[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06079879":3,"trial-entities:NCT06079879":1312,"trial-summary:NCT06079879":1315},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":25,"primary_purpose":26,"phases":27,"enrollment_info":29,"interventions":32,"primary_outcomes":56,"secondary_outcomes":61,"sex":98,"minimum_age":99,"maximum_age":17,"healthy_volunteers":100,"eligibility_criteria":101,"std_ages":117,"locations":120,"central_contacts":1302,"overall_officials":1303,"references":1307,"see_also_links":1308},"NCT06079879","3543-006","A Study of Bomedemstat (IMG-7289\u002FMK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)","A Phase 3, Randomized, Open-label, Active-Comparator-Controlled Clinical Study to Evaluate the Safety and Efficacy of Bomedemstat (MK-3543\u002FIMG-7289) Versus Best Available Therapy (BAT) in Participants With Essential Thrombocythemia Who Have an Inadequate Response to or Are Intolerant of Hydroxyurea","ACTIVE_NOT_RECRUITING","2028-08-18","2026-08","2026-08-13","2023-12-31","Merck Sharp & Dohme LLC","INDUSTRY",true,"This is a study evaluating the safety and efficacy of bomedemstat (MK-3543) compared with the best available therapy (BAT) in participants with essential thrombocythemia (ET) who have an inadequate response to or are intolerant of hydroxyurea. The primary study hypothesis is that bomedemstat is superior to the best available therapy with respect to durable clinicohematologic response (DCHR).",null,[19],"Essential Thrombocythemia",[21,22,23,24],"essential thrombocythemia","ET","bomedemstat","IMG-7289","INTERVENTIONAL","TREATMENT",[28],"PHASE3",{"count":30,"type":31},340,"ESTIMATED",[33,41,45,49,53],{"type":34,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"DRUG","Bomedemstat","Oral Capsule",[35],[39,24,40],"MK-3543","Bomedemstat tosylate",{"type":34,"name":42,"description":36,"armGroupLabels":43},"Anagrelide",[44],"Best Available Therapy",{"type":34,"name":46,"description":47,"armGroupLabels":48},"Busulfan","Oral Tablet",[44],{"type":34,"name":50,"description":51,"armGroupLabels":52},"Interferon alfa\u002Fpegylated interferon alfa 2a\u002Fpegylated interferon alfa 2b","Subcutaneous Solution",[44],{"type":34,"name":54,"description":47,"armGroupLabels":55},"Ruxolitinib",[44],[57],{"measure":58,"description":59,"timeFrame":60},"Durable Clinicohematologic Response (DCHR) Rate","DCHR rate is the percentage of participants with DCHR, defined as a confirmed reduction of platelet count to ≤400 × 10\\^9\u002FL and absence of white blood cell (WBC) count elevation to \\>10 × 10\\^9\u002FL locally assessed to be due to ET, starting by Week 24 and maintained for at least 24 weeks, and the absence of any thrombotic or major hemorrhagic events or disease progression to myelofibrosis (MF), myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) by Week 52.","Up to approximately 52 weeks",[62,65,68,72,75,78,81,84,87,90,93,96],{"measure":63,"description":64,"timeFrame":60},"Clinicohematologic Response (CHR) Rate","CHR rate is the percentage of participants with CHR, defined as a confirmed reduction of platelet count to ≤400 × 10\\^9\u002FL and absence of WBC count elevation to \\>10 × 10\\^9\u002FL locally assessed to be due to ET, maintained for at least 12 weeks, and the absence of any thrombotic or major hemorrhagic events or disease progression to MF, MDS or AML by Week 52.",{"measure":66,"description":67,"timeFrame":60},"Hematologic Response (HR) Rate","HR rate is the percentage of participants with HR, HR is defined as the time from the first confirmed hematologic response to first documented evidence of confirmed platelet increase or confirmed WBC increase after latest confirmed hematologic response date.",{"measure":69,"description":70,"timeFrame":71},"Change From Baseline in Patient-reported Outcomes Measurement Information System (PROMIS) Fatigue SF-7a Total Fatigue Score","The PROMIS Fatigue SF-7a is a 7-item participant-reported assessment that measures both the experience of fatigue and the interference of fatigue on daily activities over the past week. Response options are on a 5-point Likert scale, ranging from 1 = never to 5 = always. The total score is used in the analysis and is obtained by summing keyed scores of all items. Scores can range from 7 to 35, with higher scores indicating greater fatigue.","Baseline and pre-specified timepoints through Week 52",{"measure":73,"description":74,"timeFrame":71},"Change From Baseline in Total Symptom Score as Measured on the MFSAF v4.0","The MFSAF v4.0 is a 7-item participant-reported myelofibrosis symptom assessment which asks respondents to report symptom severity at its worst for each of the 7 items on a 0 (Absent) to 10 (Worst Imaginable) numeric rating scale.",{"measure":76,"description":77,"timeFrame":60},"Duration of Durable Clinicohematologic Response (DODCHR)","For participants who demonstrate DCHR, DODCHR is defined as the time from the first documented evidence of confirmed reduction of platelet and WBC counts until confirmed increase of platelet and WBC counts to above acceptable threshold, thrombotic or major hemorrhagic events, or disease progression to MF, MDS or AML.",{"measure":79,"description":80,"timeFrame":60},"Duration of Clinicohematologic Response (DOCHR)","For participants who demonstrate CHR, DOCHR is defined as the time from the first documented evidence of confirmed reduction of platelet and WBC counts until confirmed increase of platelet and WBC count to above acceptable threshold, thrombotic or major hemorrhagic events, or disease progression to MF, MDS or AML.",{"measure":82,"description":83,"timeFrame":60},"Duration of Hematologic Response (DOHR)","For participants who demonstrate HR, DOHR is defined as the time from the first