[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT04885322":3,"trial-entities:NCT04885322":109,"trial-summary:NCT04885322":112},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":19,"study_type":20,"primary_purpose":21,"phases":22,"enrollment_info":24,"interventions":27,"primary_outcomes":36,"secondary_outcomes":64,"sex":65,"minimum_age":66,"maximum_age":67,"healthy_volunteers":68,"eligibility_criteria":69,"std_ages":80,"locations":82,"central_contacts":101,"overall_officials":106,"references":107,"see_also_links":108},"NCT04885322","1344169-8","Effects of PFC tDCS on Cognitive Control, Attention Lapses and Coordinated Neural Activity in the Theta and Alpha Bands","RECRUITING","2027-06-30","2025-12","2025-12-05","2021-04-14","University of California, Davis","OTHER",false,"The purpose of this study is to better understand the neural correlates of higher-order cognition, both in the healthy brain and in schizophrenia, and to determine how these mechanisms are modulated by transcranial direct current stimulation (tDCS) at frontal and occipital scalp sites. Testing the effects of tDCS at these scalp sites on cognitive task performance will help us understand the roles of the brain regions corresponding to these sites during higher-order cognitive processing (language comprehension, cognitive control, and related attention and memory processes). Behavioral and electrophysiological (EEG) measures will be used to assess cognitive performance. Our overarching hypothesis is that stimulating prefrontal circuits with tDCS can improve cognitive control performance, and ultimately performance on a range of cognitive tasks, as compared to stimulating a different cortical region (occipital cortex) or using sham stimulation.\n\nThis study is solely intended as basic research in order to understand brain function in healthy individuals and individuals with schizophrenia. This study is not intended to diagnose, cure or treat schizophrenia or any other disease.",null,[18],"Healthy",[],"INTERVENTIONAL","BASIC_SCIENCE",[23],"NA",{"count":25,"type":26},75,"ESTIMATED",[28],{"type":29,"name":30,"description":31,"armGroupLabels":32},"DEVICE","Transcranial Direct Current Stimulation","In tDCS, saline-soaked electrodes are temporary affixed to the scalp and connected to a battery-powered current generator. A weak (2 mA) constant current is then briefly applied (\\~20 minutes) to stimulate the targeted brain area. The targeted brain area is determined by the Study Arm.",[33,34,35],"DLPFC Stimulation","Occipital Stimulation","Sham Stimulation",[37,41,44,47,50,53,56,59,61],{"measure":38,"description":39,"timeFrame":40},"Behavioral Cognitive Control Measures on the Stroop Task","Incongruent versus Congruent difference in error rate and reaction time","Through study completion, an average of 1 month",{"measure":42,"description":43,"timeFrame":40},"EEG Cognitive Control Measures on the Stroop Task","response-locked power in the theta frequency band (4-7 Hz)",{"measure":45,"description":46,"timeFrame":40},"Behavioral Attention Lapse Measures on the Stroop Task","Error Rate on Incorrect Congruent trials (Full Lapses) and Slow-but-Correct Congruent trials (Partial Lapses)",{"measure":48,"description":49,"timeFrame":40},"EEG Attention Lapse Measures on the Stroop Task EEG Attention Lapse Measures on the Stroop Task","Pre-trial power in the alpha frequency band (8-12 Hz)",{"measure":51,"description":52,"timeFrame":40},"Behavioral Cognitive Control Measures on the Change Detection Task Behavioral Cognitive Control Measures on the Change Detection Task","WM storage capacity (k-max)",{"measure":54,"description":55,"timeFrame":40},"EEG Cognitive Control Measures on the Change Detection Task","delay period power in the theta frequency band (4-7 Hz)",{"measure":57,"description":58,"timeFrame":40},"Behavioral Attention Lapse Measures on the Change Detection Task","Attention factor (a); Guess factor (g)",{"measure":60,"description":49,"timeFrame":40},"EEG Attention Lapse Measures on the Change Detection Task",{"measure":62,"description":63,"timeFrame":40},"Delivered tDCS Dose to PFC","Estimated electric field in PFC region of interest",[],"ALL","18 Years","50 Years",true,{"inclusion":70,"exclusion":74,"raw_text":79},[71,72,73],"between ages of 18 and 50","ability to sufficiently speak and understand English so as to be able to understand and complete cognitive tasks","ability to give valid informed consent",[75,76,77,78],"no history of head trauma","no current or previous history of treatment with psychotropic medication","corrected vision 20\u002F30 or better","tDCS\u002FMRI contraindications, including: pregnancy, ferrous metal in any part of the body, serious medical conditions, claustrophobia, metallic implants, skin damage, conditions such as eczema at electrode sites, cranial pathologies","Inclusion Criteria:\n\n* between ages of 18 and 50\n* ability to sufficiently speak and understand English so as to be able to understand and complete cognitive tasks\n* ability to give valid informed consent\n\nExclusion Criteria:\n\n* no history of head trauma\n* no current or previous history of treatment with psychotropic medication\n* corrected vision 20\u002F30 or better\n* tDCS\u002FMRI contraindications, including: pregnancy, ferrous metal in any part of the body, serious medical conditions, claustrophobia, metallic implants, skin damage, conditions such as eczema at electrode sites, cranial pathologies",[81],"ADULT",[83],{"facility":84,"status":7,"city":85,"state":86,"zip":87,"country":88,"contacts":89,"geoPoint":98},"Imaging Research Center","Sacramento","California","95817","United States",[90,95],{"name":91,"role":92,"phone":93,"email":94},"Vanessa Zarubin, BS\u002FBA","CONTACT","916-734-3749","vczarubin@ucdavis.edu",{"name":96,"role":97},"Cameron Carter, M.D.","PRINCIPAL_INVESTIGATOR",{"lat":99,"lon":100},38.58157,-121.4944,[102],{"name":103,"role":92,"phone":104,"email":105},"Minhtrang Chu","1-916-734-1482","mihchu@ucdavis.edu",[],[],[],{"nct_id":4,"conditions":110,"biomarkers":111},[18],[],{"nct_id":4,"found":68,"summary":113,"prompt_version":123},{"design":114,"status":115,"heading":116,"summary":117,"follow_up":118,"word_count":119,"commitments":120,"compensation":121,"drugs_mentioned":122},"This interventional study plans to enroll 75 healthy participants. It uses Transcranial Direct Current Stimulation (tDCS) as an intervention.","completed","PFC tDCS for Cognitive Control and Attention","This study is looking at how Transcranial Direct Current Stimulation (tDCS) affects thinking skills like cognitive control (your ability to manage thoughts and actions) and attention in healthy adults. Researchers want to understand how tDCS, which uses a weak electrical current applied to the scalp, changes brain activity and performance on tasks. They will measure your behavior and brain waves (EEG) while you complete tasks like the Stroop Task. You may be able to join if you are between 18 and 50 years old, can understand English, and have no history of head trauma or certain medical conditions. The study aims to understand how the brain works and how tDCS might influence these processes.","Your cognitive control and attention will be measured through study completion, an average of 1 month.",114,"Not specified in the trial record.","Not stated in the trial record.",[30],"v2"]