[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT05415501":3,"trial-entities:NCT05415501":105,"trial-summary:NCT05415501":108},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":25,"primary_purpose":26,"phases":27,"enrollment_info":29,"interventions":32,"primary_outcomes":39,"secondary_outcomes":50,"sex":59,"minimum_age":60,"maximum_age":61,"healthy_volunteers":62,"eligibility_criteria":63,"std_ages":77,"locations":80,"central_contacts":95,"overall_officials":100,"references":103,"see_also_links":104},"NCT05415501","IRB-2021-659","Sentence Production Training in Aphasia","Structural Priming as a Treatment Component in Aphasia","RECRUITING","2026-05-30","2024-12","2024-12-18","2021-08-01","Purdue University","OTHER",false,"This project focuses on developing a novel treatment for sentence production and comprehension in aphasia, using implicit priming. First set of experiments will aim examine which learning conditions are most effective in creating maximal training gains. Then, in a later study, the investigators will develop and test the efficacy of a novel treatment study based on findings from the first set of the studies.","Over five years, the investigators will conduct a series of studies to develop a novel intervention strategy for improving sentence production and comprehension in persons with aphasia. Specifically, the investigators will use implicit learning of grammar as a novel facilitator for language recovery in aphasia. The planned studies seek to test the hypothesis that implicit learning alters the central language system in PWA, creating lasting and generalized improvements in both sentence production and comprehension. Aim 1 will determine the extent to which different learning conditions modulate immediate and long-term improvement in sentence production. The investigators integrate multiple theories of language learning and apply them to make predictions about the trajectory of priming-induced learning in PWA. In Aim 2, using a set of eyetracking and sentence comprehension tasks, it will be investigated whether the effects of priming in production generalize to off-line (accuracy) and on-line (eye fixations) sentence comprehension and determine which learning conditions result in greater cross-modality generalization. In Aim 3, the investigators will develop and establish Phase I efficacy data of an implicit priming treatment, incorporating the crucial learning conditions supporting maximal retention from Aims 1 and 2. The project will recruit both individuals with aphasia and without aphasia.",[19],"Aphasia",[21,22,23,24],"aphasia training","aphasia treatment","sentences","grammar","INTERVENTIONAL","TREATMENT",[28],"NA",{"count":30,"type":31},104,"ESTIMATED",[33],{"type":34,"name":35,"description":36,"armGroupLabels":37},"BEHAVIORAL","Sentence training","Participants will be trained to read, make, and recall sentences during each session.",[38],"Structural priming training",[40,44,47],{"measure":41,"description":42,"timeFrame":43},"Production of target sentences on action description pictures","Production accuracy (percent correct)","From baseline up to 1-week post training or 2-month post treatment",{"measure":45,"description":46,"timeFrame":43},"Comprehension of target sentences in a sentence-to-picture matching task","Comprehension accuracy (percent correct)",{"measure":48,"description":49,"timeFrame":43},"Real-time comprehension of target sentences in a sentence-to-picture matching task","Changes in eye fixations to the target picture",[51,54,57],{"measure":52,"description":42,"timeFrame":53},"Production of untrained sentences","From baseline up to 2-month post treatment",{"measure":55,"description":56,"timeFrame":53},"Connected speech production - story retell","Increased production of complex utterances as measured by proportion of sentence-level utterances out of all utterances",{"measure":58,"description":56,"timeFrame":53},"Connected speech production - picture description","ALL","21 Years","85 Years",true,{"inclusion":64,"exclusion":71,"raw_text":76},[65,66,67,68,69,70],"Individuals with post-stroke aphasia","At least 6 months post-onset of eft hemisphere stroke","Native speaker of English","Normal or corrected to normal hearing and vision","High-school educated","Difficulty communicating in sentences, with some ability to use words independently",[72,73,74,75],"Severe apraxia of speech","Other neurological conditions affecting communication (e.g., dementia)","Uncontrolled psychiatric\u002Fpsychological conditions affecting thinking and communication","Active alcohol\u002Fsubstance abuse","Inclusion Criteria:\n\n* Individuals with post-stroke aphasia\n* At least 6 months post-onset of eft hemisphere stroke\n* Native speaker of English\n* Normal or corrected to normal hearing and vision\n* High-school educated\n* Difficulty communicating in sentences, with some ability to use words independently\n\nExclusion Criteria:\n\n* Severe apraxia of speech\n* Other neurological conditions affecting communication (e.g., dementia)\n* Uncontrolled psychiatric\u002Fpsychological conditions affecting thinking and communication\n* Active alcohol\u002Fsubstance abuse",[78,79],"ADULT","OLDER_ADULT",[81],{"facility":13,"status":8,"city":82,"state":83,"zip":84,"country":85,"contacts":86,"geoPoint":92},"West Lafayette","Indiana","47907","United States",[87],{"name":88,"role":89,"phone":90,"email":91},"Jiyeon Lee","CONTACT","765-494-3810","lee1704@purdue.edu",{"lat":93,"lon":94},40.42587,-86.90807,[96,99],{"name":97,"role":89,"phone":98,"email":91},"Jiyeon Lee, PhD","7654943810",{"name":88,"role":89,"phone":98,"email":91},[101],{"name":97,"affiliation":13,"role":102},"PRINCIPAL_INVESTIGATOR",[],[],{"nct_id":4,"conditions":106,"biomarkers":107},[19],[],{"nct_id":4,"found":62,"summary":109,"prompt_version":119},{"design":110,"status":111,"heading":112,"summary":113,"follow_up":114,"word_count":115,"commitments":116,"compensation":117,"drugs_mentioned":118},"This is an interventional study with a planned enrollment of 104 participants. It is not specified if the study is randomized or blinded.","completed","Sentence Production Training for Aphasia","This study is testing a behavioral intervention called Sentence training for people with aphasia. Aphasia is a condition that affects your ability to communicate after a stroke. The training involves learning to read, create, and remember sentences. Researchers want to see if this training can improve your ability to produce and understand sentences. You might be able to join if you are 21 to 85 years old, had a stroke on the left side of your brain at least six months ago, are a native English speaker, and have difficulty speaking in sentences but can use words on their own. The study is currently unclear about its recruitment status and plans to enroll 104 participants.","Your sentence production and comprehension will be measured from the start of the study up to one week after training or two months after treatment.",115,"Participants will be trained to read, make, and recall sentences during each session. The duration of the training is not specified.","Not stated in the trial record.",[35],"v2"]