[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT04511013":3,"trial-entities:NCT04511013":3279,"trial-summary:NCT04511013":3284},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":26,"study_type":27,"primary_purpose":28,"phases":29,"enrollment_info":31,"interventions":34,"primary_outcomes":75,"secondary_outcomes":80,"sex":94,"minimum_age":95,"maximum_age":96,"healthy_volunteers":97,"eligibility_criteria":98,"std_ages":135,"locations":138,"central_contacts":3264,"overall_officials":3275,"references":3277,"see_also_links":3278},"NCT04511013","S2000","A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases","A Randomized Phase 2 Trial of Encorafenib + Binimetinib + Nivolumab vs Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases","RECRUITING","2027-06-30","2025-09","2025-09-11","2021-01-06","SWOG Cancer Research Network","NETWORK",true,"This phase II trial compares the effect of encorafenib, binimetinib, and nivolumab versus ipilimumab and nivolumab in treating patients with BRAF- V600 mutant melanoma that has spread to the brain (brain metastases). Encorafenib and binimetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Ipilimumab and nivolumab are monoclonal antibodies that may interfere with the ability of tumor cells to grow and spread. This trial aims to find out which approach is more effective in shrinking and controlling brain metastases from melanoma.","PRIMARY OBJECTIVE:\n\nI. To compare progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 between participants randomized to the triplet combination of encorafenib + binimetinib + nivolumab versus the doublet combination of ipilimumab + nivolumab among participants with BRAF-V600 mutant melanoma that has metastasized to the brain.\n\nSECONDARY OBJECTIVES:\n\nI. To estimate the overall survival (OS) of participants in each treatment arm. II. To estimate the objective response rate (ORR) (confirmed and unconfirmed, complete and partial responses) per RECIST 1.1 in each treatment arm.\n\nIII. To estimate the intracranial response rate (ICRR), defined as confirmed and unconfirmed complete and partial response per modified RECIST for brain metastases (mRECIST).\n\nIV. To evaluate the duration of response, per RECIST 1.1 and the duration of ICRR per mRECIST, and per Response Assessment in Neuro-Oncology (RANO)-Brain Metastases (BM) (and immunotherapy \\[i\\]RANO) in each treatment arm.\n\nV. To evaluate the toxicity profile of each treatment arm. VI. To evaluate current and emerging radiographic response criteria (modified RECIST 1.1, modified RANO-BM and iRANO) by a retrospective blinded independent centralized review (BICR) of banked images.\n\nBANKING OBJECTIVE:\n\nI. To bank tumor tissue, cerebral spinal fluid (CSF), stool and blood samples for future correlative studies.\n\nOUTLINE: Patients are randomized to 1 of 2 arms.\n\nARM I: Patients receive encorafenib orally (PO) once daily (QD) on days 1-28, binimetinib PO twice daily (BID) on days 1-28, and nivolumab intravenously (IV) on day 1. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.\n\nARM II: Patients receive nivolumab IV on day 1 of all cycles and ipilimumab IV over 30 minutes on day 1 of cycles 1-4. Cycles repeat every 21 days for 4 cycles and then every 28 days in the absence of disease progression or unacceptable toxicity.\n\nAfter completion of study treatment, patients are followed up every 6 months for 2 years, and then annually until 3 years after randomization.",[19,20,21,22,23,24,25],"Acral Lentiginous Melanoma","Clinical Stage IV Cutaneous Melanoma AJCC v8","Metastatic Cutaneous Melanoma","Metastatic Malignant Neoplasm in the Brain","Metastatic Melanoma","Metastatic Mucosal Melanoma","Pathologic Stage IV Cutaneous Melanoma AJCC v8",[],"INTERVENTIONAL","TREATMENT",[30],"PHASE2",{"count":32,"type":33},112,"ESTIMATED",[35,46,54,66],{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":41},"DRUG","Binimetinib","Given PO",[40],"Arm I (encorafenib, binimetinib, nivolumab)",[42,43,44,45],"ARRY-162","ARRY-438162","MEK162","Mektovi",{"type":36,"name":47,"description":38,"armGroupLabels":48,"otherNames":49},"Encorafenib",[40],[50,51,52,53],"Braftovi","LGX 818","LGX-818","LGX818",{"type":55,"name":56,"description":57,"armGroupLabels":58,"otherNames":60},"BIOLOGICAL","Ipilimumab","Given IV",[59],"Arm II (nivolumab, ipilimumab)",[61,62,63,64,65],"Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody","BMS-734016","MDX-010","MDX-CTLA4","Yervoy",{"type":55,"name":67,"description":57,"armGroupLabels":68,"otherNames":69},"Nivolumab",[40,59],[70,71,72,73,74],"BMS-936558","MDX-1106","NIVO","ONO-4538","Opdivo",[76],{"measure":77,"description":78,"timeFrame":79},"Progression-free survival","Will be assessed