[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06340568":3,"trial-entities:NCT06340568":1318,"trial-summary:NCT06340568":1323},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":31,"primary_purpose":32,"phases":33,"enrollment_info":35,"interventions":38,"primary_outcomes":60,"secondary_outcomes":68,"sex":112,"minimum_age":113,"maximum_age":114,"healthy_volunteers":115,"eligibility_criteria":116,"std_ages":145,"locations":148,"central_contacts":1301,"overall_officials":1308,"references":1312,"see_also_links":1317},"NCT06340568","BNT323-01","A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer","A Phase III, Randomized, Multi-site, Open-label Trial of BNT323\u002FDB-1303 Versus Investigator's Choice of Chemotherapy in Previously Treated Patients With HER2- Expressing Recurrent Endometrial Cancer","RECRUITING","2029-11","2026-07","2026-07-21","2025-06-10","BioNTech SE","INDUSTRY",true,"The study is divided into two cohorts (Cohort 1 and Cohort 2), to which participants will be enrolled based on the amount of human epidermal growth factor receptor 2 (HER2) in their tumor sample.\n\nIn Cohort 1, the main goal is to assess how well BNT323 (also known as DB-1303) or chemotherapy (doxorubicin or paclitaxel \\[or docetaxel, if participants cannot take paclitaxel\\]) works by determining the progression-free survival (PFS) of participants who have been previously treated with immune checkpoint inhibitors (ICIs).\n\nIn Cohort 2, the main goal is to assess how well BNT323 works by determining the objective response rate (ORR), that is, the percentage of participants whose tumor shrinks (partial response) or disappears (complete response) after treatment.\n\nThe safety of BNT323 will also be assessed by following the occurrence of unfavorable\u002Fadverse effects that are seen after treatment. Other measures include the pharmacokinetics of BNT323 (or how BNT323 moves through and out of the body), the body's immune response, and the impact on quality of life.","This is an open-label, randomized, multi-site, Phase III, interventional clinical study designed to determine the efficacy and safety of BNT323 compared with investigator's choice of single agent chemotherapy in previously treated participants with recurrent endometrial cancer (including HER2 1+ or 2+ score as determined using a centralized immunohistochemistry \\[IHC\\] analysis method), whose disease has progressed on at least one line of platinum-based therapy and ICI (Cohort 1). In addition, participants with recurrent endometrial cancer with HER2 IHC 3+ score will be enrolled in a BNT323 monotherapy arm (Cohort 2) to further investigate the efficacy and safety of BNT323.\n\nIn Cohort 1, participants will be randomized 2:1 to receive either BNT323\u002FDB-1303 or investigator's choice of single agent chemotherapy, preferably doxorubicin or paclitaxel (or docetaxel if contraindicated to paclitaxel and available at the site) until Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) defined progressive disease (PD) unless there is unacceptable toxicity, withdrawal of consent, or another criterion for discontinuation is met.\n\nIn Cohort 2, participants will receive BNT323 monotherapy until RECIST v1.1 defined PD unless there is unacceptable toxicity, withdrawal of consent, or another criterion for discontinuation is met.\n\nThe study consists of a screening period, a treatment period, a safety follow-up period, an efficacy follow-up period, and a long-term survival follow-up. The expected treatment duration per participant is \\~6 months, followed by an anticipated long-term survival follow-up period of up to 53 months.",[19],"Endometrial Cancer",[21,22,23,24,25,26,27,28,29,30],"Human epidermal growth factor receptor 2 (HER2)","HER2-expressing tumors","Recurrent endometrial cancer","IHC scores 1+, 2+, and 3+","Immune checkpoint inhibitor","Platinum-based therapy","HER2 protein expression","HER2-expressing endometrial cancer","ErbB-2 