[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06168461":3,"trial-entities:NCT06168461":102,"trial-summary:NCT06168461":105},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":22,"primary_purpose":23,"phases":24,"enrollment_info":26,"interventions":29,"primary_outcomes":41,"secondary_outcomes":52,"sex":56,"minimum_age":57,"maximum_age":58,"healthy_volunteers":15,"eligibility_criteria":59,"std_ages":78,"locations":80,"central_contacts":96,"overall_officials":99,"references":100,"see_also_links":101},"NCT06168461","202303799","Daily Aspirin Treatment After Preeclampsia","Aspirin for the Treatment of Vascular Dysfunction After Preeclampsia","RECRUITING","2026-06","2025-12","2025-12-15","2023-11-01","Anna Stanhewicz, PhD","OTHER",false,"Women who develop preeclampsia during pregnancy are four times more likely to develop cardiovascular disease later in life, even if they are otherwise healthy. The reason why this occurs may be related to lasting blood vessel damage after the pregnancy but there are currently no specific treatment strategies to prevent this disease progression. This study addresses this public health issue by examining whether starting low dose aspirin therapy after pregnancy is an effective treatment for lasting blood vessel damage in order to inform better clinical management of cardiovascular disease risk in women who have had preeclampsia.",null,[19],"Preeclampsia",[21],"preeclampsia","INTERVENTIONAL","BASIC_SCIENCE",[25],"EARLY_PHASE1",{"count":27,"type":28},40,"ESTIMATED",[30,36],{"type":31,"name":32,"description":33,"armGroupLabels":34},"DRUG","Aspirin","162mg aspirin capsule",[35],"aspirin",{"type":31,"name":37,"description":38,"armGroupLabels":39},"Placebo","placebo capsule",[40],"placebo",[42,46,49],{"measure":43,"description":44,"timeFrame":45},"magnitude of microvascular endothelial function","skin blood flow response to acetylcholine delivered via intradermal microdialysis","baseline, 12 weeks",{"measure":47,"description":48,"timeFrame":45},"magnitude of brachial artery endothelial function","brachial artery flow mediated dilation",{"measure":50,"description":51,"timeFrame":45},"magnitude of microvascular endothelin-1 mediated constriction","skin blood flow response to endothelin-1 delivered via intradermal microdialysis",[53],{"measure":54,"description":55,"timeFrame":45},"magnitude of microvascular nitric oxide-dependent dilation","skin blood flow response to acetylcholine + L-NAME delivered via intradermal microdialysis","FEMALE","18 Years","50 Years",{"inclusion":60,"exclusion":63,"raw_text":77},[61,62],"had preeclampsia in the past 5 years,","18 years or older",[64,65,66,67,68,69,70,71,72,73,74,75,76],"current daily aspirin use,","skin diseases,","current tobacco or nicotine use (including vaping),","diagnosed or suspected hepatic or metabolic disease including chronic kidney disease (CKD) defined as reduced eGFR \\\u003C 60 mL\u002Fmin\u002F1.73m2,","statin or other cholesterol-lowering medication,","current antihypertensive medication,","history of hypertension prior to pregnancy,","history of gestational diabetes,","currently pregnancy,","body mass index \\\u003C18.5 kg\u002Fm2,","allergy to materials used during the experiment.(e.g. latex),","known allergies to study drugs,","bleeding disorders, peptic ulcer disease, gastritis, GI bleeding and gastroesophageal reflux disease (GERD).","Inclusion Criteria:\n\n* had preeclampsia in the past 5 years,\n* 18 years or older\n\nExclusion criteria:\n\n* current daily aspirin use,\n* skin diseases,\n* current tobacco or nicotine use (including vaping),\n* diagnosed or suspected hepatic or metabolic disease including chronic kidney disease (CKD) defined as reduced eGFR \\\u003C 60 mL\u002Fmin\u002F1.73m2,\n* statin or other cholesterol-lowering medication,\n* current antihypertensive medication,\n* history of hypertension prior to pregnancy,\n* history of gestational diabetes,\n* currently pregnancy,\n* body mass index \\\u003C18.5 kg\u002Fm2,\n* allergy to materials used during the experiment.(e.g. latex),\n* known allergies to study drugs,\n* bleeding disorders, peptic ulcer disease, gastritis, GI bleeding and gastroesophageal reflux disease (GERD).",[79],"ADULT",[81],{"facility":82,"status":8,"city":83,"state":84,"zip":85,"country":86,"contacts":87,"geoPoint":93},"University of Iowa","Iowa City","Iowa","52242","United States",[88],{"name":89,"role":90,"phone":91,"email":92},"Anna Stanhewicz","CONTACT","319-467-1732","anna-stanhewicz@uiowa.edu",{"lat":94,"lon":95},41.66113,-91.53017,[97],{"name":98,"role":90,"phone":91,"email":92},"Anna Reid-Stanhewicz, PHD",[],[],[],{"nct_id":4,"conditions":103,"biomarkers":104},[19],[],{"nct_id":4,"found":106,"summary":107,"prompt_version":116},true,{"design":108,"status":109,"heading":6,"summary":110,"follow_up":111,"word_count":112,"commitments":113,"compensation":114,"drugs_mentioned":115},"This study is comparing daily aspirin (162mg) to a placebo (an inactive pill) in 40 women. It is an interventional study, meaning participants will receive a specific treatment.","completed","This study is looking at whether taking a daily low-dose aspirin (162mg) after experiencing preeclampsia can help prevent lasting blood vessel damage. Preeclampsia is a serious condition during pregnancy that can increase a woman's risk of heart disease later in life. Researchers want to see if aspirin can improve how your blood vessels work. You may be able to join if you are a woman between 18 and 50 years old and had preeclampsia within the last five years. The study will measure changes in your blood vessel function to see if aspirin is effective. The current status of this study is unclear.","Participants will be followed for 12 weeks after starting treatment to measure blood vessel function.",103,"The study will measure your blood vessel function at the beginning and again after 12 weeks. Specific details about visits or other procedures are not provided.","Not stated in the trial record.",[32],"v2"]