by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1.","From date of registration to date of first documentation of progression, or symptomatic deterioration, or death due to any cause, assessed up to 3 years after randomization",[81,85,89,92],{"measure":82,"description":83,"timeFrame":84},"Overall survival (OS)","Will be assessed by Immunotherapy Response Assessment Criteria for Intracranial Metastases (RANO-BM). Will construct Kaplan-Meier plots and estimate the median OS and construct 95% Brookmeyer-Crowley Confidence intervals.","From date of registration to date of death due to any cause, assessed up to 3 years after randomization",{"measure":86,"description":87,"timeFrame":88},"Intracranial response rate (ICRR)","The ICRR is defined as the best response when applying modified (m)RECIST criteria. Will compare intracranial response based on assessments per mRECIST, RANO-BM and immunotherapy (i)RANO criteria based on a review of the banked images. For each of these methods, the best response to treatment will be summarized by treatment arm, the percent agreement between each pair of methods will be reported along with a 95% confidence interval, and a p-value based on a two-sided McNemar's test will be calculated.","Up to 3 years after randomization",{"measure":90,"description":91,"timeFrame":88},"Objective response rate","Will be assessed by RECIST 1.1.",{"measure":93,"timeFrame":88},"Duration of response","ALL","18 Years",null,false,{"inclusion":99,"exclusion":124,"raw_text":134},[100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123],"Participants must have histologically and pathologically confirmed melanoma that has metastasized to the brain","Any primary (cutaneous, acral\u002Fmucosal, etc) or unknown origin are permitted, except that participants with uveal primary are not eligible","Participants must have BRAF-V600 mutant melanoma documented by a Clinical Laboratory Improvement Act (CLIA)-certified laboratory","All participants must have an magnetic resonance imaging (MRI) of the brain within 28 days prior to registration and must have central nervous system metastases with at least one measurable brain metastasis \\>= 0.5 cm in size (per modified RECIST 1.1) that has not been irradiated, or progressed (in the opinion of the treating physician) after prior radiation therapy. Participating sites MUST use MRI slice thickness of =\\\u003C 1.5 mm and are recommended to adhere to the 'minimum' Brain Tumor Imaging Protocol for Clinical Trials in Brain Metastases (BTIP-BM) compliant MRI acquisition protocol. Computed tomography (CT) of the head cannot substitute for brain MRI. (NOTE: All central nervous system \\[CNS\\] disease must be documented on BOTH the Brain Metastases Baseline Tumor Assessment Form, using modified RECIST, and the Baseline Tumor Assessment Form \\[RECIST 1.1\\] using RECIST 1.1.)","Participants may have measurable or non-measurable extracranial disease. All measurable disease must be assessed within 28 days prior to randomization; all non-measurable disease must be assessed within 42 days prior to randomization. Please note, while any extracranial disease will also be assessed and followed, participants are NOT required to have extracranial disease for randomization. NOTE: All disease must be assessed and documented on the Baseline Tumor Assessment Form (RECIST 1.1). CNS disease must be documented on BOTH the Brain Metastases Baseline Tumor Assessment Form, using modified RECIST, and the Baseline Tumor Assessment Form (RECIST 1.1) using RECIST 1.1","Participants may have leptomeningeal disease","Participants may be receiving corticosteroids for brain metastases at a dose of up to 8 mg of dexamethasone per day. The dose must not have exceeded 8 mg per day for at least 7 days prior to randomization","Participants must have Zubrod performance status =\\\u003C 2","Participants must have complete history and physical examination within 28 days prior to randomization","Participants must be able to swallow and retain pills","Hemoglobin \\>= 8.0 g\u002FdL (within 28 days prior to randomization)","Absolute neutrophil count \\>= 1,500\u002FmcL (within 28 days prior to randomization)","Platelets \\>= 75,000\u002FmcL (within 28 days prior to randomization)","Total bilirubin =\\\u003C 1.5 institutional upper limit of normal (ULN) (within 28 days prior to randomization)","Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\\\u003C 2.5 x institutional ULN (in participants with liver metastases =\\\u003C 5 x ULN) (within 28 days prior to randomization)","Creatinine =\\\u003C 2.0 institutional ULN (within 28 days prior to randomization)","Participants with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, must