confirmed hematologic response to first documented evidence of confirmed platelet increase or confirmed WBC increase after latest confirmed hematologic response date.",{"measure":85,"description":86,"timeFrame":60},"Percentage of Participants with Thrombotic Events","Thrombotic events include but are not limited to new or recurrent acute myocardial infarction, unstable angina, stroke, transient ischemic attack, deep venous thrombosis, pulmonary embolism, thrombotic digital ischemia, or other thrombotic events.",{"measure":88,"description":89,"timeFrame":60},"Percentage of Participants with Major Hemorrhagic Events","Major hemorrhagic events include but are not limited to fatal bleeding, and\u002For symptomatic bleeding in a critical area or organ such as intracranial, intraspinal, intraocular, retroperitoneal, intra-articular or pericardial, or intramuscular with compartment syndrome, and\u002For bleeding causing a decrease in hemoglobin level of 2 g\u002FdL or more, or leading to transfusion of 2 or more units of whole blood or red cells.",{"measure":91,"description":92,"timeFrame":60},"Percentage of Participants with Disease Progression to Post-ET MF or MDS\u002FAML","Disease progression rate is the percentage of participants with disease progression, defined as the transformation to post-ET MF, MDS, or AML as assessed by the adjudication committee.",{"measure":94,"description":95,"timeFrame":60},"Number of Participants with An Adverse Event (AE)","An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention.",{"measure":97,"description":95,"timeFrame":60},"Number of Participants Discontinuing From Study Therapy Due to an AE","ALL","18 Years",false,{"inclusion":102,"exclusion":110,"raw_text":116},[103,104,105,106,107,108,109],"Has a diagnosis of ET per WHO 2016 diagnostic criteria for myeloproliferative neoplasms (confirmed by a central pathologist)","Has a centrally assessed bone marrow fibrosis score of Grade 0 or Grade 1, as per a modified version of the European Consensus Criteria for Grading Myelofibrosis","Has a history of inadequate response to or intolerance of hydroxyurea based on modified European LeukemiaNet (ELN) criteria for hydroxyurea resistance or intolerance","Has an inadequate or loss of response to their most recent prior ET therapy, requiring a change of cytoreductive therapy","Has a platelet count \\> 450 × 10\\^9\u002FL (450k \u002FμL) assessed up to 72 hours before first dose of study intervention","Has an absolute neutrophil count (ANC) ≥0.75 × 10\\^9\u002FL assessed up to 72 hours before first dose of study intervention","Participants may have received up to 3 prior ET-directed cytoreductive agents including hydroxyurea",[111,112,113,114,115],"Known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to bomedemstat or lysine demethylase or monoamine oxidase inhibitor (LSDi or MAOi) or the chosen best available therapy (including anagrelide, interferon alfa\u002Fpegylated interferon, ruxolitinib, or busulfan) that contraindicates participation","History of any illness\u002Fimpairment of GI function that might interfere with drug absorption (eg, chronic diarrhea or history of gastric bypass surgical procedure), confound the study results or pose an additional risk to the individual by participation in the study","Evidence at the time of Screening of increased risk of bleeding","History of a malignancy, unless potentially curative treatment has been completed with no evidence of malignancy for 2 years. Note: The time requirement does not apply to participants who underwent successful definitive resection of basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or carcinoma in situ, excluding carcinoma in situ of the bladder","Human immunodeficiency virus (HIV)-infected participants with a history of Kaposi's sarcoma and\u002For Multicentric Castleman's Disease","Inclusion Criteria:\n\n* Has a diagnosis of ET per WHO 2016 diagnostic criteria for myeloproliferative neoplasms (confirmed by a central pathologist)\n* Has a centrally assessed bone marrow fibrosis score of Grade 0 or Grade 1, as per a modified version of the European Consensus Criteria for Grading Myelofibrosis\n* Has a history of inadequate response to or intolerance of hydroxyurea based on modified European LeukemiaNet (ELN) criteria for hydroxyurea resistance or intolerance\n* Has an inadequate or loss of response to their most recent prior ET therapy, requiring a change of cytoreductive therapy\n* Has a platelet count \\> 450 × 10\\^9\u002FL (450k \u002FμL) assessed up to 72 hours before first dose of study intervention\n* Has an absolute neutrophil count (ANC) ≥0.75 × 10\\^9\u002FL assessed up to 72 hours before first dose of study intervention\n* Participants may have received up to 3 prior ET-directed cytoreductive agents including hydroxyurea\n\nExclusion Criteria:\n\n* Known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to bomedemstat or lysine demethylase or monoamine oxidase inhibitor (LSDi or MAOi) or the chosen best available therapy (including anagrelide, interferon alfa\u002Fpegylated interferon, ruxolitinib, or busulfan) that contraindicates participation\n* History of any illness\u002Fimpairment of GI function that might interfere with drug absorption (eg, chronic diarrhea or history of gastric bypass surgical procedure), confound the study results or pose an additional risk to the individual by participation in the study\n* Evidence at the time of Screening of increased risk of bleeding\n* History of a malignancy, unless potentially curative treatment has been completed with no evidence of malignancy for 2 years. Note: The time requirement does not apply to participants who underwent successful definitive resection of basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or