[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT05248659":3,"trial-entities:NCT05248659":1176,"trial-summary:NCT05248659":1180},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":24,"primary_purpose":25,"phases":26,"enrollment_info":29,"interventions":32,"primary_outcomes":39,"secondary_outcomes":43,"sex":55,"minimum_age":56,"maximum_age":57,"healthy_volunteers":58,"eligibility_criteria":59,"std_ages":77,"locations":80,"central_contacts":1166,"overall_officials":1167,"references":1168,"see_also_links":1169},"NCT05248659","417-201-00012","Trial of Sibeprenlimab in the Treatment of Immunoglobulin A Nephropathy (IgAN)","A Phase 2\u002F3, Multicenter, Open-label Trial to Evaluate the Long-term Safety, Tolerability, and Efficacy of Sibeprenlimab Administered Subcutaneously in Subjects With Immunoglobulin A Nephropathy.","ENROLLING_BY_INVITATION","2029-12-31","2026-04","2026-05-05","2022-04-05","Otsuka Pharmaceutical Development & Commercialization, Inc.","INDUSTRY",true,"To evaluate the long-term safety and tolerability of sibeprenlimab in subjects with IgAN","This is a phase 2\u002F3, multicenter, open-label trial to evaluate the long-term safety, tolerability, and efficacy of sibeprenlimab administered subcutaneously (SC) to subjects with IgAN.\n\nEligible subjects will have participated in trials 417-201-00007 or VIS649-201 and, in the investigator's judgement, could benefit from continued treatment with sibeprenlimab.",[19],"Immunoglobulin A Nephropathy",[21,22,23],"Sibeprenlimab","VIS649","IgAN","INTERVENTIONAL","TREATMENT",[27,28],"PHASE2","PHASE3",{"count":30,"type":31},600,"ESTIMATED",[33],{"type":34,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"DRUG","Sibeprenlimab 400 mg s.c. Q4weeks","Sibeprenlimab 400 mg s.c. q 4 weeks",[36],[22],[40],{"measure":41,"timeFrame":42},"Adverse Events","From baseline to the end-of-trial visit in Week 112.",[44,47,50,52],{"measure":45,"timeFrame":46},"Annualized slope of Estimated Glomerular Filtration Rate (eGFR)","Over 12 and 24 months",{"measure":48,"timeFrame":49},"Urine protein\u002Fcreatinine ratio (uPCR) in a 24-hour collection","At 12 and 24 months",{"measure":51,"timeFrame":49},"Proportion of Subjects with Clinical Remission as defined in the protocol",{"measure":53,"timeFrame":54},"Time to Progression of Chronic Kidney Disease, as defined in the protocol","Over 24 months","ALL","18 Years",null,false,{"inclusion":60,"exclusion":63,"raw_text":76},[61,62],"Subjects who completed Trial 417-201-00007 (at least 20 of the 26 doses over a 2-year duration and the end-of-trial visit) or Trial VIS649-201 (at least 9 of the 12 doses over a 1-year duration and the end-of-trial visit) without safety concerns and who, in the opinion of the investigator, could potentially benefit from treatment with sibeprenlimab for IgAN.","Ability to provide written, informed consent prior to initiation of any trial-specific procedures, and ability, in the opinion of the principal investigator, to comply with all the requirements of the trial.",[64,65,66,67,68,69,70,71,72,73,74,75],"Subjects who have not completed participation in Trials 417-201-00007 or VIS649-201.","Subjects with treatment-limiting AEs during Trials 417-201-00007 or VIS649-201 considered related to IMP per investigator judgement.","Noncompliance, due to subject's repeated failure to follow trial procedures during the course of their participation in Trials 417-201-00007 and VIS649-201 (eg, subjects deemed to be noncompliant with the visit schedule, trial assessments, or treatment regimen). The medical monitor should be contacted if the investigator is unsure of a subject's eligibility.","Subjects who have a positive pregnancy test result prior to receiving IMP.","Heterosexually active biological males or subjects of childbearing potential, or their partners, who do not agree to adhere to contraceptive requirements from the time of consent through the end of the subject's