[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT05797831":3,"trial-entities:NCT05797831":703,"trial-summary:NCT05797831":707},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":22,"primary_purpose":23,"phases":24,"enrollment_info":27,"interventions":30,"primary_outcomes":48,"secondary_outcomes":57,"sex":75,"minimum_age":76,"maximum_age":17,"healthy_volunteers":77,"eligibility_criteria":78,"std_ages":92,"locations":95,"central_contacts":694,"overall_officials":700,"references":701,"see_also_links":702},"NCT05797831","KRT-232-118","Study of Navtemadlin as Maintenance Therapy in TP53WT Advanced or Recurrent Endometrial Cancer","A Phase 2\u002F3 Study of Navtemadlin as Maintenance Therapy in Subjects With TP53WT Advanced or Recurrent Endometrial Cancer Who Responded to Chemotherapy","RECRUITING","2027-07","2024-04","2024-05-02","2023-07-17","Kartos Therapeutics, Inc.","INDUSTRY",true,"This study evaluates navtemadlin as maintenance treatment for patients with advanced or recurrent endometrial cancer (EC) who have achieved complete response or partial response on chemotherapy.\n\nThe study will be conducted in 2 parts. Part 1 will evaluate safety and efficacy of two different doses of navtemadlin alongside an observational control arm to determine the Phase 3 navtemadlin dose. Part 2 will evaluate the efficacy and safety of navtemadlin Phase 3 dose compared to placebo.",null,[19],"Endometrial Cancer",[21],"navtemadlin","INTERVENTIONAL","TREATMENT",[25,26],"PHASE2","PHASE3",{"count":28,"type":29},268,"ESTIMATED",[31,42],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":40},"DRUG","Navtemadlin","Navtemadlin is an experimental MDM2 anticancer drug taken by mouth",[36,37,38,39],"Part 1 Arm 1","Part 1 Arm 2","Part 2 Arm A","Part 2 Arm B",[41],"KRT-232",{"type":32,"name":43,"description":44,"armGroupLabels":45},"Navtemadlin Placebo","Navtemadlin placebo is a placebo that is the same in appearance to navtemadlin drug taken by mouth",[46,47],"Part 2 Arm C","Part 2 Arm D",[49,53],{"measure":50,"description":51,"timeFrame":52},"Part 1: To determine the navtemadlin Phase 3 dose","Safety review committee (SRC) will determine the navtemadlin Phase 3 dose for Part 2 based on safety data from Part 1","12 months",{"measure":54,"description":55,"timeFrame":56},"Part 2: To compare progression-free (PFS) survival by independent review committee (IRC) between navtemadlin and placebo","PFS defined as the time from randomization to disease progression by IRC or death, whichever occurs first","50 months",[58,61,64,68,70,72],{"measure":59,"description":60,"timeFrame":56},"Part 1: To evaluate the treatment effect of navtemadlin on PFS by IRC and investigator assessment","PFS defined as the time from randomization to disease progression by IRC\u002Finvestigator assessment or death, whichever occurs first",{"measure":62,"description":63,"timeFrame":56},"Part 2: To evaluate the treatment effect of navtemadlin on the time to first subsequent treatment (TFST)","TFST defined as the time from randomization to initiation of first subsequent anticancer therapy or death, whichever occurs first",{"measure":65,"description":66,"timeFrame":67},"Parts 1 and 2: To determine the pharmacokinetic (PK) profile of navtemadlin","Will determine the Maximum observed concentration (Cmax)","1 day",{"measure":65,"description":69,"timeFrame":67},"Will determine the area under the plasma concentration versus time curve (AUC)",{"measure":65,"description":71,"timeFrame":67},"Will determine the time of maximum plasma concentration (Tmax)",{"measure":73,"description":74,"timeFrame":56},"Parts 1 and 2: To evaluate the treatment