carcinoma in situ, excluding carcinoma in situ of the bladder\n* Human immunodeficiency virus (HIV)-infected participants with a history of Kaposi's sarcoma and\u002For Multicentric Castleman's Disease",[118,119],"ADULT","OLDER_ADULT",[121,130,137,144,151,159,167,175,182,190,198,206,213,221,229,237,244,253,258,266,275,282,289,296,304,312,319,327,335,344,352,361,368,376,380,388,395,403,407,415,423,431,439,446,454,462,470,478,486,490,498,506,514,521,530,538,546,555,563,571,579,587,595,602,607,616,624,632,636,644,652,659,666,674,681,685,692,699,706,713,720,729,737,745,753,760,768,775,782,789,796,803,812,820,828,836,844,852,860,868,876,883,888,891,899,906,913,920,927,936,944,951,955,963,967,976,984,992,999,1006,1015,1022,1026,1030,1039,1043,1050,1054,1062,1070,1078,1085,1089,1093,1100,1107,1114,1123,1131,1140,1147,1154,1161,1168,1177,1184,1188,1192,1199,1206,1213,1220,1227,1234,1243,1251,1259,1266,1274,1278,1282,1287,1295],{"facility":122,"city":123,"state":124,"zip":125,"country":126,"geoPoint":127},"Palo Verde Hematology\u002F Oncology Center, Ltd. ( Site 3496)","Glendale","Arizona","85304","United States",{"lat":128,"lon":129},33.53865,-112.18599,{"facility":131,"city":123,"state":132,"zip":133,"country":126,"geoPoint":134},"Los Angeles Cancer Network ( Site 3491)","California","91206",{"lat":135,"lon":136},34.14251,-118.25508,{"facility":138,"city":139,"state":132,"zip":140,"country":126,"geoPoint":141},"Stanford Cancer Institute ( Site 0107)","Stanford","94305-5826",{"lat":142,"lon":143},37.42411,-122.16608,{"facility":145,"city":146,"state":132,"zip":147,"country":126,"geoPoint":148},"The Lundquist Institute ( Site 3423)","Torrance","90502",{"lat":149,"lon":150},33.83585,-118.34063,{"facility":152,"city":153,"state":154,"zip":155,"country":126,"geoPoint":156},"University of Colorado Anschutz Medical Campus ( Site 3425)","Aurora","Colorado","80045",{"lat":157,"lon":158},39.72943,-104.83192,{"facility":160,"city":161,"state":162,"zip":163,"country":126,"geoPoint":164},"Tufts Medical Center ( Site 3408)","Boston","Massachusetts","02111",{"lat":165,"lon":166},42.35843,-71.05977,{"facility":168,"city":169,"state":170,"zip":171,"country":126,"geoPoint":172},"University of Michigan ( Site 0008)","Ann Arbor","Michigan","48109",{"lat":173,"lon":174},42.27756,-83.74088,{"facility":176,"city":177,"state":170,"zip":178,"country":126,"geoPoint":179},"Henry Ford Hospital ( Site 3413)","Detroit","48202",{"lat":180,"lon":181},42.33143,-83.04575,{"facility":183,"city":184,"state":185,"zip":186,"country":126,"geoPoint":187},"Optum Care Cancer Center ( Site 3497)","Las Vegas","Nevada","89102",{"lat":188,"lon":189},36.17497,-115.13722,{"facility":191,"city":192,"state":193,"zip":194,"country":126,"geoPoint":195},"Roswell Park Cancer Institute ( Site 3421)","Buffalo","New York","14263",{"lat":196,"lon":197},42.88645,-78.87837,{"facility":199,"city":200,"state":201,"zip":202,"country":126,"geoPoint":203},"Duke University Health System (DUHS) ( Site 0016)","Durham","North Carolina","27710",{"lat":204,"lon":205},35.99403,-78.89862,{"facility":207,"city":208,"state":201,"zip":209,"country":126,"geoPoint":210},"Wake Forest Baptist Health-Internal Medicine, Section on Hematology & Oncology ( Site 3400)","Winston-Salem","27157",{"lat":211,"lon":212},36.09986,-80.24422,{"facility":214,"city":215,"state":216,"zip":217,"country":126,"geoPoint":218},"Oncology Associates of Oregon, P.C.(Willamette Valley Cancer Institute) (WVCI) ( Site 8000)","Eugene","Oregon","97401",{"lat":219,"lon":220},44.05207,-123.08675,{"facility":222,"city":223,"state":224,"zip":225,"country":126,"geoPoint":226},"Medical University of South Carolina-Hollings Cancer Center ( Site 3426)","Charleston","South Carolina","29425",{"lat":227,"lon":228},32.77632,-79.93275,{"facility":230,"city":231,"state":232,"zip":233,"country":126,"geoPoint":234},"University of Virginia ( Site 3422)","Charlottesville","Virginia","22908",{"lat":235,"lon":236},38.02931,-78.47668,{"facility":238,"city":239,"state":232,"zip":240,"country":126,"geoPoint":241},"VCU Health Adult Outpatient Pavillion ( Site 3416)","Richmond","23219",{"lat":242,"lon":243},37.55376,-77.46026,{"facility":245,"city":246,"state":247,"zip":248,"country":249,"geoPoint":250},"Hospital Universitario Austral ( Site 0104)","Pilar","Buenos Aires","B1629AHJ","Argentina",{"lat":251,"lon":252},-34.45867,-58.91398,{"facility":254,"city":255,"state":256,"zip":257,"country":249},"Hospital Italiano de Buenos Aires ( Site 0105)","ABB","Buenos Aires F.D.","C1199ABB",{"facility":259,"city":260,"state":261,"zip":262,"country":249,"geoPoint":263},"C.I.C.E. 9 de Julio ( Site 1001)","San Miguel de Tucumán","Tucumán Province","T4000IKO",{"lat":264,"lon":265},-26.81601,-65.21051,{"facility":267,"city":268,"state":269,"zip":270,"country":271,"geoPoint":272},"Royal Prince Alfred Hospital ( Site 1100)","Camperdown","New South Wales","2050","Australia",{"lat":273,"lon":274},-33.88965,151.17642,{"facility":276,"city":277,"state":269,"zip":278,"country":271,"geoPoint":279},"Liverpool Hospital-Haematology ( Site 0501)","Liverpool","2170",{"lat":280,"lon":281},-33.91938,150.92588,{"facility":283,"city":284,"state":269,"zip":285,"country":271,"geoPoint":286},"Royal North Shore Hospital ( Site 0003)","St Leonards","2065",{"lat":287,"lon":288},-33.82344,151.19836,{"facility":290,"city":291,"state":269,"zip":292,"country":271,"geoPoint":293},"Calvary Mater Newcastle ( Site 0505)","Waratah","2298",{"lat":294,"lon":295},-32.90667,151.72647,{"facility":297,"city":298,"state":299,"zip":300,"country":271,"geoPoint":301},"Royal Adelaide Hospital-Haematology Clinical Trials Unit ( Site 0001)","Adelaide","South Australia","5000",{"lat":302,"lon":303},-34.92866,138.59863,{"facility":305,"city":306,"state":307,"zip":308,"country":271,"geoPoint":309},"Monash