[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT05566795":3,"trial-entities:NCT05566795":1170,"trial-summary:NCT05566795":1176},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":22,"study_type":27,"primary_purpose":28,"phases":29,"enrollment_info":31,"interventions":34,"primary_outcomes":52,"secondary_outcomes":57,"sex":120,"minimum_age":121,"maximum_age":122,"healthy_volunteers":123,"eligibility_criteria":124,"std_ages":136,"locations":139,"central_contacts":1159,"overall_officials":1160,"references":1161,"see_also_links":1169},"NCT05566795","DAY101-002","DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC\u002FFIREFLY-2)","LOGGIC\u002FFIREFLY-2: A Phase 3, Randomized, International Multicenter Trial of DAY101 Monotherapy Versus Standard of Care Chemotherapy in Patients With Pediatric Low-Grade Glioma Harboring an Activating RAF Alteration Requiring First-Line Systemic Therapy","ACTIVE_NOT_RECRUITING","2031-06","2026-05","2026-05-14","2023-02-27","Day One Biopharmaceuticals, Inc.","INDUSTRY",true,"This is a 2-arm, randomized, open-label, multicenter, global, Phase 3 trial to evaluate the efficacy, safety, and tolerability of tovorafenib monotherapy versus standard of care (SoC) chemotherapy in participants with pediatric low-grade glioma (LGG) harboring an activating rapidly accelerated fibrosarcoma (RAF) alteration requiring first-line systemic therapy.","Approximately 400 treatment-naïve LGG participants will be randomized 1:1 to either tovorafenib (Arm 1) or an Investigator's choice of SoC chemotherapy (Arm 2).\n\nArm 1 (tovorafenib): Treatment cycles will repeat every 28 days in the absence of disease progression. Participants will continue tovorafenib until any of the following occurs: disease progression, unacceptable toxicity, withdrawal of consent to treatment, or end of study.\n\nArm 2 (Investigator's Choice of SoC Chemotherapy): Participants will receive one of 4 SoC chemotherapy options selected by the treating Investigator: Children's Oncology Group - Vincristine\u002FCarboplatin (COG-V\u002FC) regimen, International Society for Paediatric Oncology - Low-Grade Glioma Vincristine\u002FCarboplatin (SIOPe-LGG-V\u002FC) regimen, vinblastine (VBL) regimen, or monthly carboplatin. The choice of SoC chemotherapy regimen will be selected prior to participant randomization. Treatment will continue until completion of therapy or until any of the following occurs: disease progression, unacceptable toxicity, withdrawal of consent to treatment, or end of study.\n\nParticipants who discontinue treatment due to disease progression will have (1) radiographic evidence of disease progression, as determined by the Investigator, or (2) clinical progression, as determined by the Investigator. Investigators are encouraged to discuss cases of clinical progression and early radiographic progression without clinical symptoms with the Sponsor Medical Monitor prior to treatment discontinuation or initiation of a different form of treatment for the malignancy. Participants may continue therapy beyond progressive disease (PD).",[19,20,21],"Low-grade Glioma","Rapidly Accelerated Fibrosarcoma (RAF) Altered Glioma","Pediatric Low-grade Glioma",[23,24,25,26],"Rapidly accelerated fibrosarcoma","RAF alteration glioma","Glioneural tumor","Ojemda","INTERVENTIONAL","TREATMENT",[30],"PHASE3",{"count":32,"type":33},418,"ACTUAL",[35,42],{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":40},"DRUG","Tovorafenib","Oral