[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT05257551":3,"trial-entities:NCT05257551":302,"trial-summary:NCT05257551":306},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":32,"primary_purpose":17,"phases":33,"enrollment_info":34,"interventions":37,"primary_outcomes":44,"secondary_outcomes":52,"sex":58,"minimum_age":59,"maximum_age":17,"healthy_volunteers":15,"eligibility_criteria":60,"std_ages":64,"locations":67,"central_contacts":204,"overall_officials":209,"references":213,"see_also_links":301},"NCT05257551","TP-CA-003","Tempus Small Cell Lung Cancer Observational Study (Sculptor)","Tempus SCLC Observational Study: A Tissue and Longitudinal Circulating Tumor DNA (ctDNA) Biomarker Profiling Study of Patients With Small Cell Lung Cancer (SCLC) Using Comprehensive Next-Generation Sequencing (NGS) Assays","RECRUITING","2029-03","2026-06","2026-06-15","2022-07-13","Tempus AI","INDUSTRY",false,"The study is a non-interventional evaluation of participants with extensive stage (ES) SCLC who will receive diagnostic and (where possible) post-progression tumor tissue profiling, alongside plasma ctDNA and CTC biomarker profiling during standard of care therapy in both first and second line treatment.",null,[19],"Small Cell Lung Cancer",[21,22,23,24,25,26,19,27,28,29,30,31],"Cancer","Oncology","Observational","Genomic Profiling","Precision medicine","SCLC","NGS","Biomarkers","ctDNA","Transcriptomics","Extensive Stage","OBSERVATIONAL",[],{"count":35,"type":36},200,"ESTIMATED",[38],{"type":39,"name":40,"description":41,"armGroupLabels":42},"OTHER","Observation","No intervention",[43],"Patients with Extensive Stage (ES) Small Cell Lung Cancer (SCLC)",[45,49],{"measure":46,"description":47,"timeFrame":48},"To determine if tumor tissue transcriptional subtypes can be detected","To determine prospectively if SCLC tumor tissue transcriptional subtypes can be detected by RNAseq","Up to 4 years",{"measure":50,"description":51,"timeFrame":48},"To characterize relationship between tissue transcriptional subtype and clinical outcomes","To characterize the relationship between tissue transcriptional subtype and clinical outcomes for first and second line based on collection of longitudinal information from medical records",[53,55],{"measure":54,"timeFrame":48},"To characterize the relationship between longitudinal ctDNA methylation and CTC results with clinical outcomes for first and second line therapy based on collection of longitudinal information from medical records",{"measure":56,"description":57,"timeFrame":48},"To evaluate the relationship between initial molecular SCLC subtypes (e.g., SCLC-A, SCLC-N, SCLC-I) and the subsequent development of therapeutic resistance","To longitudinally evaluate the relationship between initial molecular SCLC subtypes (e.g., SCLC-A, SCLC-N, SCLC-I) and the subsequent development of therapeutic resistance, identifying the specific genomic and cellular mechanisms (e.g., non-NE phenotypic emergence) that occur during clinical progression on first- and second-line treatments","ALL","18 Years",{"inclusion":61,"exclusion":62,"raw_text":63},[],[],"The following are the inclusion criteria. Participants are eligible to be included in this study only if all the following criteria apply. The participant has\u002Fis:\n\n1. Histologically confirmed small cell lung cancer diagnosis\n2. Diagnosis made with excisional or core needle biopsy specimen (fine needle aspirate may be permitted with approval from the Medical Monitor)\n3. Subjects must submit tumor sample per the laboratory manual, defined as follows: 1L Cohort - Tissue obtained prior to the initiation of 1L therapy; 2L Cohort - Tissue obtained prior to the initiation of 1L therapy and\u002For a standard of care re-biopsy prior to the start of 2L therapy, if performed.