[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT04649242":3,"trial-entities:NCT04649242":1629,"trial-summary:NCT04649242":1632},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":15,"conditions":17,"keywords":19,"study_type":28,"primary_purpose":29,"phases":30,"enrollment_info":32,"interventions":35,"primary_outcomes":47,"secondary_outcomes":52,"sex":101,"minimum_age":102,"maximum_age":103,"healthy_volunteers":104,"eligibility_criteria":105,"std_ages":109,"locations":111,"central_contacts":1614,"overall_officials":1620,"references":1624,"see_also_links":1625},"NCT04649242","BHV3000-311","Randomized Study in Children and Adolescents With Migraine: Acute Treatment","Phase 3, Multicenter, Randomized, Double-blind, Group Sequential, Placebo-controlled Study to Assess Efficacy and Safety of Rimegepant for the Treatment of Migraine (With or Without Aura) in Children and Adolescents ≥ 6 to \u003C 18 Years of Age","RECRUITING","2029-01-09","2026-08","2026-08-14","2021-01-15","Pfizer","INDUSTRY",null,"The purpose of this study is to test the safety and efficacy of BHV-3000 versus placebo in the acute treatment of moderate or severe migraine in children and adolescents.",[18],"Pediatric Migraine",[20,21,22,23,24,25,26,27,18],"Migraine","Acute treatment","Phonophobia","Photophobia","Nausea","Pediatric","Children","Adolescent","INTERVENTIONAL","TREATMENT",[31],"PHASE3",{"count":33,"type":34},2100,"ESTIMATED",[36,42],{"type":37,"name":38,"description":39,"armGroupLabels":40},"DRUG","Rimegepant\u002FBHV3000","BHV3000 (rimegepant) 75 mg or 50 mg ODT",[41],"BHV3000 (active drug)",{"type":37,"name":43,"description":44,"armGroupLabels":45},"Matching placebo","Matching 75 mg or 50 mg ODT placebo",[46],"Placebo",[48],{"measure":49,"description":50,"timeFrame":51},"To evaluate the efficacy of rimegepant compared with placebo in the acute treatment of migraine in adolescent population (≥ 12 to \u003C18 years of age) as measured by pain freedom using the number of patients reporting no pain.","Pain freedom will be assessed in adolescent population (≥ 12 to \\\u003C 18 years of age) on a 4-point numeric rating scale (0=none, 1=mild, 2=moderate, 3=severe).","2 hours post-dose",[53,56,59,63,67,69,72,75,78,82,84,85,88,91,94,97],{"measure":54,"description":55,"timeFrame":51},"To compare rimegepant with placebo for pain freedom in children and adolescents combined.","Pain freedom will be assessed in children and adolescents (≥ 6 to \\\u003C 18 years of age) using a 4-point numeric rating scale (0=none, 1=mild, 2=moderate, 3=severe).\n\nPain freedom will be assessed in children (\\> 6 to \\\u003C 12 years of age) using the 5-Face VAS (Face 5 = 'severe pain', Faces 4 and 3 = 'moderate pain', Face 2 = 'mild pain', Face 1 = 'no pain').",{"measure":57,"description":58,"timeFrame":51},"To compare rimegepant with placebo on freedom from the most bothersome symptom (MBS) associated with migraine in adolescents.","Freedom from MBS (nausea, phonophobia or photophobia) will be measured using a binary scale (0=absent, 1=present).",{"measure":60,"description":61,"timeFrame":62},"To compare rimegepant with placebo on the probabilities of requiring rescue medication within in adolescents.","Use of rescue medication will be assessed using the numbers of participants that take rescue medication.","Within 24 hours and 48 hours of initial treatment",{"measure":64,"description":65,"timeFrame":66},"To compare rimegepant with placebo on sustained pain freedom in adolescents.","Sustained pain freedom will be assessed using the number of participants that do not use any rescue medications and do not experience any headache pain post dose.","2 to 24 hours post-dose",{"measure":64,"description":65,"timeFrame":68},"2 to 48 hours post-dose",{"measure":70,"description":71,"timeFrame":51},"To compare rimegepant with placebo on the ability to function normally as reported on the Functional Disability scale in adolescents.","The proportion of participants able to function normally will be assessed using the number that self-report as \"normal\" on the Functional Disability scale.",{"measure":73,"description":74,"timeFrame":51},"To compare rimegepant with placebo for pain freedom in