[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06274112":3,"trial-entities:NCT06274112":88,"trial-summary:NCT06274112":92},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":22,"study_type":23,"primary_purpose":24,"phases":25,"enrollment_info":27,"interventions":30,"primary_outcomes":38,"secondary_outcomes":46,"sex":47,"minimum_age":48,"maximum_age":49,"healthy_volunteers":50,"eligibility_criteria":51,"std_ages":67,"locations":69,"central_contacts":84,"overall_officials":85,"references":86,"see_also_links":87},"NCT06274112","1K23MH135222","Using TMS to Understand Neural Processes of Social Motivation","Personalized Neuromodulation Targeting Dysregulated Motivational Responses Underlying Social Avoidance Behavior","RECRUITING","2029-07-31","2026-02","2026-03-03","2025-09-30","Auburn University","OTHER",true,"The purpose of this study is to use transcranial magnetic stimulation (TMS) to better understand the neural circuits associated with social motivation.\n\nParticipant includes four study visits each that range from 1.5 - 3.0 hours in duration over approximately a one month period. The first study visit involves answering survey questions, a clinical interview, and computer tasks. The second study visit involves a magnetic resonance imaging (MRI) scan, computer tasks, and a brief TMS protocol. The second and third study visits involve a full session of TMS followed by an MRI scan and computer tasks.\n\nAdults in the Auburn\u002FOpelika area and surrounding areas who avoid social situations, experience symptoms of depression or social anxiety, and are between 25 years old and 50 years old are eligible to participate.",null,[19,20,21],"Social Avoidant Behavior","Major Depressive Disorder","Social Anxiety Disorder",[],"INTERVENTIONAL","BASIC_SCIENCE",[26],"NA",{"count":28,"type":29},40,"ESTIMATED",[31],{"type":32,"name":33,"description":34,"armGroupLabels":35},"DEVICE","TMS","TMS will be administered using a Cool B-65 coil to a personalized right dlPFC region.",[36,37],"TMS A","TMS B",[39,43],{"measure":40,"description":41,"timeFrame":42},"Social motivation","Motivational responses to facial expressions as measured by the Social Approach Avoidance Paradigm (SAAP; Evans, Esterman, \\& Britton, 2022). In the SAAP, participants self-report how much they would like to approach or avoid emotional facial expressions.","Immediately post-intervention",{"measure":44,"description":45,"timeFrame":42},"Neural circuit function","Brain connectivity during motivational responses to facial expression during the Social Approach-Avoidance Paradigm (SAAP; Evans, Esterman, \\& Britton, 2022) and during resting state conditions. In the SAAP, participants self-report how much they would like to approach or avoid emotional facial expressions. During resting state conditions, participants simply lie still with their eyes open without completing any type of task.",[],"ALL","25 Years","50 Years",false,{"inclusion":52,"exclusion":55,"raw_text":66},[53,54],"A diagnosis of Major Depressive Disorder OR a diagnosis of Social Anxiety Disorder (assessed\u002Fconfirmed at screening visit).","Scoring above clinical threshold on a measure of social avoidant behavior (assessed\u002Fconfirmed at phone screen).",[56,57,58,59,60,61,62,63,64,65],"Unstable psychotropic medication regimen (i.e., changes in psychotropic medication or dosage in past 3 months).","Current or lifetime diagnosis of Bipolar Disorder.","A diagnosis of substance use disorder within past 12 months.","A diagnosis of psychotic-spectrum disorder such as Schizophrenia.","Pregnancy or probable pregnancy.","Medical illness or medical treatment that would preclude or inhibit study participation.","Neurological disorder associated with brain damage.","History of seizures or head trauma with loss of consciousness \\> 5 minutes.","Family history of epilepsy or personal epilepsy\u002Fseizures","Ferromagnetic implants or ferrmagnetic objects within body (e.g., pacemaker).","Inclusion Criteria:\n\n* A diagnosis of Major Depressive Disorder OR a diagnosis of Social Anxiety Disorder (assessed\u002Fconfirmed at screening visit).\n* Scoring above clinical threshold on a measure of social avoidant behavior (assessed\u002Fconfirmed at phone screen).\n\nExclusion Criteria:\n\n* Unstable psychotropic medication regimen (i.e., changes in psychotropic medication or dosage in past 3 months).\n* Current or lifetime diagnosis of Bipolar Disorder.\n* A diagnosis of substance use disorder within past 12 months.\n* A diagnosis of psychotic-spectrum disorder such as Schizophrenia.\n* Pregnancy or probable pregnancy.\n* Medical illness or medical treatment that would preclude or inhibit study participation.\n* Neurological disorder associated with brain damage.\n* History of seizures or head trauma with loss of consciousness \\> 5 minutes.\n* Family history of epilepsy or personal epilepsy\u002Fseizures\n* Ferromagnetic implants or ferrmagnetic objects within body (e.g., pacemaker).",[68],"ADULT",[70],{"facility":13,"status":8,"city":71,"state":72,"zip":73,"country":74,"contacts":75,"geoPoint":81},"Auburn","Alabama","36849","United States",[76],{"name":77,"role":78,"phone":79,"email":80},"Travis Evans, PhD","CONTACT","3348444550","tce0018@auburn.edu",{"lat":82,"lon":83},32.60986,-85.48078,[],[],[],[],{"nct_id":4,"conditions":89,"biomarkers":91},[21,19,90],"Unipolar Depression",[],{"nct_id":4,"found":15,"summary":93,"prompt_version":103},{"design":94,"status":95,"heading":96,"summary":97,"follow_up":98,"word_count":99,"commitments":100,"compensation":101,"drugs_mentioned":102},"This is an interventional study planning to enroll 40 participants. It is not specified if it is randomized or blinded.","completed","Understanding Social Motivation with TMS for Depression and Social Anxiety","This study is exploring how transcranial magnetic stimulation (TMS) affects brain activity related to social motivation. TMS uses magnetic pulses to stimulate specific brain areas. Researchers want to understand the brain circuits involved in social motivation in people with Major Depressive Disorder or Social Anxiety Disorder who also experience social avoidance. You may be eligible if you are between 25 and 50 years old and have one of these diagnoses and social avoidant behavior. The study will measure your social motivation and brain function immediately after the TMS intervention. The current status of this study is unclear, and it aims to enroll 40 participants.","Your social motivation and neural circuit function will be measured immediately after the intervention.",104,"You would have four study visits over approximately one month, each lasting 1.5 to 3 hours. These visits include surveys, interviews, computer tasks, MRI scans, and TMS sessions.","Not stated in the trial record.",[33],"v2"]