Tablet Powder for Oral Suspension",[37],[41],"DAY101, Ojemda",{"type":36,"name":43,"description":44,"armGroupLabels":45,"otherNames":47},"Chemotherapeutic Agent","Intravenous solution for injection",[46],"Investigator's choice of Standard of care therapy",[48,49,50,51],"COG-V\u002FC","SIOPe-LGG-V\u002FC","VBL","Carboplatin",[53],{"measure":54,"description":55,"timeFrame":56},"Objective response rate (ORR) of tovorafenib monotherapy versus SoC chemotherapy","ORR assessed per Response Assessment in Pediatric Neuro Oncology (RAPNO) criteria by Independent Review Committee (IRC), and defined as the proportion of participants with overall confirmed response of complete response (CR), partial response (PR), or minor response (MR).","Up to 60 months",[58,61,64,67,70,73,77,80,83,86,89,93,96,99,102,105,108,111,114,117],{"measure":59,"description":60,"timeFrame":56},"Progression-free survival (PFS) of tovorafenib monotherapy versus SoC chemotherapy","PFS assessed per RAPNO criteria by IRC, and defined as time from randomization to PD or death from any cause, whichever comes first.",{"measure":62,"description":63,"timeFrame":56},"Event-free survival (EFS) of tovorafenib monotherapy versus SoC chemotherapy","EFS assessed per RAPNO criteria by IRC, defined as time from randomization to PD, death from any cause, or initiation of any new anticancer therapy, whichever comes first.",{"measure":65,"description":66,"timeFrame":56},"Overall survival (OS) of tovorafenib monotherapy versus SoC chemotherapy","Overall survival is defined as time from randomization up to death from any cause.",{"measure":68,"description":69,"timeFrame":56},"Number of participants with any treatment-emergent adverse events, and Serious adverse events","Type, frequency, and severity of adverse events of tovorafenib monotherapy versus SoC chemotherapy will be assessed.",{"measure":71,"description":72,"timeFrame":56},". Number of participants with clinically significant vital signs and laboratory abnormalities findings","Type, frequency, and severity of vital signs and laboratory abnormalities of tovorafenib monotherapy versus SoC chemotherapy will be assessed.",{"measure":74,"description":75,"timeFrame":76},"Change from baseline in Adaptive Behavior Composite Score (ABS) of tovorafenib monotherapy versus SoC chemotherapy","Adaptive behavior Composite Score will be evaluated using domain scores collected from the comprehensive Vineland III Adaptive Behavior Scale (VABS).","Baseline, Year 1, 2 and 5",{"measure":78,"description":79,"timeFrame":76},"Change from baseline in the Motor Skills Domain Score of tovorafenib monotherapy versus SoC chemotherapy","The motor skills (gross and fine) will be assessed using the Motor Skills Score domain of the VABS in pediatric participants.",{"measure":81,"description":82,"timeFrame":76},"Change from baseline in the Daily Living Domain Score of tovorafenib monotherapy versus SoC chemotherapy","The daily living (personal, domestic and community) will be assessed using Daily Living Domain Score of VABS.",{"measure":84,"description":85,"timeFrame":76},"Change from baseline in the Communication Domain Score of tovorafenib monotherapy versus SoC chemotherapy","The communication skills (receptive, expressive and written) will be assessed using Communication Domain Score of VABS.",{"measure":87,"description":88,"timeFrame":76},"Change from baseline in the Socialization Domain Score of tovorafenib