Health-Haematology Research ( Site 0006)","Clayton","Victoria","3168",{"lat":310,"lon":311},-37.91667,145.11667,{"facility":313,"city":314,"state":307,"zip":315,"country":271,"geoPoint":316},"Western Health-Sunshine & Footscray Hospitals-Cancer Services-Cancer Research ( Site 0502)","Melbourne","3021",{"lat":317,"lon":318},-37.814,144.96332,{"facility":320,"city":321,"state":322,"zip":323,"country":271,"geoPoint":324},"Royal Perth Hospital-Haematology ( Site 0504)","Perth","Western Australia","6000",{"lat":325,"lon":326},-31.95224,115.8614,{"facility":328,"city":329,"zip":330,"country":331,"geoPoint":332},"ZAS Cadix ( Site 1200)","Antwerp","2030","Belgium",{"lat":333,"lon":334},51.22047,4.40026,{"facility":336,"city":337,"state":338,"zip":339,"country":340,"geoPoint":341},"University Of Alberta Hospital ( Site 1504)","Edmonton","Alberta","T6G 2B7","Canada",{"lat":342,"lon":343},53.55014,-113.46871,{"facility":345,"city":346,"state":347,"zip":348,"country":340,"geoPoint":349},"The Moncton Hospital-Oncology ( Site 1500)","Moncton","New Brunswick","E1C 6Z8",{"lat":350,"lon":351},46.09454,-64.7965,{"facility":353,"city":354,"state":355,"zip":356,"country":357,"geoPoint":358},"The First Afflilated Hospital of Bengbu Medical College ( Site 3509)","Bengbu","Anhui","233004","China",{"lat":359,"lon":360},32.94083,117.36083,{"facility":362,"city":363,"state":355,"zip":364,"country":357,"geoPoint":365},"Anhui Provincial Hospital ( Site 3513)","Hefei","230071",{"lat":366,"lon":367},31.86389,117.28083,{"facility":369,"city":370,"state":371,"zip":372,"country":357,"geoPoint":373},"Peking University Third Hospital-Hematology ( Site 3502)","Beijing","Beijing Municipality","100191",{"lat":374,"lon":375},39.9075,116.39723,{"facility":377,"city":370,"state":371,"zip":378,"country":357,"geoPoint":379},"Peking Union Medical College Hospital ( Site 3531)","100730",{"lat":374,"lon":375},{"facility":381,"city":382,"state":383,"zip":384,"country":357,"geoPoint":385},"The Second Affiliated Hospital Of Fujian Medical University ( Site 3525)","Quanzhou","Fujian","362000",{"lat":386,"lon":387},24.91389,118.58583,{"facility":389,"city":390,"state":383,"zip":391,"country":357,"geoPoint":392},"The First Affiliated hospital of Xiamen University ( Site 3515)","Xiamen","361003",{"lat":393,"lon":394},24.47979,118.08187,{"facility":396,"city":397,"state":398,"zip":399,"country":357,"geoPoint":400},"Sun Yat-sen Memorial Hospital of Sun Yat-sen University ( Site 3524)","Guangzhou","Guangdong","510120",{"lat":401,"lon":402},23.11667,113.25,{"facility":404,"city":397,"state":398,"zip":405,"country":357,"geoPoint":406},"Southern Medical University Nanfang Hospital-Department of Hematopathology ( Site 3511)","510515",{"lat":401,"lon":402},{"facility":408,"city":409,"state":410,"zip":411,"country":357,"geoPoint":412},"The First Hospital of Hebei Medical University ( Site 3510)","Shijiazhuang","Hebei","050031",{"lat":413,"lon":414},38.04139,114.47861,{"facility":416,"city":417,"state":418,"zip":419,"country":357,"geoPoint":420},"Henan Cancer Hospital-hematology department ( Site 3504)","Zhengzhou","Henan","450008",{"lat":421,"lon":422},34.75778,113.64861,{"facility":424,"city":425,"state":426,"zip":427,"country":357,"geoPoint":428},"Wuhan Union Hospital ( Site 3500)","Wuhan","Hubei","430022",{"lat":429,"lon":430},30.58333,114.26667,{"facility":432,"city":433,"state":434,"zip":435,"country":357,"geoPoint":436},"Jiangsu Province Hospital ( Site 3507)","Nanjing","Jiangsu","210029",{"lat":437,"lon":438},32.06167,118.77778,{"facility":440,"city":441,"state":434,"zip":442,"country":357,"geoPoint":443},"Affiliated Hospital of Nantong University ( Site 3527)","Nantong","226001",{"lat":444,"lon":445},32.03028,120.87472,{"facility":447,"city":448,"state":449,"zip":450,"country":357,"geoPoint":451},"The First affiliated hospital of Nanchang University (Xianghu campus) ( Site 3505)","Nanchang","Jiangxi","330209",{"lat":452,"lon":453},28.68396,115.85306,{"facility":455,"city":456,"state":457,"zip":458,"country":357,"geoPoint":459},"The First Hospital of Jilin University-Hematology ( Site 3526)","Changchun","Jilin","130021",{"lat":460,"lon":461},43.88,125.32278,{"facility":463,"city":464,"state":465,"zip":466,"country":357,"geoPoint":467},"Shaanxi provincial people's hospital ( Site 3516)","Xi'an","Shaanxi","710068",{"lat":468,"lon":469},34.25833,108.92861,{"facility":471,"city":472,"state":473,"zip":474,"country":357,"geoPoint":475},"Jinan Central Hospital ( Site 3523)","Jinan","Shandong","250013",{"lat":476,"lon":477},36.66833,116.99722,{"facility":479,"city":480,"state":481,"zip":482,"country":357,"geoPoint":483},"Zhongshan Hospital,Fudan University-Hematology ( Site 3530)","Shanghai","Shanghai Municipality","200032",{"lat":484,"lon":485},31.22222,121.45806,{"facility":487,"city":480,"state":481,"zip":488,"country":357,"geoPoint":489},"Huashan Hospital, Fudan University ( Site 3529)","200040",{"lat":484,"lon":485},{"facility":491,"city":492,"state":493,"zip":494,"country":357,"geoPoint":495},"West China Hospital, Sichuan University ( Site 3518)","Chengdu","Sichuan","610041",{"lat":496,"lon":497},30.66667,104.06667,{"facility":499,"city":500,"state":501,"zip":502,"country":357,"geoPoint":503},"Institute of hematology&blood disease hospital ( Site 3501)","Tianjin","Tianjin Municipality","300020",{"lat":504,"lon":505},39.14222,117.17667,{"facility":507,"city":508,"state":509,"zip":510,"country":357,"geoPoint":511},"The first Affiliated Hospital, Zhejiang University School of Medicine ( Site 3508)","Hangzhou","Zhejiang","310006",{"lat":512,"lon":513},30.29365,120.16142,{"facility":515,"city":516,"state":509,"zip":517,"country":357,"geoPoint":518},"Zhejiang