receptor","Antibody drug conjugate (ADC)","INTERVENTIONAL","TREATMENT",[34],"PHASE3",{"count":36,"type":37},480,"ESTIMATED",[39,48,53,57],{"type":40,"name":41,"description":42,"armGroupLabels":43,"otherNames":46},"DRUG","BNT323\u002FDB-1303","intravenous (IV) infusion",[44,45],"Cohort 1 (HER2 IHC score 1+ or 2+): BNT323\u002FDB-1303","Cohort 2 (HER2 IHC score 3+) - BNT323\u002FDB-1303",[47],"trastuzumab pamirtecan",{"type":40,"name":49,"description":50,"armGroupLabels":51},"Doxorubicin","IV bolus or infusion",[52],"Cohort 1 - Doxorubicin or paclitaxel (or docetaxel)",{"type":40,"name":54,"description":55,"armGroupLabels":56},"Paclitaxel","IV infusion",[52],{"type":40,"name":58,"description":55,"armGroupLabels":59},"Docetaxel",[52],[61,65],{"measure":62,"description":63,"timeFrame":64},"Cohort 1: PFS assessed by blinded independent central review (BICR) in participants with HER2 IHC 1+\u002F2+ recurrent endometrial cancer","By treatment arm. Defined as the time from randomization to the first objective tumor progression (per RECIST v1.1) or death from any cause, whichever occurs first.","Up to approximately 53 months",{"measure":66,"description":67,"timeFrame":64},"Cohort 2: ORR assessed by BICR in participants with HER2 IHC 3+ recurrent endometrial cancer","Defined as the proportion of participants with a CR or PR (per RECIST v1.1) as best overall response with confirmation.",[69,72,74,77,79,82,84,88,91,94,97,99,102,104,107,110],{"measure":70,"description":71,"timeFrame":64},"Cohort 1: Overall survival (OS) in participants with HER2 IHC 1+\u002F2+ recurrent endometrial cancer","By treatment arm. Defined as the time from randomization to death from any cause.",{"measure":73,"description":63,"timeFrame":64},"Cohort 1: PFS assessed by the investigator in participants with HER2 IHC 1+\u002F2+ recurrent endometrial cancer",{"measure":75,"description":76,"timeFrame":64},"Cohort 1: ORR assessed by BICR in participants with HER2 IHC 1+\u002F2+ recurrent endometrial cancer","By treatment arm. Defined as the proportion of participants with a CR or PR (per RECIST v1.1) as best overall response with confirmation.",{"measure":78,"description":76,"timeFrame":64},"Cohort 1: ORR assessed by the investigator in participants with HER2 IHC 1+\u002F2+ recurrent endometrial cancer",{"measure":80,"description":81,"timeFrame":64},"Cohort 1: Duration of response (DoR) assessed by BICR in participants with HER2 IHC 1+\u002F2+ recurrent endometrial cancer","By treatment arm. Defined as the time from first objective response (CR or PR per RECIST v1.1) to first occurrence of objective tumor progression (PD per RECIST v1.1) or death from any cause, whichever occurs first.",{"measure":83,"description":81,"timeFrame":64},"Cohort 1: DoR assessed by the investigator in participants with HER2 IHC 1+\u002F2+ recurrent endometrial cancer",{"measure":85,"description":86,"timeFrame":87},"Cohort 1: Percentage of participants with HER2 IHC 1+\u002F2+ recurrent endometrial cancer with occurrence of treatment-emergent adverse events (TEAEs)","By treatment arm. TEAEs including Grade ≥3, serious, and fatal TEAEs by relationship.","Up to 35 days after the last dose of study treatment",{"measure":89,"description":90,"timeFrame":87},"Cohort 1: Percentage of participants with HER2 IHC 1+\u002F2+ recurrent endometrial cancer with occurrence of TEAEs leading to drug interruption, dose reduction, or discontinuation of study treatment.","By treatment arm.",{"measure":92,"description":93,"timeFrame":64},"Cohort 2: ORR assessed by the investigator participants with HER2 IHC 3+ recurrent endometrial cancer","Defined as the proportion of participants in whom a CR or PR (per RECIST v1.1) is observed as best overall response with confirmation.",{"measure":95,"description":96,"timeFrame":64},"Cohort 2: DoR assessed by BICR in participants with HER2 IHC 3+ recurrent endometrial cancer","Defined as the time from first objective response (CR or PR