\n4. ECOG performance status of 0-2 at time of enrollment\n5. For participants entering prior to first line therapy, planned extensive stage first-line therapy of etoposide plus platinum plus PD-L1 inhibitor (atezolizumab or durvalumab)\n6. For participants entering post completion of standard of care first line prior to second line therapy, completion of an EP+CPI with or without maintenance therapy. Note: Participants who received 1L therapy that is not standard of care i.e., investigational therapy, are not eligible.\n7. Extensive stage disease at time of diagnosis according to NCCN definition: Extensive Stage Small Cell Lung Cancer (SCLC) as either Stage IV disease (any T, any N, with M1a\u002Fb\u002Fc) or T3-4 disease due to multiple lung nodules that are too extensive or have a tumor\u002Fnodal volume that is too large to be encompassed in a tolerable radiation plan (NCCN version 2.2026-September 16, 2025).\n8. Willing and able to provide informed consent\n9. Palliative radiotherapy is permitted as long as there is measurable disease outside of the radiotherapy port with which to assess response to therapy delivered\n\nParticipants will be excluded from the study if any of the following criteria apply. The participant has\u002Fis:\n\n1. Patients with a secondary malignancy must have been both diagnosed \\> 3 years from the lung cancer of interest and have completed all therapy for that malignancy \\> 3 years prior to diagnosis of the lung cancer of interest, with the exception of the following:\n\n   1. Patients with superficial basal cell carcinoma of low-risk histology per NCCN Guidelines (Low-risk histologic subtypes include nodular, superficial, and other non-aggressive growth patterns such as keratotic, infundibulocystic, and fibroepithelioma of Pinkus) and low-risk for recurrence per NCCN Guidelines (location on trunk or extremities, size \\\u003C 2 cm, primary (not recurrent), with well-defined borders) can be included even if they are diagnosed \\\u003C 3 years from the lung cancer of interest.\n   2. Patients with superficial squamous cell carcinoma of low-risk pathology per NCCN Guidelines (verrucous, keratoacanthomatous) and low-risk for recurrence per NCCN Guidelines (located on trunk or extremities; ≤ 2 cm in size; primary lesion (vs. recurrent); well to moderately differentiated; \\\u003C 2 mm thick and no invasion beyond subcutaneous fat; negative for perineural invasion; and negative for lymphatic or vascular involvement) can be included even if they are diagnosed \\\u003C 3 years from the lung cancer of interest.\n2. Mixed small cell and non-small cell histology\n3. Small cell cancers of origin in other organs or suspected metastatic cancer from other sites (i.e., those without a known or suspected lung primary diagnosis)\n4. Large Cell Neuroendocrine cancers\n5. Carcinoids or atypical carcinoid tumors\n6. Transformed small cell lung cancer emerging in the setting of targeted therapy for NSCLC\n7. Treated with an investigational agent of another immunotherapy class (i.e., non PD-1 or PD-L1 inhibitor)\n8. Not willing to have additional blood samples collected",[65,66],"ADULT","OLDER_ADULT",[68,78,95,110,125,133,148,163,177,181,189],{"facility":69,"status":70,"city":71,"state":72,"zip":73,"country":74,"geoPoint":75},"Cancer and Blood Specialty Clinic","WITHDRAWN","Los Alamitos","California","90720","United States",{"lat":76,"lon":77},33.80307,-118.07256,{"facility":79,"status":8,"city":80,"state":81,"zip":82,"country":74,"contacts":83,"geoPoint":92},"University of Colorado","Aurora","Colorado","80045",[84,89],{"name":85,"role":86,"phone":87,"email":88},"Emily Adam","CONTACT","303-724-9682","EMILY.ADAM@cuanschutz.edu",{"name":90,"role":91},"Tejas