[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT05386394":3,"trial-entities:NCT05386394":188,"trial-summary:NCT05386394":193},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":22,"study_type":26,"primary_purpose":27,"phases":28,"enrollment_info":30,"interventions":33,"primary_outcomes":45,"secondary_outcomes":60,"sex":71,"minimum_age":72,"maximum_age":73,"healthy_volunteers":15,"eligibility_criteria":74,"std_ages":99,"locations":102,"central_contacts":150,"overall_officials":157,"references":159,"see_also_links":187},"NCT05386394","IRB00326681","Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia","Phase II Clinical Trial of Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia","RECRUITING","2028-02-01","2026-04","2026-05-05","2024-02-13","Johns Hopkins University","OTHER",true,"While many have strongly suggested that transcranial direct current stimulation (tDCS) may represent a beneficial intervention for patients with primary progressive aphasia (PPA), this promising technology has not yet been applied widely in clinical settings. This treatment gap is underscored by the absence of any neurally-focused standard-of-care treatments to mitigate the devastating impact of aphasia on patients' family, work, and social lives. Given that tDCS is inexpensive, easy to use (it is potentially amenable to home use by patients and caregivers), minimally invasive, and safe there is great promise to advance this intervention toward clinical use. The principal reason that tDCS has not found wide clinical application yet is that its efficacy has not been tested in large, multi-center, clinical trials. In this study, scientists in the three sites that have conducted tDCS clinical trials in North America-Johns Hopkins University and the University of Pennsylvania in the US, and the University of Toronto in Canada, will collaborate to conduct a multi-site, Phase II clinical trial of tDCS a population in dire need of better treatments.","Aim 1: To determine whether tDCS over the left perisylvian language areas paired with naming treatment will improve oral and written naming outcomes in two variants of PPA (nfvPPA and lvPPA).\n\nThe investigators will use a double-blind, sham-controlled, within-subject, cross-over design. Participants will receive Naming and Spelling (NASP) treatment + tDCS condition or NASP treatment + sham condition, in Period 1 or 2, randomized for the Period 1 stimulation condition. Each treatment period will last 3 weeks, with 5 language therapy sessions\u002Fweek, for 15 sessions in total, and a 3-month (stimulation-free) wash-out time between the two periods of stimulation to evaluate clinically meaningful effects.\n\nLanguage therapy (NASP treatment) will be delivered by a speech-language pathologist or a trained research associate. The participant will be shown a picture on the screen, asked to orally name it, and subsequently write the name. If the participant cannot, the participant will be asked to provide 3 semantic attributes to reinforce semantic representations, as in Semantic Feature Analysis treatment (Boyle, 2010). If the word still cannot be named or written, the clinician will provide the correct name and spelling and the participant will be asked to repeat or copy it 3 times, in a spell-study-spell procedure (Rapp \\& Glucroft, 2009). There will be two word-sets: trained (targeted during therapy) and untrained (not targeted during therapy), both individually tailored to the participant based on severity of spelling deficit. Treatment stimuli will consist of 10-30 words depending on individual severity. General procedures and the outcome measure (letter accuracy) will be maintained across all participants. Consistent with the investigators previous work, the NASP treatment will be conducted in English, which, for most participants, will be the participant's first language.