have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, participants must be class 2B or better","Participants with a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial","Participants with known human immunodeficiency virus (HIV)-infection are eligible providing they are on effective anti-retroviral therapy and have undetectable viral load at their most recent viral load test and within 90 days prior to randomization","Participants with a known history of hepatitis C virus (HCV) infection must have been treated and cured. Participants with HCV infection who are currently on treatment must have an undetectable HCV viral load prior to randomization","Participants must agree to participate in image banking. Images must be submitted via the Triad System","Participants must be offered the opportunity to participate in specimen and blood collections","Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines","As a part of the OPEN registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system",[125,126,127,128,129,130,131,132,133],"Participants must not have received prior systemic therapy for metastatic disease. Prior systemic therapy received only in the neoadjuvant and\u002For adjuvant setting (e.g., BRAF\u002FMEK inhibitor therapy, anti-PD-1 therapy or anti-CTLA4 therapy, alfa-interferon, etc.) is permitted. If patients received prior neoadjuvant\u002Fadjuvant therapy, they must have had eventual disease relapse prior to randomization","Participants must not have had prior radiation therapy within 7 days prior to randomization","Participants must not be planning to require any additional form of systemic anti-tumor therapy for melanoma while on protocol treatment","Participants must not be planning to use hormonal contraceptives","Participants must not have a serious active infection requiring systemic therapy at time of randomization in the opinion of the treating physician","Participants must not have active autoimmune disease that has required treatment in the past 6 months with use of biologic disease modifying agents (.e.g. infliximab, adalimumab). Patients on non-biologic disease modifying agents (e.g. methotrexate) or patients on corticosteroids =\\\u003C 10 mg prednisone daily or equivalent (to treat auto-immune disease), or on replacement therapy (e.g., thyroxine, insulin) are eligible if deemed in the best interest of the patient by treating physician","Participants must not have had grade 3 or 4 immune-related adverse events on ipilimumab or nivolumab that required more than 12 weeks of immune suppression with corticosteroids","Participants must not have had adverse events related to encorafenib and\u002For binimetinib specifically, that required discontinuation of one or both drugs. (Please note this does not apply to other BRAF\u002FMEK inhibitor drugs.)","Participants must not be pregnant or nursing. Women\u002Fmen of reproductive potential must have agreed to use an effective method of contraception. (NOTE: Patients must agree to not use hormonal contraceptives, as encorafenib can result in decreased concentration and loss of efficacy.) A woman is considered to be of \"reproductive potential\" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, \"effective contraception\" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate participant chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he\u002Fshe is responsible for beginning contraceptive measures","Inclusion Criteria:\n\n* Participants must have histologically and pathologically confirmed melanoma that has metastasized to the brain\n* Any primary (cutaneous, acral\u002Fmucosal, etc) or unknown origin are permitted, except that participants with uveal primary are not eligible\n* Participants must have BRAF-V600 mutant melanoma documented by a Clinical Laboratory Improvement Act (CLIA)-certified laboratory\n* All participants must have an magnetic resonance imaging (MRI) of the brain within 28 days prior to registration and must have central nervous system metastases with at least one measurable brain metastasis \\>= 0.5 cm in size (per modified RECIST 1.1) that has not been irradiated, or progressed (in the opinion of the treating physician) after prior radiation therapy. Participating sites MUST use MRI slice thickness of =\\\u003C 1.5 mm and are recommended to adhere to the 'minimum' Brain Tumor Imaging Protocol for Clinical Trials in Brain Metastases (BTIP-BM) compliant MRI acquisition protocol. Computed tomography (CT) of the head cannot substitute for brain MRI. (NOTE: All central nervous system \\[CNS\\] disease must be documented on BOTH the Brain Metastases Baseline Tumor Assessment Form, using modified RECIST, and the Baseline Tumor Assessment Form \\[RECIST 1.1\\] using RECIST 1.1.)