Patil, MD","PRINCIPAL_INVESTIGATOR",{"lat":93,"lon":94},39.72943,-104.83192,{"facility":96,"status":8,"city":97,"state":98,"zip":99,"country":74,"contacts":100,"geoPoint":107},"Illinois Cancer Care","Peoria","Illinois","61615",[101,105],{"name":102,"role":86,"phone":103,"email":104},"Beth Heilman","309-243-3617","bheilman@illinoiscancercare.com",{"name":106,"role":91},"Mohammad (Fahad) Asad, MD",{"lat":108,"lon":109},40.69365,-89.58899,{"facility":111,"status":8,"city":112,"state":113,"zip":114,"country":74,"contacts":115,"geoPoint":122},"Johns Hopkins University","Baltimore","Maryland","21287",[116,120],{"name":117,"role":86,"phone":118,"email":119},"Cheryl Pai","410-614-1926","cpai3@jhu.edu",{"name":121,"role":91},"Lonny Yarmus, MD",{"lat":123,"lon":124},39.29038,-76.61219,{"facility":126,"status":70,"city":127,"state":128,"zip":129,"country":74,"geoPoint":130},"Englewood Health Medical Center","Englewood","New Jersey","07631",{"lat":131,"lon":132},40.89288,-73.97264,{"facility":134,"status":8,"city":135,"state":136,"zip":137,"country":74,"contacts":138,"geoPoint":145},"University of North Carolina","Chapel Hill","North Carolina","27599",[139,143],{"name":140,"role":86,"phone":141,"email":142},"Ashley Delgado","984-520-7329","ashley_delgado@med.unc.edu",{"name":144,"role":91},"Jason Akulian, MD",{"lat":146,"lon":147},35.9132,-79.05584,{"facility":149,"status":8,"city":150,"state":151,"zip":152,"country":74,"contacts":153,"geoPoint":160},"TriHealth Cancer Institute","Cincinnati","Ohio","45220",[154,158],{"name":155,"role":86,"phone":156,"email":157},"Patrick Newbury","513 865 5249","Patrick_Newbury@trihealth.com",{"name":159,"role":91},"James Maher, MD",{"lat":161,"lon":162},39.12711,-84.51439,{"facility":164,"status":8,"city":165,"state":151,"zip":166,"country":74,"contacts":167,"geoPoint":174},"Ohio State University","Columbus","43210",[168,172],{"name":169,"role":86,"phone":170,"email":171},"Nicole Bullock","614-366-6489","nicole.bullock@osumc.edu",{"name":173,"role":91},"Asrar Alahmadi",{"lat":175,"lon":176},39.96118,-82.99879,{"facility":178,"status":70,"city":165,"state":151,"zip":179,"country":74,"geoPoint":180},"OhioHealth Research Institute","43214",{"lat":175,"lon":176},{"facility":182,"status":70,"city":183,"state":184,"zip":185,"country":74,"geoPoint":186},"Oklahoma Cancer Specialists and Research Institutes","Tulsa","Oklahoma","74146",{"lat":187,"lon":188},36.15398,-95.99277,{"facility":190,"status":8,"city":191,"state":192,"zip":193,"country":74,"contacts":194,"geoPoint":201},"Cancer Care Association of York","York","Pennsylvania","17403",[195,197,199],{"name":196,"role":86},"Jennifer Stough",{"role":86,"phone":198},"717-741-9229",{"name":200,"role":91},"Chanh Huynh, MD",{"lat":202,"lon":203},39.9626,-76.72774,[205],{"name":206,"role":86,"phone":207,"email":208},"Sculptor Study","833-514-4187","sculptor-study@tempus.com",[210],{"name":211,"affiliation":212,"role":91},"Virginia Rhodes, MD","Tempus AI, Inc.",[214,218,220,222,224,226,229,231,234,236,239,242,245,248,251,254,257,260,263,266,269,272,275,278,281,284,287,290,293,296,299],{"pmid":215,"type":216,"citation":217},"41254986","BACKGROUND","Kepp O, Kroemer G. FDA approves lurbinectedin in combination with atezolizumab for extensive-stage small cell lung cancer. Oncoimmunology. 2025 Dec 31;14(1):2584898. doi: 10.1080\u002F2162402X.2025.2584898. Epub 2025 Nov 18.",{"type":216,"citation":219},"U.S. Food and Drug Administration. FDA grants accelerated approval to lurbinectedin for metastatic small cell lung cancer. FDA website. 