University School of Medicine-The Fourth Affiliated Hospital ( Site 3517)","Yiwu","322000",{"lat":519,"lon":520},29.31506,120.07676,{"facility":522,"city":523,"state":524,"zip":525,"country":526,"geoPoint":527},"Fundacion Colombiana de Cancerología Clinica Vida ( Site 1403)","Medellín","Antioquia","050030","Colombia",{"lat":528,"lon":529},6.245,-75.57151,{"facility":531,"city":532,"state":533,"zip":534,"country":526,"geoPoint":535},"Los Cobos Medical Center ( Site 1404)","Bogotá","Bogota D.C.","110121",{"lat":536,"lon":537},4.60971,-74.08175,{"facility":539,"city":540,"state":541,"zip":542,"country":526,"geoPoint":543},"IMAT S.A.S ( Site 1401)","Montería","Departamento de Córdoba","230002",{"lat":544,"lon":545},8.75081,-75.87823,{"facility":547,"city":548,"state":549,"zip":550,"country":551,"geoPoint":552},"Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou ( Site 0417)","Rennes","Brittany Region","35000","France",{"lat":553,"lon":554},48.11109,-1.67431,{"facility":556,"city":557,"state":558,"zip":559,"country":551,"geoPoint":560},"Centre Hospitalier Régional Universitaire de Tours - Hôpital-Hématologie et Thérapie Cellulaire ( Site 0413)","Tours","Indre-et-Loire","37000",{"lat":561,"lon":562},47.39484,0.70398,{"facility":564,"city":565,"state":566,"zip":567,"country":551,"geoPoint":568},"Centre Hospitalier Universitaire de Limoges - Hôpital Dupuyt-Hématologie Clinique et Thérapie Cellu ( Site 1701)","Limoges","Limousin","87042",{"lat":569,"lon":570},45.83362,1.24759,{"facility":572,"city":573,"state":574,"zip":575,"country":551,"geoPoint":576},"Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois-HEMATOLOGY ( Site 0407)","Vandœuvre-lès-Nancy","Lorraine","54511",{"lat":577,"lon":578},48.66115,6.17114,{"facility":580,"city":581,"state":582,"zip":583,"country":551,"geoPoint":584},"Centre Hospitalier de Roubaix ( Site 1703)","Roubaix","Nord","59100",{"lat":585,"lon":586},50.69421,3.17456,{"facility":588,"city":589,"state":590,"zip":591,"country":551,"geoPoint":592},"centre hospitalier lyon sud ( Site 0406)","Pierre-Bénite","Rhone","69310",{"lat":593,"lon":594},45.70359,4.82424,{"facility":596,"city":597,"zip":598,"country":551,"geoPoint":599},"Hôpital Saint-Louis-Centre d'Investigations Cliniques ( Site 0405)","Paris","75010",{"lat":600,"lon":601},48.85341,2.3488,{"facility":603,"city":597,"state":604,"zip":605,"country":551,"geoPoint":606},"Hôpital Saint Antoine-Service d'Hématologie et de Thérapie Cellulaire ( Site 1702)","Île-de-France Region","75571",{"lat":600,"lon":601},{"facility":608,"city":609,"state":610,"zip":611,"country":612,"geoPoint":613},"Universitätsklinikum Aachen ( Site 1801)","Aachen","North Rhine-Westphalia","52074","Germany",{"lat":614,"lon":615},50.77664,6.08342,{"facility":617,"city":618,"state":619,"zip":620,"country":612,"geoPoint":621},"Universitaetsklinikum Carl Gustav Carus Dresden-Medical Dept I - Medical Oncology ( Site 0402)","Dresden","Saxony","01307",{"lat":622,"lon":623},51.05089,13.73832,{"facility":625,"city":626,"state":627,"zip":628,"country":612,"geoPoint":629},"Universitätsklinikum Halle ( Site 0401)","Halle","Saxony-Anhalt","06120",{"lat":630,"lon":631},51.48158,11.97947,{"facility":633,"city":634,"country":635},"Queen Mary Hospital ( Site 1901)","Hksar","Hong Kong",{"facility":637,"city":638,"state":639,"country":640,"geoPoint":641},"Petz Aladar Egyetemi Oktato Korhaz ( Site 2000)","Győr","Győr-Moson-Sopron","Hungary",{"lat":642,"lon":643},47.68333,17.63512,{"facility":645,"city":646,"state":647,"zip":648,"country":640,"geoPoint":649},"Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókór-Haematológia osztály ( Site 0706)","Nyíregyháza","Szabolcs-Szatmár-Bereg","4400",{"lat":650,"lon":651},47.95539,21.71671,{"facility":653,"city":654,"zip":655,"country":640,"geoPoint":656},"Semmelweis Egyetem-Belgyógyászati és Hematológiai Klinika ( Site 0708)","Budapest","1088",{"lat":657,"lon":658},47.49835,19.04045,{"facility":660,"city":661,"zip":662,"country":640,"geoPoint":663},"Debreceni Egyetem Klinikai Kozpont-Belgyógyászati Klinika (Haematologia) ( Site 0707)","Debrecen","4032",{"lat":664,"lon":665},47.53167,21.62444,{"facility":667,"city":668,"zip":669,"country":670,"geoPoint":671},"Soroka Medical Center ( Site 2100)","Beersheba","8410101","Israel",{"lat":672,"lon":673},31.25181,34.7913,{"facility":675,"city":676,"zip":677,"country":670,"geoPoint":678},"Rambam Health Care Campus ( Site 2102)","Haifa","3109601",{"lat":679,"lon":680},32.81303,34.99928,{"facility":682,"city":676,"zip":683,"country":670,"geoPoint":684},"Carmel Hospital ( Site 0906)","3436212",{"lat":679,"lon":680},{"facility":686,"city":687,"zip":688,"country":670,"geoPoint":689},"Hadassah Medical Center ( Site 0904)","Jerusalem","9112001",{"lat":690,"lon":691},31.76904,35.21633,{"facility":693,"city":694,"zip":695,"country":670,"geoPoint":696},"Rabin Medical Center ( Site 0905)","Petah Tikva","4941492",{"lat":697,"lon":698},32.0888,34.88666,{"facility":700,"city":701,"zip":702,"country":670,"geoPoint":703},"Sheba Medical Center ( Site 2101)","Ramat Gan","5265601",{"lat":704,"lon":705},32.08227,34.81065,{"facility":707,"city":708,"zip":709,"country":670,"geoPoint":710},"Sourasky Medical Center ( Site 0902)","Tel Aviv","6423906",{"lat":711,"lon":712},32.08088,34.78057,{"facility":714,"city":715,"zip":716,"country":670,"geoPoint":717},"Yitzhak Shamir Medical Center. ( Site 0901)","Ẕerifin","7033001",{"lat":718,"lon":719},31.95731,34.84852,{"facility":721,"city":722,"state":723,"zip":724,"country":725,"geoPoint":726},"Azienda Ospedaliero Universitaria di Ferrara ( Site 0304)","Cona","Ferrara","44124","Italy",{"lat":727,"lon":728},44.80583,11.7069,{"facility":730,"city":731,"state":732,"zip":733,"country":725,"geoPoint":734},"IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\" ( Site 