children.","Pain freedom will be assessed using the number of children (≥ 6 to \\\u003C 12 years of age) that report no pain measured by a 5-Face VAS (Face 5 = 'severe pain', Faces 4 and 3 = 'moderate pain', Face 2 = 'mild pain', Face 1 = 'no pain').",{"measure":76,"description":77,"timeFrame":51},"To compare rimegepant with placebo on freedom from the most bothersome symptom (MBS) associated with migraine in children and combined children and adolescents.","Freedom from the most bothersome symptom (nausea, phonophobia or photophobia) will be assessed using the number of participants that report the absence of MBS measured using a binary scale (0=absent, 1=present).",{"measure":79,"description":80,"timeFrame":81},"To compare rimegepant with placebo on the probabilities of requiring rescue medication in children and combined children and adolescents.","The probabilities of requiring rescue medication will be assessed using the numbers of participants that take rescue medication within initial treatment.","Within 24 hours and 48 hours of initial treatment.",{"measure":83,"description":65,"timeFrame":66},"To compare rimegepant with placebo on sustained pain freedom in children and combined children and adolescents.",{"measure":83,"description":65,"timeFrame":68},{"measure":86,"description":87,"timeFrame":51},"To compare rimegepant with placebo on freedom from photophobia in adolescents, children and combined children and adolescents.","Freedom from photophobia will be assessed by the number of participants that report the absence of photophobia post dose that reported the presence of photophobia at baseline.",{"measure":89,"description":90,"timeFrame":51},"To compare rimegepant with placebo on freedom from phonophobia in adolescents, children and combined children and adolescents.","Freedom from phonophobia will be assessed by the number of participants that report the absence of phonophobia post dose that reported the presence of phonophobia at baseline.",{"measure":92,"description":93,"timeFrame":51},"To compare rimegepant with placebo on freedom from nausea in adolescents, children and combined children and adolescents.","Freedom from nausea will be assessed by the number of participants that report the absence of nausea post dose that reported the presence of nausea at baseline.",{"measure":95,"description":96,"timeFrame":51},"To compare rimegepant with placebo on pain relief in adolescents, children and combined children and adolescents.","Pain relief will be assessed using the number of participants that report a pain level of moderate or severe at baseline and then report a pain level of none or mild post dose.",{"measure":98,"description":99,"timeFrame":100},"To compare rimegepant with placebo in adolescents, children and combined children and adolescents on pain relief.","Time to first report of pain relief will be based on the first time point a participant reports a pain level of none or mild.","Time to patients first report of pain relief of none or mild post dose up to 48 hours.","ALL","6 Years","17 Years",false,{"inclusion":106,"exclusion":107,"raw_text":108},[],[],"Inclusion Criteria:\n\n1. History of migraine (with or without aura) for \\> 6 months before Screening according to the IHS Classification ICHD-319 specifications for pediatric migraine. History may be verified using both medical records and recall by the participant and\u002For participant's parent(s)\u002Flegal representative(s).\n2. History of 1 to 8 moderate or severe attacks per month during the 2 months prior to enrollment, with attacks lasting \\> 3 hours without treatment, and attacks occurring at intervals \\> 24 hours.\n3. Prophylactic migraine medication are permitted if the dose has been stable for at least 12 weeks prior to the Baseline Visit, and the dose is not expected to change during the course of the study.\n\n   1. Participants may remain on one (1) medication with possible migraine prophylactic effects, excluding CGRP antagonists \\[biologic or small molecule\\], during the treatment phases.\n   2. Concomitant use of a CGRP antagonist, such as erenumab or fremanezumab, is prohibited.\n   3. Previously discontinued prophylactic migraine medication must have done so at least 90 days prior to the Screening Visit.