[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT04616508":3,"trial-entities:NCT04616508":93,"trial-summary:NCT04616508":96},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":20,"study_type":24,"primary_purpose":25,"phases":26,"enrollment_info":28,"interventions":31,"primary_outcomes":38,"secondary_outcomes":49,"sex":50,"minimum_age":51,"maximum_age":52,"healthy_volunteers":53,"eligibility_criteria":54,"std_ages":66,"locations":69,"central_contacts":85,"overall_officials":89,"references":91,"see_also_links":92},"NCT04616508","1358328-5","Online Motor Control in People With Parkinson's Disease","RECRUITING","2026-12-12","2020-10","2020-11-05","2018-12-12","University of Delaware","OTHER",false,"This study aims to better understand how people with Parkinson's control reaching movements. Specifically, we are asking how these individuals respond to different environmental perturbations. Testing includes reaching movements made within a virtual reality set-up.","Parkinson's disease (PD) is the second most common neurodegenerative disease, affecting approximately up to 10 million people worldwide and with 60,000 new cases diagnosed annually in the U.S. alone. Some of the most common signs and symptoms in individuals with PD are slowed and small movements and difficulty in movement initiation. The ability to correct movements online in response to environmental changes is an important part of daily living. Online movement corrections in reaching refer to the ability to smoothly change how and where you reach in response to a change in the environment. For example, one can adjust the position of the hand and arm when trying to catch a butterfly flying in the air. Generally speaking, online movement corrections can happen in response to visual perturbations (e.g., trying to catch a butterfly) or to force perturbations (e.g., someone knocks your hand while you're holding a coffee mug). Since individuals with PD have trouble with movements, it stands to reason that they may have problems with online movement corrections. Surprisingly, very little is known about online movement corrections in individuals with PD. The current evidence suggests that individuals with PD can make online movement corrections to small visual perturbations, but whether they can successfully respond to large visual perturbations is debatable. Furthermore, whether individuals with PD can make online movement corrections to force perturbations has not been studied. The aim of this project is to investigate if individuals with PD can make online movement corrections during reaching to visual and\u002For force perturbations. We will test both individuals with PD and age-matched healthy controls. They will perform reaching movements while visual or force perturbations are applied. We will use various perturbation strengths in order to test for potential differences in responses to small and large perturbations. Results from this study will provide new information on how individuals with PD make online movement corrections, and possibly provide insight to improving rehabilitation for PD.",[18,19],"Motor Control","Parkinson Disease",[21,22,23],"motor control","Parkinson disease","motor learning","INTERVENTIONAL","BASIC_SCIENCE",[27],"NA",{"count":29,"type":30},100,"ESTIMATED",[32],{"type":33,"name":34,"description":35,"armGroupLabels":36},"BEHAVIORAL","motor control assessment","Basic science study of control of reaching movements",[37],"Behavioral testing",[39,43,46],{"measure":40,"description":41,"timeFrame":42},"End-point errors","Euclidean distance from target to final hand position (units: cm); measurement derived from position data sampled at 1000 Hz","during intervention",{"measure":44,"description":45,"timeFrame":42},"Reaction times","Time from visual target presentation to movement onset (units: ms); measurement derived from position data sampled at 1000 Hz",{"measure":47,"description":48,"timeFrame":42},"Movement times","Time from movement onset to movement end (units: ms); measurement derived from position data sampled at 1000 Hz",[],"ALL","18 Years","85 Years",true,{"inclusion":55,"exclusion":62,"raw_text":65},[56,57,58,59,60,61],"Age 18-85 years","Able to perform reaching movements of \\~20 cm (8 inches)","MMSE score ≥ 26\u002F30","Willing and able to attend all testing sessions","Diagnosis of idiopathic Parkinson's disease per self report","Currently taking dopaminergic\u002Fdopamine agonist medication",[63,64],"Any chronic or recent upper extremity musculoskeletal conditions that affects reaching","Any neurological disorders other than Parkinson's disease (e.g., seizure disorders, closed head injuries with loss of consciousness greater than 15 minutes, CNS neoplasm, history of stroke)","Inclusion criteria (all participants):\n\n* Age 18-85 years\n* Able to perform reaching movements of \\~20 cm (8 inches)\n* MMSE score ≥ 26\u002F30\n* Willing and able to attend all testing sessions\n\nInclusion criteria (PD group only):\n\n* Diagnosis of idiopathic Parkinson's disease per self report\n* Currently taking dopaminergic\u002Fdopamine agonist medication\n\nExclusion criteria (all participants):\n\n* Any chronic or recent upper extremity musculoskeletal conditions that affects reaching\n* Any neurological disorders other than Parkinson's disease (e.g., seizure disorders, closed head injuries with loss of consciousness greater than 15 minutes, CNS neoplasm, history of stroke)",[67,68],"ADULT","OLDER_ADULT",[70],{"facility":12,"status":7,"city":71,"state":72,"zip":73,"country":74,"contacts":75,"geoPoint":82},"Newark","Delaware","19713","United States",[76,79],{"name":77,"role":78},"Joie Tang","CONTACT",{"name":80,"role":81},"Hyosub Kim, PhD","PRINCIPAL_INVESTIGATOR",{"lat":83,"lon":84},39.68372,-75.74966,[86],{"name":80,"role":78,"phone":87,"email":88},"302-831-4263","hyosub@udel.edu",[90],{"name":80,"affiliation":12,"role":81},[],[],{"nct_id":4,"conditions":94,"biomarkers":95},[19],[],{"nct_id":4,"found":53,"summary":97,"prompt_version":106},{"design":98,"status":99,"heading":6,"summary":100,"follow_up":101,"word_count":102,"commitments":103,"compensation":104,"drugs_mentioned":105},"This is an interventional study planning to enroll 100 participants. It is a basic science study of control of reaching movements.","completed","This study is looking to understand how people with Parkinson's disease control their reaching movements, especially when their environment changes. Researchers will use a motor control assessment, which involves making reaching movements in a virtual reality setting. The study aims to see how accurately and quickly people can adjust their movements. You might be able to join if you are 18-85 years old, can perform reaching movements of about 8 inches, have a good score on a memory test (MMSE score ≥ 26\u002F30), and are able to attend all testing sessions. If you have Parkinson's disease, you also need to be taking dopaminergic\u002Fdopamine agonist medication. The study plans to enroll 100 participants, but its current status is unclear.","The primary endpoints (end-point errors, reaction times, movement times) are measured during the intervention.",118,"You would participate in testing sessions that involve making reaching movements within a virtual reality setup.","Not stated in the trial record.",[34],"v2"]