0308)","Meldola","Forli-Cesena","47014",{"lat":735,"lon":736},44.12775,12.0626,{"facility":738,"city":739,"state":740,"zip":741,"country":725,"geoPoint":742},"Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico ( Site 2201)","Milan","Lombardy","20122",{"lat":743,"lon":744},45.46427,9.18951,{"facility":746,"city":747,"state":748,"zip":749,"country":725,"geoPoint":750},"Azienda Ospedaliera Universitaria Careggi ( Site 0030)","Florence","Tuscany","50134",{"lat":751,"lon":752},43.77925,11.24626,{"facility":754,"city":755,"state":748,"zip":756,"country":725,"geoPoint":757},"Azienda Ospedaliero Universitaria Pisana-UO Ematologia UNIV ( Site 0309)","Pisa","56126",{"lat":758,"lon":759},43.70853,10.4036,{"facility":761,"city":762,"state":763,"zip":764,"country":725,"geoPoint":765},"Istituto Oncologico Veneto IRCCS-Oncoematologia ( Site 0306)","Castelfranco Veneto","Veneto","31033",{"lat":766,"lon":767},45.67146,11.92755,{"facility":769,"city":770,"zip":771,"country":725,"geoPoint":772},"Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo ( Site 0034)","Alessandria","15121",{"lat":773,"lon":774},44.90924,8.61007,{"facility":776,"city":777,"zip":778,"country":725,"geoPoint":779},"Azienda Ospedaliero Universitaria delle Marche ( Site 0302)","Ancona","60126",{"lat":780,"lon":781},43.60717,13.5103,{"facility":783,"city":784,"zip":785,"country":725,"geoPoint":786},"Arcispedale Santa Maria Nuova ( Site 0301)","Reggio Emilia","42123",{"lat":787,"lon":788},44.69825,10.63125,{"facility":790,"city":791,"zip":792,"country":725,"geoPoint":793},"Ospedale Mauriziano ( Site 0305)","Torino","10128",{"lat":794,"lon":795},44.88856,11.99138,{"facility":797,"city":798,"zip":799,"country":725,"geoPoint":800},"Ospedale di Circolo e Fondazione Macchi Varese ( Site 2200)","Varese","21100",{"lat":801,"lon":802},45.82058,8.82511,{"facility":804,"city":805,"state":806,"zip":807,"country":808,"geoPoint":809},"Fujita Health University Hospital ( Site 3613)","Toyoake","Aichi-ken","470-1192","Japan",{"lat":810,"lon":811},35.038,136.99931,{"facility":813,"city":814,"state":815,"zip":816,"country":808,"geoPoint":817},"National Cancer Center Hospital East ( Site 3610)","Kashiwa","Chiba","277-8577",{"lat":818,"lon":819},35.86224,139.97732,{"facility":821,"city":822,"state":823,"zip":824,"country":808,"geoPoint":825},"Ehime University Hospital ( Site 3612)","Tōon","Ehime","791-0295",{"lat":826,"lon":827},33.79427,132.89011,{"facility":829,"city":830,"state":831,"zip":832,"country":808,"geoPoint":833},"Hokkaido University Hospital ( Site 3601)","Sapporo","Hokkaido","060-8648",{"lat":834,"lon":835},43.06667,141.35,{"facility":837,"city":838,"state":839,"zip":840,"country":808,"geoPoint":841},"Kobe City Medical Center General Hospital ( Site 3603)","Kobe","Hyōgo","650-0047",{"lat":842,"lon":843},34.6913,135.183,{"facility":845,"city":846,"state":847,"zip":848,"country":808,"geoPoint":849},"Kanazawa University Hospital ( Site 3614)","Kanazawa","Ishikawa-ken","920-8641",{"lat":850,"lon":851},36.6,136.61667,{"facility":853,"city":854,"state":855,"zip":856,"country":808,"geoPoint":857},"Mie University Hospital ( Site 3615)","Tsu","Mie-ken","514-8507",{"lat":858,"lon":859},34.73333,136.51667,{"facility":861,"city":862,"state":863,"zip":864,"country":808,"geoPoint":865},"National Hospital Organization Sendai Medical Center ( Site 3617)","Sendai","Miyagi","983-8520",{"lat":866,"lon":867},38.26667,140.86667,{"facility":869,"city":870,"state":871,"zip":872,"country":808,"geoPoint":873},"Kansai Medical University Hospital ( Site 3607)","Hirakata","Osaka","573-1191",{"lat":874,"lon":875},34.81352,135.64914,{"facility":877,"city":878,"state":871,"zip":879,"country":808,"geoPoint":880},"Kindai University Hospital ( Site 3600)","Sakai","590-0197",{"lat":881,"lon":882},34.58216,135.46653,{"facility":884,"city":885,"state":886,"zip":887,"country":808},"Juntendo University Hospital ( Site 3611)","Bunkyo-ku","Tokyo","113-8431",{"facility":889,"city":885,"state":886,"zip":890,"country":808},"Nippon Medical School Hospital ( Site 3608)","113-8603",{"facility":892,"city":893,"state":894,"zip":895,"country":808,"geoPoint":896},"University of Yamanashi Hospital ( Site 3606)","Chūō","Yamanashi","409-3898",{"lat":897,"lon":898},35.59465,138.50275,{"facility":900,"city":901,"zip":902,"country":808,"geoPoint":903},"Kyushu University Hospital ( Site 3605)","Fukuoka","812-8582",{"lat":904,"lon":905},33.6,130.41667,{"facility":907,"city":908,"zip":909,"country":808,"geoPoint":910},"Fukushima Medical University Hospital ( Site 3616)","Fukushima","960-1295",{"lat":911,"lon":912},37.75,140.46667,{"facility":914,"city":915,"zip":916,"country":808,"geoPoint":917},"University of Miyazaki Hospital ( Site 3609)","Miyazaki","889-1692",{"lat":918,"lon":919},31.91667,131.41667,{"facility":921,"city":922,"zip":923,"country":808,"geoPoint":924},"Okayama University Hospital ( Site 3604)","Okayama","700-8558",{"lat":925,"lon":926},34.65,133.93333,{"facility":928,"city":929,"state":930,"zip":931,"country":932,"geoPoint":933},"Spaarne Gasthuis - Hoofddorp-Oncology ( Site 2301)","Hoofddorp","North Holland","2134 TM","Netherlands",{"lat":934,"lon":935},52.3025,4.68889,{"facility":937,"city":938,"state":939,"zip":940,"country":932,"geoPoint":941},"Albert Schweitzer Ziekenhuis, locatie Dordwijk-Internal Medicine ( Site 2302)","Dordrecht","South Holland","3318 AT",{"lat":942,"lon":943},51.81,4.67361,{"facility":945,"city":946,"zip":947,"country":932,"geoPoint":948},"University Medical Center Groningen ( Site 2304)","Groningen","9713 GZ",{"lat":949,"lon":950},53.21917,6.56667,{"facility":952,"city":946,"zip":953,"country":932,"geoPoint":954},"Martini Ziekenhuis ( Site 2300)","9728 