monotherapy versus SoC chemotherapy","The socialization skills (Interpersonal relationships, play and leisure time and coping skills) will be assessed using Socialization Domain Score of VABS.",{"measure":90,"description":91,"timeFrame":92},"Change in age-adjusted visual acuity (VA) of tovorafenib monotherapy versus SoC chemotherapy in optic pathway glioma (OPG) participants aged \u003C 3 years","Visual acuity testing using current age-appropriate testing methodology will be performed for all participants at Screening. For participants with OPG or an underlying visual deficit related to the primary malignancy, visual acuity testing will be performed every time participants have a radiographic response assessment. Assessments will be performed in each eye separately at a recommended testing distance of 3 meters.","Baseline and up to 5 years",{"measure":94,"description":95,"timeFrame":92},"Change in best corrected visual acuity of tovorafenib monotherapy versus SoC chemotherapy in OPG participants aged ≥ 3 years","Visual acuity assessments to be performed by an ophthalmologist or another qualified site clinical personnel.",{"measure":97,"description":98,"timeFrame":56},"Visual progression-free survival (v-PFS) of tovorafenib monotherapy versus SoC chemotherapy","Visual progression-free survival is defined as the time from start of treatment to visual event for OPG participants aged ≥ 3 years.",{"measure":100,"description":101,"timeFrame":56},"ORR of tovorafenib monotherapy versus SoC chemotherapy","ORR, defined as the proportion of participants with overall confirmed response per Response Assessment in Neuro-Oncology for High-Grade Glioma (RANO-HGG) criteria (CR or PR) and RANO-LGG criteria (CR, PR, or MR), as applicable.",{"measure":103,"description":104,"timeFrame":56},"Clinical benefit rate (CBR) of tovorafenib monotherapy versus SoC chemotherapy","CBR, defined as the proportion of participants with radiological tumor stabilization or regression per RANO-LGG (CR, PR, MR, or SD lasting 12 months or more), RANO-HGG (CR, PR, or SD lasting 12 months or more) or RAPNO criteria (CR, PR, MR or SD lasting 12 months or more), as applicable.",{"measure":106,"description":107,"timeFrame":56},"Time to response (TTR) of tovorafenib monotherapy versus SoC chemotherapy","TTR, measured by the time following randomization to first imaging of tumor response that was subsequently confirmed per RANO-HGG criteria (CR or PR), RANO-LGG criteria (CR, or PR, or MR), or RAPNO criteria (CR, PR, or MR), as applicable.",{"measure":109,"description":110,"timeFrame":56},"PFS of tovorafenib monotherapy versus SoC chemotherapy","PFS per RANO-HGG or RANO-LGG criteria (as applicable), defined as time from randomization to PD or death from any cause, whichever occurs first.",{"measure":112,"description":113,"timeFrame":56},"EFS of tovorafenib monotherapy versus SoC chemotherapy","EFS per RANO-HGG or RANO-LGG criteria (as applicable), defined as time from randomization to PD, death from any cause, or initiation of any new anticancer therapy, whichever comes first.",{"measure":115,"description":116,"timeFrame":56},"Duration of response (DOR) of tovorafenib monotherapy versus SoC chemotherapy","DOR, defined as time from first imaging of tumor response per RANO-LGG, RANO-HGG or RAPNO criteria, as applicable, that was subsequently confirmed to radiographic PD or death from any cause, whichever comes first.",{"measure":118,"description":119,"timeFrame":76},"Change