\n4. Verbally distinguish between migraine and other types of headaches.\n5. Participants must have a weight \\> 40 kg at the Screening Visit.\n6. Adequate venous access for blood sampling.\n7. Male and female participants ≥ 6 to \\\u003C 18 years of age (participants must not reach their 18th birthday during the study).\n\nExclusion Criteria:\n\n1. History of cluster headache or hemiplegic migraine headache.\n2. Confounding and clinically significant pain syndrome that may interfere with the participant's ability to participate in this study.\n3. Current psychiatric condition that is uncontrolled and\u002For untreated for a minimum of 6 months prior to the Screening Visit. Participants with a lifetime history of psychosis and\u002For mania.\n4. History of suicidal behavior or major psychiatric disorder.\n5. Current diagnosis or history of substance abuse; positive drug test at Screening.\n6. History of moderate or severe head trauma or other neurological disorder (including seizure disorder) or systemic medical disease that is likely to affect central nervous system functioning.\n7. Recent or planned surgery, requiring general anesthesia, \\\u003C8 weeks prior to the Screening Visit.\n8. Participant has had gastrointestinal surgery that interferes with physiological absorption and motility (i.e., gastric bypass, duodenectomy, or gastric banding).\n9. Current diagnosis of viral hepatitis or a history of liver disease.\n10. Conditions considered clinically relevant in the context of the study such as uncontrolled hypertension (high blood pressure), diabetes, a life-threatening allergy",[110],"CHILD",[112,122,130,137,145,152,159,166,173,180,186,189,196,203,211,214,217,224,231,235,238,245,252,259,267,270,277,280,288,295,302,310,318,326,334,341,348,355,362,365,372,376,380,384,391,395,402,409,416,423,430,438,441,444,451,458,466,473,481,489,496,504,511,519,523,526,534,541,549,556,564,571,574,581,588,596,599,602,610,618,625,633,639,642,649,652,654,662,669,677,680,688,695,702,709,712,718,722,726,730,733,736,739,742,749,755,762,770,774,781,789,796,800,807,814,817,824,832,839,847,854,857,865,869,877,885,889,893,901,904,911,914,917,924,932,936,940,944,951,958,962,965,969,972,976,983,990,997,1001,1005,1009,1013,1020,1028,1031,1039,1047,1050,1053,1060,1063,1067,1074,1082,1089,1096,1099,1107,1114,1120,1128,1137,1144,1152,1160,1168,1176,1184,1192,1196,1204,1212,1219,1223,1231,1235,1239,1247,1254,1261,1265,1272,1279,1287,1295,1303,1307,1314,1322,1329,1337,1345,1352,1359,1365,1371,1377,1383,1386,1392,1395,1400,1405,1409,1417,1425,1430,1435,1439,1444,1448,1455,1461,1469,1477,1484,1493,1500,1507,1511,1514,1517,1524,1531,1540,1547,1551,1558,1565,1572,1581,1588,1595,1603,1610],{"facility":113,"status":114,"city":115,"state":116,"zip":117,"country":118,"geoPoint":119},"Achieve Clinical Research, LLC d\u002Fb\u002Fa Accel Research Sites-Neurology and Neurodiagnostic of Alabama","ACTIVE_NOT_RECRUITING","Birmingham","Alabama","35244","United States",{"lat":120,"lon":121},33.52066,-86.80249,{"facility":123,"status":8,"city":124,"state":125,"zip":126,"country":118,"geoPoint":127},"Perseverance Research Center, LLC","Scottsdale","Arizona","85253",{"lat":128,"lon":129},33.50921,-111.89903,{"facility":131,"status":114,"city":132,"state":125,"zip":133,"country":118,"geoPoint":134},"Physicians Research Group","Tempe","85284",{"lat":135,"lon":136},33.41477,-111.90931,{"facility":138,"status":8,"city":139,"state":140,"zip":141,"country":118,"geoPoint":142},"Advanced Research Center, Inc.","Anaheim","California","92805",{"lat":143,"lon":144},33.83529,-117.9145,{"facility":146,"status":8,"city":147,"state":140,"zip":148,"country":118,"geoPoint":149},"Adult & Child Neurology Medical Associates","Costa Mesa","92627",{"lat":150,"lon":151},33.64113,-117.91867,{"facility":153,"status":114,"city":154,"state":140,"zip":155,"country":118,"geoPoint":156},"ProScience Research Group","Culver City","90230",{"lat":157,"lon":158},34.02112,-118.39647,{"facility":160,"status":8,"city":161,"state":140,"zip":162,"country":118,"geoPoint":163},"Memorial Health Services","Fountain