\n\nTo deliver tDCS, the investigators will use the Soterix 1x1 platform. The anode will be placed over the left frontal lobe, centered on F7 in the 10-20 electrode placement system (Homan, 1988), and cathode will be placed over the right cheek. Non-metallic, conductive rubber electrodes (5 cm x 5 cm), fitted with saline-soaked sponges to limit skin-electrode reactions will be used so the full left inferior frontal gyrus (IFG) will be covered. Current will be delivered with an intensity of 2 mA (estimated current density 0.08 milliamps (mA)\u002Fcm2) for a total of 20 minutes each tDCS session. Delivery of tDCS will be simultaneous with the start of language therapy, which will continue for an additional 25 minutes beyond the cessation of tDCS in each session. In contrast to actual tDCS, sham stimulation involves the delivery of 30 seconds of current ramping up to 2 mA and back down to 0 mA simultaneous with the start of language therapy.\n\nBehavioral\u002Flanguage assessments will involve: oral and written naming, spelling, connected speech\u002Fdiscourse, sentence comprehension and production, verbal fluency, short-term\u002Fworking memory tasks, etc. Other global cognitive assessments will be conducted, as well as quality of life assessments. Bilingual assessments will be conducted for those who bilingual or multilingual.\n\nAim 2: To identify clinical, neural, cognitive, biological, and demographic predictors of tDCS vs sham effects on primary outcomes.\n\nImaging will be performed at before Period 1, before Period 2 and 3-months post Period 2 for a total of 3 scans per participant. Scans will be done on a 3T Philips system and will consist of magnetization prepared rapid gradient echoresting state (MPRAGE), resting state functional MRI (rsfMRI), and diffusion tensor imaging (DTI). Each scanning session will last approximately 1 hour.\n\nSaliva samples will be collected for exploratory analysis and DNA will be extracted using standard methodology. Genotyping will be carried out by the Johns Hopkins DNA Diagnostic Laboratory using standard methods.",[19,20,21],"Primary Progressive Aphasia","Logopenic Progressive Aphasia","Non-Fluent Primary Progressive Aphasia",[23,24,25],"transcranial direct current stimulation","language treatment","primary progressive aphasia","INTERVENTIONAL","TREATMENT",[29],"PHASE2",{"count":31,"type":32},180,"ESTIMATED",[34,41],{"type":35,"name":36,"description":37,"armGroupLabels":38},"DEVICE","Active tDCS + Language Therapy","Active tDCS stimulation will be delivered by a battery-driven constant current stimulator. The electrical current will be administered to a pre-specified region of the brain (inferior frontal gyrus). The stimulation will be delivered at an intensity of 2mA (estimated current density 0.04 milliamps (mA)\u002Fcm2; estimated total charge 0.048 Coulombs (C)\u002Fcm2) in a ramp-like fashion for a maximum of 20 minutes. Language therapy will be conducted in conjunction with stimulation and will target oral and written naming.",[39,40],"Active tDCS + Language Therapy first","Sham tDCS + Language Therapy first",{"type":35,"name":42,"description":43,"armGroupLabels":44},"Sham tDCS + Language Therapy","During sham stimulation, current will be administered in a ramp-line fashion but after the ramping the intensity will drop to 0 mA. Language therapy targeting oral and written naming will be administered during sham tDCS stimulation.",[39,40],[46,50,53,57],{"measure":47,"description":48,"timeFrame":49},"Immediate Change in Phonemic Accuracy","The primary outcome measure will be tDCS-induced change in performance on phonemic accuracy of trained items. Phonemic accuracy will be calculated on a scale of 0-100% with a higher number reflecting higher accuracy. The change in performance from baseline will be compared between the tDCS condition and the sham condition.","Baseline and Immediate follow-up of 3-week intervention period",{"measure":51,"description":52,"timeFrame":49},"Immediate Change in Letter Accuracy","The primary outcome measure will be tDCS-induced change in performance on letter accuracy of trained items. Letter accuracy will be calculated on a scale of 0-100% with a higher number reflecting higher accuracy. The change in performance from baseline will be compared between the tDCS condition and the sham condition.",{"measure":54,"description":55,"timeFrame":56},"Change in Phonemic Accuracy at 3-month follow-up visit","The primary outcome measure will be tDCS-induced change in performance on phonemic accuracy of trained items, 3 months following