[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT04427462":3,"trial-entities:NCT04427462":83,"trial-summary:NCT04427462":86},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":21,"primary_purpose":22,"phases":23,"enrollment_info":24,"interventions":27,"primary_outcomes":28,"secondary_outcomes":33,"sex":34,"minimum_age":35,"maximum_age":36,"healthy_volunteers":37,"eligibility_criteria":38,"std_ages":53,"locations":55,"central_contacts":71,"overall_officials":77,"references":81,"see_also_links":82},"NCT04427462","260376","Bioenergetic Phenotypes and Cardiometabolic Health","Linking Bioenergetic Phenotypes in Circulating Cells with Cardiometabolic Health in School-age Children","RECRUITING","2026-06","2024-09","2025-02-07","2020-09-01","Arkansas Children's Hospital Research Institute","OTHER",false,"This research study is about how daily activities, behaviors, and fitness affect the health and function of blood cells and their mitochondria, which are the powerhouses of the cells. These small mitochondria inside the cells make energy, and are very important for the health of the body.","Determine the impact of physical activity and obesity status on circulating cells mitochondrial function (e.g., fat vs. carbohydrates combustion capacity, total oxidative capacity, mitochondrial number and proton leak).",[19],"Healthy",[],"OBSERVATIONAL",null,[],{"count":25,"type":26},300,"ESTIMATED",[],[29],{"measure":30,"description":31,"timeFrame":32},"Platelet mitochondrial respiration and its association with adiposity and peak aerobic capacity in children 8 to 10 years old.","Platelet mitochondrial respiration from isolated platelets will be measured using a flux analyzer. Adiposity will be measured with dual X-ray absorptiometry, and peak aerobic capacity with an incremental cycle ergometer test. measure physical activity","8 days",[],"ALL","8 Years","10 Years",true,{"inclusion":39,"exclusion":40,"raw_text":52},[],[41,42,43,44,45,46,47,48,49,50,51],"Opposition defiant disorder","conduct disorder","epilepsy","chronic kidney disease","hormonal disease","autoimmune diseases","bleeding disorders","chronic infections","mental health disorder","Type 2 and Type 1 diabetes","Other pre-existing medical conditions or medications as determined by the investigators to affect the outcomes of interest","Inclusion Criteria:\n\nAges 8-10 years Boys and girls All ethnicity All BMI\n\nExclusion Criteria:\n\nsevere persistent asthma exercise induced asthma autism spectrum disorder attention deficit hyperactivity disorder attention deficit disorder\n\n* Opposition defiant disorder\n* conduct disorder\n* epilepsy\n* chronic kidney disease\n* hormonal disease\n* autoimmune diseases\n* bleeding disorders\n* chronic infections\n* mental health disorder\n* Type 2 and Type 1 diabetes\n* Other pre-existing medical conditions or medications as determined by the investigators to affect the outcomes of interest",[54],"CHILD",[56],{"facility":57,"status":8,"city":58,"state":59,"zip":60,"country":61,"contacts":62,"geoPoint":68},"Arkansas Children's Nutrition Center","Little Rock","Arkansas","72203","United States",[63],{"name":64,"role":65,"phone":66,"email":67},"Tonja Nolen, MS","CONTACT","501-364-2853","acncstudies@archildrens.org",{"lat":69,"lon":70},34.74648,-92.28959,[72,75],{"name":73,"role":65,"phone":74,"email":67},"Tonja C Nolen, MS","501-364-3309",{"name":76,"role":65,"phone":74,"email":67},"Audrey Martinez, MS, RD, LD",[78],{"name":79,"affiliation":57,"role":80},"Elisabet Borsheim, Ph","PRINCIPAL_INVESTIGATOR",[],[],{"nct_id":4,"conditions":84,"biomarkers":85},[19],[],{"nct_id":4,"found":37,"summary":87,"prompt_version":97},{"design":88,"status":89,"heading":90,"summary":91,"follow_up":92,"word_count":93,"commitments":94,"compensation":95,"drugs_mentioned":96},"This is an observational study, meaning researchers will observe participants without providing any interventions. It plans to enroll 300 healthy children.","completed","Observational Study on Bioenergetic Phenotypes and Cardiometabolic Health in Children","This research study is looking at how daily activities, behaviors, and fitness affect the health of blood cells and their mitochondria (the powerhouses of cells that make energy). Researchers want to understand how these tiny energy makers in your cells are connected to body fat and how well you can exercise. The study is for healthy children aged 8 to 10 years old. To join, you must not have certain health conditions like severe asthma, autism, ADHD, or epilepsy. The main goal is to measure platelet mitochondrial respiration (how well mitochondria in blood cells use oxygen) and see how it relates to body fat and peak aerobic capacity (how much oxygen your body can use during exercise) in children. The study aims to enroll 300 participants, but its current recruitment status is unclear.","The primary endpoint is measured at 8 days, suggesting a short follow-up period.",133,"Not specified in the trial record.","Not stated in the trial record.",[],"v2"]