Valley","92708",{"lat":164,"lon":165},33.70918,-117.95367,{"facility":167,"status":8,"city":168,"state":140,"zip":169,"country":118,"geoPoint":170},"Neuro-Pain Research Center","Fresno","93710",{"lat":171,"lon":172},36.74773,-119.77237,{"facility":174,"status":8,"city":175,"state":140,"zip":176,"country":118,"geoPoint":177},"Altman Clinical and Translational Research Institute, University of California San Diego","La Jolla","92037",{"lat":178,"lon":179},32.84727,-117.2742,{"facility":146,"status":8,"city":181,"state":140,"zip":182,"country":118,"geoPoint":183},"Long Beach","90806",{"lat":184,"lon":185},33.76696,-118.18923,{"facility":187,"status":8,"city":181,"state":140,"zip":182,"country":118,"geoPoint":188},"Miller Children's & Women's Hospital Long Beach",{"lat":184,"lon":185},{"facility":190,"status":114,"city":191,"state":140,"zip":192,"country":118,"geoPoint":193},"National Research Institute","Los Angeles","90057",{"lat":194,"lon":195},34.05223,-118.24368,{"facility":197,"status":114,"city":198,"state":140,"zip":199,"country":118,"geoPoint":200},"Velocity Clinical Research - North Hollywood","North Hollywood","91606",{"lat":201,"lon":202},34.17223,-118.37897,{"facility":204,"status":205,"city":206,"state":140,"zip":207,"country":118,"geoPoint":208},"Children's Hospital of Orange County - Inpatient Pharmacy","NOT_YET_RECRUITING","Orange","92868",{"lat":209,"lon":210},33.78779,-117.85311,{"facility":212,"status":205,"city":206,"state":140,"zip":207,"country":118,"geoPoint":213},"Children's Hospital of Orange County - Neuroscience Center",{"lat":209,"lon":210},{"facility":215,"status":205,"city":206,"state":140,"zip":207,"country":118,"geoPoint":216},"Children's Hospital of Orange County",{"lat":209,"lon":210},{"facility":218,"status":8,"city":219,"state":140,"zip":220,"country":118,"geoPoint":221},"The Neurology Group","Pomona","91767",{"lat":222,"lon":223},34.05529,-117.75228,{"facility":225,"status":114,"city":226,"state":140,"zip":227,"country":118,"geoPoint":228},"University of California, Davis Midtown Clinic","Sacramento","95816",{"lat":229,"lon":230},38.58157,-121.4944,{"facility":232,"status":114,"city":226,"state":140,"zip":233,"country":118,"geoPoint":234},"UC Davis Medical Center, Investigational Drug Service (IDS) Pharmacy","95817",{"lat":229,"lon":230},{"facility":236,"status":114,"city":226,"state":140,"zip":233,"country":118,"geoPoint":237},"University of California, Davis Clinical and Translational Science Center Clinical Research (CCRC)",{"lat":229,"lon":230},{"facility":239,"status":8,"city":240,"state":140,"zip":241,"country":118,"geoPoint":242},"Velocity Clinical Research, San Bernardino (IP Delivery and Administering Location)","San Bernardino","92408",{"lat":243,"lon":244},34.10834,-117.28977,{"facility":246,"status":114,"city":247,"state":140,"zip":248,"country":118,"geoPoint":249},"Pacific Clinical Research Management Group LLC","Upland","91786",{"lat":250,"lon":251},34.09751,-117.64839,{"facility":253,"status":8,"city":254,"state":140,"zip":255,"country":118,"geoPoint":256},"Sunwise Clinical Research","Walnut Creek","94596",{"lat":257,"lon":258},37.90631,-122.06496,{"facility":260,"status":8,"city":261,"state":262,"zip":263,"country":118,"geoPoint":264},"Children's Hospital Colorado- lnvestigational Drug Services","Aurora","Colorado","80045",{"lat":265,"lon":266},39.72943,-104.83192,{"facility":268,"status":8,"city":261,"state":262,"zip":263,"country":118,"geoPoint":269},"Children's Hospital Colorado",{"lat":265,"lon":266},{"facility":271,"status":114,"city":272,"state":262,"zip":273,"country":118,"geoPoint":274},"Colorado Springs Neurological Associates, PC","Colorado Springs","80907",{"lat":275,"lon":276},38.83388,-104.82136,{"facility":271,"status":114,"city":272,"state":262,"zip":278,"country":118,"geoPoint":279},"80919",{"lat":275,"lon":276},{"facility":281,"status":8,"city":282,"state":283,"zip":284,"country":118,"geoPoint":285},"CT Clinical Research","Cromwell","Connecticut","06416",{"lat":286,"lon":287},41.5951,-72.64537,{"facility":289,"status":114,"city":290,"state":283,"zip":291,"country":118,"geoPoint":292},"Connecticut Children's Medical Center","Hartford","06106",{"lat":293,"lon":294},41.76371,-72.68509,{"facility":296,"status":8,"city":297,"state":283,"zip":298,"country":118,"geoPoint":299},"Ki