NT",{"lat":949,"lon":950},{"facility":956,"city":957,"zip":958,"country":959,"geoPoint":960},"North Shore Hospital-Department of Haematology ( Site 0051)","Auckland","0622","New Zealand",{"lat":961,"lon":962},-36.84853,174.76349,{"facility":964,"city":957,"zip":965,"country":959,"geoPoint":966},"Aotearoa Clinical Trials ( Site 0050)","2025",{"lat":961,"lon":962},{"facility":968,"city":969,"state":970,"zip":971,"country":972,"geoPoint":973},"Pratia Onkologia Katowice ( Site 0702)","Katowice","Silesian Voivodeship","40-519","Poland",{"lat":974,"lon":975},50.2597,19.02173,{"facility":977,"city":978,"state":979,"zip":980,"country":972,"geoPoint":981},"Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zakl-Klinika Hematologii i Transplantacji S ( Site 2504)","Kielce","Świętokrzyskie Voivodeship","25-734",{"lat":982,"lon":983},50.87033,20.62752,{"facility":985,"city":986,"zip":987,"country":988,"geoPoint":989},"Unidade Local de Saude de Braga - Hospital de Braga ( Site 0415)","Braga","4710-243","Portugal",{"lat":990,"lon":991},41.5514,-8.42311,{"facility":993,"city":994,"zip":995,"country":988,"geoPoint":996},"Unidade Local de Saude Lisboa Ocidental - Hospital de São Francisco Xavier ( Site 2600)","Lisbon","1449-005",{"lat":997,"lon":998},38.72509,-9.1498,{"facility":1000,"city":1001,"zip":1002,"country":988,"geoPoint":1003},"Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 0414)","Porto","4200-072",{"lat":1004,"lon":1005},41.1485,-8.61097,{"facility":1007,"city":1008,"state":1009,"zip":1010,"country":1011,"geoPoint":1012},"Seoul National University Bundang Hospital-Hematology ( Site 0605)","Seongnam","Kyonggi-do","13620","South Korea",{"lat":1013,"lon":1014},35.48474,129.30505,{"facility":1016,"city":1017,"zip":1018,"country":1011,"geoPoint":1019},"Korea University Anam Hospital ( Site 0604)","Seoul","02841",{"lat":1020,"lon":1021},37.566,126.9784,{"facility":1023,"city":1017,"zip":1024,"country":1011,"geoPoint":1025},"Asan Medical Center ( Site 0603)","05505",{"lat":1020,"lon":1021},{"facility":1027,"city":1017,"zip":1028,"country":1011,"geoPoint":1029},"The Catholic Univ. of Korea Seoul St. Mary's Hospital ( Site 0606)","06591",{"lat":1020,"lon":1021},{"facility":1031,"city":1032,"state":1033,"zip":1034,"country":1035,"geoPoint":1036},"Hospital Germans Trias i Pujol-Instituto Catalán de Oncología de Badalona ( Site 0409)","Badalona","Barcelona","08916","Spain",{"lat":1037,"lon":1038},41.45004,2.24741,{"facility":1040,"city":1041,"state":1033,"zip":1042,"country":1035},"Institut Català d'Oncologia - L'Hospitalet-Haematology Department ( Site 2801)","L'Hospitalet Del Llobregat","08908",{"facility":1044,"city":1033,"state":1045,"zip":1046,"country":1035,"geoPoint":1047},"Hospital del Mar ( Site 2807)","Catalonia","08003",{"lat":1048,"lon":1049},41.38879,2.15899,{"facility":1051,"city":1033,"state":1045,"zip":1052,"country":1035,"geoPoint":1053},"HOSPITAL CLÍNIC DE BARCELONA ( Site 2800)","08036",{"lat":1048,"lon":1049},{"facility":1055,"city":1056,"state":1057,"zip":1058,"country":1035,"geoPoint":1059},"CHUS - Hospital Clinico Universitario ( Site 0421)","Santiago de Compostela","La Coruna","19706",{"lat":1060,"lon":1061},42.88052,-8.54569,{"facility":1063,"city":1064,"state":1065,"zip":1066,"country":1035,"geoPoint":1067},"Hospital Universitario Ramón y Cajal-Hematology ( Site 2803)","Madrid","Madrid, Comunidad de","28034",{"lat":1068,"lon":1069},40.4165,-3.70256,{"facility":1071,"city":1072,"state":1073,"zip":1074,"country":1035,"geoPoint":1075},"Hospital Costa del Sol-Hematology Service ( Site 0412)","Marbella","Malaga","29603",{"lat":1076,"lon":1077},36.51543,-4.88583,{"facility":1079,"city":1080,"zip":1081,"country":1035,"geoPoint":1082},"Hospital General Universitario de Albacete ( Site 0408)","Albacete","02006",{"lat":1083,"lon":1084},38.99424,-1.85643,{"facility":1086,"city":1033,"zip":1087,"country":1035,"geoPoint":1088},"Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 0404)","08035",{"lat":1048,"lon":1049},{"facility":1090,"city":1064,"zip":1091,"country":1035,"geoPoint":1092},"Hospital Universitario 12 de Octubre ( Site 2806)","28041",{"lat":1068,"lon":1069},{"facility":1094,"city":1095,"zip":1096,"country":1035,"geoPoint":1097},"Hospital Universitario Virgen de la Victoria ( Site 0418)","Málaga","29010",{"lat":1098,"lon":1099},36.72016,-4.42034,{"facility":1101,"city":1102,"zip":1103,"country":1035,"geoPoint":1104},"Hospital Universitario de Salamanca - Complejo Asistencial U-Servicio de Hematologia ( Site 0419)","Salamanca","37007",{"lat":1105,"lon":1106},40.96882,-5.66388,{"facility":1108,"city":1109,"zip":1110,"country":1035,"geoPoint":1111},"Hospital Universitario Doctor Peset ( Site 0411)","Valencia","46017",{"lat":1112,"lon":1113},39.47391,-0.37966,{"facility":1115,"city":1116,"state":1117,"zip":1118,"country":1119,"geoPoint":1120},"Karolinska Universitetssjukhuset Huddinge ( Site 2900)","Huddinge","Stockholm County","141 86","Sweden",{"lat":1121,"lon":1122},59.23705,17.98192,{"facility":1124,"city":1125,"state":1126,"zip":1127,"country":1119,"geoPoint":1128},"Universitetssjukhuset Örebro ( Site 0403)","Örebro","Örebro County","701 85",{"lat":1129,"lon":1130},59.27412,15.2066,{"facility":1132,"city":1133,"state":1134,"zip":1135,"country":1136,"geoPoint":1137},"Chang Gung Memorial Hospital- Chiayi ( Site 3102)","Chiayi City","Chiayi","613","Taiwan",{"lat":1138,"lon":1139},23.47917,120.44889,{"facility":1141,"city":1142,"zip":1143,"country":1136,"geoPoint":1144},"Chang Gung Memorial Hospital at Kaohsiung-Division of Hematology and Oncology ( Site 3104)","Kaohsiung City","83301",{"lat":1145,"lon":1146},22.61626,120.31333,{"facility":1148,"city":1149,"zip":1150,"country":1136,"geoPoint":1151},"National Cheng Kung University Hospital-Clinical Trial Center ( Site 