[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT05848713":3,"trial-entities:NCT05848713":722,"trial-summary:NCT05848713":726},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":19,"study_type":29,"primary_purpose":30,"phases":31,"enrollment_info":33,"interventions":36,"primary_outcomes":42,"secondary_outcomes":47,"sex":73,"minimum_age":74,"maximum_age":75,"healthy_volunteers":76,"eligibility_criteria":77,"std_ages":81,"locations":84,"central_contacts":701,"overall_officials":706,"references":716,"see_also_links":721},"NCT05848713","ATTACC-CAP","AntiThrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia","RECRUITING","2029-03-31","2026-04","2026-04-21","2023-10-10","University of Manitoba","OTHER",true,"This is an international, open-label, stratified randomized controlled trial with Bayesian adaptive stopping rules to compare the effects of therapeutic-dose heparin vs. usual care pharmacological thromboprophylaxis on outcomes in patients admitted to hospital with community acquired pneumonia (CAP).","The global incidence of hospitalization due to CAP is high and associated with substantive morbidity and mortality. Thrombotic complications - including venous, arterial, and possibly microvascular - occur commonly in hospitalized patients across many etiologies of CAP. Poor outcomes may be mediated by both inflammatory and thrombotic processes leading to respiratory, cardiac, and other end organ dysfunction. There are currently no established therapies that modify the potentially maladaptive immunothrombosis pathway in CAP.\n\nTherapeutic-dose anticoagulation with heparin reduces disease progression and mortality in non-critically ill patients hospitalized with COVID-19 with an acceptable safety profile. COVID-19 shares pathogenic features, including activation of the inflammatory and coagulation cascades, with other pneumonias. Whether therapeutic-dose heparin confers similar clinical benefits in non-COVID-19 CAP is unknown.",[18],"Community-acquired Pneumonia",[20,21,22,23,24,25,26,27,28],"Pneumonia","Heparin","Anticoagulation","Community acquired pneumonia","Unfractionated Heparin","Low Molecular Weight Heparin","Dalteparin","Enoxaparin","Tinzaparin","INTERVENTIONAL","TREATMENT",[32],"PHASE3",{"count":34,"type":35},4000,"ESTIMATED",[37],{"type":38,"name":21,"description":39,"armGroupLabels":40},"DRUG","Preference is for LMWH given ease of administration and possibility of a more favorable safety profile, if no contraindication is present. Enoxaparin, dalteparin, or tinzaparin are acceptable LMWHs to be used for patients in the investigational arm and dose should be based on measured or estimated weight of the patient.\n\nAlternatively, intravenous UFH may be used and may be preferred in the presence of significant renal compromise. Intravenous UFH is typically dosed according to total body weight and pragmatically adjusted according to local institutional policy to achieve an activated partial thromboplastin time (aPTT) of 1.5-2.5x the reference value, or a corresponding UFH anti-Xa level. If UFH is used, the availability of a local site policy that specifies an aPTT target in this range or a corresponding anti-Xa value is a requirement.",[41],"Therapeutic-Dose Heparin",[43],{"measure":44,"description":45,"timeFrame":46},"Ordinal endpoint reflecting survival","Survival to hospital discharge without ICU-level organ support. Organ support is defined as receipt of high flow nasal oxygen, invasive or non-invasive mechanical ventilation, vasopressor\u002Finotropic therapy, or