from Baseline in health-related quality of life (HRQoL) total score of tovorafenib monotherapy versus SoC chemotherapy","The Patient-Reported Outcomes Measurement Information System (PROMIS®) Pediatric\u002FParent Proxy Profile 49 v2.0 will be used to assess mental and social HRQoL.","ALL",null,"25 Years",false,{"inclusion":125,"exclusion":130,"raw_text":135},[126,127,128,129],"Less than 25 years of age with LGG with known activating RAF alteration.","Histopathologic diagnosis of glioma or glioneuronal tumor.","At least one measurable lesion as defined by RANO criteria.","Meet indication for first-line systemic therapy.",[131,132,133,134],"Participant has any of the following tumor-histological findings:","Participant's tumor has additional pathogenic molecular alterations, including but not limited to a) isocitrate dehydrogenase (IDH) 1\u002F2 mutation, b) Histone H3 mutation, and c) neurofibromatosis Type 1 (NF-1) loss of function alteration.","Known or suspected diagnosis of NF-1\u002F neurofibromatosis Type 2 (NF-2).","Prior or ongoing nonsurgical anticancer therapy for this indication (eg, chemotherapy, oral\u002FIV targeted therapy) including radiation.","Inclusion Criteria:\n\n* Less than 25 years of age with LGG with known activating RAF alteration.\n* Histopathologic diagnosis of glioma or glioneuronal tumor.\n* At least one measurable lesion as defined by RANO criteria.\n* Meet indication for first-line systemic therapy.\n\nExclusion Criteria:\n\n* Participant has any of the following tumor-histological findings:\n\n  1. Schwannoma\n  2. Subependymal giant cell astrocytoma (Tuberous Sclerosis)\n  3. Diffuse intrinsic pontine glioma, even if histologically diagnosed as World Health Organization (WHO) Grade I-II\n* Participant's tumor has additional pathogenic molecular alterations, including but not limited to a) isocitrate dehydrogenase (IDH) 1\u002F2 mutation, b) Histone H3 mutation, and c) neurofibromatosis Type 1 (NF-1) loss of function alteration.\n* Known or suspected diagnosis of NF-1\u002F neurofibromatosis Type 2 (NF-2).\n* Prior or ongoing nonsurgical anticancer therapy for this indication (eg, chemotherapy, oral\u002FIV targeted therapy) including radiation.",[137,138],"CHILD","ADULT",[140,149,157,165,172,179,186,194,202,210,218,225,232,239,247,255,259,267,275,283,291,299,307,315,323,331,339,347,353,357,364,372,380,388,396,403,410,418,426,435,442,449,456,463,470,479,486,494,501,508,516,525,532,540,548,555,562,570,574,581,588,596,603,612,619,628,636,643,651,658,665,672,679,688,696,703,710,718,726,734,742,749,756,763,770,777,785,788,796,805,813,820,828,836,844,851,858,865,872,879,886,895,903,911,920,927,935,942,950,958,962,970,977,981,988,992,999,1006,1014,1021,1028,1036,1043,1051,1058,1066,1073,1080,1087,1094,1101,1109,1117,1125,1133,1141,1148,1155],{"facility":141,"city":142,"state":143,"zip":144,"country":145,"geoPoint":146},"Children's of Alabama","Birmingham","Alabama","35233","United States",{"lat":147,"lon":148},33.52066,-86.80249,{"facility":150,"city":151,"state":152,"zip":153,"country":145,"geoPoint":154},"Phoenix Children's Hospital","Phoenix","Arizona","85016",{"lat":155,"lon":156},33.44838,-112.07404,{"facility":158,"city":159,"state":160,"zip":161,"country":145,"geoPoint":162},"Children's Hospital Los Angeles","Los Angeles","California","90027",{"lat":163,"lon":164},34.05223,-118.24368,{"facility":166,"city":167,"state":160,"zip":168,"country":145,"geoPoint":169},"Children's