3105)","Tainan","704",{"lat":1152,"lon":1153},22.99083,120.21333,{"facility":1155,"city":1156,"zip":1157,"country":1136,"geoPoint":1158},"National Taiwan University Hospital ( Site 3101)","Taipei","10048",{"lat":1159,"lon":1160},25.05306,121.52639,{"facility":1162,"city":1163,"zip":1164,"country":1136,"geoPoint":1165},"Chang Gung Medical Foundation-Linkou Branch ( Site 3103)","Taoyuan","33305",{"lat":1166,"lon":1167},24.99368,121.29696,{"facility":1169,"city":1170,"state":1171,"zip":1172,"country":1173,"geoPoint":1174},"Ege Universitesi Hastanesi ( Site 3202)","Bornova","İzmir","35100","Turkey (Türkiye)",{"lat":1175,"lon":1176},38.47921,27.2399,{"facility":1178,"city":1179,"zip":1180,"country":1173,"geoPoint":1181},"Hacettepe Universite Hastaneleri-Department of Hematology ( Site 3204)","Ankara","06230",{"lat":1182,"lon":1183},39.91987,32.85427,{"facility":1185,"city":1179,"zip":1186,"country":1173,"geoPoint":1187},"Ankara UTF Cebeci Arastırma ve Uygulama Hastanesi ( Site 3210)","06620",{"lat":1182,"lon":1183},{"facility":1189,"city":1179,"zip":1190,"country":1173,"geoPoint":1191},"Ankara Bilkent Şehir Hastanesi ( Site 3201)","06800",{"lat":1182,"lon":1183},{"facility":1193,"city":1194,"zip":1195,"country":1173,"geoPoint":1196},"Antalya Egitim ve Arastırma Hastanesi ( Site 3207)","Antalya","07100",{"lat":1197,"lon":1198},36.90812,30.69556,{"facility":1200,"city":1201,"zip":1202,"country":1173,"geoPoint":1203},"Trakya University Medical Faculty Hospital-Hematology ( Site 3200)","Edirne","22030",{"lat":1204,"lon":1205},41.67719,26.55597,{"facility":1207,"city":1208,"zip":1209,"country":1173,"geoPoint":1210},"Medipol Mega Universite Hastanesi-oncology ( Site 3203)","Istanbul","34214",{"lat":1211,"lon":1212},41.01384,28.94966,{"facility":1214,"city":1215,"zip":1216,"country":1173,"geoPoint":1217},"Kocaeli Üniversitesi-Hematology ( Site 3205)","Kocaeli","41380",{"lat":1218,"lon":1219},39.62497,27.51145,{"facility":1221,"city":1222,"zip":1223,"country":1173,"geoPoint":1224},"VM Medical Park Mersin Hastanesi ( Site 3208)","Mersin","33440",{"lat":1225,"lon":1226},36.81196,34.63886,{"facility":1228,"city":1229,"zip":1230,"country":1173,"geoPoint":1231},"Ondokuz Mayıs Universitesi-hematology ( Site 3206)","Samsun","55270",{"lat":1232,"lon":1233},41.27976,36.3361,{"facility":1235,"city":1236,"state":1237,"zip":1238,"country":1239,"geoPoint":1240},"Addenbrooke's Hospital ( Site 3303)","Cambridge","Cambridgeshire","CB2 2QQ","United Kingdom",{"lat":1241,"lon":1242},52.2,0.11667,{"facility":1244,"city":1245,"state":1246,"zip":1247,"country":1239,"geoPoint":1248},"Gloucestershire Royal Hospital ( Site 3302)","Gloucester","Gloucestershire","Gl1 3NN",{"lat":1249,"lon":1250},51.86568,-2.2431,{"facility":1252,"city":1253,"state":1254,"zip":1255,"country":1239,"geoPoint":1256},"Lincoln County Hospital ( Site 3310)","Lincoln","Great Britain","LN2 5QY",{"lat":1257,"lon":1258},53.22683,-0.53792,{"facility":1260,"city":161,"state":1261,"zip":1262,"country":1239,"geoPoint":1263},"Boston Pilgrim Hospital ( Site 3301)","Lincolnshire","PE21 9QS",{"lat":1264,"lon":1265},52.97633,-0.02664,{"facility":1267,"city":1268,"state":1269,"zip":1270,"country":1239,"geoPoint":1271},"University College London Hospital ( Site 3300)","London","London, City of","NW1 2PG",{"lat":1272,"lon":1273},51.50853,-0.12574,{"facility":1275,"city":1268,"state":1269,"zip":1276,"country":1239,"geoPoint":1277},"Guy's & St Thomas' NHS Foundation Trust ( Site 3305)","SE1 9RT",{"lat":1272,"lon":1273},{"facility":1279,"city":1268,"state":1269,"zip":1280,"country":1239,"geoPoint":1281},"King's College Hospital ( Site 3308)","SE5 9RS",{"lat":1272,"lon":1273},{"facility":1283,"city":1284,"state":1285,"zip":1286,"country":1239},"Royal Gwent Hospital ( Site 3304)","Gwent","Newport","NP20 2UB",{"facility":1288,"city":1289,"state":1290,"zip":1291,"country":1239,"geoPoint":1292},"GenesisCare - Windsor ( Site 3309)","Windsor","Windsor And Maidenhead","SL4 3HD",{"lat":1293,"lon":1294},51.48333,-0.6,{"facility":1296,"city":1297,"zip":1298,"country":1239,"geoPoint":1299},"The Christie NHS Foundation Trust ( Site 3307)","Manchester","m20 4bx",{"lat":1300,"lon":1301},53.48095,-2.23743,[],[1304],{"name":1305,"affiliation":13,"role":1306},"Medical Director","STUDY_DIRECTOR",[],[1309],{"label":1310,"url":1311},"Merck Clinical Trials Information","http:\u002F\u002Fwww.merckclinicaltrials.com",{"nct_id":4,"conditions":1313,"biomarkers":1314},[19],[],{"nct_id":4,"found":15,"summary":1316,"prompt_version":1326},{"design":1317,"status":1318,"heading":1319,"summary":1320,"follow_up":1321,"word_count":1322,"commitments":1323,"compensation":1324,"drugs_mentioned":1325},"This study is comparing bomedemstat to other available treatments in about 340 participants. It is an interventional study, meaning participants will receive a specific treatment.","completed","A Study of Bomedemstat for Essential Thrombocythemia","This study is looking at a new medication called bomedemstat (also known as MK-3543) for people with essential thrombocythemia (ET). ET is a condition where your body makes too many platelets, which are blood cells that help with clotting. You might be able to join if you have ET and your current treatment with hydroxyurea hasn't worked well or you couldn't tolerate it. Researchers want to see if bomedemstat is better than other common treatments like anagrelide, busulfan, interferon alfa, or ruxolitinib. The main goal is to see if bomedemstat leads to a lasting improvement in your blood counts and symptoms, called a durable clinicohematologic response, over about a year.","The main goal of the study is measured for up to approximately 52 weeks.",110,"Not specified in the trial record.","Not stated in the trial record.",[35,42,46,54],"v2"]