extracorporeal life support (ECLS) within an ICU. This outcome reflects disease progression to ICU-level organ failure or the worst possible outcome (death). It was chosen because of its importance to patients, clinicians, and other stakeholders. Given the limited number of ICU beds, reducing the burden of critical illness has important health system capacity implications.","30 days",[48,52,55,59,62,65,68,71],{"measure":49,"description":50,"timeFrame":51},"Bleeding events","Number of participants with major bleeds as defined by the ISTH definition.","14 days",{"measure":53,"description":54,"timeFrame":51},"HIT events","Number of participants with laboratory confirmed heparin induced thrombocytopenia (HIT)",{"measure":56,"description":57,"timeFrame":58},"Thrombotic events","Number of participants with deep vein thrombosis, pulmonary embolism, systemic arterial thromboembolism, myocardial infarction, or ischemic stroke","30 days and 90 days",{"measure":60,"description":61,"timeFrame":46},"Invasive mechanical ventilation","Ordered categorical endpoint with three possible outcomes based on the worst status of each patient through day 30 following randomization",{"measure":63,"timeFrame":64},"All cause mortality","30 days, 90 days, and 180 days",{"measure":66,"description":67,"timeFrame":64},"Hospital-free days","Days alive outside hospital",{"measure":69,"description":70,"timeFrame":64},"Health related quality of life","Using the EQ-5D-5L instrument",{"measure":69,"description":72,"timeFrame":64},"Using the Clinical Frailty Scale instrument","ALL","18 Years",null,false,{"inclusion":78,"exclusion":79,"raw_text":80},[],[],"Inclusion Criteria:\n\n1. Patients ≥18 years of age\n2. Admitted to hospital for a suspected or confirmed diagnosis of CAP defined by:\n\n   1. Radiographic evidence of new or worsening infiltrate\n   2. One or more of the following signs and\u002For symptoms of lower respiratory tract infection\n\n   i. New or increased cough or sputum production ii. Fever of \\> 37.8C or temperature \\\u003C 36C iii. WBC \\> 11 x 109\u002FL or \\\u003C 4 x 109\u002FL c. The primary diagnosis is believed to be CAP as per the attending physician\n3. Requires supplemental oxygen to treat hypoxemia (or requires an increased level of supplemental oxygen if on chronic oxygen therapy)\n4. Hospital admission anticipated to last ≥72 hours from randomization\n\nExclusion Criteria:\n\n1. Suspected or confirmed active COVID-19 infection\n2. Hospital admission for \\>72 hours prior to randomization\n3. Patients receiving non-invasive or invasive ventilation, vasopressors, or extracorporeal life support (ECLS) within an ICU at the time of enrollment\n4. Requirement for chronic mechanical ventilation via tracheostomy prior to hospitalization\n5. Patients for whom the intent is to not use pharmacologic thromboprophylaxis\n6. Patients with an independent indication for therapeutic-dose anticoagulation\n7. Patients with a contraindication to therapeutic-dose anticoagulation, including:\n\n   1. Non-traumatic bleeding that requires medical evaluation or hospitalization within 30 days prior to CAP hospital admission\n   2. History of an inherited or acquired bleeding disorder\n   3. Cerebral aneurysm or mass lesions of the central nervous system\n   4. Ischemic stroke within 3 months of hospital admission\n   5. Gastrointestinal bleeding within 3 months of hospital admission\n   6. Platelet count \\\u003C50 x109\u002FL OR INR \\>2.0 OR hemoglobin \\\u003C80 g\u002FL at the time of screening\n   7. Other physician-perceived