[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT05177822":3,"trial-entities:NCT05177822":101,"trial-summary:NCT05177822":105},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":21,"primary_purpose":22,"phases":23,"enrollment_info":25,"interventions":28,"primary_outcomes":42,"secondary_outcomes":47,"sex":48,"minimum_age":49,"maximum_age":50,"healthy_volunteers":51,"eligibility_criteria":52,"std_ages":75,"locations":78,"central_contacts":94,"overall_officials":95,"references":99,"see_also_links":100},"NCT05177822","HM20022826","Interleukin-1 Blockade in Acute Myocardial Infarction to Prevent Heart Failure","Interleukin-1 Blockade in Acute Myocardial Infarction to Prevent Heart Failure: The Virginia - Anakinra Remodeling Trial 4","ACTIVE_NOT_RECRUITING","2027-12-30","2026-05","2026-05-06","2022-05-24","Virginia Commonwealth University","OTHER",true,"Patients who have a heart attack are at high risk for future development of heart failure ('weakening of the heart'). The researchers believe that the reaction of the heart muscle to injury (inflammation) during a heart attack may be contributing to the risk of heart failure. The current study will test the ability of an anti-inflammatory medicine (anakinra) to block the inflammation in the body during and after a heart attack.","Anakinra (Kineret®) is a 'copy' of a naturally occurring protein made by the body to block inflammation. The US Food and Drug Administration (FDA) has approved anakinra 100 mg daily for the treatment of rheumatoid arthritis but anakinra is not currently approved for the treatment of heart disease. Anakinra is generally well-tolerated, but can cause pain or redness at the injection site and may affect risk of infections. The study team will work with participants to help avoid (or manage) any side effects throughout the study.\n\nThe study is designed to measure how well anakinra can protect participants from developing heart failure. Participation in this study will last approximately 1 year. During the first 2 weeks of the study, participants will receive an injection with anakinra or placebo (a liquid that looks like anakinra but contains no active medicine). While hospitalized, a nurse will do the injections for participants; upon discharge participants will be taught to give the remaining injections at home. Assignment to treatment with anakinra or placebo will be determined by randomization (like the \"flip of a coin\"). Approximately 84 people will participate in this study over the course of 4 years.",[19],"Heart Failure",[],"INTERVENTIONAL","PREVENTION",[24],"PHASE2",{"count":26,"type":27},84,"ESTIMATED",[29,37],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":35},"DRUG","Anakinra","Anakinra 100 mg\u002F0.67 mL daily subcutaneous injection for up to 14 days, including up to 9 days outpatient treatment;",[34],"anakinra",[36],"Kineret",{"type":14,"name":38,"description":39,"armGroupLabels":40},"Placebo","0.9% NaCl\u002F0.67 mL daily subcutaneous injection for up to 14 days, including up to 9 days outpatient treatment.",[41],"placebo",[43],{"measure":44,"description":45,"timeFrame":46},"Peak oxygen consumption (peak VO2)","Peak VO2 (expressed as % of predicted) will be assess using cardiopulmonary exercise testing (CPET)","6 weeks",[],"ALL","21 Years",null,false,{"inclusion":53,"exclusion":69,"raw_text":74},[54,55,56,57,58,59,60,61,62,63,64,65,66,67,68],"Acute ST segment elevation myocardial infarction defined as:","chest pain, consistent with angina, within the prior 12 hours (for intermittent pain lasting more than 12 hours, the time from the when the pain became severe and constant);","ST segment elevation on ECG \\>1 mm in 2 or more anatomically contiguous leads;","Reperfusion strategy planned or completed (including percutaneous coronary intervention or fibrinolysis)","Age \\>21 years.","Failed reperfusion strategy (unsuccessful percutaneous coronary intervention);","Need or plan for emergent cardiac surgery;","Anticipated inability to complete a cardiopulmonary exercise test (CPET) on a treadmill at follow up visit at 42 days (i.e. amputee, wheel-chair bound, severe non-cardiac illness limiting mobility).","Active infection (such as acute, i.e. COVID-19, or chronic\u002Frecurrent infectious disease i.e HBV, HCV, and HIV\u002FAIDS-but excluding HCV+ patients with undetectable plasma RNA)","Acute or chronic inflammatory disease or immunosuppressive therapies (including oral corticosteroids at a dose of prednisone equivalent of 0.5 mg\u002Fkg\u002Fday but not including inhaled or low dose oral corticosteroids or non-steroidal anti-inflammatory drugs).","Neutropenia (\\\u003C1,500\u002Fmm3 or \\\u003C1,000\u002Fmm3 in African-American patients).","Active acute or chronic psychiatric illness that in the opinion of the investigator may prevent from complying with study instructions;","Stage V chronic kidney disease (estimated glomerular filtration rate 15 mL\u002Fmin\u002F1.73m2 or less) or on renal-replacement therapy (a GFR ≥45 mL\u002Fmin\u002F1.73m2 is required for the cardiac magnetic resonance portion of the study);","Limited English Proficiency that in the opinion of the investigator may prevent from understanding the content of the informed consent form and instructions during the tests required for the study.","Any comorbidity limiting survival or ability to complete the study.",[70,71,72,73],"Pregnancy;","Inability to obtain consent from patient;","History of prior STEMI or of systolic heart failure (LVEF\\\u003C40%);","Contraindications to treatment with anakinra (i.e. prior allergic reaction to Kineret® or E. coli derived products);","Inclusion Criteria:\n\nAll criteria need to be met.