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Eligible participants will receive eplontersen once every 4 weeks for up to 36 months or until after eplontersen is approved and available in the site's country, whichever occurs first. Participants will also receive daily supplemental doses of the recommended daily allowance (RDA) of vitamin A.",[19],"Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)",[21],"Amyloidosis","INTERVENTIONAL","TREATMENT",[25],"PHASE3",{"count":27,"type":28},1400,"ESTIMATED",[30],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"DRUG","Eplontersen","Eplontersen will be administered by SC injection.",[32],[36,37],"ION-682884","IONIS-TTR-LRx",[39,42,44,46],{"measure":40,"timeFrame":41},"Number of Participants With Adverse Events (AE) and Serious Adverse Events (SAE)","Baseline up to 36 months",{"measure":43,"timeFrame":41},"Change From Baseline in Platelet Count",{"measure":45,"timeFrame":41},"Change From Baseline in Estimated Glomerular Filtration Rate (eGFR)",{"measure":47,"timeFrame":41},"Change From Baseline in Urine Protein Creatinine Ratio (UPCR)",[49,51,53],{"measure":50,"timeFrame":41},"Change From Baseline in Transthyretin (TTR) Serum Levels",{"measure":52,"timeFrame":41},"Change From Baseline in 6-minute Walk Test (6MWT)",{"measure":54,"timeFrame":41},"Change From Baseline in Kansas City Cardiomyopathy Questionnaire (KCCQ)","ALL","18 Years",null,{"inclusion":59,"exclusion":60,"raw_text":61},[],[],"Inclusion Criteria:\n\n1. 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