Hospital of Orange County Main Campus - Orange","Orange","92868",{"lat":170,"lon":171},33.78779,-117.85311,{"facility":173,"city":174,"state":160,"zip":175,"country":145,"geoPoint":176},"Packard Children's Hospital Stanford","Palo Alto","94304",{"lat":177,"lon":178},37.44188,-122.14302,{"facility":180,"city":181,"state":160,"zip":182,"country":145,"geoPoint":183},"UCSF Benioff Children's Hospital","San Francisco","94158",{"lat":184,"lon":185},37.77493,-122.41942,{"facility":187,"city":188,"state":189,"zip":190,"country":145,"geoPoint":191},"Children's Hospital Colorado","Aurora","Colorado","80045",{"lat":192,"lon":193},39.72943,-104.83192,{"facility":195,"city":196,"state":197,"zip":198,"country":145,"geoPoint":199},"Connecticut Children's Medical Center","Hartford","Connecticut","06106-3322",{"lat":200,"lon":201},41.76371,-72.68509,{"facility":203,"city":204,"state":205,"zip":206,"country":145,"geoPoint":207},"Children's National Medical Center","Washington D.C.","District of Columbia","20010",{"lat":208,"lon":209},38.89511,-77.03637,{"facility":211,"city":212,"state":213,"zip":214,"country":145,"geoPoint":215},"University of Florida Health","Gainesville","Florida","32610",{"lat":216,"lon":217},29.65163,-82.32483,{"facility":219,"city":220,"state":213,"zip":221,"country":145,"geoPoint":222},"Nicklaus Children's Hospital","Miami","33155",{"lat":223,"lon":224},25.77427,-80.19366,{"facility":226,"city":227,"state":213,"zip":228,"country":145,"geoPoint":229},"Arnold Palmer Hospital for Children","Orlando","32806",{"lat":230,"lon":231},28.53834,-81.37924,{"facility":233,"city":234,"state":213,"zip":235,"country":145,"geoPoint":236},"Johns Hopkins All Children's Hospital","St. Petersburg","33701",{"lat":237,"lon":238},27.77086,-82.67927,{"facility":240,"city":241,"state":242,"zip":243,"country":145,"geoPoint":244},"Children's Healthcare of Atlanta","Atlanta","Georgia","30322",{"lat":245,"lon":246},33.749,-84.38798,{"facility":248,"city":249,"state":250,"zip":251,"country":145,"geoPoint":252},"Ann & Robert H. Lurie Children's Hospital of Chicago","Chicago","Illinois","60611",{"lat":253,"lon":254},41.85003,-87.65005,{"facility":256,"city":249,"state":250,"zip":257,"country":145,"geoPoint":258},"University of Chicago","60637",{"lat":253,"lon":254},{"facility":260,"city":261,"state":262,"zip":263,"country":145,"geoPoint":264},"Riley Hospital for Children at Indiana University Health","Indianapolis","Indiana","46202",{"lat":265,"lon":266},39.76838,-86.15804,{"facility":268,"city":269,"state":270,"zip":271,"country":145,"geoPoint":272},"University of Iowa Hospitals Clinics","Iowa City","Iowa","52242",{"lat":273,"lon":274},41.66113,-91.53017,{"facility":276,"city":277,"state":278,"zip":279,"country":145,"geoPoint":280},"Norton Children's Hospital","Louisville","Kentucky","40202",{"lat":281,"lon":282},38.25424,-85.75941,{"facility":284,"city":285,"state":286,"zip":287,"country":145,"geoPoint":288},"Maine Children's Cancer Program","Scarborough","Maine","04074",{"lat":289,"lon":290},43.57814,-70.32172,{"facility":292,"city":293,"state":294,"zip":295,"country":145,"geoPoint":296},"Dana-Farber Cancer Institute","Boston","Massachusetts","02215",{"lat":297,"lon":298},42.35843,-71.05977,{"facility":300,"city":301,"state":302,"zip":303,"country":145,"geoPoint":304},"University of Michigan - - C.S. Mott Children's Hospital","Ann