effect of navtemadlin on the disease control rate (DCR)","Best response of complete response (CR), partial response (PR) or stable disease (SD) by IRC\u002Finvestigator assessment among subjects with PR as best response from prior chemotherapy","FEMALE","18 Years",false,{"inclusion":79,"exclusion":84,"raw_text":91},[80,81,82,83],"ECOG 0-1","Histologically or cytologically confirmed diagnosis of endometrial cancer documented as TP53WT","Subjects with advanced or recurrent disease must have completed a single line of up to 6 cycles of taxane-platinum based chemo and achieved a CR or PR per RECIST V1.1","Adequate hematologic, hepatic and renal function (within 14 days)",[85,86,87,88,89,90],"Has any sarcomas or small-cell carcinomas with neuroendocrine differentiation","Prior immune therapy, cytokine therapy, or any investigational therapy (within 28 days)","Indwelling surgical drains","Grade 2 or higher QTc prolongation","History of major organ transplant","History of bleeding diathesis; major hemorrhage or intracranial hemorrhage (within 24 weeks)","Inclusion Criteria:\n\n* ECOG 0-1\n* Histologically or cytologically confirmed diagnosis of endometrial cancer documented as TP53WT\n* Subjects with advanced or recurrent disease must have completed a single line of up to 6 cycles of taxane-platinum based chemo and achieved a CR or PR per RECIST V1.1\n* Adequate hematologic, hepatic and renal function (within 14 days)\n\nExclusion Criteria:\n\n* Has any sarcomas or small-cell carcinomas with neuroendocrine differentiation\n* Prior immune therapy, cytokine therapy, or any investigational therapy (within 28 days)\n* Indwelling surgical drains\n* Grade 2 or higher QTc prolongation\n* History of major organ transplant\n* History of bleeding diathesis; major hemorrhage or intracranial hemorrhage (within 24 weeks)",[93,94],"ADULT","OLDER_ADULT",[96,105,113,120,128,136,143,151,159,167,175,183,191,199,207,215,222,230,237,244,252,259,266,274,281,289,297,305,312,319,326,330,338,345,352,359,366,374,381,388,395,402,409,416,423,430,437,444,451,458,466,473,481,488,495,503,510,514,521,528,535,542,549,556,564,571,578,582,589,596,600,608,615,623,630,637,644,651,658,665,672,679,687],{"facility":97,"status":8,"city":98,"state":99,"zip":100,"country":101,"geoPoint":102},"Kaiser Permanente Center","Vallejo","California","94589","United States",{"lat":103,"lon":104},38.10409,-122.25664,{"facility":106,"status":8,"city":107,"state":108,"zip":109,"country":101,"geoPoint":110},"Northside Hospital","Atlanta","Georgia","30342",{"lat":111,"lon":112},33.749,-84.38798,{"facility":114,"status":8,"city":115,"state":108,"zip":116,"country":101,"geoPoint":117},"St. Joseph","Savannah","31405",{"lat":118,"lon":119},32.08354,-81.09983,{"facility":121,"status":8,"city":122,"state":123,"zip":124,"country":101,"geoPoint":125},"Dr. Sudarshan K. Sharma, Ltd.","Hinsdale","Illinois","60521",{"lat":126,"lon":127},41.80086,-87.93701,{"facility":129,"status":8,"city":130,"state":131,"zip":132,"country":101,"geoPoint":133},"Parkview Research Center","Fort Wayne","Indiana","46845",{"lat":134,"lon":135},41.1306,-85.12886,{"facility":137,"status":8,"city":138,"state":131,"zip":139,"country":101,"geoPoint":140},"Indiana University","Indianapolis","46202",{"lat":141,"lon":142},39.76838,-86.15804,{"facility":144,"status":8,"city":145,"state":146,"zip":147,"country":101,"geoPoint":148},"Maryland Oncology Hematology, P.A.","Silver Spring","Maryland","20904",{"lat":149,"lon":150},38.99067,-77.02609,{"facility":152,"status":8,"city":153,"state":154,"zip":155,"country":101,"geoPoint":156},"Minnesota Oncology