the discontinuation of intervention. Phonemic accuracy will be calculated on a scale of 0-100% with a higher number reflecting higher accuracy. The change in performance from baseline will be compared between the tDCS condition and the sham condition.","Baseline and 3 months post intervention",{"measure":58,"description":59,"timeFrame":56},"Change in Letter Accuracy at 3-month follow-up visit","The primary outcome measure will be tDCS-induced change in performance on letter accuracy of trained items, 3 months following the discontinuation of intervention. Letter accuracy will be calculated on a scale of 0-100% with a higher number reflecting higher accuracy. The change in performance from baseline will be compared between the tDCS condition and the sham condition.",[61,64,67],{"measure":62,"description":63,"timeFrame":56},"Change in Untrained Naming Items (phonemic accuracy)","The outcome measure will be tDCS-induced change of phonemic accuracy of untrained stimuli (those not targeted in therapy). Phonemic accuracy will be calculated on a scale of 0-100% with a higher number reflecting higher accuracy. The change in performance from baseline will be compared between the tDCS condition and the sham condition.",{"measure":65,"description":66,"timeFrame":56},"Change in Untrained Naming Items (letter accuracy)","The outcome measure will be tDCS-induced change of letter accuracy of untrained stimuli (those not targeted in therapy). Letter accuracy will be calculated on a scale of 0-100% with a higher number reflecting higher accuracy. The change in performance from baseline will be compared between the tDCS condition and the sham condition.",{"measure":68,"description":69,"timeFrame":70},"Change in functional connectivity of select brain regions (z-correlations)","Using resting stage functional MRI (rs-fMRI) investigators will detect activity of various brain regions under a resting\u002Ftask-negative condition, which will help evaluate functional regional interactions as indicated by the z-correlations between the selected brain area.","Immediate follow-up of 3-week intervention period and 3-month follow-up","ALL","50 Years","90 Years",{"inclusion":75,"exclusion":80,"raw_text":98},[76,77,78,79],"Presence of aphasia attributable to non-fluent PPA or logopenic PPA","High school education (or more)","Between the ages of 50 and 90","Must be able to understand the nature of the study and give informed consent",[81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97],"Cognitive impairment of sufficient severity to preclude giving informed consent (Mini Mental State Examination \\[MMSE\\] less than 15)","Any unrelated neurologic or physical condition that impairs communication ability","History of unrelated neurological conditions, including but not limited to traumatic brain injury (TBI), stroke, or small vessel disease, that has resulted in a neurologic deficit","Any additional neurological condition that would likely reduce the safety of study participation, including central nervous system (CNS) vasculitis, intracranial tumor, intracranial aneurysm, multiple sclerosis, or arteriovenous malformations","A medically unstable cardiopulmonary or metabolic disorder","Individuals with pacemakers or implantable cardiac defibrillators","Terminal illness associated with survival of less than 12 months","Major active psychiatric illness that may interfere with required study procedures or treatments, as determined by the enrolling physician","Current abuse of alcohol or drugs, prescription or otherwise","Participant in another drug, device, or biologics trial within 30 days prior to enrollment","Nursing a child, pregnant, or intending to become pregnant during the study","Left-handedness","History of spontaneous or partial complex seizures or unexplained loss of consciousness within 6 months of enrollment","Subjects with metallic objects in the face or head other than dental apparatus, such as braces, fillings, or implants","Subjects with previous craniotomy or any breach in the skull","Presence of any of the following devices: cardiac pacemaker, other pacemakers (for carotid sinus, insulin pumps, nerve stimulators, lead wires or similar wires), optic