Arbor","Michigan","48109",{"lat":305,"lon":306},42.27756,-83.74088,{"facility":308,"city":309,"state":310,"zip":311,"country":145,"geoPoint":312},"Children's Minnesota","Minneapolis","Minnesota","55404",{"lat":313,"lon":314},44.97997,-93.26384,{"facility":316,"city":317,"state":318,"zip":319,"country":145,"geoPoint":320},"Childrens MS Cncr Ctr Bld Dsr","Jackson","Mississippi","39216",{"lat":321,"lon":322},32.29876,-90.18481,{"facility":324,"city":325,"state":326,"zip":327,"country":145,"geoPoint":328},"St. Louis Children's Hospital","St Louis","Missouri","63110",{"lat":329,"lon":330},38.62727,-90.19789,{"facility":332,"city":333,"state":334,"zip":335,"country":145,"geoPoint":336},"University of Nebraska Medical Center","Omaha","Nebraska","68198-6878",{"lat":337,"lon":338},41.25626,-95.94043,{"facility":340,"city":341,"state":342,"zip":343,"country":145,"geoPoint":344},"Albany Medical Center","Albany","New York","12208",{"lat":345,"lon":346},42.65258,-73.75623,{"facility":348,"city":342,"state":342,"zip":349,"country":145,"geoPoint":350},"New York University Langone Health","10016",{"lat":351,"lon":352},40.71427,-74.00597,{"facility":354,"city":342,"state":342,"zip":355,"country":145,"geoPoint":356},"Columbia University","10032",{"lat":351,"lon":352},{"facility":358,"city":359,"state":342,"zip":360,"country":145,"geoPoint":361},"University of Rochester","Rochester","14642",{"lat":362,"lon":363},43.15478,-77.61556,{"facility":365,"city":366,"state":367,"zip":368,"country":145,"geoPoint":369},"Duke Cancer Institute","Durham","North Carolina","27705",{"lat":370,"lon":371},35.99403,-78.89862,{"facility":373,"city":374,"state":375,"zip":376,"country":145,"geoPoint":377},"Cleveland Clinic Main Campus","Cleveland","Ohio","44195",{"lat":378,"lon":379},41.4995,-81.69541,{"facility":381,"city":382,"state":383,"zip":384,"country":145,"geoPoint":385},"Oregon Health Science University","Portland","Oregon","97239",{"lat":386,"lon":387},45.52345,-122.67621,{"facility":389,"city":390,"state":391,"zip":392,"country":145,"geoPoint":393},"Dell Children's Medical Center of Central Texas","Austin","Texas","78723",{"lat":394,"lon":395},30.26715,-97.74306,{"facility":397,"city":398,"state":391,"zip":399,"country":145,"geoPoint":400},"University of Texas Southwestern Medical Center","Dallas","75390",{"lat":401,"lon":402},32.78306,-96.80667,{"facility":404,"city":405,"state":391,"zip":406,"country":145,"geoPoint":407},"Texas Children's Hospital","Houston","77030",{"lat":408,"lon":409},29.76328,-95.36327,{"facility":411,"city":412,"state":413,"zip":414,"country":145,"geoPoint":415},"Seattle Children's Hospital","Seattle","Washington","98105",{"lat":416,"lon":417},47.60621,-122.33207,{"facility":419,"city":420,"state":421,"zip":422,"country":145,"geoPoint":423},"University of Wisconsin - Madison","Madison","Wisconsin","53792",{"lat":424,"lon":425},43.07305,-89.40123,{"facility":427,"city":428,"state":429,"zip":430,"country":431,"geoPoint":432},"Children's Health Queensland Hospital and Health Service","South Brisbane","Queensland","4101","Australia",{"lat":433,"lon":434},-27.48034,153.02049,{"facility":436,"city":437,"zip":438,"country":431,"geoPoint":439},"Perth Children's Hospital","Nedlands","6009",{"lat":440,"lon":441},-31.98184,115.8073,{"facility":443,"city":444,"zip":445,"country":431,"geoPoint":446},"Women's and Children's Health Network","North Adelaide","5006",{"lat":447,"lon":448},-34.90733,138.59141,{"facility":450,"city":451,"zip":452,"country":431,"geoPoint":453},"The