Hematology, P.A.","Minneapolis","Minnesota","55404",{"lat":157,"lon":158},44.97997,-93.26384,{"facility":160,"status":8,"city":161,"state":162,"zip":163,"country":101,"geoPoint":164},"Washington University School of Medicine","St Louis","Missouri","63108",{"lat":165,"lon":166},38.62727,-90.19789,{"facility":168,"status":8,"city":169,"state":170,"zip":171,"country":101,"geoPoint":172},"Women's Cancer Center of Nevada","Las Vegas","Nevada","89106",{"lat":173,"lon":174},36.17497,-115.13722,{"facility":176,"status":8,"city":177,"state":178,"zip":179,"country":101,"geoPoint":180},"Good Samaritan Hospital Medical Center","West Islip","New York","11795",{"lat":181,"lon":182},40.70621,-73.30623,{"facility":184,"status":8,"city":185,"state":186,"zip":187,"country":101,"geoPoint":188},"FirstHealth Carolinas","Pinehurst","North Carolina","28374",{"lat":189,"lon":190},35.19543,-79.46948,{"facility":192,"status":8,"city":193,"state":194,"zip":195,"country":101,"geoPoint":196},"OhioHealth Institute","Columbus","Ohio","43214",{"lat":197,"lon":198},39.96118,-82.99879,{"facility":200,"status":8,"city":201,"state":202,"zip":203,"country":101,"geoPoint":204},"Oklahoma Cancer Specialists and Research Institute","Tulsa","Oklahoma","74146",{"lat":205,"lon":206},36.15398,-95.99277,{"facility":208,"status":8,"city":209,"state":210,"zip":211,"country":101,"geoPoint":212},"Oncology Associates of Oregon","Eugene","Oregon","97401",{"lat":213,"lon":214},44.05207,-123.08675,{"facility":216,"status":8,"city":217,"state":210,"zip":218,"country":101,"geoPoint":219},"Northwest Cancer Specialists","Portland","97227",{"lat":220,"lon":221},45.52345,-122.67621,{"facility":223,"status":8,"city":224,"state":225,"zip":226,"country":101,"geoPoint":227},"Texas Oncology-Austin Central","Austin","Texas","78745",{"lat":228,"lon":229},30.26715,-97.74306,{"facility":231,"status":8,"city":232,"state":225,"zip":233,"country":101,"geoPoint":234},"Texas Oncology-Fort Worth Cancer Center","Fort Worth","76104",{"lat":235,"lon":236},32.72541,-97.32085,{"facility":238,"status":8,"city":239,"state":225,"zip":240,"country":101,"geoPoint":241},"Texas Oncology-San Antonio Medical Center","San Antonio","78130",{"lat":242,"lon":243},29.42412,-98.49363,{"facility":245,"status":8,"city":246,"zip":247,"country":248,"geoPoint":249},"University Hospital Graz, Department of Gynecology and Obstetrics","Graz","8036","Austria",{"lat":250,"lon":251},47.06733,15.44197,{"facility":253,"status":8,"city":254,"zip":255,"country":248,"geoPoint":256},"Medizinische Universität Innsbruck","Innsbruck","6020",{"lat":257,"lon":258},47.26266,11.39454,{"facility":260,"status":8,"city":261,"zip":262,"country":248,"geoPoint":263},"Medizinische Universität Wien","Vienna","1090",{"lat":264,"lon":265},48.20849,16.37208,{"facility":267,"status":8,"city":268,"zip":269,"country":270,"geoPoint":271},"Cross Cancer Institute","Edmonton","T6G 1Z2","Canada",{"lat":272,"lon":273},53.55014,-113.46871,{"facility":275,"status":8,"city":276,"zip":277,"country":270,"geoPoint":278},"CHUM - University of Montreal Hospital Centre","Montreal","H2X 3E4",{"lat":279,"lon":280},45.50884,-73.58781,{"facility":282,"status":8,"city":283,"zip":284,"country":285,"geoPoint":286},"Odense University Hospital","Odense","DK-5000","Denmark",{"lat":287,"lon":288},55.39594,10.38831,{"facility":290,"status":8,"city":291,"zip":292,"country":293,"geoPoint":294},"Tartu University Hospital","Tartu","50406","Estonia",{"lat":295,"lon":296},58.38062,26.72509,{"facility":298,"status":8,"city":299,"zip":300,"country":301,"geoPoint":302},"Kuopio University Hospital","Kuopio","70200","Finland",{"lat":303,"lon":304},62.89238,27.67703,{"facility":306,"status":8,"city":307,"zip":308,"country":301,"geoPoint":309},"Turku