per RECIST v1.1) to first occurrence of objective tumor progression (PD per RECIST v1.1) or death from any cause, whichever occurs first.",{"measure":98,"description":96,"timeFrame":64},"Cohort 2: DoR assessed by the investigator in participants with HER2 IHC 3+ recurrent endometrial cancer",{"measure":100,"description":101,"timeFrame":64},"Cohort 2: PFS assessed by BICR in participants with HER2 IHC 3+ recurrent endometrial cancer","Defined as the time from the first dose of study treatment to the first objective tumor progression (per RECIST v1.1) or death from any cause, whichever occurs first.",{"measure":103,"description":101,"timeFrame":64},"Cohort 2: PFS assessed by the investigator in participants with HER2 IHC 3+ recurrent endometrial cancer",{"measure":105,"description":106,"timeFrame":64},"Cohort 2: OS in participants with HER2 IHC 3+ recurrent endometrial cancer","Defined as the time from the first dose of trial treatment to death from any cause.",{"measure":108,"description":109,"timeFrame":87},"Cohort 2: Percentage of participants with HER2 IHC 3+ recurrent endometrial cancer with occurrence of TEAEs","BNT323 monotherapy. TEAEs including Grade ≥3, serious, and fatal TEAEs by relationship.",{"measure":111,"timeFrame":87},"Cohort 2: Percentage of participants with HER2 IHC 3+ recurrent endometrial cancer with occurrence of TEAEs leading to drug interruption, dose reduction, or discontinuation of study treatment.","FEMALE","18 Years",null,false,{"inclusion":117,"exclusion":130,"raw_text":144},[118,119,120,121,122,123,124,125,126,127,128,129],"Are female adults (defined as ≥18 years of age or acceptable age according to local regulations at the time of voluntarily giving informed consent).","Have histologically confirmed endometrial cancer that:","Is recurrent,","Has a HER2 IHC score of 1+, 2+ (Cohort 1), or 3+ (Cohort 2) as determined by central laboratory testing for HER2 expression, and","Is not defined as a true sarcoma (i.e., leiomyosarcoma or endometrial stromal sarcoma). Note: Uterine carcinosarcoma is allowed.","Have measurable disease defined by RECIST v1.1.","Have Eastern Cooperative Oncology Group (ECOG) Performance Status of 0, 1 or 2.","Have recurrent endometrial cancer and meet any of the following:","developed recurrence \\\u003C12 months from completing platinum-based chemotherapy given as adjuvant therapy for Stage I to III disease, or","developed recurrence after platinum-based chemotherapy in the recurrent\u002Fmetastatic setting.","Have received prior ICI treatment (i.e., anti-programmed death 1\u002Fanti-programmed death-ligand 1)","Have a life expectancy of ≥12 weeks at screening.",[131,132,133,134,135,136,137,138,139,140,141,142,143],"Are ineligible for all options in the investigator's choice of chemotherapy arm, per local prescribing information and institutional guidelines (applicable to Cohort 1 only).","Have a history of small bowel obstruction requiring hospitalization within the past 3 months prior the first dose of study treatment.","Have an uncontrolled intercurrent illness that would limit compliance with study requirement or substantially increase risk of incurring adverse events.","Have clinically uncontrolled pleural effusion, ascites or pericardial effusion requiring drainage, or peritoneal shunt within 2 weeks prior to the first dose of study treatment.","Have a history of (non-infectious) interstitial lung disease (ILD)\u002Fpneumonitis that required steroids, have current ILD\u002Fpneumonitis, or where suspected ILD\u002Fpneumonitis cannot be ruled out by imaging at screening.","Participants with prior use of immunosuppressive medication within 14 days prior to the first dose of study treatment, except for intranasal and inhaled corticosteroids or systemic corticosteroids at doses of less than 10 mg\u002Fday of prednisone or equivalent, and topical corticosteroids. Participants receiving corticosteroids may continue if the dose is stable upon