implant, implanted cardiac defibrillator, aneurysm clip, any electronically\u002Fmagnetically\u002Fmechanically activated implant, ferromagnetic implants (coils, filters, stents; metal sutures or staples)","Presence of any of the following: pregnancy, claustrophobia, metal in eye or orbit, tattooed eyeliner","Inclusion Criteria:\n\n* Presence of aphasia attributable to non-fluent PPA or logopenic PPA\n* High school education (or more)\n* Between the ages of 50 and 90\n* Must be able to understand the nature of the study and give informed consent\n\nExclusion Criteria:\n\n* Cognitive impairment of sufficient severity to preclude giving informed consent (Mini Mental State Examination \\[MMSE\\] less than 15)\n* Any unrelated neurologic or physical condition that impairs communication ability\n* History of unrelated neurological conditions, including but not limited to traumatic brain injury (TBI), stroke, or small vessel disease, that has resulted in a neurologic deficit\n* Any additional neurological condition that would likely reduce the safety of study participation, including central nervous system (CNS) vasculitis, intracranial tumor, intracranial aneurysm, multiple sclerosis, or arteriovenous malformations\n* A medically unstable cardiopulmonary or metabolic disorder\n* Individuals with pacemakers or implantable cardiac defibrillators\n* Terminal illness associated with survival of less than 12 months\n* Major active psychiatric illness that may interfere with required study procedures or treatments, as determined by the enrolling physician\n* Current abuse of alcohol or drugs, prescription or otherwise\n* Participant in another drug, device, or biologics trial within 30 days prior to enrollment\n* Nursing a child, pregnant, or intending to become pregnant during the study\n* Left-handedness\n\nExclusion for tDCS, specifically:\n\n* History of spontaneous or partial complex seizures or unexplained loss of consciousness within 6 months of enrollment\n* Subjects with metallic objects in the face or head other than dental apparatus, such as braces, fillings, or implants\n* Subjects with previous craniotomy or any breach in the skull\n\nExclusion for MRI, specifically:\n\n* Presence of any of the following devices: cardiac pacemaker, other pacemakers (for carotid sinus, insulin pumps, nerve stimulators, lead wires or similar wires), optic implant, implanted cardiac defibrillator, aneurysm clip, any electronically\u002Fmagnetically\u002Fmechanically activated implant, ferromagnetic implants (coils, filters, stents; metal sutures or staples)\n* Presence of any of the following: pregnancy, claustrophobia, metal in eye or orbit, tattooed eyeliner",[100,101],"ADULT","OLDER_ADULT",[103,120,135],{"facility":104,"status":8,"city":105,"state":106,"zip":107,"country":108,"contacts":109,"geoPoint":117},"Johns Hopkins Hospital","Baltimore","Maryland","21287","United States",[110,115],{"name":111,"role":112,"phone":113,"email":114},"Kyrana Tsapkini, PhD","CONTACT","410-736-2940","tsapkini@jhmi.edu",{"name":111,"role":116},"PRINCIPAL_INVESTIGATOR",{"lat":118,"lon":119},39.29038,-76.61219,{"facility":121,"status":8,"city":122,"state":123,"zip":124,"country":108,"contacts":125,"geoPoint":132},"University of Pennsylvania","Philadelphia","Pennsylvania","19104",[126,130],{"name":127,"role":112,"phone":128,"email":129},"Daniela Sacchetti, MS","215-573-8485","danielas@pennmedicine.upenn.edu",{"name":131,"role":116},"Roy Hamilton, PhD",{"lat":133,"lon":134},39.95238,-75.16362,{"facility":136,"status":8,"city":137,"state":138,"zip":139,"country":140,"contacts":141,"geoPoint":147},"Baycrest Centre for Geriatric Care","Toronto","Ontario","M6A 2E1","Canada",[142,146],{"name":143,"role":112,"phone":144,"email":145},"Howard Chertkow, PhD","416-785-2500","hchertkow@research.baycrest.org",{"name":143,"role":116},{"lat":148,"lon":149},43.70643,-79.39864,[151,155],{"name":152,"role":112,"phone":153,"email":154},"Kelly Eun, B.S.","(410) 929 - 0279","krmeun@jhmi.edu",{"name":156,"role":112,"phone":113,"email":114},"Kyrana Tsapkini, PhD.",[158],{"name":156,"affiliation":13,"role":116},[160,164,167,170,173,176,179,182,185],{"pmid":161,"type":162,"citation":163},"26097278","BACKGROUND","Tsapkini K, Frangakis C, Gomez Y, Davis C, Hillis AE. Augmentation of spelling therapy with transcranial direct current stimulation in primary progressive aphasia: Preliminary results and challenges. Aphasiology. 