University Hospital","Turku","20520",{"lat":310,"lon":311},60.45148,22.26869,{"facility":313,"status":8,"city":314,"zip":315,"country":108,"geoPoint":316},"LTD High Technology hospital Medcenter","Batumi","6000",{"lat":317,"lon":318},41.64077,41.6306,{"facility":320,"status":8,"city":321,"zip":322,"country":108,"geoPoint":323},"American Hospital Network LLC","Tbilisi","0102",{"lat":324,"lon":325},41.69143,44.83412,{"facility":327,"status":8,"city":321,"zip":328,"country":108,"geoPoint":329},"Caucasus Medical Centre","0186",{"lat":324,"lon":325},{"facility":331,"status":8,"city":332,"zip":333,"country":334,"geoPoint":335},"National Institute of Oncology","Budapest","H-1122","Hungary",{"lat":336,"lon":337},47.49835,19.04045,{"facility":339,"status":8,"city":340,"zip":341,"country":334,"geoPoint":342},"University of Debrecen Clinical Center","Debrecen","4032",{"lat":343,"lon":344},47.53167,21.62444,{"facility":346,"status":8,"city":347,"zip":346,"country":348,"geoPoint":349},"Rambam Medical Center","Haifa","Israel",{"lat":350,"lon":351},32.81303,34.99928,{"facility":353,"status":8,"city":354,"zip":355,"country":348,"geoPoint":356},"Shaare Zedek Medical Center","Jerusalem","9103102",{"lat":357,"lon":358},31.76904,35.21633,{"facility":360,"status":8,"city":361,"zip":362,"country":348,"geoPoint":363},"Sourasky Medical Center","Tel Aviv","6423906",{"lat":364,"lon":365},32.08088,34.78057,{"facility":367,"status":8,"city":368,"zip":369,"country":370,"geoPoint":371},"A.O. Cannizzaro","Catania","95126","Italy",{"lat":372,"lon":373},37.49223,15.07041,{"facility":375,"status":8,"city":376,"zip":377,"country":370,"geoPoint":378},"IRCCS Istituto Romangolo per lo Studio dei Tumori \"Dino Amadori\"","Forlì","47014",{"lat":379,"lon":380},44.22177,12.04144,{"facility":382,"status":8,"city":383,"zip":384,"country":370,"geoPoint":385},"Ospedale Policlinico San Martino","Genoa","16132",{"lat":386,"lon":387},44.40478,8.94439,{"facility":389,"status":8,"city":390,"zip":391,"country":370,"geoPoint":392},"ASST di Lecco-Ospedale Alessandro Manzoni","Lecco","23900",{"lat":393,"lon":394},45.85589,9.39704,{"facility":396,"status":8,"city":397,"zip":398,"country":370,"geoPoint":399},"Ospedale San Luca","Lucca","55100",{"lat":400,"lon":401},43.84369,10.50447,{"facility":403,"status":8,"city":404,"zip":405,"country":370,"geoPoint":406},"Osp. Niguarda","Milan","20162",{"lat":407,"lon":408},45.46427,9.18951,{"facility":410,"status":8,"city":411,"zip":412,"country":370,"geoPoint":413},"University Hospital of Parma","Parma","43126",{"lat":414,"lon":415},44.79935,10.32618,{"facility":417,"status":8,"city":418,"zip":419,"country":370,"geoPoint":420},"Ospedale Guglielmo da Saliceto","Piacenza","29121",{"lat":421,"lon":422},45.05242,9.69342,{"facility":424,"status":8,"city":425,"zip":426,"country":370,"geoPoint":427},"Ospedale di Prato S. Stefano","Prato","59100",{"lat":428,"lon":429},43.8805,11.09699,{"facility":431,"status":8,"city":432,"zip":433,"country":370,"geoPoint":434},"Ospedale Santa Maria delle Croci","Ravenna","48121",{"lat":435,"lon":436},44.41344,12.20121,{"facility":438,"status":8,"city":439,"zip":440,"country":370,"geoPoint":441},"\"Azienda Unità Sanitaria Locale della Romagna - Hospital \"\"Infermi\"\" of Rimini Oncology Department\"","Rimini","47923",{"lat":442,"lon":443},44.05755,12.56528,{"facility":445,"status":8,"city":446,"zip":447,"country":370,"geoPoint":448},"Policlinico Umberto","Rome","00161",{"lat":449,"lon":450},41.89193,12.51133,{"facility":452,"status":8,"city":453,"zip":454,"country":370,"geoPoint":455},"Ospedale Filippo Del