Health Partners, LLc, dba New England Institute for Clinical Research","Stamford","06905",{"lat":300,"lon":301},41.05343,-73.53873,{"facility":303,"status":114,"city":304,"state":305,"zip":306,"country":118,"geoPoint":307},"Nemours Children's Hospital, Delaware","Wilmington","Delaware","19803",{"lat":308,"lon":309},39.74595,-75.54659,{"facility":311,"status":8,"city":312,"state":313,"zip":314,"country":118,"geoPoint":315},"Children's National Medical Center","Washington D.C.","District of Columbia","20010",{"lat":316,"lon":317},38.89511,-77.03637,{"facility":319,"status":114,"city":320,"state":321,"zip":322,"country":118,"geoPoint":323},"Topaz Clinical Research, Inc.","Apopka","Florida","32703",{"lat":324,"lon":325},28.67617,-81.51186,{"facility":327,"status":328,"city":329,"state":321,"zip":330,"country":118,"geoPoint":331},"Beautiful Minds Clinical Research Center","TERMINATED","Cutler Bay","33157",{"lat":332,"lon":333},25.5783,-80.3377,{"facility":335,"status":328,"city":336,"state":321,"zip":337,"country":118,"geoPoint":338},"DeLand Clinical Research Unit","DeLand","32720",{"lat":339,"lon":340},29.02832,-81.30312,{"facility":342,"status":114,"city":343,"state":321,"zip":344,"country":118,"geoPoint":345},"Sarkis Clinical Trials","Gainesville","32607",{"lat":346,"lon":347},29.65163,-82.32483,{"facility":349,"status":114,"city":350,"state":321,"zip":351,"country":118,"geoPoint":352},"Multi-Specialty Research Associates, Inc.","Lake City","32055",{"lat":353,"lon":354},30.18968,-82.63929,{"facility":356,"status":328,"city":357,"state":321,"zip":358,"country":118,"geoPoint":359},"Watson Clinic Center for Research, Inc.","Lakeland","33805",{"lat":360,"lon":361},28.03947,-81.9498,{"facility":363,"status":328,"city":357,"state":321,"zip":358,"country":118,"geoPoint":364},"Watson Clinic LLP",{"lat":360,"lon":361},{"facility":366,"status":114,"city":367,"state":321,"zip":368,"country":118,"geoPoint":369},"AppleMed Research Group, LLC","Miami","33126",{"lat":370,"lon":371},25.77427,-80.19366,{"facility":373,"status":114,"city":367,"state":321,"zip":374,"country":118,"geoPoint":375},"Medical Research Center of Miami II, Inc","33134",{"lat":370,"lon":371},{"facility":377,"status":8,"city":367,"state":321,"zip":378,"country":118,"geoPoint":379},"South Florida Research Phase I-IV, Inc","33166",{"lat":370,"lon":371},{"facility":381,"status":114,"city":367,"state":321,"zip":382,"country":118,"geoPoint":383},"Brainstorm Research","33176",{"lat":370,"lon":371},{"facility":385,"status":114,"city":386,"state":321,"zip":387,"country":118,"geoPoint":388},"Advanced Research for Health Improvement, LLC\u002F Dr. Cordero's Pediatric Office","Naples","34102",{"lat":389,"lon":390},26.14234,-81.79596,{"facility":392,"status":8,"city":386,"state":321,"zip":393,"country":118,"geoPoint":394},"Aqualane Clinical Research","34105",{"lat":389,"lon":390},{"facility":396,"status":114,"city":397,"state":321,"zip":398,"country":118,"geoPoint":399},"Coastal Clinical Research Specialists","Orange Park","32073",{"lat":400,"lon":401},30.16607,-81.70648,{"facility":403,"status":8,"city":404,"state":321,"zip":405,"country":118,"geoPoint":406},"Clinical Associates of Orlando, LLC","Orlando","32819",{"lat":407,"lon":408},28.53834,-81.37924,{"facility":410,"status":328,"city":411,"state":321,"zip":412,"country":118,"geoPoint":413},"Bioresearch Institute","Pembroke Pines","33026",{"lat":414,"lon":415},26.00315,-80.22394,{"facility":417,"status":114,"city":418,"state":321,"zip":419,"country":118,"geoPoint":420},"Forcare Clinical Research","Tampa","33613",{"lat":421,"lon":422},27.94752,-82.45843,{"facility":424,"status":114,"city":425,"state":321,"zip":426,"country":118,"geoPoint":427},"Premiere Research Institute at Palm Beach Neurology","West Palm Beach","33407",{"lat":428,"lon":429},26.71534,-80.05337,{"facility":431,"status":114,"city":432,"state":433,"zip":434,"country":118,"geoPoint":435},"Children's Healthcare of Atlanta, Inc.","Atlanta","Georgia","30329",{"lat":436,"lon":437},33.749,-84.38798,{"facility":439,"status":114,"city":432,"state":433,"zip":434,"country":118,"geoPoint":440},"Childrens Healthcare of