\n* Participants may have measurable or non-measurable extracranial disease. All measurable disease must be assessed within 28 days prior to randomization; all non-measurable disease must be assessed within 42 days prior to randomization. Please note, while any extracranial disease will also be assessed and followed, participants are NOT required to have extracranial disease for randomization. NOTE: All disease must be assessed and documented on the Baseline Tumor Assessment Form (RECIST 1.1). CNS disease must be documented on BOTH the Brain Metastases Baseline Tumor Assessment Form, using modified RECIST, and the Baseline Tumor Assessment Form (RECIST 1.1) using RECIST 1.1\n* Participants may have leptomeningeal disease\n* Participants may be receiving corticosteroids for brain metastases at a dose of up to 8 mg of dexamethasone per day. The dose must not have exceeded 8 mg per day for at least 7 days prior to randomization\n* Participants must have Zubrod performance status =\\\u003C 2\n* Participants must have complete history and physical examination within 28 days prior to randomization\n* Participants must be able to swallow and retain pills\n* Hemoglobin \\>= 8.0 g\u002FdL (within 28 days prior to randomization)\n* Absolute neutrophil count \\>= 1,500\u002FmcL (within 28 days prior to randomization)\n* Platelets \\>= 75,000\u002FmcL (within 28 days prior to randomization)\n* Total bilirubin =\\\u003C 1.5 institutional upper limit of normal (ULN) (within 28 days prior to randomization)\n* Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\\\u003C 2.5 x institutional ULN (in participants with liver metastases =\\\u003C 5 x ULN) (within 28 days prior to randomization)\n* Creatinine =\\\u003C 2.0 institutional ULN (within 28 days prior to randomization)\n* Participants with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, must have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, participants must be class 2B or better\n* Participants with a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial\n* Participants with known human immunodeficiency virus (HIV)-infection are eligible providing they are on effective anti-retroviral therapy and have undetectable viral load at their most recent viral load test and within 90 days prior to randomization\n* Participants with a known history of hepatitis C virus (HCV) infection must have been treated and cured. Participants with HCV infection who are currently on treatment must have an undetectable HCV viral load prior to randomization\n* Participants must agree to participate in image banking. Images must be submitted via the Triad System\n* Participants must be offered the opportunity to participate in specimen and blood collections\n* Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines\n* As a part of the OPEN registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system\n\nExclusion Criteria:\n\n* Participants must not have received prior systemic therapy for metastatic disease. Prior systemic therapy received only in the neoadjuvant and\u002For adjuvant setting (e.g., BRAF\u002FMEK inhibitor therapy, anti-PD-1 therapy or anti-CTLA4 therapy, alfa-interferon, etc.) is permitted. If patients received prior neoadjuvant\u002Fadjuvant therapy, they must have had eventual disease relapse prior to randomization\n* Participants must not have had prior radiation therapy within 7 days prior to randomization\n* Participants must not be planning to require any additional form of systemic anti-tumor therapy for melanoma while on protocol treatment\n* Participants must not be planning to use hormonal contraceptives\n* Participants must not have a serious active infection requiring systemic therapy at time of randomization in the opinion of the treating physician\n* Participants must not have active autoimmune disease that has required treatment in the past 6 months with use of biologic disease modifying agents (.e.g. infliximab, adalimumab). Patients on non-biologic disease modifying agents (e.g. methotrexate) or patients on corticosteroids =\\\u003C 10 mg prednisone daily or equivalent (to treat auto-immune disease), or on replacement therapy (e.g., thyroxine, insulin) are eligible if deemed in the best interest of the patient by treating physician\n* Participants must not have had grade 3 or 4 immune-related adverse events on ipilimumab or nivolumab that required more than 12 weeks of immune suppression with corticosteroids\n* Participants must not have had adverse events related to encorafenib and\u002For binimetinib specifically, that required discontinuation of one or both drugs. (Please note this does not apply to other BRAF\u002FMEK inhibitor drugs.)