Ponte","Varese","21110",{"lat":456,"lon":457},45.82058,8.82511,{"facility":459,"status":8,"city":460,"zip":461,"country":462,"geoPoint":463},"Health Sciences Kaunas Clinics","Kaunas","LT-45434","Lithuania",{"lat":464,"lon":465},54.90156,23.90909,{"facility":467,"status":8,"city":468,"zip":469,"country":462,"geoPoint":470},"Nation Cancer Institute of Lithuania, Vilnius","Vilnius","LT-08660",{"lat":471,"lon":472},54.68916,25.2798,{"facility":474,"status":8,"city":475,"zip":476,"country":477,"geoPoint":478},"Southern Hospital Sorlandet","Kristiansand","4604","Norway",{"lat":479,"lon":480},58.14671,7.9956,{"facility":482,"status":8,"city":483,"zip":484,"country":477,"geoPoint":485},"Oslo University Hospital HF","Oslo","0379",{"lat":486,"lon":487},59.91273,10.74609,{"facility":489,"status":8,"city":490,"zip":491,"country":477,"geoPoint":492},"Sykehusapotek Nord Tromsø","Tromsø","9038",{"lat":493,"lon":494},69.6489,18.95508,{"facility":496,"status":8,"city":497,"zip":498,"country":499,"geoPoint":500},"Białostockie Centrum Onkologii","Bialystok","15-027","Poland",{"lat":501,"lon":502},53.13333,23.16433,{"facility":504,"status":8,"city":505,"zip":506,"country":499,"geoPoint":507},"Szpitale Pomorskie","Gdansk","80-210",{"lat":508,"lon":509},54.35227,18.64912,{"facility":511,"status":8,"city":505,"zip":512,"country":499,"geoPoint":513},"Uniwersyteckie Centrum Kliniczne","80-214",{"lat":508,"lon":509},{"facility":515,"status":8,"city":516,"zip":517,"country":499,"geoPoint":518},"NIO-PIB Oddzial w Gliwicach","Gliwice","44-102",{"lat":519,"lon":520},50.29761,18.67658,{"facility":522,"status":8,"city":523,"zip":524,"country":499,"geoPoint":525},"Centrum Badań klinicznych Jagiellońskie Centrum Innowacji","Krakow","31-115",{"lat":526,"lon":527},50.06143,19.93658,{"facility":529,"status":8,"city":530,"zip":531,"country":499,"geoPoint":532},"Siedleckie Centrum Onkologii","Olsztyn","10-228",{"lat":533,"lon":534},53.78376,20.49272,{"facility":536,"status":8,"city":537,"zip":538,"country":499,"geoPoint":539},"Uniwersytecki Szpital","Poznan","60-569",{"lat":540,"lon":541},52.40692,16.92993,{"facility":543,"status":8,"city":544,"zip":545,"country":499,"geoPoint":546},"NIO-PIB Klinika Gine-Onk","Warsaw","02-781",{"lat":547,"lon":548},52.22977,21.01178,{"facility":550,"status":8,"city":551,"zip":552,"country":499,"geoPoint":553},"Lower Silesian Oncology, Pulmonology and Hematology Center, Department of Oncological Gynecology","Wroclaw","53-413",{"lat":554,"lon":555},51.10286,17.03006,{"facility":557,"status":8,"city":558,"zip":559,"country":560,"geoPoint":561},"Bucharest CF2 Hospital","Bucharest","012244","Romania",{"lat":562,"lon":563},44.43225,26.10626,{"facility":565,"status":8,"city":566,"zip":567,"country":560,"geoPoint":568},"Ovidius Clinical Hospital SRL","Constanța","905900",{"lat":569,"lon":570},44.18073,28.63432,{"facility":572,"status":8,"city":573,"zip":574,"country":560,"geoPoint":575},"Onco Clinic Consult S.A.","Craiova","200094",{"lat":576,"lon":577},44.31667,23.8,{"facility":579,"status":8,"city":573,"zip":580,"country":560,"geoPoint":581},"Oncology Center \"Sf. Nectarie\"","200542",{"lat":576,"lon":577},{"facility":583,"status":8,"city":584,"zip":585,"country":560,"geoPoint":586},"Gral Medical S.R.L. - Oncofort Hospital","Piteşti","110283",{"lat":587,"lon":588},44.85,24.86667,{"facility":590,"status":8,"city":591,"zip":592,"country":560,"geoPoint":593},"Oncocenter, Oncology Clinic SRL","Timișoara","300166",{"lat":594,"lon":595},45.75372,21.22571,{"facility":597,"status":8,"city":591,"zip":598,"country":560,"geoPoint":599},"SC Oncomed SRL","300239",{"lat":594,"lon":595},{"facility":601,"status":8,"city":602,"zip":603,"country":604,"geoPoint":605},"Institute