2020",{"type":216,"citation":221},"Saunders LR, et al. A highly efficacious bispecific antibody targeting DLL3 and CD3 in small cell lung cancer. Sci Transl Med. 2015;7(312):312ra179.",{"type":216,"citation":223},"Rudin CM. Second-line tarlatamab shows improved survival over chemotherapy in previously treated SCLC. ASCO Daily News. 2025 Jun 2.",{"type":216,"citation":225},"Rudin CM, et al. Molecular mechanisms of plasticity in small-cell lung cancer. Cold Spring Harb Perspect Med. 2019;9(12):a035252.",{"pmid":227,"type":216,"citation":228},"40473449","Paz-Ares L, Borghaei H, Liu SV, Peters S, Herbst RS, Stencel K, Majem M, Sendur MAN, Czyzewicz G, Caro RB, Lee KH, Johnson ML, Karadurmus N, Grohe C, Baka S, Csoszi T, Ahn JS, Califano R, Yang TY, Kemal Y, Ballinger M, Cuchelkar V, Graupner V, Lin YC, Chakrabarti D, Bhatt K, Cai G, Iannone R, Reck M; IMforte investigators. Efficacy and safety of first-line maintenance therapy with lurbinectedin plus atezolizumab in extensive-stage small-cell lung cancer (IMforte): a randomised, multicentre, open-label, phase 3 trial. Lancet. 2025 Jun 14;405(10495):2129-2143. doi: 10.1016\u002FS0140-6736(25)01011-6. Epub 2025 Jun 2.",{"type":216,"citation":230},"Paz-Ares L, et al. Tarlatamab in previously treated small-cell lung cancer: a phase 2, open-label, multicentre study (DeLLphi-301). Lancet. 2024.",{"pmid":232,"type":216,"citation":233},"37079341","Hanvesakul R, Rengarajan B, Naveh N, Boccuti A, Park JE, Adeyemi A, Caisip C, Jansen JP, Wilson FR. Indirect treatment comparison of lurbinectedin versus other second-line treatments for small-cell lung cancer. J Comp Eff Res. 2023 May;12(5):e220098. doi: 10.57264\u002Fcer-2022-0098. Epub 2023 Apr 20.",{"type":216,"citation":235},"Abbosh C, et al. Sequencing of tumor-informed circulating tumor DNA to monitor disease in patients with small cell lung cancer. Sci Transl Med. 2021.",{"pmid":237,"type":216,"citation":238},"34653364","Chan JM, Quintanal-Villalonga A, Gao VR, Xie Y, Allaj V, Chaudhary O, Masilionis I, Egger J, Chow A, Walle T, Mattar M, Yarlagadda DVK, Wang JL, Uddin F, Offin M, Ciampricotti M, Qeriqi B, Bahr A, de Stanchina E, Bhanot UK, Lai WV, Bott MJ, Jones DR, Ruiz A, Baine MK, Li Y, Rekhtman N, Poirier JT, Nawy T, Sen T, Mazutis L, Hollmann TJ, Pe'er D, Rudin CM. Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer. Cancer Cell. 2021 Nov 8;39(11):1479-1496.e18. doi: 10.1016\u002Fj.ccell.2021.09.008. Epub 2021 Oct 14.",{"pmid":240,"type":216,"citation":241},"25336398","Byers LA, Rudin CM. Small cell lung cancer: where do we go from here? Cancer. 2015 Mar 1;121(5):664-72. doi: 10.1002\u002Fcncr.29098. Epub 2014 Oct 21.",{"pmid":243,"type":216,"citation":244},"27452466","Borromeo MD, Savage TK, Kollipara RK, He M, Augustyn A, Osborne JK, Girard L, Minna JD, Gazdar AF, Cobb MH, Johnson JE. ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs. Cell Rep. 2016 Aug 2;16(5):1259-1272. doi: 10.1016\u002Fj.celrep.2016.06.081. Epub 2016 Jul 21.",{"pmid":246,"type":216,"citation":247},"23836314","Crowley E, Di Nicolantonio F, Loupakis F, Bardelli A. Liquid biopsy: monitoring cancer-genetics in the blood. Nat Rev Clin Oncol. 2013 Aug;10(8):472-84. doi: 10.1038\u002Fnrclinonc.2013.110. Epub 2013 Jul 9.",{"pmid":249,"type":216,"citation":250},"32513672","Drapkin BJ, Rudin CM. Advances in Small-Cell Lung Cancer (SCLC) Translational Research. Cold Spring Harb Perspect Med. 2021 Apr 1;11(4):a038240. doi: 10.1101\u002Fcshperspect.a038240.",{"pmid":252,"type":216,"citation":253},"33482121","Gay CM, Stewart CA, Park EM, Diao L, Groves SM, Heeke S, Nabet BY, Fujimoto J, Solis LM, Lu W, Xi Y, Cardnell RJ, Wang Q, Fabbri G, Cargill KR, Vokes NI, Ramkumar K, Zhang B, Della Corte CM, Robson P, Swisher SG, Roth JA, Glisson BS, Shames DS, Wistuba II, Wang J, Quaranta V, Minna J, Heymach JV, Byers LA. Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities. Cancer Cell. 2021 Mar 8;39(3):346-360.e7. doi: 10.1016\u002Fj.ccell.2020.12.014. Epub 2021 Jan 21.",{"pmid":255,"type":216,"citation":256},"33285097","Goldman JW, Dvorkin M, Chen Y, Reinmuth N, Hotta K, Trukhin D, Statsenko G, Hochmair MJ, Ozguroglu M, Ji JH, Garassino MC, Voitko O, Poltoratskiy A, Ponce S, Verderame F, Havel L, Bondarenko I, Kazarnowicz A, Losonczy G, Conev NV, Armstrong J, Byrne N, Thiyagarajah P, Jiang H, Paz-Ares L; CASPIAN investigators. Durvalumab, with or without tremelimumab, plus platinum-etoposide versus platinum-etoposide alone in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): updated results from a randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 2021 Jan;22(1):51-65. doi: 10.1016\u002FS1470-2045(20)30539-8. Epub 2020 Dec 4.",{"pmid":258,"type":216,"citation":259},"30280641","Horn L, Mansfield AS, Szczesna A, Havel L, Krzakowski M, Hochmair MJ, Huemer F, Losonczy G, Johnson ML, Nishio M, Reck M, Mok T, Lam S, Shames DS, Liu J, Ding B, Lopez-Chavez A, Kabbinavar F, Lin W, Sandler A, Liu SV; IMpower133 Study Group. First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer. N Engl J Med. 2018 Dec 6;379(23):2220-2229. doi: 10.1056\u002FNEJMoa1809064. Epub 2018 Sep 25.",{"pmid":261,"type":216,"citation":262},"30323087","Kalemkerian GP, Loo BW, Akerley W, Attia A, Bassetti M, Boumber Y, Decker R, Dobelbower MC, Dowlati A, Downey RJ, Florsheim C, Ganti AKP, Grecula JC, Gubens MA, Hann CL, Hayman JA, Heist RS, Koczywas M, Merritt RE, Mohindra N, Molina J, Moran CA, Morgensztern D, Pokharel S, Portnoy DC, Rhodes D, Rusthoven C, Sands J, Santana-Davila R, Williams CC, Hoffmann KG, Hughes M. NCCN Guidelines Insights: Small Cell Lung Cancer, Version 2.2018. J Natl Compr Canc Netw. 2018 Oct;16(10):1171-1182. doi: 10.6004\u002Fjnccn.2018.0079.",{"pmid":264,"type":216,"citation":265},"33506766","Liu MC, Oxnard GR, Klein EA, Swanton C, Seiden MV; CCGA Consortium. Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA. Ann Oncol. 2020 Jun;31(6):745-759. doi: 10.1016\u002Fj.annonc.2020.02.011. Epub 2020 Mar 30.",{"pmid":267,"type":216,"citation":268},"33707236","Mahadevan NR, Knelson EH, Wolff JO, Vajdi A, Saigi M, Campisi M, Hong D, Thai TC, Piel B, Han S, Reinhold BB, Duke-Cohan JS, Poitras MJ, Taus LJ, Lizotte PH, Portell A, Quadros V, Santucci AD, Murayama T, Canadas I, Kitajima S, Akitsu A, Fridrikh M, Watanabe H, Reardon B, Gokhale PC, Paweletz CP, Awad MM, Van Allen EM, Lako A, Wang XT, Chen B, Hong F, Sholl LM, Tolstorukov MY, Pfaff K, Janne PA, Gjini E, Edwards R, Rodig S, Reinherz EL, Oser MG, Barbie DA. Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity. Cancer Discov. 2021 Aug;11(8):1952-1969. doi: 10.1158\u002F2159-8290.CD-20-0913. Epub 2021 Mar 11.",{"pmid":270,"type":216,"citation":271},"28855354","Ooki A, Maleki Z, Tsay JJ, Goparaju C, Brait M, Turaga N, Nam HS, Rom WN, Pass HI, Sidransky D, Guerrero-Preston R, Hoque MO. A Panel of Novel Detection and Prognostic Methylated DNA Markers in Primary Non-Small Cell Lung Cancer and Serum DNA. Clin Cancer Res. 2017 Nov 15;23(22):7141-7152. doi: 10.1158\u002F1078-0432.CCR-17-1222. Epub 2017 Aug 29.",{"pmid":273,"type":216,"citation":274},"34663914","Rekhtman N. Lung neuroendocrine neoplasms: recent progress and persistent challenges. Mod Pathol. 2022 Jan;35(Suppl 1):36-50. doi: 10.1038\u002Fs41379-021-00943-2. Epub 2021 Oct 18.",{"pmid":276,"type":216,"citation":277},"34162872","Roper N, Velez MJ, Chiappori A, Kim YS, Wei JS, Sindiri S, Takahashi N, Mulford D, Kumar S, Ylaya K, Trindade C, Manukyan I, Brown AL, Trepel JB, Lee JM, Hewitt S, Khan J, Thomas A. Notch signaling and efficacy of PD-1\u002FPD-L1 blockade in relapsed small cell lung cancer. Nat Commun. 2021 Jun 23;12(1):3880. doi: 10.1038\u002Fs41467-021-24164-y.",{"pmid":279,"type":216,"citation":280},"30926931","Rudin CM, Poirier JT, Byers LA, Dive C, Dowlati A, George J, Heymach JV, Johnson JE, Lehman JM, MacPherson D, Massion PP, Minna JD, Oliver TG, Quaranta V, Sage J, Thomas RK, Vakoc CR, Gazdar AF. Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. Nat Rev Cancer. 2019 May;19(5):289-297. doi: 10.1038\u002Fs41568-019-0133-9.",{"pmid":282,"type":216,"citation":283},"31912902","Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020 Jan;70(1):7-30. doi: 10.3322\u002Fcaac.21590. Epub 2020 Jan 8.",{"pmid":285,"type":216,"citation":286},"28252003","Siravegna G, Marsoni S, Siena S, Bardelli A. Integrating liquid biopsies into the management of cancer. Nat Rev Clin Oncol. 2017 Sep;14(9):531-548. doi: 10.1038\u002Fnrclinonc.2017.14. Epub 2017 Mar 2.",{"pmid":288,"type":216,"citation":289},"33521652","Stewart CA, Gay CM, Xi Y, Sivajothi S, Sivakamasundari V, Fujimoto J, Bolisetty M, Hartsfield PM, Balasubramaniyan V, Chalishazar MD, Moran C, Kalhor N, Stewart J, Tran H, Swisher SG, Roth JA, Zhang J, de Groot J, Glisson B, Oliver TG, Heymach JV, Wistuba I, Robson P, Wang J, Byers LA. Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer. Nat Cancer. 2020 Apr;1:423-436. doi: 10.1038\u002Fs43018-019-0020-z. Epub 2020 Feb 17.",{"pmid":291,"type":216,"citation":292},"33086069","Tlemsani C, Pongor L, Elloumi F, Girard L, Huffman KE, Roper N, Varma S, Luna A, Rajapakse VN, Sebastian R, Kohn KW, Krushkal J, Aladjem MI, Teicher BA, Meltzer PS, Reinhold WC, Minna JD, Thomas A, Pommier Y. SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures. Cell Rep. 2020 Oct 20;33(3):108296. doi: 10.1016\u002Fj.celrep.2020.108296.",{"pmid":294,"type":216,"citation":295},"31217577","Zepp JA, Morrisey EE. Cellular crosstalk in the development and regeneration of the respiratory system. Nat Rev Mol Cell Biol. 2019 Sep;20(9):551-566. doi: 10.1038\u002Fs41580-019-0141-3. Epub 2019 Jun 19.",{"pmid":297,"type":216,"citation":298},"29535911","Zhang W, Girard L, Zhang YA, Haruki T, Papari-Zareei M, Stastny V, Ghayee HK, Pacak K, Oliver TG, Minna JD, Gazdar AF. Small cell lung cancer tumors and preclinical models display heterogeneity of neuroendocrine phenotypes. Transl Lung Cancer Res. 2018 Feb;7(1):32-49. doi: 10.21037\u002Ftlcr.2018.02.02.",{"type":216,"citation":300},"Howlader, Nnam, A. M. Noone, Me Krapcho, D. Miller, A. Brest, M. Yu, J. Ruhl, et al. 2020.\"SEER Cancer Statistics Review, 1975--2017.\" National Cancer Institute.",[],{"nct_id":4,"conditions":303,"biomarkers":305},[304],"Lung Small Cell Carcinoma",[],{"nct_id":4,"found":307,"summary":308,"prompt_version":318},true,{"design":309,"status":310,"heading":311,"summary":312,"follow_up":313,"word_count":314,"commitments":315,"compensation":316,"drugs_mentioned":317},"This is an observational study, meaning no intervention is given. It plans to include 200 participants.","completed","Observational Study for Small Cell Lung Cancer","This is an observational study called SCULPTOR for people with small cell lung cancer (SCLC). Researchers are not testing a new treatment; instead, they are observing participants who are receiving standard care. The study aims to understand if different patterns in tumor tissue (called transcriptional subtypes) can be found and how these patterns relate to how well patients do over time. To join, you must have a confirmed diagnosis of small cell lung cancer from a biopsy. The study plans to enroll 200 participants and is currently unclear about its recruitment status.","Researchers will follow up with participants for up to 4 years to see how their tumor tissue patterns relate to their clinical outcomes.",92,"You would have your tumor tissue profiled at diagnosis and potentially after your disease progresses. Your blood will also be tested for biomarkers (like ctDNA and CTC) during your standard of care treatment.","Not stated in the trial record.",[40],"v2"]