\n* Participants must not be pregnant or nursing. Women\u002Fmen of reproductive potential must have agreed to use an effective method of contraception. (NOTE: Patients must agree to not use hormonal contraceptives, as encorafenib can result in decreased concentration and loss of efficacy.) A woman is considered to be of \"reproductive potential\" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, \"effective contraception\" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate participant chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he\u002Fshe is responsible for beginning contraceptive measures",[136,137],"ADULT","OLDER_ADULT",[139,157,169,180,194,201,208,214,220,226,232,238,251,264,277,289,300,307,319,330,341,349,357,370,380,387,399,412,415,424,434,441,451,461,468,474,480,487,490,493,503,509,515,522,529,539,549,559,562,569,579,588,595,602,609,613,626,633,646,653,659,667,681,690,700,712,722,732,742,748,758,765,775,785,795,807,819,832,842,854,865,875,887,894,901,913,923,929,940,951,957,967,977,984,994,1001,1011,1022,1032,1042,1052,1062,1069,1079,1086,1096,1107,1114,1123,1130,1140,1146,1156,1166,1180,1193,1201,1211,1224,1235,1242,1250,1258,1268,1275,1285,1295,1306,1319,1329,1342,1355,1368,1378,1388,1394,1400,1410,1416,1423,1430,1440,1450,1460,1470,1480,1486,1496,1506,1514,1523,1533,1543,1553,1563,1573,1583,1589,1599,1606,1613,1623,1633,1642,1652,1662,1672,1679,1689,1699,1709,1719,1729,1738,1750,1760,1771,1783,1790,1801,1813,1825,1833,1845,1852,1863,1873,1882,1889,1900,1908,1915,1923,1933,1943,1953,1964,1976,1986,1996,2002,2012,2024,2031,2045,2051,2059,2072,2085,2095,2106,2117,2128,2139,2153,2163,2176,2186,2196,2199,2209,2220,2227,2234,2244,2257,2265,2272,2279,2286,2293,2301,2309,2316,2323,2326,2337,2344,2353,2360,2370,2376,2382,2389,2396,2407,2417,2423,2433,2439,2448,2455,2466,2477,2488,2498,2508,2518,2528,2538,2549,2555,2565,2575,2585,2595,2605,2614,2621,2631,2638,2648,2651,2661,2671,2678,2688,2698,2708,2719,2733,2741,2752,2764,2776,2782,2794,2804,2814,2824,2834,2841,2851,2864,2872,2886,2898,2909,2918,2930,2942,2952,2964,2974,2986,2997,3004,3011,3018,3025,3037,3047,3058,3070,3080,3094,3107,3120,3132,3142,3154,3164,3174,3184,3194,3201,3212,3222,3233,3244,3254],{"facility":140,"status":8,"city":141,"state":142,"zip":143,"country":144,"contacts":145,"geoPoint":154},"University of Alabama at Birmingham Cancer Center","Birmingham","Alabama","35233","United States",[146,151],{"name":147,"role":148,"phone":149,"email":150},"Site Public Contact","CONTACT","205-934-0220","tmyrick@uab.edu",{"name":152,"role":153},"Maya Khalil","PRINCIPAL_INVESTIGATOR",{"lat":155,"lon":156},33.52066,-86.80249,{"facility":158,"status":8,"city":159,"state":142,"zip":160,"country":144,"contacts":161,"geoPoint":166},"Thomas Hospital","Fairhope","36532",[162,164],{"name":147,"role":148,"phone":163},"251-435-4584",{"name":165,"role":153},"Furhan Yunus",{"lat":167,"lon":168},30.52297,-87.90333,{"facility":170,"status":8,"city":171,"state":142,"zip":172,"country":144,"contacts":173,"geoPoint":177},"Mobile Infirmary Medical Center","Mobile","36607",[174,176],{"name":147,"role":148,"phone":175},"251-435-3942",{"name":165,"role":153},{"lat":178,"lon":179},30.69436,-88.04305,{"facility":181,"status":8,"city":182,"state":183,"zip":184,"country":144,"contacts":185,"geoPoint":191},"Anchorage Associates in Radiation Medicine","Anchorage","Alaska","98508",[186,189],{"name":147,"role":148,"phone":187,"email":188},"907-212-6871","AKPAMC.OncologyResearchSupport@providence.org",{"name":190,"role":153},"Charles W. 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It compares two different drug combinations to see which is more effective.","completed","Study of Encorafenib, Binimetinib, and Nivolumab for BRAF-V600 Mutant Melanoma with Brain Metastases","This study is comparing two different treatment approaches for melanoma that has spread to the brain and has a specific genetic change called BRAF-V600 mutation. One group of patients will receive a combination of three drugs: encorafenib, binimetinib, and nivolumab. Encorafenib and binimetinib work by blocking certain enzymes that help cancer cells grow. Nivolumab is an immunotherapy that helps your body's immune system fight cancer. The other group will receive ipilimumab and nivolumab, which are also immunotherapies. The main goal is to see which combination is better at stopping the cancer from growing or spreading. You may be able to join if you are 18 or older, have melanoma that has spread to your brain, and your melanoma has the BRAF-V600 mutation.","Participants will be followed to see how long it takes for their cancer to progress, up to 3 years after starting the study.",122,"Not specified in the trial record.","Not stated in the trial record.",[37,47,56,67],"v2"]