of Oncology Ljubljana","Ljubljana","1000","Slovenia",{"lat":606,"lon":607},46.05108,14.50513,{"facility":609,"status":8,"city":610,"zip":611,"country":604,"geoPoint":612},"University Clinical Center Maribor","Maribor","2000",{"lat":613,"lon":614},46.55583,15.64593,{"facility":616,"status":8,"city":617,"zip":618,"country":619,"geoPoint":620},"CHUAC (Hospital de Coruña)","A Coruña","15006","Spain",{"lat":621,"lon":622},43.37135,-8.396,{"facility":624,"status":8,"city":625,"zip":626,"country":619,"geoPoint":627},"Hospital del Mar","Barcelona","08003",{"lat":628,"lon":629},41.38879,2.15899,{"facility":631,"status":8,"city":632,"zip":633,"country":619,"geoPoint":634},"Hospital Galdakao-Usansolo","Galdakao","48960",{"lat":635,"lon":636},43.23073,-2.8429,{"facility":638,"status":8,"city":639,"zip":640,"country":619,"geoPoint":641},"Hospital Universitario de Jaen","Jaén","23007",{"lat":642,"lon":643},37.76922,-3.79028,{"facility":645,"status":8,"city":646,"zip":647,"country":619,"geoPoint":648},"H.G.U. Jerez de la Frontera","Jerez de la Frontera","11407",{"lat":649,"lon":650},36.68645,-6.13606,{"facility":652,"status":8,"city":653,"zip":654,"country":619,"geoPoint":655},"Hospital U Insular de GC","Las Palmas","35016",{"lat":656,"lon":657},28.58232,-16.16555,{"facility":659,"status":8,"city":660,"zip":661,"country":619,"geoPoint":662},"Hospital de Leon","León","24008",{"lat":663,"lon":664},42.60003,-5.57032,{"facility":666,"status":8,"city":667,"zip":668,"country":619,"geoPoint":669},"HCU Santiago de Compostela","Santiago de Compostela","15706",{"lat":670,"lon":671},42.88052,-8.54569,{"facility":673,"status":8,"city":674,"zip":675,"country":619,"geoPoint":676},"Hospital Universitario de Valme","Seville","41014",{"lat":677,"lon":678},37.38283,-5.97317,{"facility":680,"status":8,"city":681,"zip":682,"country":683,"geoPoint":684},"Linkoping University Hospital","Linköping","581 85","Sweden",{"lat":685,"lon":686},58.41086,15.62157,{"facility":688,"status":8,"city":689,"zip":690,"country":683,"geoPoint":691},"Karolinska University Hospital","Stockholm","SE-171 76",{"lat":692,"lon":693},59.32938,18.06871,[695],{"name":696,"role":697,"phone":698,"email":699},"John Mei","CONTACT","650-542-0136","jmei@kartosthera.com",[],[],[],{"nct_id":4,"conditions":704,"biomarkers":706},[705],"Endometrial Carcinoma",[],{"nct_id":4,"found":15,"summary":708,"prompt_version":718},{"design":709,"status":710,"heading":711,"summary":712,"follow_up":713,"word_count":714,"commitments":715,"compensation":716,"drugs_mentioned":717},"This interventional study has two parts. Part 1 will compare two doses of navtemadlin to an observational control, and Part 2 will compare the chosen navtemadlin dose to a placebo.","completed","Navtemadlin as Maintenance Therapy for Endometrial Cancer","This study is testing an experimental oral drug called navtemadlin as a maintenance treatment for advanced or recurrent endometrial cancer. You may be able to join if you are a woman aged 18 or older, have endometrial cancer that is TP53WT (a specific genetic marker), and have completed chemotherapy with a good response (complete or partial response). The study aims to see if navtemadlin can help prevent the cancer from growing or returning for a longer time compared to a placebo (an inactive pill that looks the same). The study is currently unclear on its recruitment status and plans to enroll 268 participants.","The study will measure how long participants live without their cancer progressing for up to 50 months.",103,"Not specified in the trial record.","Not stated in the trial record.",[33],"v2"]