participation in the trial and an additional 90 days (biological male subjects) or 30 days (biological female subjects) thereafter.","Biological male subjects who do not agree to avoid donation of sperm from the time of consent through the end of the subject's participation in the trial and an additional 90 days thereafter.","Subject has nephrotic syndrome, defined for this purpose as 24-hour urine protein \\> 3.5 g with concurrent hypoalbuminemia (serum albumin \\\u003C 2.5 g\u002FdL), hyperlipidemia (total cholesterol \\> 350 mg\u002FdL), and edema. Subjects with isolated nephrotic range proteinuria (\\> 3.5 g\u002Fday) will be eligible.","Subject has a history or current evidence of a serious and\u002For unstable cardiovascular, respiratory, gastrointestinal, hematologic, autoimmune, rheumatologic, blood dyscrasias or other medical disorder, including psychiatric disorders, cirrhosis, or ongoing malignancy. History of minor skin cancers (not including melanoma) or surgically treated, limited cervical carcinomas (ie, carcinoma in situ) are not exclusionary.","History of a previous hypersensitivity or severe allergic reaction with generalized urticaria, angioedema or anaphylaxis to any of the ingredients of the sibeprenlimab SC injection formulation.","Subject has a body mass index \\\u003C 16 kg\u002Fm\\^2.","Subject has received an organ transplant (ie, solid or a bone marrow or hematologic stem cell transplantation).","Subject is currently receiving, or has received within 16 weeks prior to enrollment, systemic immunosuppressive therapy (ie, steroids such as targeted release budesonide, complement inhibitors, mycophenolate, rituximab). Note: topical, ophthalmic, rectal, intra-articular, inhaled corticosteroids, and short courses of oral\u002Fintravenous steroids (\\\u003C= 14 days) are allowed.","Inclusion Criteria:\n\n* Subjects who completed Trial 417-201-00007 (at least 20 of the 26 doses over a 2-year duration and the end-of-trial visit) or Trial VIS649-201 (at least 9 of the 12 doses over a 1-year duration and the end-of-trial visit) without safety concerns and who, in the opinion of the investigator, could potentially benefit from treatment with sibeprenlimab for IgAN.\n* Ability to provide written, informed consent prior to initiation of any trial-specific procedures, and ability, in the opinion of the principal investigator, to comply with all the requirements of the trial.\n\nExclusion Criteria:\n\n* Subjects who have not completed participation in Trials 417-201-00007 or VIS649-201.\n* Subjects with treatment-limiting AEs during Trials 417-201-00007 or VIS649-201 considered related to IMP per investigator judgement.\n* Noncompliance, due to subject's repeated failure to follow trial procedures during the course of their participation in Trials 417-201-00007 and VIS649-201 (eg, subjects deemed to be noncompliant with the visit schedule, trial assessments, or treatment regimen). The medical monitor should be contacted if the investigator is unsure of a subject's eligibility.\n* Subjects who have a positive pregnancy test result prior to receiving IMP.\n* Heterosexually active biological males or subjects of childbearing potential, or their partners, who do not agree to adhere to contraceptive requirements from the time of consent through the end of the subject's participation in the trial and an additional 90 days (biological male subjects) or 30 days (biological female subjects) thereafter.\n* Biological male subjects who do not agree to avoid donation of sperm from the time of consent through the end of the subject's participation in the trial and an additional 90 days thereafter.\n* Subject has nephrotic syndrome, defined for this purpose as 24-hour urine protein \\> 3.5 g with concurrent hypoalbuminemia (serum albumin \\\u003C 2.5 g\u002FdL), hyperlipidemia (total cholesterol \\> 350 mg\u002FdL), and edema. Subjects with isolated nephrotic range proteinuria (\\> 3.5 g\u002Fday) will be eligible.