giving main informed consent.","Have a lung-specific intercurrent clinically significant illness including, but not limited to, any underlying pulmonary disorder (e.g., pulmonary emboli within 3 months prior to the first dose of study treatment, severe asthma, chronic obstructive pulmonary disorder with moderate acute exacerbations, restrictive lung disease, pulmonary fibrosis, radiation pneumonitis, significant pleural effusion etc.), or any autoimmune, connective tissue or inflammatory disorder with pulmonary involvement (i.e., rheumatoid arthritis, Sjogren's syndrome, sarcoidosis etc.), and\u002For prior pneumonectomy (complete).","Have uncontrolled infection requiring systemic antibiotics, antivirals, or antifungals within 2 weeks prior to the first dose of study treatment.","Have unresolved toxicities from previous anti-cancer therapy, defined as toxicities (other than alopecia, fatigue, or endocrinopathies that are well controlled) not yet resolved to Grade ≤1 or baseline.","Are pregnant or breastfeeding or are planning pregnancy during the study or within 7 months after the last dose of study treatment.","Have a history of allergies, hypersensitivities, or intolerance to study treatments (investigational medicinal products and auxiliary medicinal product) including any excipients thereof or to other monoclonal antibodies. Participants who have successfully undergone a desensitization process and are able to tolerate the drug are eligible.","Had prior treatment with topoisomerase I inhibitors, including ADCs.","Have left ventricular ejection fraction \\\u003C55% by either echocardiography or multiple-gated acquisition within 28 days prior to the first dose of study treatment. This includes participants with tissue doppler E\u002Fe' ratio \\>15.","Key Inclusion Criteria:\n\n* Are female adults (defined as ≥18 years of age or acceptable age according to local regulations at the time of voluntarily giving informed consent).\n* Have histologically confirmed endometrial cancer that:\n\n  * Is recurrent,\n  * Has a HER2 IHC score of 1+, 2+ (Cohort 1), or 3+ (Cohort 2) as determined by central laboratory testing for HER2 expression, and\n  * Is not defined as a true sarcoma (i.e., leiomyosarcoma or endometrial stromal sarcoma). Note: Uterine carcinosarcoma is allowed.\n* Have measurable disease defined by RECIST v1.1.\n* Have Eastern Cooperative Oncology Group (ECOG) Performance Status of 0, 1 or 2.\n* Have recurrent endometrial cancer and meet any of the following:\n\n  * developed recurrence \\\u003C12 months from completing platinum-based chemotherapy given as adjuvant therapy for Stage I to III disease, or\n  * developed recurrence after platinum-based chemotherapy in the recurrent\u002Fmetastatic setting.\n* Have received prior ICI treatment (i.e., anti-programmed death 1\u002Fanti-programmed death-ligand 1)\n* Have a life expectancy of ≥12 weeks at screening.\n\nKey Exclusion Criteria:\n\n* Are ineligible for all options in the investigator's choice of chemotherapy arm, per local prescribing information and institutional guidelines (applicable to Cohort 1 only).\n* Have a history of small bowel obstruction requiring hospitalization within the past 3 months prior the first dose of study treatment.\n* Have an uncontrolled intercurrent illness that would limit compliance with study requirement or substantially increase risk of incurring adverse events.\n* Have clinically uncontrolled pleural effusion, ascites or pericardial effusion requiring drainage, or peritoneal shunt within 2 weeks prior to the first dose of study treatment.\n* Have a history of (non-infectious) interstitial lung disease (ILD)\u002Fpneumonitis that required steroids, have current ILD\u002Fpneumonitis, or where suspected ILD\u002Fpneumonitis cannot be ruled out by imaging at screening.