contraindications to therapeutic anticoagulation\n8. History of heparin induced thrombocytopenia (HIT) or other heparin allergy\n9. Current or recent (within 7 days of screening) use of dual anti-platelet inhibitors (For example; Aspirin + one of the following; clopidogrel, ticagrelor, prasugrel)\n10. Patients in whom imminent death is anticipated\n11. Anticipated transfer to another hospital that is not a study site within 72 hours of randomization\n12. Enrollment in other interventional trials related to anticoagulation or antiplatelet therapy during current hospitalization",[82,83],"ADULT","OLDER_ADULT",[85,99,110,123,132,144,156,169,179,189,196,203,210,218,230,237,244,256,259,270,280,283,294,305,315,325,336,343,354,364,374,385,392,402,412,422,431,439,446,453,468,479,490,501,512,520,529,541,553,565,572,585,594,600,609,620,628,640,650,656,664,673,679,689],{"facility":86,"status":87,"city":88,"state":89,"zip":90,"country":91,"contacts":92,"geoPoint":96},"University of Chicago","NOT_YET_RECRUITING","Chicago","Illinois","60637","United States",[93],{"name":94,"role":95},"Jonathan Paul, MD","CONTACT",{"lat":97,"lon":98},41.85003,-87.65005,{"facility":100,"status":7,"city":101,"state":102,"zip":103,"country":91,"contacts":104,"geoPoint":107},"Ochsner Clinic","Jefferson","Louisiana","70121",[105],{"name":106,"role":95},"Derek Vondehaar, MD",{"lat":108,"lon":109},29.96604,-90.15313,{"facility":111,"status":7,"city":112,"state":113,"zip":114,"country":91,"contacts":115,"geoPoint":120},"Maine Medical Centre","Portland","Maine","04102",[116,118],{"name":117,"role":95},"Daniel Meyer, MD",{"name":117,"role":119},"PRINCIPAL_INVESTIGATOR",{"lat":121,"lon":122},43.65737,-70.2589,{"facility":124,"status":125,"city":126,"state":127,"zip":128,"country":91,"geoPoint":129},"Henry Ford Health System","COMPLETED","Dearborn","Michigan","48128",{"lat":130,"lon":131},42.32226,-83.17631,{"facility":133,"status":7,"city":134,"state":135,"zip":136,"country":91,"contacts":137,"geoPoint":141},"Cooper University Health Care","Camden","New Jersey","08103",[138,140],{"name":139,"role":95},"Adam Green, MD",{"name":139,"role":119},{"lat":142,"lon":143},39.92595,-75.11962,{"facility":145,"status":7,"city":146,"state":147,"zip":148,"country":91,"contacts":149,"geoPoint":153},"Medical College of Wisconsin","Milwaukee","Wisconsin","53226",[150,152],{"name":151,"role":95},"Alisha Sharma, MD",{"name":151,"role":119},{"lat":154,"lon":155},43.0389,-87.90647,{"facility":157,"status":7,"city":158,"state":159,"zip":160,"country":161,"contacts":162,"geoPoint":166},"Hospital Estadual Dr. Jayme Santos Neves","Serra","Espírito Santo","29166-828","Brazil",[163,165],{"name":164,"role":95},"Marcus Matos, MD",{"name":164,"role":119},{"lat":167,"lon":168},-20.12861,-40.30778,{"facility":170,"status":7,"city":171,"state":159,"country":161,"contacts":172,"geoPoint":176},"Hospital Evangelico de Vila Velha","Vila Velha",[173,175],{"name":174,"role":95},"Joao Moraes Junior, MD",{"name":174,"role":119},{"lat":177,"lon":178},-20.32972,-40.2925,{"facility":180,"status":87,"city":181,"state":159,"country":161,"contacts":182,"geoPoint":186},"Hospital Universitário Cassiano Antonio Moraes","Vitória",[183,185],{"name":184,"role":95},"Felipe Vieira, MD",{"name":184,"role":119},{"lat":187,"lon":188},-20.31944,-40.33778,{"facility":190,"status":125,"city":191,"state":192,"country":161,"geoPoint":193},"Santa Casa de Misericordia de Itabuna","Itabuna","Estado de Bahia",{"lat":194,"lon":195},-14.78556,-39.28028,{"facility":197,"status":125,"city":198,"state":199,"country":161,"geoPoint":200},"Hospital