\n* Subject has a history or current evidence of a serious and\u002For unstable cardiovascular, respiratory, gastrointestinal, hematologic, autoimmune, rheumatologic, blood dyscrasias or other medical disorder, including psychiatric disorders, cirrhosis, or ongoing malignancy. History of minor skin cancers (not including melanoma) or surgically treated, limited cervical carcinomas (ie, carcinoma in situ) are not exclusionary.\n* History of a previous hypersensitivity or severe allergic reaction with generalized urticaria, angioedema or anaphylaxis to any of the ingredients of the sibeprenlimab SC injection formulation.\n* Subject has a body mass index \\\u003C 16 kg\u002Fm\\^2.\n* Subject has received an organ transplant (ie, solid or a bone marrow or hematologic stem cell transplantation).\n* Subject is currently receiving, or has received within 16 weeks prior to enrollment, systemic immunosuppressive therapy (ie, steroids such as targeted release budesonide, complement inhibitors, mycophenolate, rituximab). Note: topical, ophthalmic, rectal, intra-articular, inhaled corticosteroids, and short courses of oral\u002Fintravenous steroids (\\\u003C= 14 days) are allowed.",[78,79],"ADULT","OLDER_ADULT",[81,90,98,105,113,121,129,136,144,151,159,167,175,183,191,199,207,211,218,227,235,242,249,253,261,269,276,283,291,294,303,311,319,327,334,341,350,358,366,375,379,387,395,403,411,419,427,434,442,449,457,466,474,482,490,495,504,512,520,527,531,534,540,545,554,563,571,578,586,593,601,608,616,624,629,634,642,650,658,665,672,676,684,691,698,705,714,718,725,729,737,744,749,757,765,770,774,781,788,795,802,811,819,826,830,834,841,850,858,862,870,878,886,893,900,904,911,915,919,928,936,944,952,956,963,969,976,980,984,988,992,996,1004,1008,1012,1018,1022,1029,1033,1040,1044,1052,1059,1066,1073,1081,1088,1095,1102,1106,1114,1118,1125,1132,1139,1147,1154,1158],{"facility":82,"city":83,"state":84,"zip":85,"country":86,"geoPoint":87},"Clinical Research Site #336","Birmingham","Alabama","35233","United 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3G4",{"lat":356,"lon":357},43.73899,-79.22124,{"facility":359,"city":360,"state":361,"zip":362,"country":346,"geoPoint":363},"CISSS de la Monteregie centre-Centre de recherche Hopital Charles Lemoyne","Greenfield Park","Quebec","J4V 2H1",{"lat":364,"lon":365},45.48649,-73.46223,{"facility":367,"city":368,"state":369,"zip":370,"country":371,"geoPoint":372},"Clinical Research Site #036","Beijing","Beijing Municipality","100029","China",{"lat":373,"lon":374},39.9075,116.39723,{"facility":376,"city":368,"state":369,"zip":377,"country":371,"geoPoint":378},"Clinical Research Site #020","100034",{"lat":373,"lon":374},{"facility":380,"city":381,"state":382,"zip":383,"country":371,"geoPoint":384},"Clinical Research Site #028","Guangzhou","Guangdong","510120",{"lat":385,"lon":386},23.11667,113.25,{"facility":388,"city":389,"state":390,"zip":391,"country":371,"geoPoint":392},"Clinical Research Site #044","Changsha","Hunan","410011",{"lat":393,"lon":394},28.19874,112.97087,{"facility":396,"city":397,"state":398,"zip":399,"country":371,"geoPoint":400},"Clinical Research Site #030","Wuxi","Jiangsu","214023",{"lat":401,"lon":402},31.56887,120.28857,{"facility":404,"city":405,"state":406,"zip":407,"country":371,"geoPoint":408},"Clinical Research Site #022","Nanchang","Jiangxi","330006",{"lat":409,"lon":410},28.68396,115.85306,{"facility":412,"city":413,"state":414,"zip":415,"country":371,"geoPoint":416},"Clinical Research Site #026","Jinan","Shandong","250013",{"lat":417,"lon":418},36.66833,116.99722,{"facility":420,"city":421,"state":422,"zip":423,"country":371,"geoPoint":424},"Clinical Research Site #038","Chengdu","Sichuan","610072",{"lat":425,"lon":426},30.66667,104.06667,{"facility":428,"city":429,"state":422,"zip":430,"country":371,"geoPoint":431},"Clinical Research Site 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