type":21,"primary_purpose":22,"phases":23,"enrollment_info":24,"interventions":27,"primary_outcomes":33,"secondary_outcomes":38,"sex":39,"minimum_age":40,"maximum_age":41,"healthy_volunteers":14,"eligibility_criteria":42,"std_ages":47,"locations":50,"central_contacts":100,"overall_officials":103,"references":108,"see_also_links":109},"NCT04376229","J2008","Proton Radiation Therapy Registry","RECRUITING","2040-12","2026-06","2026-06-30","2020-04-07","Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins","OTHER",false,"The Johns Hopkins Proton Therapy center is establishing a registry to capture the full 3D radiation dosimetry delivered to the patient, baseline clinical data, and disease, toxicity and quality of life outcomes. The goal is to have all patients treated at the proton center to be included in the registry to enable future comparisons of treatment outcomes to assist in understanding which patients can benefit from the use of protons.","Proton based radiation therapy has considerable dosimetric advantages over the standard photon based radiation therapy, with a significantly higher cost. The clinical advantages, however, may not be realized for all patient populations, even with the improved dose distributions. Establishing the clinical efficacy of proton therapy requires years of experience treating patients. The goal is to accelerate the knowledge gain through the use of the registry that allows for detailed information to be captured and is inclusive of every patient treated.",[18],"Cancer, Therapy-Related",[20],"proton therapy","OBSERVATIONAL",null,[],{"count":25,"type":26},5000,"ESTIMATED",[28],{"type":13,"name":29,"description":30,"armGroupLabels":31},"Registry","Registry of cancer patients who receive proton radiation therapy",[32],"Cancer patients receiving proton radiation therapy",[34],{"measure":35,"description":36,"timeFrame":37},"Research registry of cancer patients receiving proton radiation therapy","This is a clinic based registry of cancer patients' data from participants to be collected over 15 years. The registry will be populated with 3D anatomy and radiation dosimetry from the RayStation treatment planning system used to plan all proton therapy patients. Clinical data will be extracted electronically from the MOSAIQ oncology information system used to manage the radiation therapy treatments. Structured clinical assessments will be routinely captured in the clinical workflow during patient encounters. Patient reported outcomes will be captured with iPad's using the OncoBrowser tools developed in radiotherapy that also interface with MOSAIQ.","15 years",[],"ALL","18 Years","100 Years",{"inclusion":43,"exclusion":45,"raw_text":46},[44],"All patients treated at the proton center.",[],"Inclusion Criteria:\n\n* All patients treated at the proton center.\n\nExclusion Criteria:\n\n* Any other than what is supplied in the inclusion criteria",[48,49],"ADULT","OLDER_ADULT",[51,70,78,88],{"facility":52,"status":7,"city":53,"state":54,"zip":55,"country":56,"contacts":57,"geoPoint":67},"Sibley Memorial Hospital","Washington D.C.","District of Columbia","20016","United States",[58,63],{"name":59,"role":60,"phone":61,"email":62},"Akila Viswanathan, MD","CONTACT","410-502-1421","anv@jhmi.edu",{"name":64,"role":60,"phone":65,"email":66},"Dana Kaplin, MPH","41--614-3950","dkaplin1@jhmi.edu",{"lat":68,"lon":69},38.89511,-77.03637,{"facility":71,"status":7,"city":53,"state":54,"zip":72,"country":56,"contacts":73,"geoPoint":77},"Suburban Hospital","20814",[74,75],{"name":59,"role":60,"phone":61,"email":62},{"name":64,"role":60,"phone":76,"email":66},"410-614-3950",{"lat":68,"lon":69},{"facility":79,"status":7,"city":80,"state":81,"zip":82,"country":56,"contacts":83,"geoPoint":85},"Bayview Hospital","Baltimore","Maryland","21224",[84],{"name":64,"role":60,"phone":76,"email":66},{"lat":86,"lon":87},39.29038,-76.61219,{"facility":89,"status":7,"city":80,"state":81,"zip":90,"country":56,"contacts":91,"geoPoint":99},"Johns Hopkins Hospital","21287",[92,93,94,97],{"name":59,"role":60,"phone":61,"email":62},{"name":64,"role":60,"phone":76,"email":66},{"name":95,"role":96},"Todd McNutt, PhD","SUB_INVESTIGATOR",{"name":98,"role":96},"Zhi Cheng, MD",{"lat":86,"lon":87},[101,102],{"name":59,"role":60,"phone":61,"email":62},{"name":64,"role":60,"phone":76,"email":66},[104],{"name":105,"affiliation":106,"role":107},"Curtiland Deville, MD","Johns Hopkins University","PRINCIPAL_INVESTIGATOR",[],[],{"nct_id":4,"conditions":111,"biomarkers":113},[112],"Malignant Neoplasm",[],{"nct_id":4,"found":115,"summary":116,"prompt_version":125},true,{"design":117,"status":118,"heading":6,"summary":119,"follow_up":120,"word_count":121,"commitments":122,"compensation":123,"drugs_mentioned":124},"This is an observational study, meaning researchers will collect information without giving new treatments. The study plans to include 5000 participants.","completed","This study is creating a registry (a collection of information) for cancer patients who receive proton radiation therapy at the Johns Hopkins Proton Therapy center. The goal is to gather detailed information about your treatment, your health before treatment, and how you feel and recover over time. This will help researchers understand which patients benefit most from proton radiation therapy. If you are 18 to 100 years old and are treated at this proton center, you can be included in this registry. The study will track information for 15 years to see how well the treatment works.","Participants' information will be tracked for 15 years.",97,"Not specified in the trial record.","Not stated in the trial record.",[29],"v2"]