[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT05600933":3,"trial-entities:NCT05600933":82,"trial-summary:NCT05600933":91},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":26,"study_type":32,"primary_purpose":14,"phases":33,"enrollment_info":34,"interventions":37,"primary_outcomes":38,"secondary_outcomes":43,"sex":48,"minimum_age":49,"maximum_age":14,"healthy_volunteers":50,"eligibility_criteria":51,"std_ages":59,"locations":62,"central_contacts":72,"overall_officials":73,"references":77,"see_also_links":78},"NCT05600933","10000958","Prospective Procurement of Tumor Tissue to Identify Novel Therapeutic Targets and Study the Tumor Microenvironment","ENROLLING_BY_INVITATION","2033-06-15","2026-05-22","2026-05-29","2023-05-15","National Cancer Institute (NCI)","NIH",null,"Background:\n\nMany advances have been made in cancer treatments, but more research is needed. Comparing samples of cancerous tissue to samples of normal, noncancerous tissues may help find differences between them. These differences may help researchers find new ways to treat cancer.\n\nObjective:\n\nTo collect tissues and blood samples from people with known or suspected cancer. The samples will be used to help identify new targets for cancer treatments.\n\nEligibility:\n\nPeople aged 18 years and older with a known or suspected cancer that requires surgery or biopsy.\n\nDesign:\n\nParticipants will be screened. They will answer questions about their health. They can do this on the phone or in person.\n\nResearchers will collect information from participants medical records. Data may include information about any prior or current cancers. Data about other medical conditions may also be collected.\n\nParticipants will have blood drawn. Some of the blood will be tested for HIV and hepatitis B and C. Some of the blood will be used for genetic research.\n\nParticipants will have tissue samples collected during surgeries or biopsies. These are procedures the participants would have had as part of their standard care. No new procedures will be done just for this study. Researchers may also seek out samples from prior procedures the participant had done.\n\nParticipants will remain in the study for 6 months. They may have blood drawn again. Researchers may also collect tissue samples from any procedures performed during that time.","Background:\n\n* Recent advances and insights into the molecular pathogenesis of cancer have led to the development of novel molecular and biologic targeted therapies for the treatment of advanced cancer participants. A critical challenge in extending these studies involves the identification and validation of new therapeutic targets for future cancer therapies.\n* The development of immuno-oncology therapeutics across a wide spectrum of malignancies has emphasized a need to understand the intratumoral immunologic landscape of metastatic cancer. The techniques of cultivating and examining tumor infiltrating lymphocytes developed in the Surgery Branch can be expanded and refined by the exploration of solid tumors.\n* The Surgery Branch, NCI has an interest in identifying novel molecular and biologic targets to facilitate the development of future cancer therapies for solid and hematologic malignancies. Through close collaborations with the Surgical Oncology Program and Thoracic Surgery Branch, our internal staff surgeons, and our medical oncology staff clinicians, we are uniquely positioned to acquire and perform important studies on solid tumor tissue and bone marrow to help identify therapeutic targets that may have significant clinical ramifications.\n\nObjective:\n\nTo collect biologic samples from participants undergoing diagnostic or therapeutic interventions for known or suspected cancer for the purpose of identifying novel molecular and biologic therapeutic targets and studying the intratumoral immune landscape.\n\nEligibility:\n\nParticipants \\>=18 years of age with suspected or confirmed malignancies planning diagnostic or therapeutic intervention from which biologic samples may be obtained.\n\nDesign:\n\n* A tissue acquisition trial in which tissues will be obtained at the time of intervention.\n* Tissue and blood will be processed at the time of collection, stored and then transferred to the Surgery Branch Cell Production Facility for further processing.