[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT05384158":3,"trial-entities:NCT05384158":93,"trial-summary:NCT05384158":99},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":24,"primary_purpose":25,"phases":26,"enrollment_info":28,"interventions":31,"primary_outcomes":46,"secondary_outcomes":51,"sex":62,"minimum_age":63,"maximum_age":64,"healthy_volunteers":15,"eligibility_criteria":65,"std_ages":71,"locations":73,"central_contacts":89,"overall_officials":90,"references":91,"see_also_links":92},"NCT05384158","RDOC","Valuation in Depressed Mood, Anhedonia, and Anxiety","Evaluating Overlap and Distinctiveness in Neurocomputational Loss and Reward Elements of the RDoC Matrix","RECRUITING","2027-07","2026-08","2026-08-28","2021-08-01","Virginia Polytechnic Institute and State University","OTHER",false,"This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and\u002For anxiety.","This study tests relationships among neural and behavioral valuation mechanisms, and how these mechanisms change (or not) over time, with task instructions, and following cognitive behavior therapy.",[19],"Neurobehavioral Components of Reward and Loss Valuation",[21,22,23],"depression","anxiety","anhedonia","INTERVENTIONAL","BASIC_SCIENCE",[27],"NA",{"count":29,"type":30},252,"ESTIMATED",[32,37,42],{"type":33,"name":34,"description":34,"armGroupLabels":35},"BEHAVIORAL","cognitive behavioral therapy",[36],"Cognitive behavioral therapy",{"type":33,"name":38,"description":39,"armGroupLabels":40},"valuation with instruction","repeat laboratory sessions of computerized learning game",[41],"Valuation with instruction",{"type":33,"name":43,"description":39,"armGroupLabels":44},"valuation without instruction",[45],"Valuation without instruction",[47],{"measure":48,"description":49,"timeFrame":50},"change in proportion correct on the 'N-arm bandit learning task'","change in proportion correct on 'N-arm bandit reinforcement learning task' from study entrance to study exit","study entrance to study exit, an average of 12 weeks",[52,56,59],{"measure":53,"description":54,"timeFrame":55},"change in depression symptoms (Beck Depression Inventory)","change in depression symptoms from study entrance to study exit","study entrance to exit, an average of 12 weeks",{"measure":57,"description":58,"timeFrame":55},"change in anxiety symptoms (anxiety subscale; Mood and Anxiety Symptom Questionnaire)","change in anxiety symptoms from study entrance to study exit",{"measure":60,"description":61,"timeFrame":55},"change in anhedonia symptoms (anhedonia subscale; Mood and Anxiety Symptom Questionnaire)","change in anhedonia symptoms from study entrance to study exit","ALL","25 Years","50 Years",{"inclusion":66,"exclusion":68,"raw_text":70},[67],"mood, anxiety, or anhedonia symptoms that affect functioning; fluent in English; able to see computer display; able to perform simple computer games.",[69],"history of seizure disorder, stroke, or head injury with more than 10 minutes of unconsciousness; hormone disorder; electroconvulsive therapy within 5 years; history of chemotherapy for cancer; current pregnancy; contraindications to MRI","Inclusion Criteria:\n\n* mood, anxiety, or anhedonia symptoms that affect functioning; fluent in English; able to see computer display; able to perform simple computer games.\n\nExclusion Criteria:\n\n* history of seizure disorder, stroke, or head injury with more than 10 minutes of unconsciousness; hormone disorder; electroconvulsive therapy within 5 years; history of chemotherapy for cancer; current pregnancy; contraindications to MRI",[72],"ADULT",[74],{"facility":75,"status":8,"city":76,"state":77,"zip":78,"country":79,"contacts":80,"geoPoint":86},"Fralin Biomedical Research Institute at Virginia Tech Carilion","Roanoke","Virginia","24014","United States",[81],{"name":82,"role":83,"phone":84,"email":85},"Pearl Chiu, PhD","CONTACT","540-526-2032","chiup@vtc.vt.edu",{"lat":87,"lon":88},37.27097,-79.94143,[],[],[],[],{"nct_id":4,"conditions":94,"biomarkers":98},[95,96,97],"Anhedonia","Anxiety","Depression",[],{"nct_id":4,"found":100,"summary":101,"prompt_version":111},true,{"design":102,"status":103,"heading":104,"summary":105,"follow_up":106,"word_count":107,"commitments":108,"compensation":109,"drugs_mentioned":110},"This is an interventional study planning to enroll 252 participants. It is not specified if it is randomized or blinded.","completed","Study on Reward and Loss in Mood, Anhedonia, and Anxiety","This study is looking for 252 participants aged 25-50 who are experiencing depressed mood, anhedonia (loss of pleasure), or anxiety that affects their daily life. It aims to understand how people respond to rewards and losses, and if these responses are different for those with these conditions. You might receive cognitive behavioral therapy or participate in computerized learning games, either with or without instructions. The study will measure changes in your performance on a specific learning task over about 12 weeks to see if the interventions are successful. The current recruitment status is unclear.","The primary endpoint is measured from study entrance to study exit, an average of 12 weeks.",94,"You would participate in repeat laboratory sessions involving a computerized learning game. The study will last an average of 12 weeks.","Not stated in the trial record.",[34],"v2"]