[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06208878":3,"trial-entities:NCT06208878":230,"trial-summary:NCT06208878":234},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":21,"study_type":22,"primary_purpose":23,"phases":24,"enrollment_info":25,"interventions":28,"primary_outcomes":34,"secondary_outcomes":39,"sex":43,"minimum_age":44,"maximum_age":23,"healthy_volunteers":15,"eligibility_criteria":45,"std_ages":51,"locations":54,"central_contacts":226,"overall_officials":227,"references":228,"see_also_links":229},"NCT06208878","CRSP-ONC-LTF","A Long-term Follow-up Study of Subjects Who Received CRISPR CAR T Cellular Therapies","A Long-term Follow-up Study of Subjects With Malignancies Treated With CRISPR CAR T Cellular Therapies","ENROLLING_BY_INVITATION","2038-08","2025-08","2025-08-14","2023-11-22","CRISPR Therapeutics AG","INDUSTRY",false,"This study will evaluate the long-term safety and efficacy of CRISPR CAR T cellular therapies","All subjects with hematological and solid malignancies who are enrolled in a parent study and were exposed to allogeneic CRISPR CAR T cellular therapy will be asked to participate in this long-term follow-up (LTFU) study. Subjects who have completed the parent study for the protocol-defined duration, or who have discontinued the parent study early, or who are in secondary follow-up (follow up of subjects with progressive disease or who receive a subsequent line of anticancer therapy) in the parent study may enroll in this LTFU study. This will allow for collection of long-term efficacy data (as applicable) and safety data up to 15 years post-treatment with CRISPR CAR T cellular therapies.",[19,20],"Hematologic Malignancy","Solid Malignancy",[],"OBSERVATIONAL",null,[],{"count":26,"type":27},70,"ESTIMATED",[29],{"type":30,"name":31,"description":32,"armGroupLabels":33},"OTHER","Non Interventional","Safety and Efficacy Assessment",[31],[35],{"measure":36,"description":37,"timeFrame":38},"The incidence of adverse events, serious adverse events and adverse events of special interest related to CRISPR CAR T cellular therapy treatment.","The number and percentage of subjects with CRISPR CAR T cellular therapy related SAEs and AESIs will be summarized.","15 years",[40],{"measure":41,"description":42,"timeFrame":38},"The overall survival and duration of remission\u002Fresponse following CRISPR CAR T cellular therapy treatment","Overall survival will be calculated as the time between the initial dose of CRISPR CAR T cellular therapy in the parent study and death due to any cause. Duration of remission\u002Fresponse will be calculated as the time between the first objective response to first disease progression or death due to any cause.","ALL","18 Years",{"inclusion":46,"exclusion":49,"raw_text":50},[47,48],"Able to understand and comply with protocol-required study procedures and voluntarily sign and date a written informed consent document.","Must have received CRISPR CAR T cellular therapy.",[],"Inclusion Criteria:\n\n* Able to understand and comply with protocol-required study procedures and voluntarily sign and date a written informed consent document.\n* Must have received CRISPR CAR T cellular therapy.