Brasilia","Brasília","Federal District",{"lat":201,"lon":202},-15.77972,-47.92972,{"facility":204,"status":87,"city":198,"state":199,"country":161,"contacts":205,"geoPoint":209},"Hospital Sao Brasilia",[206,208],{"name":207,"role":95},"Mauricio Pompilio, MD",{"name":207,"role":119},{"lat":201,"lon":202},{"facility":211,"status":7,"city":198,"state":199,"country":161,"contacts":212,"geoPoint":217},"Instituto de Cardiologia e Transplantes do Distrito Federal",[213,215],{"name":214,"role":95},"Adegil Silva",{"name":216,"role":119},"Adegil Silva, MD",{"lat":201,"lon":202},{"facility":219,"status":7,"city":220,"state":221,"country":161,"contacts":222,"geoPoint":227},"Hospital de Messejana Dr. Carlos Alberto Studart Gomes","Goiânia","Goiás",[223,225],{"name":224,"role":95},"Sandra Nivea dos Reis Saraiva, MD",{"name":226,"role":119},"Sandra Navea do Reis Saraiva, MD",{"lat":228,"lon":229},-16.67861,-49.25389,{"facility":231,"status":7,"city":220,"state":221,"country":161,"contacts":232,"geoPoint":236},"Hospital Ruy Azeredo",[233,235],{"name":234,"role":95},"Rafael Bastos, MD",{"name":234,"role":119},{"lat":228,"lon":229},{"facility":238,"status":7,"city":220,"state":221,"country":161,"contacts":239,"geoPoint":243},"Instituto Goiano de Oncologia e Hematologia - INGOH",[240,242],{"name":241,"role":95},"Mayler Santos, MD",{"name":241,"role":119},{"lat":228,"lon":229},{"facility":245,"status":7,"city":246,"state":247,"country":161,"contacts":248,"geoPoint":253},"Hospital Felicio Rocho","Belo Horizonte","Minas Gerais",[249,251],{"name":250,"role":95},"Ana Carolina Procopio",{"name":252,"role":119},"Ana Carolina Procopio, MD",{"lat":254,"lon":255},-19.92083,-43.93778,{"facility":257,"status":125,"city":246,"state":247,"country":161,"geoPoint":258},"NUPEC-Orizonti",{"lat":254,"lon":255},{"facility":260,"status":7,"city":261,"state":262,"zip":263,"country":161,"contacts":264,"geoPoint":267},"Hospital do Rocio","Campo Largo","Paraná","83606-177",[265],{"name":266,"role":95},"CESAR DUSILEK, MD",{"lat":268,"lon":269},-25.45955,-49.53014,{"facility":271,"status":7,"city":272,"state":262,"country":161,"contacts":273,"geoPoint":277},"Hospital Santa Cruz","Curitiba",[274,276],{"name":275,"role":95},"Marcelo Carneiro, MD",{"name":275,"role":119},{"lat":278,"lon":279},-25.42778,-49.27306,{"facility":281,"status":125,"city":272,"state":262,"country":161,"geoPoint":282},"PUCPR",{"lat":278,"lon":279},{"facility":284,"status":7,"city":285,"state":286,"country":161,"contacts":287,"geoPoint":291},"Hospital Bruno Born","Lajeado","Rio Grande do Sul",[288,290],{"name":289,"role":95},"Lucas Mallmann, MD",{"name":289,"role":119},{"lat":292,"lon":293},-29.46694,-51.96139,{"facility":295,"status":7,"city":296,"state":286,"country":161,"contacts":297,"geoPoint":302},"Hospital Sao Vicente de Paulo","Passo Fundo",[298,300],{"name":299,"role":95},"Alexandre Tognon, MD",{"name":301,"role":119},"Alexandre Tognon",{"lat":303,"lon":304},-28.26278,-52.40667,{"facility":306,"status":7,"city":307,"state":286,"country":161,"contacts":308,"geoPoint":312},"Hospital de Clínicas de Porto Alegre","Porto Alegre",[309,311],{"name":310,"role":95},"Paulo Dalcin, MD",{"name":310,"role":119},{"lat":313,"lon":314},-30.03283,-51.23019,{"facility":316,"status":7,"city":317,"state":286,"country":161,"contacts":318,"geoPoint":322},"Hospital Universitario de Santa Maria","Santa Maria",[319,321],{"name":320,"role":95},"Ariovaldo