[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT05124132":3,"trial-entities:NCT05124132":80,"trial-summary:NCT05124132":84},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":19,"study_type":24,"primary_purpose":25,"phases":26,"enrollment_info":28,"interventions":31,"primary_outcomes":44,"secondary_outcomes":49,"sex":50,"minimum_age":51,"maximum_age":16,"healthy_volunteers":52,"eligibility_criteria":53,"std_ages":59,"locations":61,"central_contacts":70,"overall_officials":71,"references":75,"see_also_links":76},"NCT05124132","201810006","Resilience and Brain Health of Older Adults (MEDEX-2)","ENROLLING_BY_INVITATION","2027-08-31","2026-06","2026-06-12","2019-04-16","Washington University School of Medicine","OTHER",true,"This project capitalizes on a natural experiment imposed by the COVID-19 pandemic in conjunction with an extensive set of cognitive, emotional, biological, and neuroimaging variables already collected at multiple time points in older adults participating in a clinical trial of exercise and mindfulness. This project will elucidate the effects of stress on cognitive function and emotional health in later life, including biological measures of Alzheimer Disease risk, stress, and aging, with the ultimate goal of discovering how to mitigate these effects, among older adults who have made and maintained a lifestyle change.",null,[18],"Age-related Cognitive Decline",[20,21,22,23],"Exercise","Mindfulness","Education","Elderly","INTERVENTIONAL","TREATMENT",[27],"NA",{"count":29,"type":30},468,"ESTIMATED",[32,36,38,41],{"type":33,"name":34,"description":34,"armGroupLabels":35},"BEHAVIORAL","Mindfulness-Based Stress Reduction",[34],{"type":33,"name":20,"description":20,"armGroupLabels":37},[20],{"type":33,"name":39,"description":39,"armGroupLabels":40},"Mindfulness-Based Stress Reduction + Exercise",[39],{"type":33,"name":42,"description":42,"armGroupLabels":43},"Health Education",[42],[45],{"measure":46,"description":47,"timeFrame":48},"Effects of the interventions on changes in cognitive performance","Test effects of mindfulness and exercise on changes in change in memory and cognitive control composites.","Approximately three years",[],"ALL","65 Years",false,{"inclusion":54,"exclusion":56,"raw_text":58},[55],"Participated in the parent study, Protocol ID #201410093",[57],"Inability to safely continue classes or complete assessments, as per PI discretion","Inclusion Criteria:\n\n* Participated in the parent study, Protocol ID #201410093\n\nExclusion Criteria:\n\n* Inability to safely continue classes or complete assessments, as per PI discretion",[60],"OLDER_ADULT",[62],{"facility":12,"city":63,"state":64,"zip":65,"country":66,"geoPoint":67},"St Louis","Missouri","63110","United States",{"lat":68,"lon":69},38.62727,-90.19789,[],[72],{"name":73,"affiliation":12,"role":74},"Eric J Lenze, MD","PRINCIPAL_INVESTIGATOR",[],[77],{"label":78,"url":79},"Visit the Healthy Mind Lab for more information about the MEDEX study and our other areas of research. STL: http:\u002F\u002Fhealthymind.wustl.edu\u002Fmedex UCSD: http:\u002F\u002Fwww.medexstudy.com\u002F","http:\u002F\u002Fhealthymind.wustl.edu\u002Fmedex",{"nct_id":4,"conditions":81,"biomarkers":83},[82],"Age-related cognitive decline",[],{"nct_id":4,"found":52,"summary":16,"prompt_version":16}]