Royal Children's Hospital - Children's Cancer Centre","Parkville","3052",{"lat":454,"lon":455},-37.78333,144.95,{"facility":457,"city":458,"zip":459,"country":431,"geoPoint":460},"Sydney Children's Hospital - Randwick","Randwick","2031",{"lat":461,"lon":462},-33.91439,151.24895,{"facility":464,"city":465,"zip":466,"country":431,"geoPoint":467},"Children's Hospital at Westmead","Westmead","2145",{"lat":468,"lon":469},-33.80383,150.98768,{"facility":471,"city":472,"state":473,"zip":474,"country":475,"geoPoint":476},"Medizinische Universität Innsbruck","Innsbruck","Tyrol","6020","Austria",{"lat":477,"lon":478},47.26266,11.39454,{"facility":480,"city":481,"zip":482,"country":475,"geoPoint":483},"Medizinische Universität Wien","Vienna","1090",{"lat":484,"lon":485},48.20849,16.37208,{"facility":487,"city":488,"zip":489,"country":490,"geoPoint":491},"Cliniques Universitaires Saint-Luc","Brussels","1200","Belgium",{"lat":492,"lon":493},50.85045,4.34878,{"facility":495,"city":496,"zip":497,"country":490,"geoPoint":498},"Universitair Ziekenhuis Gent","Ghent","9000",{"lat":499,"lon":500},51.05,3.71667,{"facility":502,"city":503,"zip":504,"country":490,"geoPoint":505},"Universitair Ziekenhuis Leuven - Campus Gasthuisberg","Leuven","3000",{"lat":506,"lon":507},50.87959,4.70093,{"facility":509,"city":510,"zip":511,"country":512,"geoPoint":513},"Grupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC)","São Paulo","04039-001","Brazil",{"lat":514,"lon":515},-23.5475,-46.63611,{"facility":517,"city":518,"state":519,"zip":520,"country":521,"geoPoint":522},"Alberta Children's Hospital","Calgary","Alberta","T3B 6A8","Canada",{"lat":523,"lon":524},51.05011,-114.08529,{"facility":526,"city":527,"state":519,"zip":528,"country":521,"geoPoint":529},"Stollery Children's Hospital","Edmonton","T6G 2B7",{"lat":530,"lon":531},53.55014,-113.46871,{"facility":533,"city":534,"state":535,"zip":536,"country":521,"geoPoint":537},"British Columbia Children's Hospital","Vancouver","British Columbia","V6H 3N1",{"lat":538,"lon":539},49.24966,-123.11934,{"facility":541,"city":542,"state":543,"zip":544,"country":521,"geoPoint":545},"McMaster Children's Hospital","Hamilton","Ontario","L8S 4L8",{"lat":546,"lon":547},43.25011,-79.84963,{"facility":549,"city":550,"state":543,"zip":551,"country":521,"geoPoint":552},"Children's Hospital London Health Sciences Centre","London","N6A 5W9",{"lat":553,"lon":554},42.98339,-81.23304,{"facility":556,"city":557,"state":543,"zip":558,"country":521,"geoPoint":559},"Children's Hospital of Eastern Ontario","Ottawa","K1H 8L1",{"lat":560,"lon":561},45.41117,-75.69812,{"facility":563,"city":564,"state":565,"zip":566,"country":521,"geoPoint":567},"CHU Sainte-Justine","Montreal","Quebec","H3T IC5",{"lat":568,"lon":569},45.50884,-73.58781,{"facility":571,"city":564,"state":565,"zip":572,"country":521,"geoPoint":573},"The Montreal Children's Hospital","H4A 3J1",{"lat":568,"lon":569},{"facility":575,"city":576,"zip":577,"country":521,"geoPoint":578},"Centre Hospitalier de l'Université Laval et Centre Mère-Enfant Soleil","Québec","G1V 4G2",{"lat":579,"lon":580},46.81228,-71.21454,{"facility":582,"city":583,"zip":584,"country":521,"geoPoint":585},"SickKids - The Hospital for Sick Children","Toronto","M5G 1X8",{"lat":586,"lon":587},43.70643,-79.39864,{"facility":589,"city":590,"zip":591,"country":592,"geoPoint":593},"Fakultní Nemocnice Brno - D?tská Nemocnice","Brno","625 