Fagudes, MD",{"name":320,"role":119},{"lat":323,"lon":324},-29.68417,-53.80694,{"facility":326,"status":7,"city":327,"state":328,"country":161,"contacts":329,"geoPoint":333},"Hospital Sao Jose","Criciúma","Santa Catarina",[330,332],{"name":331,"role":95},"Felipe Pizzol, MD",{"name":331,"role":119},{"lat":334,"lon":335},-28.6775,-49.36972,{"facility":337,"status":125,"city":338,"state":339,"country":161,"geoPoint":340},"Hospital Regional Homero Miranda Gomes","São José","South Carolina",{"lat":341,"lon":342},-27.61528,-48.6275,{"facility":344,"status":87,"city":345,"state":346,"country":161,"contacts":347,"geoPoint":351},"Hospital de Reabilitacao de Anomalias Craniofaciais","Bauru","São Paulo",[348,350],{"name":349,"role":95},"Lucas Soler, MD",{"name":349,"role":119},{"lat":352,"lon":353},-22.31472,-49.06056,{"facility":355,"status":7,"city":356,"state":346,"country":161,"contacts":357,"geoPoint":361},"UPECLIN - Unidade de Pesquisa Clínica da Faculdade de Medicina de Botucatu","Botucatu",[358,360],{"name":359,"role":95},"Suzana Erico Tanni, MD",{"name":359,"role":119},{"lat":362,"lon":363},-22.88583,-48.445,{"facility":365,"status":7,"city":366,"state":346,"country":161,"contacts":367,"geoPoint":371},"Hospital Universitario Sao Francisco na Providencia na Deus","Bragança Paulista",[368,370],{"name":369,"role":95},"Gustavo Mamprin, MD",{"name":369,"role":119},{"lat":372,"lon":373},-22.9527,-46.54418,{"facility":375,"status":7,"city":376,"state":346,"zip":377,"country":161,"contacts":378,"geoPoint":382},"Fundação Centro Médico de Campinas","Campinas","13083-190",[379,381],{"name":380,"role":95},"Otavio Coelho, MD",{"name":380,"role":119},{"lat":383,"lon":384},-22.90556,-47.06083,{"facility":386,"status":7,"city":376,"state":346,"country":161,"contacts":387,"geoPoint":391},"IPECC",[388,390],{"name":389,"role":95},"Jose Francisco Kerr Saraiva, MD",{"name":389,"role":119},{"lat":383,"lon":384},{"facility":393,"status":7,"city":394,"state":346,"country":161,"contacts":395,"geoPoint":399},"CiTen - Centro Hospital Municipal Antonio Giglio","Osasco",[396,398],{"name":397,"role":95},"Enrico Fortunato, MD",{"name":397,"role":119},{"lat":400,"lon":401},-23.5325,-46.79167,{"facility":403,"status":7,"city":404,"state":346,"country":161,"contacts":405,"geoPoint":409},"Hospital Regional de Presidente Prudente","Presidente Prudente",[406,408],{"name":407,"role":95},"Luis Felipe Pires, MD",{"name":407,"role":119},{"lat":410,"lon":411},-22.12556,-51.38889,{"facility":413,"status":87,"city":414,"state":346,"country":161,"contacts":415,"geoPoint":419},"Hospital Estadual de Serrana","Ribeirão Preto",[416,418],{"name":417,"role":95},"Marcos Borges, MD",{"name":417,"role":119},{"lat":420,"lon":421},-21.1775,-47.81028,{"facility":423,"status":7,"city":346,"state":346,"zip":424,"country":161,"contacts":425,"geoPoint":428},"Hospital Nipo-Brasileiro","02189-010",[426],{"name":427,"role":95},"Jose Victor Krasner Schubsky, MD",{"lat":429,"lon":430},-23.5475,-46.63611,{"facility":432,"status":7,"city":346,"state":346,"zip":433,"country":161,"contacts":434,"geoPoint":438},"HCFMUSP","05403-010",[435,437],{"name":436,"role":95},"Ludhmila Hajjar, MD",{"name":436,"role":119},{"lat":429,"lon":430},{"facility":440,"status":87,"city":346,"state":346,"country":161,"contacts":441,"geoPoint":445},"Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo",[442,444],{"name":443,"role":95},"Julio Alencar, MD",{"name":443,"role":119},{"lat":429,"lon":430},{"facility":447,"status":7,"city":346,"state":346,"country":161,"contacts":448,"geoPoint":452},"Santa Casa de Misericordia de Sao Paulo",[449,451],{"name":450,"role":95},"Ricardo