\n* Participants with prior use of immunosuppressive medication within 14 days prior to the first dose of study treatment, except for intranasal and inhaled corticosteroids or systemic corticosteroids at doses of less than 10 mg\u002Fday of prednisone or equivalent, and topical corticosteroids. Participants receiving corticosteroids may continue if the dose is stable upon giving main informed consent.\n* Have a lung-specific intercurrent clinically significant illness including, but not limited to, any underlying pulmonary disorder (e.g., pulmonary emboli within 3 months prior to the first dose of study treatment, severe asthma, chronic obstructive pulmonary disorder with moderate acute exacerbations, restrictive lung disease, pulmonary fibrosis, radiation pneumonitis, significant pleural effusion etc.), or any autoimmune, connective tissue or inflammatory disorder with pulmonary involvement (i.e., rheumatoid arthritis, Sjogren's syndrome, sarcoidosis etc.), and\u002For prior pneumonectomy (complete).\n* Have uncontrolled infection requiring systemic antibiotics, antivirals, or antifungals within 2 weeks prior to the first dose of study treatment.\n* Have unresolved toxicities from previous anti-cancer therapy, defined as toxicities (other than alopecia, fatigue, or endocrinopathies that are well controlled) not yet resolved to Grade ≤1 or baseline.\n* Are pregnant or breastfeeding or are planning pregnancy during the study or within 7 months after the last dose of study treatment.\n* Have a history of allergies, hypersensitivities, or intolerance to study treatments (investigational medicinal products and auxiliary medicinal product) including any excipients thereof or to other monoclonal antibodies. Participants who have successfully undergone a desensitization process and are able to tolerate the drug are eligible.\n* Had prior treatment with topoisomerase I inhibitors, including ADCs.\n* Have left ventricular ejection fraction \\\u003C55% by either echocardiography or multiple-gated acquisition within 28 days prior to the first dose of study treatment. This includes participants with tissue doppler E\u002Fe' ratio \\>15.\n\nNOTE: Other protocol defined Inclusion\u002FExclusion criteria apply.",[146,147],"ADULT","OLDER_ADULT",[149,158,166,174,182,190,198,204,212,219,227,235,242,249,256,264,267,274,281,288,292,299,306,313,320,328,332,339,346,352,359,367,374,381,385,389,393,400,407,411,419,426,433,442,450,458,466,473,481,489,496,504,512,520,528,535,543,551,559,567,575,582,589,596,604,608,616,624,632,639,647,654,661,668,672,676,683,690,697,703,711,718,725,733,740,747,754,761,768,775,782,790,793,800,807,814,822,829,836,844,851,858,865,872,880,887,894,901,908,912,916,920,927,934,941,949,956,964,971,979,986,993,1001,1008,1015,1022,1029,1036,1040,1044,1048,1052,1056,1060,1064,1072,1076,1083,1090,1097,1104,1108,1112,1119,1127,1134,1141,1149,1153,1157,1164,1171,1175,1183,1190,1194,1198,1205,1212,1220,1227,1234,1241,1248,1255,1262,1269,1273,1280,1287,1294],{"facility":150,"status":8,"city":151,"state":152,"zip":153,"country":154,"geoPoint":155},"Yale University School of Medicine","New Haven","Connecticut","06520","United States",{"lat":156,"lon":157},41.30815,-72.92816,{"facility":159,"status":8,"city":160,"state":161,"zip":162,"country":154,"geoPoint":163},"MedStar Washington Hospital Center","Washington D.C.","District of Columbia","20010",{"lat":164,"lon":165},38.89511,-77.03637,{"facility":167,"status":8,"city":168,"state":169,"zip":170,"country":154,"geoPoint":171},"Broward Health Medical Center","Fort Lauderdale","Florida","33316",{"lat":172,"lon":173},26.12231,-80.14338,{"facility":175,"status":8,"city":176,"state":177,"zip":178,"country":154,"geoPoint":179},"OSF Saint Francis Medical Center","Peoria","Illinois","61637",{"lat":180,"lon":181},40.69365,-89.58899,{"facility":183,"status":8,"city":184,"state":185,"zip":186,"country":154,"geoPoint":187},"The Center of Hope Reno","Reno","Nevada","89511",{"lat":188,"lon":189},39.52963,-119.8138,{"facility":191,"status":8,"city":192,"state":193,"zip":194,"country":154,"geoPoint":195},"NYU