[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT05643014":3,"trial-entities:NCT05643014":84,"trial-summary:NCT05643014":87},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":25,"primary_purpose":17,"phases":26,"enrollment_info":27,"interventions":30,"primary_outcomes":36,"secondary_outcomes":41,"sex":42,"minimum_age":43,"maximum_age":17,"healthy_volunteers":15,"eligibility_criteria":44,"std_ages":54,"locations":57,"central_contacts":77,"overall_officials":81,"references":82,"see_also_links":83},"NCT05643014","2018NTLS135","Observational Study of Exposure to Environmental Toxicants Among Firefighters","Evaluate the Exposure to Toxicants Emitted During a Structural Fire Assessed by Urinary and Buccal Cell Biomarkers Found in Firefighters.","RECRUITING","2027-12-31","2026-03","2026-03-12","2020-02-01","Masonic Cancer Center, University of Minnesota","OTHER",true,"Observational, within subject study design with 1 pre and 2 post-fire exposure biomarker samples collected to assess exposure to toxicants from combustion emissions related to fighting a structural fire.",null,[19],"Healthy",[21,22,23,24],"PAH","1-HOP","PheT","SPMA","OBSERVATIONAL",[],{"count":28,"type":29},60,"ESTIMATED",[31],{"type":14,"name":32,"description":33,"armGroupLabels":34},"Sample collection","This study will involve three sample collections including buccal cells and urine samples",[35],"Firefighters over 18 years old",[37],{"measure":38,"description":39,"timeFrame":40},"Studying biomarker levels in firefighters pre and post fire call.","The investigators will evaluate the differences between mean pre-exposure biomarker levels and post-exposure levels in urine and buccal samples collected within 24 hours post-exposure and 1-week post-exposure respectively using t-tests to test for statistical significance.","48 months",[],"ALL","18 Years",{"inclusion":45,"exclusion":49,"raw_text":53},[46,47,48],"Firefighter (career or volunteer)","Over 18 years of age","Able to provide written voluntary consent",[50,51,52],"Unwilling to provide a pre and post-exposure urine sample","Current cancer diagnosis","Tobacco use within the last 1 year (verified by urinary TNEs)","Inclusion Criteria:\n\n* Firefighter (career or volunteer)\n* Over 18 years of age\n* Able to provide written voluntary consent\n\nExclusion Criteria:\n\n* Unwilling to provide a pre and post-exposure urine sample\n* Current cancer diagnosis\n* Tobacco use within the last 1 year (verified by urinary TNEs)",[55,56],"ADULT","OLDER_ADULT",[58],{"facility":59,"status":8,"city":60,"state":61,"zip":62,"country":63,"contacts":64,"geoPoint":74},"Masonic Cancer Center","Minneapolis","Minnesota","55455","United States",[65,70],{"name":66,"role":67,"phone":68,"email":69},"Stephen S Hecht","CONTACT","612-624-7604","hetcht002@umn.edu",{"name":71,"role":67,"phone":72,"email":73},"Joni A Jensen","+1 612-624-7604","jense010@umn.edu",{"lat":75,"lon":76},44.97997,-93.26384,[78],{"name":79,"role":67,"phone":80,"email":73},"Joni Jensen","612-624-5178",[],[],[],{"nct_id":4,"conditions":85,"biomarkers":86},[19],[],{"nct_id":4,"found":15,"summary":88,"prompt_version":97},{"design":89,"status":90,"heading":6,"summary":91,"follow_up":92,"word_count":93,"commitments":94,"compensation":95,"drugs_mentioned":96},"This is an observational study with 60 participants. It's designed to compare samples from the same person before and after fire exposure.","completed","This observational study is looking at how firefighters are exposed to harmful chemicals (toxicants) from fire smoke. Researchers will collect samples from firefighters before and after they respond to a fire call. They want to see how the levels of these chemicals change. You can join if you are a career or volunteer firefighter, over 18 years old, and willing to provide samples. The study aims to understand these chemical exposures over 48 months. The study is currently unclear on its recruitment status and plans to enroll 60 participants.","The primary endpoint, studying biomarker levels, is measured at 48 months.",89,"You would provide three sample collections, including buccal cells (from inside your cheek) and urine samples, before and after a fire call.","Not stated in the trial record.",[],"v2"]