[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT05067231":3,"trial-entities:NCT05067231":79,"trial-summary:NCT05067231":84},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":24,"study_type":25,"primary_purpose":26,"phases":27,"enrollment_info":28,"interventions":31,"primary_outcomes":32,"secondary_outcomes":36,"sex":37,"minimum_age":38,"maximum_age":26,"healthy_volunteers":15,"eligibility_criteria":39,"std_ages":47,"locations":50,"central_contacts":68,"overall_officials":70,"references":73,"see_also_links":78},"NCT05067231","IRB - 300007834","CARBON: UAB Cardiovascular Research Biobank","UAB Cardiovascular Research Biobank","RECRUITING","2030-01-01","2026-02","2026-02-13","2022-01-01","University of Alabama at Birmingham","OTHER",true,"The UAB Cardiovascular Research Biobank (CARBON) will be a resource that contains biological materials, such as DNA samples, in addition to health and personal information on a large number of people over time. It will be set up so that it can be used in the future as a resource for researchers undertaking a wide range of medical research.","The UAB Cardiovascular Research Biobank (CARBON) will be a resource that contains pertinent genetic, health, and biological samples such as blood derived from a large-scale population. Researchers may use disease correlates and predictors identified from the genetic, health, and personal information contained in the Biobank as a resource to investigate cardiovascular disease, hypertension, diabetes, and a myriad of other disorders. Through these studies, researchers may identify the progression of risk factors in certain diseases and help develop novel strategies to detect, treat, or prevent such diseases. In addition, the Biobank serves as a valuable tool to assess how certain treatments may respond differently to individuals as a result of genotypic differences.\n\nThe investigators have demonstrated that lower natriuretic peptide (NP) levels are associated with a decreased insulin sensitivity and have a causal role in the development of diabetes and have also shown that certain populations, such as African Americans, have relatively low NP levels, which may contribute to their underlying risk for insulin resistance. Since NPs play an important role in the regulation of insulin sensitivity, one can infer that relatively low NP levels are an important biological contributor to the high prevalence rates of cardiometabolic disease in African Americans. The Biobank will contain genetic information concerning the presence of gene variants that encode NPs.",[19,20,21,22,23],"Natriuretic Peptides","Cardiovascular Diseases","Hypertension","Diabetes","Obesity",[19,20,21,22,23],"OBSERVATIONAL",null,[],{"count":29,"type":30},500,"ESTIMATED",[],[33],{"measure":34,"timeFrame":35},"Genetic Variants in the NPPA and NPPB gene of the Natriuretic Peptide family associated with the Cardiovascular and Metabolic Diseases","Baseline",[],"ALL","18 Years",{"inclusion":40,"exclusion":42,"raw_text":46},[41],"Age more than or equal to 18",[43,44,45],"Age \\\u003C18, at screening","Employees or students associated with the Division of Cardiovascular Disease at UAB will not be recruited due to their vulnerable status and susceptibility to coercion.","Women who are pregnant or who can become pregnant and not practicing an acceptable method of birth control.","Inclusion Criteria:\n\n* Age more than or equal to 18\n\nExclusion Criteria:\n\n* Age \\\u003C18, at screening\n* Employees or students associated with the Division of Cardiovascular Disease at UAB will not be recruited due to their vulnerable status and susceptibility to coercion.\n* Women who are pregnant or who can become pregnant and not practicing an acceptable method of birth control.",[48,49],"ADULT","OLDER_ADULT",[51],{"facility":13,"status":8,"city":52,"state":53,"zip":54,"country":55,"contacts":56,"geoPoint":65},"Birmingham","Alabama","35294","United States",[57,62],{"name":58,"role":59,"phone":60,"email":61},"Nehal Vekariya, MS","CONTACT","205-934-7173","nvekariya@uabmc.edu",{"name":63,"role":64},"Pankaj Arora, MD","PRINCIPAL_INVESTIGATOR",{"lat":66,"lon":67},33.52066,-86.80249,[69],{"name":58,"role":59,"phone":60,"email":61},[71],{"name":72,"affiliation":13,"role":64},"Pankaj Arora, MD, FAHA",[74],{"pmid":75,"type":76,"citation":77},"29167879","BACKGROUND","Bajaj NS, Gutierrez OM, Arora G, Judd SE, Patel N, Bennett A, Prabhu SD, Howard G, Howard VJ, Cushman M, Arora P. Racial Differences in Plasma Levels of N-Terminal Pro-B-Type Natriuretic Peptide and Outcomes: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study. JAMA Cardiol. 2018 Jan 1;3(1):11-17. doi: 10.1001\u002Fjamacardio.2017.4207.",[],{"nct_id":4,"conditions":80,"biomarkers":83},[81,82,21,23],"Cardiovascular Disorder","Diabetes Mellitus",[],{"nct_id":4,"found":15,"summary":85,"prompt_version":95},{"design":86,"status":87,"heading":88,"summary":89,"follow_up":90,"word_count":91,"commitments":92,"compensation":93,"drugs_mentioned":94},"This is an observational study aiming to enroll 500 participants. It is not testing a specific intervention or drug.","completed","UAB Cardiovascular Research Biobank (CARBON)","The UAB Cardiovascular Research Biobank (CARBON) is collecting biological samples, like DNA, and health information from many people over time. This resource will help researchers study heart and metabolic diseases (like diabetes and high blood pressure). They want to understand how genes, especially those related to natriuretic peptides (hormones that help regulate blood pressure and fluid balance), affect these conditions. Researchers hope to find new ways to detect, treat, or prevent diseases and understand why treatments might work differently for various individuals. This study is currently not recruiting, but aims to enroll 500 participants. You may be able to join if you are 18 years or older and not pregnant or an employee\u002Fstudent of the UAB Cardiovascular Disease Division.","Genetic variants are measured at baseline, but the duration of follow-up is not specified.",119,"Not specified in the trial record.","Not stated in the trial record.",[],"v2"]