[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06001736":3,"trial-entities:NCT06001736":88,"trial-summary:NCT06001736":94},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":22,"study_type":26,"primary_purpose":27,"phases":28,"enrollment_info":30,"interventions":33,"primary_outcomes":39,"secondary_outcomes":44,"sex":45,"minimum_age":46,"maximum_age":47,"healthy_volunteers":48,"eligibility_criteria":49,"std_ages":56,"locations":59,"central_contacts":78,"overall_officials":83,"references":86,"see_also_links":87},"NCT06001736","STUDY02000586","Utility of CC7 Transfer in Stroke Subtypes","Seventh Cervical Nerve Transfer for Spastic Arm Paresis: A Prospective Analysis of Efficacy in Ischemic vs. Hemorrhagic Stroke","RECRUITING","2027-03-01","2026-02","2026-02-27","2022-03-13","Dartmouth-Hitchcock Medical Center","OTHER",null,"The purpose of this study is to evaluate the limb functional improvement after contralateral C7 root transfer in stroke patients.","Spastic limb paresis after stroke is a cause of long-term disability and reduction is quality of life, with loss of hand dexterity being especially prohibitive. In the recovery phase after initial injury, neural reorganization occurs and has been observed in both ipsilateral and contralateral hemispheres. Previous studies have identified contralesional (opposite to the side of the injury), in other words, ipsilateral, activation in the recovery of paretic hand function. However, this pathway of recovery is limited due to sparse connections between the ipsilateral hemisphere and the affected arm\u002Fhand. By establishing an anatomic connection between the ipsilateral hemisphere and the paretic arm with contralateral nerve transfer, compensatory capacity of the ipsilateral hemisphere is facilitated. This cross neck C7-C7 root transfer is an established procedure for the treatment of brachial plexus injuries and recently, for the treatment of spastic arm paresis in those with cerebral injury.",[19,20,21],"Stroke, Ischemic","Stroke Hemorrhagic","Spastic Hemiparesis",[23,24,25],"Ischemic stroke","Hemorrhagic stroke","Spastic hemiparesis","INTERVENTIONAL","TREATMENT",[29],"NA",{"count":31,"type":32},95,"ESTIMATED",[34],{"type":35,"name":36,"description":37,"armGroupLabels":38},"PROCEDURE","Contralateral C7 root transfer for the treatment of spastic hemiparesis.","Performing surgery to transfer the C7 nerve to treat stroke patients experiencing spastic hemiparesis.",[36],[40],{"measure":41,"description":42,"timeFrame":43},"Change from baseline in arm function, as measured by the Fugl-Meyer upper-extremity scale.","The Fugl-Meyer is a widely used and highly recommended stroke-specific, performance-based measure of impairment with 5 domains and a possible 226 points.","12 months with visits at baseline and months 2, 4, 8, and 12 months after surgery.",[],"ALL","18 Years","65 Years",false,{"inclusion":50,"exclusion":53,"raw_text":55},[51,52],"History of ischemic or hemorrhagic stroke with resultant arm paresis that has ceased to improve within 1-5 years of rehabilitation.","baseline Fugl-Meyer score below 33",[54],"pregnancy","Inclusion Criteria:\n\n* History of ischemic or hemorrhagic stroke with resultant arm paresis that has ceased to improve within 1-5 years of rehabilitation.\n* baseline Fugl-Meyer score below 33\n\nExclusion Criteria:\n\n* pregnancy",[57,58],"ADULT","OLDER_ADULT",[60],{"facility":61,"status":8,"city":62,"state":63,"zip":64,"country":65,"contacts":66,"geoPoint":75},"Dartmouth-Health","Lebanon","New Hampshire","03677","United States",[67,72],{"name":68,"role":69,"phone":70,"email":71},"Lauren Sinks, MPH","CONTACT","603-653-9021","Lauren.J.Sinks@Hitchcock.org",{"name":73,"role":74},"Jennifer Hong, MD","PRINCIPAL_INVESTIGATOR",{"lat":76,"lon":77},43.64229,-72.25176,[79],{"name":80,"role":69,"phone":81,"email":82},"Lauren Sinks","(603) 653-9021","Lauren.J.Sinks@hitchcock.org",[84],{"name":85,"affiliation":13,"role":74},"Jennifer Hong, Dr.",[],[],{"nct_id":4,"conditions":89,"biomarkers":93},[90,91,92],"Hemorrhagic Stroke","Ischemic Stroke","Spastic Hemiplegia",[],{"nct_id":4,"found":95,"summary":96,"prompt_version":106},true,{"design":97,"status":98,"heading":99,"summary":100,"follow_up":101,"word_count":102,"commitments":103,"compensation":104,"drugs_mentioned":105},"This is an interventional study, meaning participants will receive a specific treatment. It aims to enroll 95 participants.","completed","Study of C7 Nerve Transfer for Stroke-Related Arm Weakness","This study is looking at how a surgery called contralateral C7 root transfer can help people who have arm weakness (spastic hemiparesis) after a stroke. This surgery involves moving a nerve from one side of your neck to the other to help improve arm function. You might be able to join if you are between 18 and 65 years old, have had an ischemic (clot-related) or hemorrhagic (bleed-related) stroke, and your arm weakness hasn't improved much with rehabilitation in the last 1-5 years. We will measure success by looking at changes in your arm function using a special scale. The current status of this study is unclear, and it plans to enroll about 95 participants.","Participants will be followed for 12 months after the surgery to assess changes in arm function.",115,"You would have surgery and then follow-up visits at 2, 4, 8, and 12 months after the surgery to measure your arm function.","Not stated in the trial record.",[],"v2"]