[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT05744713":3,"trial-entities:NCT05744713":143,"trial-summary:NCT05744713":146},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":20,"study_type":21,"primary_purpose":16,"phases":22,"enrollment_info":23,"interventions":26,"primary_outcomes":33,"secondary_outcomes":41,"sex":46,"minimum_age":47,"maximum_age":16,"healthy_volunteers":14,"eligibility_criteria":48,"std_ages":61,"locations":64,"central_contacts":139,"overall_officials":140,"references":141,"see_also_links":142},"NCT05744713","TARGET-LD","An Observational Study of Patients With Chronic Liver Disease","ENROLLING_BY_INVITATION","2037-12-31","2026-03","2026-03-03","2024-02-19","Target PharmaSolutions, Inc.","INDUSTRY",false,"TARGET-Liver Disease (TARGET-LD) is an observational research study to conduct a comprehensive review of outcomes for patients with chronic liver disease (CLD).",null,[18,19],"Chronic Liver Disease","Cirrhosis",[],"OBSERVATIONAL",[],{"count":24,"type":25},500000,"ESTIMATED",[27],{"type":28,"name":29,"description":29,"armGroupLabels":30},"OTHER","Observational",[31,32],"Disease Cohort","Engaged Cohort",[34,37,39],{"measure":35,"timeFrame":36},"To characterize the natural history of disease in patients with CLD from various etiologies and Cirrhosis","20 Years",{"measure":38,"timeFrame":36},"To assess safety and effectiveness of CLD\u002FCirrhosis treatments and treatments for complications of any chronic liver disease",{"measure":40,"timeFrame":36},"To establish learning health networks focused on quality of care for patients",[42,44],{"measure":43,"timeFrame":36},"To evaluate provider management practices in the treatment of patients with CLD\u002FCirrhosis",{"measure":45,"timeFrame":36},"To evaluate longitudinal and patient reported outcomes in CLD\u002FCirrhosis","ALL","18 Years",{"inclusion":49,"exclusion":52,"raw_text":60},[50,51],"Adult\\* patients diagnosed and managed for CLD\u002Fcirrhosis invited to participate","Ability to provide written informed consent",[53,54,55,56,57,58,59],"Death","Manual removal (sponsor or site request)","No EHR interface encounter \\> 3 years.","Patient expressed desire to withdraw consent to complete PROs","Failure to complete PROs within 24 weeks of initial invitation","Greater than 24 months lapse of survey completion after baseline surveys completed","Additionally, the criteria detailed for Disease Cohort apply to the Engaged Cohort.","Inclusion Criteria:\n\nDisease Cohort\n\n•Adult\\* patients at the time of enrollment with a diagnosis of CLD\u002Fcirrhosis by ICD-10 code in the EHR interface\n\nEngaged Cohort\n\n* Adult\\* patients diagnosed and managed for CLD\u002Fcirrhosis invited to participate\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\nDisease Cohort\n\n* Death\n* Manual removal (sponsor or site request)\n* No EHR interface encounter \\> 3 years.\n\nEngaged Cohort\n\n* Patient expressed desire to withdraw consent to complete PROs\n* Failure to complete PROs within 24 weeks of initial invitation\n* Greater than 24 months lapse of survey completion after baseline surveys completed\n* Additionally, the criteria detailed for Disease Cohort apply to the Engaged Cohort.",[62,63],"ADULT","OLDER_ADULT",[65,74,81,89,97,104,112,120,124,132],{"facility":66,"city":67,"state":68,"zip":69,"country":70,"geoPoint":71},"Keck School of Medicine of USC","Los Angeles","California","90033","United States",{"lat":72,"lon":73},34.05223,-118.24368,{"facility":75,"city":76,"state":68,"zip":77,"country":70,"geoPoint":78},"Stanford Medicine","Redwood City","94063",{"lat":79,"lon":80},37.48522,-122.23635,{"facility":82,"city":83,"state":84,"zip":85,"country":70,"geoPoint":86},"Georgetown Medstar Transplant Institute","Washington D.C.","District of Columbia","20007",{"lat":87,"lon":88},38.89511,-77.03637,{"facility":90,"city":91,"state":92,"zip":93,"country":70,"geoPoint":94},"Rush University Medical Center","Chicago","Illinois","60612",{"lat":95,"lon":96},41.85003,-87.65005,{"facility":98,"city":99,"state":99,"zip":100,"country":70,"geoPoint":101},"Columbia University Irving Medical Center\u002F New York Presbyterian Hospital","New York","10032",{"lat":102,"lon":103},40.71427,-74.00597,{"facility":105,"city":106,"state":107,"zip":108,"country":70,"geoPoint":109},"Atrium Health Center for Liver Disease and Transplant","Charlotte","North Carolina","28204",{"lat":110,"lon":111},35.22709,-80.84313,{"facility":113,"city":114,"state":115,"zip":116,"country":70,"geoPoint":117},"University of Pennsylvania","Philadelphia","Pennsylvania","19104",{"lat":118,"lon":119},39.95238,-75.16362,{"facility":121,"city":114,"state":115,"zip":122,"country":70,"geoPoint":123},"Temple University - Lewis Katz School of Medicine","19140",{"lat":118,"lon":119},{"facility":125,"city":126,"state":127,"zip":128,"country":70,"geoPoint":129},"Baylor Scott & White Research Institute","Dallas","Texas","75246",{"lat":130,"lon":131},32.78306,-96.80667,{"facility":133,"city":134,"state":127,"zip":135,"country":70,"geoPoint":136},"Baylor College of Medicine","Houston","77021",{"lat":137,"lon":138},29.76328,-95.36327,[],[],[],[],{"nct_id":4,"conditions":144,"biomarkers":145},[18,19],[],{"nct_id":4,"found":14,"summary":16,"prompt_version":16}]