\n\nExclusion Criteria:\n\n* There are no specific exclusion criteria.",[52,53],"ADULT","OLDER_ADULT",[55,64,71,77,85,93,101,109,117,125,132,139,147,155,163,170,177,185,194,202,209,218],{"facility":56,"city":57,"state":58,"zip":59,"country":60,"geoPoint":61},"City of Hope","Duarte","California","91010","United States",{"lat":62,"lon":63},34.13945,-117.97729,{"facility":65,"city":66,"state":58,"zip":67,"country":60,"geoPoint":68},"Cedars Sinai","Los Angeles","90048",{"lat":69,"lon":70},34.05223,-118.24368,{"facility":72,"city":72,"state":58,"zip":73,"country":60,"geoPoint":74},"Stanford","94305",{"lat":75,"lon":76},37.42411,-122.16608,{"facility":78,"city":79,"state":80,"zip":81,"country":60,"geoPoint":82},"Yale New Haven Hospital","New Haven","Connecticut","06510",{"lat":83,"lon":84},41.30815,-72.92816,{"facility":86,"city":87,"state":88,"zip":89,"country":60,"geoPoint":90},"Emory","Atlanta","Georgia","30322",{"lat":91,"lon":92},33.749,-84.38798,{"facility":94,"city":95,"state":96,"zip":97,"country":60,"geoPoint":98},"University of Chicago","Chicago","Illinois","60637",{"lat":99,"lon":100},41.85003,-87.65005,{"facility":102,"city":103,"state":104,"zip":105,"country":60,"geoPoint":106},"University of Kansas","Westwood","Kansas","66205",{"lat":107,"lon":108},39.04056,-94.6169,{"facility":110,"city":111,"state":112,"zip":113,"country":60,"geoPoint":114},"University of Minnesota","Minneapolis","Minnesota","55455",{"lat":115,"lon":116},44.97997,-93.26384,{"facility":118,"city":119,"state":120,"zip":121,"country":60,"geoPoint":122},"Washington University Saint Louis","St Louis","Missouri","63110",{"lat":123,"lon":124},38.62727,-90.19789,{"facility":126,"city":127,"state":127,"zip":128,"country":60,"geoPoint":129},"MSKCC","New York","10065",{"lat":130,"lon":131},40.71427,-74.00597,{"facility":133,"city":134,"state":127,"zip":135,"country":60,"geoPoint":136},"Montefiore Medical Center","The Bronx","10467",{"lat":137,"lon":138},40.84985,-73.86641,{"facility":140,"city":141,"state":142,"zip":143,"country":60,"geoPoint":144},"Oregon Health and Science University","Portland","Oregon","97239",{"lat":145,"lon":146},45.52345,-122.67621,{"facility":148,"city":149,"state":150,"zip":151,"country":60,"geoPoint":152},"University of Pennsylvania","Philadelphia","Pennsylvania","19104",{"lat":153,"lon":154},39.95238,-75.16362,{"facility":156,"city":157,"state":158,"zip":159,"country":60,"geoPoint":160},"UT Southwestern","Dallas","Texas","75390",{"lat":161,"lon":162},32.78306,-96.80667,{"facility":164,"city":165,"state":158,"zip":166,"country":60,"geoPoint":167},"MD Anderson Cancer Center","Houston","77030",{"lat":168,"lon":169},29.76328,-95.36327,{"facility":171,"city":172,"state":158,"zip":173,"country":60,"geoPoint":174},"Methodist Hospital-Sarah Cannon","San Antonio","78229",{"lat":175,"lon":176},29.42412,-98.49363,{"facility":178,"city":179,"state":180,"zip":181,"country":60,"geoPoint":182},"University of Utah-Huntsman Cancer Institute","Salt Lake City","Utah","84112",{"lat":183,"lon":184},40.76078,-111.89105,{"facility":186,"city":187,"state":188,"zip":189,"country":190,"geoPoint":191},"Royal Prince Alfred Hospital","Camperdown","New South Wales","2050","Australia",{"lat":192,"lon":193},-33.88965,151.17642,{"facility":195,"city":196,"state":197,"zip":198,"country":190,"geoPoint":199},"Peter MacCallum Cancer Center","Melbourne","Victoria","3000",{"lat":200,"lon":201},-37.814,144.96332,{"facility":203,"city":204,"zip":205,"country":190,"geoPoint":206},"Sir Charles Gairdner","Nedlands","6009",{"lat":207,"lon":208},-31.98184,115.8073,{"facility":210,"city":211,"state":212,"zip":213,"country":214,"geoPoint":215},"Princess Margaret","Toronto","Ontario","M5G 2M9","Canada",{"lat":216,"lon":217},43.70643,-79.39864,{"facility":219,"city":220,"zip":221,"country":222,"geoPoint":223},"University Hospital Hamburg-Eppendorf","Hamburg","D-20246","Germany",{"lat":224,"lon":225},53.55073,9.99302,[],[],[],[],{"nct_id":4,"conditions":231,"biomarkers":233},[232,20],"Malignant neoplasm of lymphoid, hematopoietic and\u002For related tissue",[],{"nct_id":4,"found":15,"summary":23,"prompt_version":23}]