Atlanta",{"lat":436,"lon":437},{"facility":442,"status":114,"city":432,"state":433,"zip":434,"country":118,"geoPoint":443},"Rare Disease Research, LLC",{"lat":436,"lon":437},{"facility":445,"status":8,"city":446,"state":433,"zip":447,"country":118,"geoPoint":448},"Pivotal Clinical Research & Associates, LLC","Brunswick","31520",{"lat":449,"lon":450},31.15013,-81.49147,{"facility":452,"status":8,"city":453,"state":433,"zip":454,"country":118,"geoPoint":455},"CenExel iResearch, LLC","Decatur","30030",{"lat":456,"lon":457},33.77483,-84.29631,{"facility":459,"status":8,"city":460,"state":461,"zip":462,"country":118,"geoPoint":463},"Chicago Headache Center & Research Institute","Chicago","Illinois","60657",{"lat":464,"lon":465},41.85003,-87.65005,{"facility":467,"status":8,"city":468,"state":461,"zip":469,"country":118,"geoPoint":470},"AMR-Baber Research Inc","Naperville","60563",{"lat":471,"lon":472},41.78586,-88.14729,{"facility":474,"status":8,"city":475,"state":476,"zip":477,"country":118,"geoPoint":478},"Options Research Group, LLC","Westfield","Indiana","46074",{"lat":479,"lon":480},40.04282,-86.12749,{"facility":482,"status":8,"city":483,"state":484,"zip":485,"country":118,"geoPoint":486},"Velocity Clinical Research, Sioux City","Sioux City","Iowa","51106",{"lat":487,"lon":488},42.49999,-96.40031,{"facility":490,"status":8,"city":491,"state":484,"zip":492,"country":118,"geoPoint":493},"Integrated Clinical Trial Services","West Des Moines","50265",{"lat":494,"lon":495},41.57721,-93.71133,{"facility":497,"status":8,"city":498,"state":499,"zip":500,"country":118,"geoPoint":501},"Clinical Associates Midwest, LLC","Kansas City","Kansas","66214",{"lat":502,"lon":503},39.11417,-94.62746,{"facility":505,"status":114,"city":506,"state":499,"zip":507,"country":118,"geoPoint":508},"College Park Family Care Center Physicians Group- Neurology Research Dept.","Overland Park","66212",{"lat":509,"lon":510},38.98223,-94.67079,{"facility":512,"status":114,"city":513,"state":514,"zip":515,"country":118,"geoPoint":516},"Kentucky Neuroscience Institute Child Neurology-- \"Patients Seen\"","Lexington","Kentucky","40504",{"lat":517,"lon":518},37.98869,-84.47772,{"facility":520,"status":114,"city":513,"state":514,"zip":521,"country":118,"geoPoint":522},"UK Center for Clinical and Translational Science (CCTS) -- \"Patients 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University","Yinchuan","Ningxia","756000",{"lat":1293,"lon":1294},38.46806,106.27306,{"facility":1296,"status":114,"city":1297,"state":1298,"zip":1299,"country":1133,"geoPoint":1300},"Shaanxi Provincial People's Hospital","Xi'an","Shaanxi","710068",{"lat":1301,"lon":1302},34.25833,108.92861,{"facility":1304,"status":114,"city":1297,"state":1298,"zip":1305,"country":1133,"geoPoint":1306},"Xi'an Gaoxin Hospital Neurology Department","710075",{"lat":1301,"lon":1302},{"facility":1308,"status":8,"city":1309,"state":1298,"zip":1310,"country":1133,"geoPoint":1311},"Yan 'an University Xianyang Hospital","Xianyang","716000",{"lat":1312,"lon":1313},34.33778,108.70261,{"facility":1315,"status":8,"city":1316,"state":1317,"zip":1318,"country":1133,"geoPoint":1319},"Shandong Provincial Qianfoshan Hospital","Jinan","Shandong","250013",{"lat":1320,"lon":1321},36.66833,116.99722,{"facility":1323,"status":8,"city":1324,"state":1317,"zip":1325,"country":1133,"geoPoint":1326},"Liaocheng People's Hospital","Liaocheng","252000",{"lat":1327,"lon":1328},36.45064,116.00247,{"facility":1330,"status":114,"city":1331,"state":1332,"zip":1333,"country":1133,"geoPoint":1334},"West China Hospital of Sichuan University","Chengdu","Sichuan","610041",{"lat":1335,"lon":1336},30.66667,104.06667,{"facility":1338,"status":8,"city":1339,"state":1340,"zip":1341,"country":1133,"geoPoint":1342},"Children's Hospital of Zhejiang University School of Medicine","Hangzhou","Zhejiang","310052",{"lat":1343,"lon":1344},30.29365,120.16142,{"facility":1346,"status":114,"city":1347,"state":1340,"zip":1348,"country":1133,"geoPoint":1349},"Ningbo Women and Children's Hospital","Ningbo","315012",{"lat":1350,"lon":1351},29.87819,121.54945,{"facility":1353,"status":8,"city":1354,"state":1340,"zip":1355,"country":1133,"geoPoint":1356},"The Second Affiliated Hospital of Wenzhou