[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT05486234":3,"trial-entities:NCT05486234":93,"trial-summary:NCT05486234":99},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":15,"conditions":17,"keywords":22,"study_type":23,"primary_purpose":24,"phases":25,"enrollment_info":27,"interventions":30,"primary_outcomes":42,"secondary_outcomes":57,"sex":58,"minimum_age":59,"maximum_age":60,"healthy_volunteers":61,"eligibility_criteria":62,"std_ages":70,"locations":72,"central_contacts":86,"overall_officials":90,"references":91,"see_also_links":92},"NCT05486234","00106723","CARS: Cannabis and Alcohol Reduction Study","Brief Computerized Intervention for Reducing Adolescent Cannabis and Alcohol Use","RECRUITING","2026-10-01","2026-08","2026-08-13","2023-01-25","Medical University of South Carolina","OTHER",null,"The study will test a computerized treatment with subjects ages 13-17 years who are seeking treatment for alcohol and\u002For cannabis use. Follow-up assessments will be conducted at one- and three-months following treatment.",[18,19,20,21],"Cannabis Use","Alcohol Use, Unspecified","Substance Use","Substance Use Disorders",[],"INTERVENTIONAL","TREATMENT",[26],"NA",{"count":28,"type":29},52,"ESTIMATED",[31,37],{"type":32,"name":33,"description":34,"armGroupLabels":35},"BEHAVIORAL","modified Approach-Avoidance Task (mAAT), which aims to modify automatic approach bias","Participants will undergo a baseline assessment before completing computerized tasks. During the baseline assessment, participants will be asked questions about alcohol and cannabis use. We will also ask questions about the way participants think about things, past life experiences related to substance use, and questions about how participants feel about reducing their substance use. Then, participants will complete a series computerized tasks where they will push and pull a joystick in response to images that are presented on a screen or where they will try to get a high score. During the computerized tasks, we will also be measuring brain activity using EEG. During the study, participants will also be asked to respond to questions about their health and behavior using an app on a smartphone or tablet using a secure program. Participants in the Treatment Group will then complete four sessions of the modified Approach-Avoidance Task (mAAT), which aims to modify automatic approach bias.",[36],"Group A: Treatment Group",{"type":32,"name":38,"description":39,"armGroupLabels":40},"modified Approach-Avoidance Task (mAAT) that does not aim to modify automatic approach bias.","Participants will undergo a baseline assessment before completing computerized tasks. During the baseline assessment, participants will be asked questions about alcohol and cannabis use. We will also ask questions about the way participants think about things, past life experiences related to substance use, and questions about how participants feel about reducing their substance use. Then, participants will complete a series computerized tasks where they will push and pull a joystick in response to images that are presented on a screen or where they will try to get a high score. During the computerized tasks, we will also be measuring brain activity using EEG. During the study, participants will also be asked to respond to questions about their health and behavior using an app on a smartphone or tablet using a secure program. Participants in the Control Group will then complete four sessions of an Approach-Avoidance Task (mAAT) that does not aim to modify automatic approach bias.",[41],"Group B: Control Group",[43,47,50,54],{"measure":44,"description":45,"timeFrame":46},"Change in cannabis use as assessed by Timeline Followback","The TLFB is a calendar-assisted semi-structured interview that will be used to assess cannabis and alcohol use since the last assessment. The TLFB will assess the number of days a person used cannabis over the past 90 days compared to the 90 days prior to enrolling in this study.","Baseline and Three-Month Follow-up",{"measure":48,"description":49,"timeFrame":46},"Change in alcohol use as assessed by Timeline Followback","The TLFB is a calendar-assisted semi-structured interview that will be used to assess cannabis and alcohol use since the last assessment. The TLFB will assess the number of days a person consumed alcohol over the past 90 days compared to the 90 days prior to enrolling in this study.",{"measure":51,"description":52,"timeFrame":53},"Change in Cannabis Approach Bias (D-Score)","D scores will be calculated for each participant at baseline, posttest, and three-month follow-up. Participants' mean reaction times (RTs) during the approach cannabis trials will be subtracted from the mean avoid cannabis trial RTs. These scores are then divided by the SD across all cannabis trials. Positive scores indicate an approach bias for cannabis stimuli.","Baseline, One-Week Follow-up, and Three-Month Follow-up",{"measure":55,"description":56,"timeFrame":53},"Change Cannabis Approach Bias (D-Score)","D scores will be calculated for each participant at baseline, posttest, and three-month follow-up. Participants' mean reaction times (RTs) during the approach alcohol trials will be subtracted from the mean avoid alcohol trial RTs. These scores are then divided by the SD across all alcohol trials. Positive scores indicate an approach bias for alcohol stimuli.",[],"ALL","13 Years","17 Years",false,{"inclusion":63,"exclusion":68,"raw_text":69},[64,65,66,67],"between the ages of 13 and 17","be seeking treatment for either cannabis or alcohol use;","report co-occurring alcohol and cannabis use during the past three months (i.e., participants who report using both alcohol and cannabis during the three months prior to participation in the study, regardless of if the use was simultaneous)","have a caregiver willing to participate and provide consent.",[],"Inclusion Criteria:\n\n* between the ages of 13 and 17\n* be seeking treatment for either cannabis or alcohol use;\n* report co-occurring alcohol and cannabis use during the past three months (i.e., participants who report using both alcohol and cannabis during the three months prior to participation in the study, regardless of if the use was simultaneous)\n* have a caregiver willing to participate and provide consent.",[71],"CHILD",[73],{"facility":13,"status":8,"city":74,"state":75,"zip":76,"country":77,"contacts":78,"geoPoint":83},"Charleston","South Carolina","29425","United States",[79],{"name":80,"role":81,"phone":82},"Austin Hahn, Ph.D.","CONTACT","854-444-9456",{"lat":84,"lon":85},32.77632,-79.93275,[87],{"name":88,"role":81,"phone":82,"email":89},"Austin M Hahn, Ph.D.","hahna@musc.edu",[],[],[],{"nct_id":4,"conditions":94,"biomarkers":98},[95,96,97],"Alcohol Consumption","Cannabis misuse","Substance use disorder",[],{"nct_id":4,"found":100,"summary":101,"prompt_version":111},true,{"design":102,"status":103,"heading":104,"summary":105,"follow_up":106,"word_count":107,"commitments":108,"compensation":109,"drugs_mentioned":110},"This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 52 participants aged 13 to 17.","completed","CARS: Cannabis and Alcohol Reduction Study for Teens","This study, called CARS, is looking for teenagers aged 13 to 17 who are seeking help for their cannabis or alcohol use. It's testing a computerized treatment called a modified Approach-Avoidance Task (mAAT). This task aims to help change automatic reactions to alcohol and cannabis. The study will compare two versions of this task to see if one is better at reducing cannabis and alcohol use. Researchers will also look at how participants' automatic reactions to cannabis change. To join, you must be between 13 and 17, seeking treatment for cannabis or alcohol use, and have used both in the past three months. A caregiver must also be willing to participate. The study's current status is unclear, but it plans to enroll 52 participants.","Participants will have follow-up assessments at one week and three months after treatment.",124,"Participants will complete a baseline assessment with questions about alcohol and cannabis use, thoughts, and past experiences. They will then complete computerized tasks and have follow-up assessments at one week and three months.","Not stated in the trial record.",[],"v2"]