Chinarelli, MD",{"name":450,"role":119},{"lat":429,"lon":430},{"facility":454,"status":7,"city":455,"state":456,"zip":457,"country":458,"contacts":459,"geoPoint":465},"Foothills Medical Centre","Calgary","Alberta","T2N 2T9","Canada",[460,464],{"name":461,"role":95,"phone":462,"email":463},"Deepa Suryanarayan, MD","4039448167","dsuryana@ucalgary.ca",{"name":461,"role":119},{"lat":466,"lon":467},51.05011,-114.08529,{"facility":469,"status":87,"city":470,"state":456,"zip":471,"country":458,"contacts":472,"geoPoint":476},"Grand Prairie Regional Hospital","Grande Prairie","T8V 4B1",[473,475],{"name":474,"role":95},"Tafi Madzimure, MD",{"name":474,"role":119},{"lat":477,"lon":478},55.16667,-118.80271,{"facility":480,"status":7,"city":481,"state":482,"country":458,"contacts":483,"geoPoint":487},"Nanaimo Regional General Hospital","Nanaimo","British Columbia",[484,486],{"name":485,"role":95},"Alistair Teale, MD",{"name":485,"role":119},{"lat":488,"lon":489},49.16638,-123.94003,{"facility":491,"status":7,"city":492,"state":482,"zip":493,"country":458,"contacts":494,"geoPoint":498},"Vancouver General Hospital","Vancouver","V5Z 1M9",[495,497],{"name":496,"role":95},"Ted Steiner, MD",{"name":496,"role":119},{"lat":499,"lon":500},49.24966,-123.11934,{"facility":502,"status":7,"city":503,"state":504,"zip":505,"country":458,"contacts":506,"geoPoint":509},"Health Sciences Center Winnipeg","Winnipeg","Manitoba","R3A 1R9",[507],{"name":508,"role":95},"Brett Houstin, MD",{"lat":510,"lon":511},49.8844,-97.14704,{"facility":513,"status":7,"city":503,"state":504,"country":458,"contacts":514,"geoPoint":519},"Grace General Hospital",[515,518],{"name":516,"role":95,"email":517},"Sylvain Lother, MD","sylvain.lother@umanitoba.ca",{"name":516,"role":119},{"lat":510,"lon":511},{"facility":521,"status":7,"city":503,"state":504,"country":458,"contacts":522,"geoPoint":528},"St. Boniface General Hospital",[523,525,527],{"name":524,"role":95},"Vi Dao, MD",{"name":526,"role":119},"Terry Wuerz, MD",{"name":524,"role":119},{"lat":510,"lon":511},{"facility":530,"status":7,"city":531,"state":532,"zip":533,"country":458,"contacts":534,"geoPoint":538},"Memorial University","St. John's","Newfoundland and Labrador","A1C 5S7",[535,537],{"name":536,"role":95},"Peter Daley, MD",{"name":536,"role":119},{"lat":539,"lon":540},47.56494,-52.70931,{"facility":542,"status":7,"city":543,"state":544,"zip":545,"country":458,"contacts":546,"geoPoint":550},"Health Sciences North Research Institute","Greater Sudbury","Ontario","P3E 2H3",[547,549],{"name":548,"role":95},"Pandma Puranam, MD",{"name":548,"role":119},{"lat":551,"lon":552},46.49,-80.99001,{"facility":554,"status":7,"city":555,"state":544,"country":458,"contacts":556,"geoPoint":562},"Hamilton Health Sciences - Juravinski","Hamilton",[557,559,560],{"name":558,"role":95},"Bram Rochwerg, MD",{"name":558,"role":119},{"name":561,"role":119},"Dominik Mertz, MD",{"lat":563,"lon":564},43.25011,-79.84963,{"facility":566,"status":7,"city":555,"state":544,"country":458,"contacts":567,"geoPoint":571},"Hamilton Health Sciences",[568,570],{"name":569,"role":95},"Alison Fox-Robichaud, MD",{"name":569,"role":119},{"lat":563,"lon":564},{"facility":573,"status":7,"city":574,"state":544,"zip":575,"country":458,"contacts":576,"geoPoint":582},"Markham Stouffville Hospital","Markham","L3P 7P3",[577,579,580],{"name":578,"role":95},"Paul Lee, MD",{"name":578,"role":119},{"name":581,"role":119},"Janet Nguyen, MD",{"lat":583,"lon":584},43.86682,-79.2663,{"facility":586,"status":7,"city":587,"state":544,"country":458,"contacts":588,"geoPoint":591},"Hôpital