Medical University","Wenzhou","325000",{"lat":1357,"lon":1358},27.99942,120.66682,{"facility":1360,"status":8,"city":1361,"country":1133,"geoPoint":1362},"Lu 'an People's Hospital","Lu'an",{"lat":1363,"lon":1364},31.73561,116.51688,{"facility":1366,"status":114,"city":1367,"country":1133,"geoPoint":1368},"Children's Hospital of Shanghai","Shanghai",{"lat":1369,"lon":1370},31.22222,121.45806,{"facility":1372,"status":8,"city":1373,"country":1133,"geoPoint":1374},"Shengjing Hospital of China Medical University","Shenyang",{"lat":1375,"lon":1376},41.79222,123.43278,{"facility":1378,"status":114,"city":1379,"country":1133,"geoPoint":1380},"The First Affiliated Hospital of Shihezi University School of Medicine","Shihezi",{"lat":1381,"lon":1382},44.3023,86.03694,{"facility":1384,"status":8,"city":1214,"country":1133,"geoPoint":1385},"Wuhan Children's Hospital",{"lat":1217,"lon":1218},{"facility":1387,"status":8,"city":1388,"state":1389,"zip":1390,"country":1391},"Jinnouchi Neurosurgical 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Clinic","Kagoshima","Kagoshima-ken","890-0052",{"lat":1423,"lon":1424},31.56667,130.55,{"facility":1426,"status":8,"city":1427,"state":1428,"zip":1429,"country":1391},"Sendai Headache and Neurology Clinic","Taihaku-ku Sendai-shi","Miyagi","982-0014",{"facility":1431,"status":8,"city":1432,"state":1433,"zip":1434,"country":1391},"Tennoji Dai Brain Clinic","Abeno-ku Osaka-shi","Osaka","545-0053",{"facility":1436,"status":8,"city":1437,"state":1433,"zip":1438,"country":1391},"Tominaga Clinic","Naniwa-ku","556-0015",{"facility":1440,"status":8,"city":1441,"state":1442,"zip":1443,"country":1391},"Tokyo Headache Clinic","Shibuya-ku","Tokyo","151-0051",{"facility":1445,"status":8,"city":1446,"state":1442,"zip":1447,"country":1391},"Tokyo Medical University Hospital","Shinjuku-ku","160-0023",{"facility":1449,"status":114,"city":1450,"zip":1451,"country":1391,"geoPoint":1452},"Local lndependent Administrative Corporation Hiroshima City Hospital Organization Hiroshima City","Hiroshima","730-8518",{"lat":1453,"lon":1454},34.4,132.45,{"facility":1456,"status":8,"city":1457,"state":1458,"zip":1459,"country":1460},"Clinstile S.A. de C.V.","Col. Roma Norte","Mexico City","C.P. 06700.","Mexico",{"facility":1462,"status":114,"city":1463,"state":1464,"zip":1465,"country":1460,"geoPoint":1466},"Neurociencias Estudios Clinicos S.C.","Culiacán","Sinaloa","800200",{"lat":1467,"lon":1468},24.80209,-107.39421,{"facility":1470,"status":8,"city":1471,"state":1472,"zip":1473,"country":1460,"geoPoint":1474},"Clinical Reseach Institute, S.C.","Tlalnepantla","State of Mexico","C.P. 54055",{"lat":1475,"lon":1476},19.54005,-99.19538,{"facility":1478,"status":8,"city":1479,"zip":1480,"country":1460,"geoPoint":1481},"Unidad de Investigacion en Salud de Chihuahua S.C.","Chihuahua City","31203",{"lat":1482,"lon":1483},28.63528,-106.08889,{"facility":1485,"status":8,"city":1486,"state":1487,"zip":1488,"country":1489,"geoPoint":1490},"MIGRE Polskie Centrum Leczenia Migreny Anna Gryglas-Dworak","Wroclaw","Lower Silesian Voivodeship","52-210","Poland",{"lat":1491,"lon":1492},51.10286,17.03006,{"facility":1494,"status":114,"city":1495,"zip":1496,"country":1489,"geoPoint":1497},"NZOZ Wielospecjalistyczna Poradnia Lekarska SYNAPSIS, Lech Szczechowski","Katowice","40-123",{"lat":1498,"lon":1499},50.2597,19.02173,{"facility":1501,"status":8,"city":1502,"zip":1503,"country":1489,"geoPoint":1504},"Centrum Medyczne Plejady","Krakow","30-363",{"lat":1505,"lon":1506},50.06143,19.93658,{"facility":1508,"status":8,"city":1502,"zip":1509,"country":1489,"geoPoint":1510},"Oddzial Kliniczny Dzieci Starszych z Pododdzialami: Neurologicznym, Reumatologicznym","31-503",{"lat":1505,"lon":1506},{"facility":1512,"status":8,"city":1502,"zip":1509,"country":1489,"geoPoint":1513},"Wojewódzki Specjalistyczny Szpital Dzieciecy im. Sw. Ludwika w Krakowie, Apteka Szpitalna",{"lat":1505,"lon":1506},{"facility":1515,"status":8,"city":1502,"zip":1509,"country":1489,"geoPoint":1516},"Wojewódzki Specjalistyczny Szpital Dzieciecy im. Sw. Ludwika w Krakowie",{"lat":1505,"lon":1506},{"facility":1518,"status":8,"city":1519,"zip":1520,"country":1489,"geoPoint":1521},"Clinical Research