2014;28(8-9):1112-1130. doi: 10.1080\u002F02687038.2014.930410.",{"pmid":165,"type":162,"citation":166},"29067331","Roncero C, Kniefel H, Service E, Thiel A, Probst S, Chertkow H. Inferior parietal transcranial direct current stimulation with training improves cognition in anomic Alzheimer's disease and frontotemporal dementia. Alzheimers Dement (N Y). 2017 Mar 24;3(2):247-253. doi: 10.1016\u002Fj.trci.2017.03.003. eCollection 2017 Jun.",{"pmid":168,"type":162,"citation":169},"28713256","McConathey EM, White NC, Gervits F, Ash S, Coslett HB, Grossman M, Hamilton RH. Baseline Performance Predicts tDCS-Mediated Improvements in Language Symptoms in Primary Progressive Aphasia. Front Hum Neurosci. 2017 Jun 30;11:347. doi: 10.3389\u002Ffnhum.2017.00347. eCollection 2017.",{"pmid":171,"type":162,"citation":172},"27522537","Gervits F, Ash S, Coslett HB, Rascovsky K, Grossman M, Hamilton R. Transcranial direct current stimulation for the treatment of primary progressive aphasia: An open-label pilot study. Brain Lang. 2016 Nov;162:35-41. doi: 10.1016\u002Fj.bandl.2016.05.007. Epub 2016 Aug 12.",{"pmid":174,"type":162,"citation":175},"31824242","Roncero C, Service E, De Caro M, Popov A, Thiel A, Probst S, Chertkow H. Maximizing the Treatment Benefit of tDCS in Neurodegenerative Anomia. Front Neurosci. 2019 Nov 22;13:1231. doi: 10.3389\u002Ffnins.2019.01231. eCollection 2019.",{"pmid":177,"type":162,"citation":178},"30258975","Tsapkini K, Webster KT, Ficek BN, Desmond JE, Onyike CU, Rapp B, Frangakis CE, Hillis AE. Electrical brain stimulation in different variants of primary progressive aphasia: A randomized clinical trial. Alzheimers Dement (N Y). 2018 Sep 5;4:461-472. doi: 10.1016\u002Fj.trci.2018.08.002. eCollection 2018.",{"pmid":180,"type":162,"citation":181},"21239365","Boyle M. Semantic feature analysis treatment for aphasic word retrieval impairments: what's in a name? Top Stroke Rehabil. 2010 Nov-Dec;17(6):411-22. doi: 10.1310\u002Ftsr1706-411.",{"pmid":183,"type":162,"citation":184},"21603153","Rapp B, Glucroft B. The benefits and protective effects of behavioural treatment for dysgraphia in a case of primary progressive aphasia. Aphasiology. 2009 Feb 1;23(2):236-265. doi: 10.1080\u002F02687030801943054.",{"type":162,"citation":186},"Homan RW. The 10-20 electrode system and cerebral location. American Journal of EEG Technology. 1988;28(4):269-279.",[],{"nct_id":4,"conditions":189,"biomarkers":192},[190,19,191],"Logopenic progressive aphasia","Primary Progressive Nonfluent Aphasia",[],{"nct_id":4,"found":15,"summary":194,"prompt_version":204},{"design":195,"status":196,"heading":197,"summary":198,"follow_up":199,"word_count":200,"commitments":201,"compensation":202,"drugs_mentioned":203},"This is a double-blind, sham-controlled study with 180 participants. You will receive both active tDCS and sham tDCS at different times during the study.","completed","Transcranial Direct Current Stimulation for Primary Progressive Aphasia","This study is investigating whether transcranial direct current stimulation (tDCS) combined with language therapy can help improve speaking and writing in people with Primary Progressive Aphasia (PPA), specifically the logopenic (lvPPA) or non-fluent (nfvPPA) types. tDCS is a gentle electrical stimulation applied to a specific brain area. Participants will receive either active tDCS or a sham (inactive) tDCS, both combined with language therapy focused on naming and spelling. Researchers will measure changes in your accuracy when speaking and writing words immediately after treatment and again three months later. The study aims to enroll 180 participants aged 50 to 90 who have PPA and can understand the study.","Your progress will be checked immediately after the 3-week intervention period and again three months after the intervention.",107,"You will participate in two 3-week treatment periods, each with 15 language therapy sessions. There will be a 3-month break between these periods.","Not stated in the trial record.",[],"v2"]