Montfort","Ottawa",[589],{"name":590,"role":95},"Marc Carrier, MD",{"lat":592,"lon":593},45.41117,-75.69812,{"facility":595,"status":7,"city":587,"state":544,"country":458,"contacts":596,"geoPoint":599},"The Ottawa Hospital",[597],{"name":598,"role":95},"Lana Castellucci, MD",{"lat":592,"lon":593},{"facility":601,"status":7,"city":602,"state":544,"zip":603,"country":458,"contacts":604},"Niagara Health System - St Catharines Site","Saint Catherines","L2S 0A9",[605,608],{"name":606,"role":95,"email":607},"Aidan Findlater, MD","Aidan.Findlater@niagarahealth.on.ca",{"name":606,"role":119},{"facility":610,"status":7,"city":611,"state":544,"zip":612,"country":458,"contacts":613,"geoPoint":617},"Sunnybrook Health Sciences Centre","Toronto","M4N 3M5",[614,616],{"name":615,"role":95},"Jonathan Zipursky, MD",{"name":615,"role":119},{"lat":618,"lon":619},43.70643,-79.39864,{"facility":621,"status":87,"city":611,"state":544,"zip":622,"country":458,"contacts":623,"geoPoint":627},"University Health Network","M5G2C4",[624,626],{"name":625,"role":95},"Jameel Abdulrehman, MD",{"name":625,"role":119},{"lat":618,"lon":619},{"facility":629,"status":87,"city":630,"state":631,"zip":632,"country":458,"contacts":633,"geoPoint":637},"Centre Hospitalier de Quebec - Hotel-Dieu de Levis","Lévis","Quebec","G6V 3Z1",[634,636],{"name":635,"role":95},"Patrick Archambault, MD",{"name":635,"role":119},{"lat":638,"lon":639},46.80326,-71.17793,{"facility":641,"status":7,"city":642,"state":631,"zip":643,"country":458,"contacts":644,"geoPoint":647},"McGill University Health Centre","Montreal","H4A3J1",[645],{"name":646,"role":95},"Emily Gibson McDonald, MD, MSc",{"lat":648,"lon":649},45.50884,-73.58781,{"facility":651,"status":7,"city":642,"state":631,"country":458,"contacts":652,"geoPoint":655},"Centre Hospitalier de l'université de Montréal (CHUM)",[653],{"name":654,"role":95},"Emmanuelle Duceppe, MD",{"lat":648,"lon":649},{"facility":657,"status":7,"city":642,"state":631,"country":458,"contacts":658,"geoPoint":663},"Jewish General Hospital",[659,661],{"name":660,"role":95},"Susan Khan, MD",{"name":662,"role":95},"Vicky Tagalakis, MD",{"lat":648,"lon":649},{"facility":665,"status":7,"city":666,"state":631,"country":458,"contacts":667,"geoPoint":670},"CHU de Quebec-University Laval","Québec",[668],{"name":669,"role":95},"Alexis Turgeon, MD, MSc",{"lat":671,"lon":672},46.81228,-71.21454,{"facility":674,"status":7,"city":666,"state":631,"country":458,"contacts":675,"geoPoint":678},"Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ)",[676],{"name":677,"role":95},"Francois Lallouche, MD",{"lat":671,"lon":672},{"facility":680,"status":7,"city":681,"state":631,"country":458,"contacts":682,"geoPoint":686},"Centre Hospitalier Universitaire de Sherbrooke","Sherbrooke",[683,685],{"name":684,"role":95},"Francois Lamontagne, MD",{"name":684,"role":119},{"lat":687,"lon":688},45.40008,-71.89908,{"facility":690,"status":7,"city":691,"state":692,"zip":693,"country":458,"contacts":694,"geoPoint":698},"Regina General Hospital","Regina","Saskatchewan","S4P 0W5",[695,697],{"name":696,"role":95},"Payam Dehghani, MD",{"name":696,"role":119},{"lat":699,"lon":700},50.45008,-104.6178,[702],{"name":703,"role":95,"phone":704,"email":705},"Chantale Pineau","2042353223","attacc.cap@umanitoba.ca",[707,709,712,713],{"name":708,"affiliation":12,"role":119},"Ryan Zarychanski, MD",{"name":710,"affiliation":711,"role":119},"Patrick Lawler, MD","University Health Network and McGill