\n\n* Acute ST segment elevation myocardial infarction defined as:\n\n  * chest pain, consistent with angina, within the prior 12 hours (for intermittent pain lasting more than 12 hours, the time from the when the pain became severe and constant);\n  * ST segment elevation on ECG \\>1 mm in 2 or more anatomically contiguous leads;\n  * Reperfusion strategy planned or completed (including percutaneous coronary intervention or fibrinolysis)\n* Age \\>21 years.\n\nExclusion Criteria:\n\nSubjects will not be eligible if they meet any of the following exclusion criteria.\n\n* Pregnancy;\n* Inability to obtain consent from patient;\n* History of prior STEMI or of systolic heart failure (LVEF\\\u003C40%);\n* Contraindications to treatment with anakinra (i.e. prior allergic reaction to Kineret® or E. coli derived products);\n* Duration of chest pain \\>12 hours at time of coronary artery catheterization (continuously - see exceptions in Inclusion Criteria) or coronary artery intervention \\>12 hours earlier (see exceptions in Inclusion Criteria)\\[max duration of chest pain 24 hours\\];\n* Failed reperfusion strategy (unsuccessful percutaneous coronary intervention);\n* Need or plan for emergent cardiac surgery;\n* Anticipated inability to complete a cardiopulmonary exercise test (CPET) on a treadmill at follow up visit at 42 days (i.e. amputee, wheel-chair bound, severe non-cardiac illness limiting mobility).\n* Active infection (such as acute, i.e. COVID-19, or chronic\u002Frecurrent infectious disease i.e HBV, HCV, and HIV\u002FAIDS-but excluding HCV+ patients with undetectable plasma RNA)\n* Acute or chronic inflammatory disease or immunosuppressive therapies (including oral corticosteroids at a dose of prednisone equivalent of 0.5 mg\u002Fkg\u002Fday but not including inhaled or low dose oral corticosteroids or non-steroidal anti-inflammatory drugs).\n* Neutropenia (\\\u003C1,500\u002Fmm3 or \\\u003C1,000\u002Fmm3 in African-American patients).\n* Active acute or chronic psychiatric illness that in the opinion of the investigator may prevent from complying with study instructions;\n* Stage V chronic kidney disease (estimated glomerular filtration rate 15 mL\u002Fmin\u002F1.73m2 or less) or on renal-replacement therapy (a GFR ≥45 mL\u002Fmin\u002F1.73m2 is required for the cardiac magnetic resonance portion of the study);\n* Limited English Proficiency that in the opinion of the investigator may prevent from understanding the content of the informed consent form and instructions during the tests required for the study.\n* Any comorbidity limiting survival or ability to complete the study.",[76,77],"ADULT","OLDER_ADULT",[79,88],{"facility":80,"city":81,"state":82,"zip":83,"country":84,"geoPoint":85},"University of Virginia","Charlottesville","Virginia","22908","United States",{"lat":86,"lon":87},38.02931,-78.47668,{"facility":13,"city":89,"state":82,"zip":90,"country":84,"geoPoint":91},"Richmond","23298",{"lat":92,"lon":93},37.55376,-77.46026,[],[96],{"name":97,"affiliation":13,"role":98},"Benjamin Van Tassell, PharmD","PRINCIPAL_INVESTIGATOR",[],[],{"nct_id":4,"conditions":102,"biomarkers":104},[103],"ST-Elevation Myocardial Infarction",[],{"nct_id":4,"found":15,"summary":106,"prompt_version":116},{"design":107,"status":108,"heading":109,"summary":110,"follow_up":111,"word_count":112,"commitments":113,"compensation":114,"drugs_mentioned":115},"This study is designed to compare anakinra to a placebo (an inactive substance) in approximately 84 participants. Assignment to either anakinra or placebo will be determined randomly, like a coin flip.","completed","Anakinra for Heart Attack Patients to Prevent Heart Failure","This study is testing if the medicine anakinra can help prevent heart failure (weakening of the heart) in people who have recently had a heart attack. Researchers believe that inflammation (the body's reaction to injury) after a heart attack might lead to heart failure. Anakinra is an anti-inflammatory medicine that works by blocking this inflammation. You might be able to join if you've had a specific type of heart attack (ST segment elevation myocardial infarction) within the last 12 hours. The study will look at how well anakinra helps improve your peak oxygen consumption (peak VO2) after 6 weeks. The current recruitment status is unclear, and about 84 people are planned to participate.","The primary outcome, peak oxygen consumption, will be measured at 6 weeks. Overall participation in the study will last approximately 1 year.",113,"You would receive daily injections of either anakinra or placebo for up to 14 days. A nurse will give injections while you are in the hospital, and you will be taught to give them at home after discharge. Your participation in the study will last approximately 1 year.","Not stated in the trial record.",[31],"v2"]