00","Czechia",{"lat":594,"lon":595},49.19522,16.60796,{"facility":597,"city":598,"zip":599,"country":592,"geoPoint":600},"Motol University Hospital","Prague","5 150 06",{"lat":601,"lon":602},50.08804,14.42076,{"facility":604,"city":605,"state":606,"zip":607,"country":608,"geoPoint":609},"Aarhus Universitetshospital","Aarhus","Central Jutland","8200","Denmark",{"lat":610,"lon":611},56.15674,10.21076,{"facility":613,"city":614,"zip":615,"country":608,"geoPoint":616},"Rigshospitalet","Copenhagen","2100",{"lat":617,"lon":618},55.67594,12.56553,{"facility":620,"city":621,"state":622,"zip":623,"country":624,"geoPoint":625},"CCHE","Cairo","Cairo Governorate","11441","Egypt",{"lat":626,"lon":627},30.06263,31.24967,{"facility":629,"city":630,"zip":631,"country":632,"geoPoint":633},"Helsingin yliopistollinen sairaala (HUS)","Helsinki","FI-00290","Finland",{"lat":634,"lon":635},60.16952,24.93545,{"facility":637,"city":638,"zip":639,"country":632,"geoPoint":640},"Tampereen Yliopistollinen Sairaala","Tampere","33520",{"lat":641,"lon":642},61.49911,23.78712,{"facility":644,"city":645,"zip":646,"country":647,"geoPoint":648},"Centre de Lutte contre le Cancer - 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Santa Maria della Misericordia","Udine","33100",{"lat":884,"lon":885},46.0693,13.23715,{"facility":887,"city":888,"state":889,"zip":890,"country":891,"geoPoint":892},"King Hussein Cancer Foundation - King Hussein Cancer Center","Amman","Muhafazat al-Asima","11941","Jordan",{"lat":893,"lon":894},31.95522,35.94503,{"facility":896,"city":897,"zip":898,"country":899,"geoPoint":900},"Prinses Maxima Centrum Kinderoncologie","Utrecht","3584 CS","Netherlands",{"lat":901,"lon":902},52.09083,5.12222,{"facility":904,"city":905,"zip":906,"country":907,"geoPoint":908},"Starship Paediatric Blood & Cancer Center","Grafton","1023","New Zealand",{"lat":909,"lon":910},-36.86029,174.76566,{"facility":912,"city":913,"state":914,"zip":915,"country":916,"geoPoint":917},"Universitetssykehuset Nord-Norge - Tromsø","Tromsø","Troms","9038","Norway",{"lat":918,"lon":919},69.6489,18.95508,{"facility":921,"city":922,"zip":923,"country":916,"geoPoint":924},"Oslo Universitetssykehus","Oslo","372",{"lat":925,"lon":926},59.91273,10.74609,{"facility":928,"city":929,"zip":930,"country":931,"geoPoint":932},"Sidra Medicine","Doha","26999","Qatar",{"lat":933,"lon":934},25.28545,51.53096,{"facility":936,"city":937,"zip":938,"country":937,"geoPoint":939},"SingHealth Group - 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Management of pediatric brain tumors in low- and middle-income countries. Adv Cancer Res. 2025;167:427-453. doi: 10.1016\u002Fbs.acr.2025.08.004. Epub 2025 Sep 9.",{"pmid":1167,"type":1164,"citation":1168},"38291372","van Tilburg CM, Kilburn LB, Perreault S, Schmidt R, Azizi AA, Cruz-Martinez O, Zapotocky M, Scheinemann K, Meeteren AYNS, Sehested A, Opocher E, Driever PH, Avula S, Ziegler DS, Capper D, Koch A, Sahm F, Qiu J, Tsao LP, Blackman SC, Manley P, Milde T, Witt R, Jones DTW, Hargrave D, Witt O. LOGGIC\u002FFIREFLY-2: a phase 3, randomized trial of tovorafenib vs. chemotherapy in pediatric and young adult patients with newly diagnosed low-grade glioma harboring an activating RAF alteration. BMC Cancer. 2024 Jan 30;24(1):147. doi: 10.1186\u002Fs12885-024-11820-x.",[],{"nct_id":4,"conditions":1171,"biomarkers":1174},[1172,1173],"Glioneuronal and Neuronal Tumors","Low Grade Glioma",[1175],"RAF1 wt Allele",{"nct_id":4,"found":123,"summary":121,"prompt_version":121}]