University",{"name":516,"affiliation":12,"role":119},{"name":714,"affiliation":715,"role":119},"Alexis Turgeon, MD","L'Universite Laval",[717],{"pmid":718,"type":719,"citation":720},"34351721","BACKGROUND","ATTACC Investigators; ACTIV-4a Investigators; REMAP-CAP Investigators; Lawler PR, Goligher EC, Berger JS, Neal MD, McVerry BJ, Nicolau JC, Gong MN, Carrier M, Rosenson RS, Reynolds HR, Turgeon AF, Escobedo J, Huang DT, Bradbury CA, Houston BL, Kornblith LZ, Kumar A, Kahn SR, Cushman M, McQuilten Z, Slutsky AS, Kim KS, Gordon AC, Kirwan BA, Brooks MM, Higgins AM, Lewis RJ, Lorenzi E, Berry SM, Berry LR, Aday AW, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Costantini TW, de Brouwer S, Derde LPG, Detry MA, Duggal A, Dzavik V, Effron MB, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Galanaud JP, Galen BT, Gandotra S, Garcia-Madrona S, Girard TD, Godoy LC, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Hamburg NM, Haniffa R, Hanna G, Hanna N, Hegde SM, Hendrickson CM, Hite RD, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Hudock K, Hunt BJ, Husain M, Hyzy RC, Iyer VN, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski AL, King AJ, Knudson MM, Kornblith AE, Krishnan V, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Lima FG, Linstrum K, Litton E, Lopez-Sendon J, Lopez-Sendon Moreno JL, Lother SA, Malhotra S, Marcos M, Saud Marinez A, Marshall JC, Marten N, Matthay MA, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Moore SC, Morillo Guerrero R, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nunez-Garcia B, Pandey A, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Perez Gonzalez YS, Pompilio M, Prekker ME, Quigley JG, Rost NS, Rowan K, Santos FO, Santos M, Olombrada Santos M, Satterwhite L, Saunders CT, Schutgens REG, Seymour CW, Siegal DM, Silva DG Jr, Shankar-Hari M, Sheehan JP, Singhal AB, Solvason D, Stanworth SJ, Tritschler T, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Wells BJ, Widmer RJ, Wilson JG, Yuriditsky E, Zampieri FG, Angus DC, McArthur CJ, Webb SA, Farkouh ME, Hochman JS, Zarychanski R. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. N Engl J Med. 2021 Aug 26;385(9):790-802. doi: 10.1056\u002FNEJMoa2105911. Epub 2021 Aug 4.",[],{"nct_id":4,"conditions":723,"biomarkers":725},[724],"Community-Acquired Pneumonia",[],{"nct_id":4,"found":14,"summary":727,"prompt_version":737},{"design":728,"status":729,"heading":730,"summary":731,"follow_up":732,"word_count":733,"commitments":734,"compensation":735,"drugs_mentioned":736},"This is an international, open-label, randomized controlled trial comparing therapeutic-dose heparin to usual care in about 4000 participants.","completed","AntiThrombotic Therapy for Community-Acquired Pneumonia","This study is looking at whether a blood thinner called heparin (specifically low molecular weight heparin like enoxaparin, dalteparin, or tinzaparin) can help patients admitted to the hospital with community-acquired pneumonia (CAP). CAP is a lung infection that develops outside of a hospital setting. Researchers want to see if heparin, given at a therapeutic dose, can improve patient outcomes compared to the usual care for preventing blood clots. The study will enroll about 4000 adults, aged 18 and older, who have CAP confirmed by X-ray and symptoms like cough or fever. The main goal is to see how many people survive 30 days after starting treatment. The current recruitment status is unclear.","Participants' survival will be measured at 30 days.",112,"Not specified in the trial record.","Not stated in the trial record.",[21],"v2"]