\n* No investigational therapy will be given.\n* It is anticipated that 1200 participants will be enrolled.",[18,19,20,21,22,23,24,25],"Solid Tumors","Hematologic Malignancy","Gastrointestinal Cancer","Liver Cancer","Pancreatic Cancer","Melanoma","Pre-Malignancy","Lung Cancer",[27,28,29,30,31],"Biologic Samples","Intratumoral Immunologic Landscape","Tumor Infiltrating Lymphocytes","Immuno-Oncology Therapeutics","Natural History","OBSERVATIONAL",[],{"count":35,"type":36},1200,"ESTIMATED",[],[39],{"measure":40,"description":41,"timeFrame":42},"To collect biologic samples from participants undergoing diagnostic or therapeutic interventions for premalignant, primary or metastatic solid tumors and hematologic malignancies","To collect biologic samples from participants undergoing diagnostic or therapeutic interventions for known or suspected cancer for the purpose of identifying novel molecular and biologic therapeutic targets and studying the intratumoral immune landscape.","At time of surgery or biopsy",[44],{"measure":45,"description":46,"timeFrame":47},"To collect detailed history, demographic, treatment data, and perioperative findings.","To collect detailed history, demographic, treatment data, and perioperative findings in order to categorize specimens.","At time of consent","ALL","18 Years",false,{"inclusion":52,"exclusion":57,"raw_text":58},[53,54,55,56],"Age \\>= 18 years","Willing to undergo serologic testing for HIV, hepatitis B and C","Participants who have a known or suspected cancer that requires surgery or biopsy as a part of the standard of care diagnosis, treatment and\u002For follow up.","Able and willing to sign an informed consent document.",[],"* INCLUSION CRITERIA:\n* Age \\>= 18 years\n* Willing to undergo serologic testing for HIV, hepatitis B and C\n* Participants who have a known or suspected cancer that requires surgery or biopsy as a part of the standard of care diagnosis, treatment and\u002For follow up.\n\nNote: Participants will not be enrolled exclusively for the procurement of tissue samples.\n\n-Able and willing to sign an informed consent document.",[60,61],"ADULT","OLDER_ADULT",[63],{"facility":64,"city":65,"state":66,"zip":67,"country":68,"geoPoint":69},"National Institutes of Health Clinical Center","Bethesda","Maryland","20892","United States",{"lat":70,"lon":71},38.98067,-77.10026,[],[74],{"name":75,"affiliation":12,"role":76},"Steven A Rosenberg, M.D.","PRINCIPAL_INVESTIGATOR",[],[79],{"label":80,"url":81},"NIH Clinical Center Detailed Web Page","https:\u002F\u002Fclinicalstudies.info.nih.gov\u002Fcgi\u002Fdetail.cgi?A_000958-C.html",{"nct_id":4,"conditions":83,"biomarkers":90},[84,85,86,87,23,88,24,89],"Liver Carcinoma","Lung Carcinoma","Malignant Digestive System Neoplasm","Malignant neoplasm of lymphoid, hematopoietic and\u002For related tissue","Pancreatic Carcinoma","Solid Neoplasm",[],{"nct_id":4,"found":92,"summary":93,"prompt_version":103},true,{"design":94,"status":95,"heading":96,"summary":97,"follow_up":98,"word_count":99,"commitments":100,"compensation":101,"drugs_mentioned":102},"This is an observational study, meaning researchers will collect information and samples without giving any specific intervention. It plans to enroll 1200 participants.","completed","Studying Tumor Tissue to Find New Cancer Treatments","This study aims to collect tissue and blood samples from people with known or suspected cancer. Researchers will compare cancerous tissue to normal tissue to find differences that could lead to new ways to treat cancer. You can join if you are 18 or older and need surgery or a biopsy (a procedure to remove a small piece of tissue for examination) as part of your standard cancer care. The study is looking to enroll 1200 participants. The main goal is to collect these samples during your surgery or biopsy to help identify new targets for future cancer treatments. The current recruitment status is unclear.","Samples will be collected at the time of surgery or biopsy. The record does not specify follow-up after this.",105,"You will be screened, which involves answering health questions by phone or in person. Researchers will also collect information from your medical records, and biological samples will be collected during your surgery or biopsy.","Not stated in the trial record.",[],"v2"]