Center Sp. z.o.o. Medic-R Spolka komandytowa","Poznan","61-731",{"lat":1522,"lon":1523},52.40692,16.92993,{"facility":1525,"status":114,"city":1526,"zip":1527,"country":1489,"geoPoint":1528},"Euromedis Sp. z o. o.","Szczecin","70-111",{"lat":1529,"lon":1530},53.42894,14.55302,{"facility":1532,"status":114,"city":1533,"state":1534,"zip":1535,"country":1536,"geoPoint":1537},"Hospital Universitario Marqués de Valdecilla","Santander","Cantabria","39008","Spain",{"lat":1538,"lon":1539},43.46589,-3.80493,{"facility":1541,"status":8,"city":1542,"zip":1543,"country":1536,"geoPoint":1544},"Hospital Universitario Vall d'Hebron","Barcelona","08035",{"lat":1545,"lon":1546},41.38879,2.15899,{"facility":1548,"status":114,"city":1542,"zip":1549,"country":1536,"geoPoint":1550},"Centre d'Atencio Primaria Balenya","08550",{"lat":1545,"lon":1546},{"facility":1552,"status":114,"city":1553,"zip":1554,"country":1536,"geoPoint":1555},"Instituto de Investigaciones del Sueno","Madrid","28036",{"lat":1556,"lon":1557},40.4165,-3.70256,{"facility":1559,"status":114,"city":1560,"zip":1561,"country":1536,"geoPoint":1562},"Hospital Universitario Virgen del Rocío","Seville","41013",{"lat":1563,"lon":1564},37.38283,-5.97317,{"facility":1566,"status":8,"city":1567,"zip":1568,"country":1536,"geoPoint":1569},"Hospital Clinico Universitario de Valladolid","Valladolid","47005",{"lat":1570,"lon":1571},41.65541,-4.72353,{"facility":1573,"status":8,"city":1574,"state":1575,"zip":1576,"country":1577,"geoPoint":1578},"ProbarE i Lund AB","Lund","Skåne LÄN [se-12]","22222","Sweden",{"lat":1579,"lon":1580},55.70584,13.19321,{"facility":1582,"status":114,"city":1583,"zip":1584,"country":1577,"geoPoint":1585},"Avdelningen för kliniska Prövningar, Universitetssjukhuset Örebro","Örebro","703 62",{"lat":1586,"lon":1587},59.27412,15.2066,{"facility":1589,"status":8,"city":1590,"zip":1591,"country":1577,"geoPoint":1592},"ProbarE i Stockholm AB","Stockholm","113 29",{"lat":1593,"lon":1594},59.32938,18.06871,{"facility":1596,"status":114,"city":1597,"zip":1598,"country":1599,"geoPoint":1600},"Leicester Royal Infirmary","Leicester","LE1 5WW","United Kingdom",{"lat":1601,"lon":1602},52.6386,-1.13169,{"facility":1604,"status":8,"city":1605,"zip":1606,"country":1599,"geoPoint":1607},"Re:Cognition Health Limited","London","W1G 9JF",{"lat":1608,"lon":1609},51.50853,-0.12574,{"facility":1611,"status":8,"city":1605,"zip":1612,"country":1599,"geoPoint":1613},"Great Ormond Street Hospital for Children NHS Foundation Trust","WC1N 3JH",{"lat":1608,"lon":1609},[1615],{"name":1616,"role":1617,"phone":1618,"email":1619},"Pfizer Pfizer CT.gov Call Center","CONTACT","1-800-718-1021","ClinicalTrials.gov_Inquiries@pfizer.com",[1621],{"name":1622,"affiliation":13,"role":1623},"Pfizer CT.gov Call Center","STUDY_DIRECTOR",[],[1626],{"label":1627,"url":1628},"To obtain contact information for a study center near you, click here.","https:\u002F\u002Fpmiform.com\u002Fclinical-trial-info-request?StudyID=BHV3000-311",{"nct_id":4,"conditions":1630,"biomarkers":1631},[20],[],{"nct_id":4,"found":1633,"summary":1634,"prompt_version":1644},true,{"design":1635,"status":1636,"heading":1637,"summary":1638,"follow_up":1639,"word_count":1640,"commitments":1641,"compensation":1642,"drugs_mentioned":1643},"This is an interventional, randomized study involving 2100 participants. It compares rimegepant to a matching placebo.","completed","Rimegepant for Acute Migraine Treatment in Children and Adolescents","This study is looking for children and adolescents aged 6 to 17 who experience migraines to test a medication called rimegepant (also known as BHV3000). The goal is to see if rimegepant, at either a 75 mg or 50 mg dose, can effectively stop migraine pain compared to a placebo (an inactive substance). Researchers will measure how many participants are completely pain-free two hours after taking the medication. You could be eligible if you have a history of migraines for at least six months. The study is currently unclear on its recruitment status.","The primary endpoint is measured at 2 hours post-dose, but overall follow-up duration is not specified.",93,"Not specified in the trial record.","Not stated in the trial record.",[],"v2"]