Langone Hospital - Long Island","Mineola","New York","11501",{"lat":196,"lon":197},40.74927,-73.64068,{"facility":199,"status":8,"city":193,"state":193,"zip":200,"country":154,"geoPoint":201},"NYU Langone Health","10016",{"lat":202,"lon":203},40.71427,-74.00597,{"facility":205,"status":8,"city":206,"state":207,"zip":208,"country":154,"geoPoint":209},"Miami Valley Hospital South","Centerville","Ohio","45459",{"lat":210,"lon":211},39.62839,-84.15938,{"facility":213,"status":8,"city":214,"state":207,"zip":215,"country":154,"geoPoint":216},"Ohio State University","Hilliard","43026",{"lat":217,"lon":218},40.0334,-83.15825,{"facility":220,"status":8,"city":221,"state":222,"zip":223,"country":154,"geoPoint":224},"Sanford Cancer Center","Sioux Falls","South Dakota","57104",{"lat":225,"lon":226},43.54369,-96.72796,{"facility":228,"status":8,"city":229,"zip":230,"country":231,"geoPoint":232},"Hospital Británico de Buenos Aires","Buenos Aires","C1280AEB","Argentina",{"lat":233,"lon":234},-34.61315,-58.37723,{"facility":236,"status":8,"city":237,"zip":238,"country":231,"geoPoint":239},"Investigaciones CORI S.R.L.","La Rioja","F5300COE",{"lat":240,"lon":241},-29.41328,-66.85637,{"facility":243,"status":8,"city":244,"zip":245,"country":231,"geoPoint":246},"Hospital Provincial del Centenario","Rosario","S2002KDS",{"lat":247,"lon":248},-32.94682,-60.63932,{"facility":250,"status":8,"city":251,"zip":252,"country":231,"geoPoint":253},"Centro Oncológico de Excelencia","San Juan","5400",{"lat":254,"lon":255},-31.53726,-68.52568,{"facility":257,"status":8,"city":258,"zip":259,"country":260,"geoPoint":261},"Adelaide Oncology & Haematology","Adelaide","5000","Australia",{"lat":262,"lon":263},-34.92866,138.59863,{"facility":265,"status":8,"city":258,"zip":259,"country":260,"geoPoint":266},"Cancer Research SA",{"lat":262,"lon":263},{"facility":268,"status":8,"city":269,"zip":270,"country":260,"geoPoint":271},"Monash Health Clinical Trial Center","Clayton","3168",{"lat":272,"lon":273},-37.91667,145.11667,{"facility":275,"status":8,"city":276,"zip":277,"country":260,"geoPoint":278},"Gosford Hospital","Gosford","2250",{"lat":279,"lon":280},-33.4244,151.34399,{"facility":282,"status":8,"city":283,"zip":284,"country":260,"geoPoint":285},"Peter MacCallum Cancer Centre","Melbourne","3000",{"lat":286,"lon":287},-37.814,144.96332,{"facility":289,"status":8,"city":283,"zip":290,"country":260,"geoPoint":291},"Frankston Hospital","VIC 3199",{"lat":286,"lon":287},{"facility":293,"status":8,"city":294,"zip":295,"country":260,"geoPoint":296},"Shoalhaven Cancer Care Centre","Nowra","2541",{"lat":297,"lon":298},-34.88422,150.60036,{"facility":300,"status":8,"city":301,"zip":302,"country":260,"geoPoint":303},"Sunshine Hospital","Saint Albans","3021",{"lat":304,"lon":305},-37.73333,144.8,{"facility":307,"status":8,"city":308,"zip":309,"country":260,"geoPoint":310},"Mater Hospital Brisbane","South Brisbane","4001",{"lat":311,"lon":312},-27.48034,153.02049,{"facility":314,"status":8,"city":315,"zip":316,"country":260,"geoPoint":317},"Wollongong Hospital","Wollongong","2500",{"lat":318,"lon":319},-34.424,150.89345,{"facility":321,"status":8,"city":322,"zip":323,"country":324,"geoPoint":325},"Institut Jules Bordet","Brussels","1070","Belgium",{"lat":326,"lon":327},50.85045,4.34878,{"facility":329,"status":8,"city":322,"zip":330,"country":324,"geoPoint":331},"Cliniques Universitaires Saint-Luc","1200",{"lat":326,"lon":327},{"facility":333,"status":8,"city":334,"zip":335,"country":324,"geoPoint":336},"Universitair Ziekenhuis Gent","Ghent","9000",{"lat":337,"lon":338},51.05,3.71667,{"facility":340,"status":8,"city":341,"zip":342,"country":324,"geoPoint":343},"AZ Groeninge VZW","Kortrijk","8500",{"lat":344,"lon":345},50.82803,3.26487,{"facility":347,"status":8,"city":348,"zip":284,"country":324,"geoPoint":349},"UZ Leuven","Leuven",{"lat":350,"lon":351},50.87959,4.70093,{"facility":353,"status":8,"city":354,"zip":355,"country":324,"geoPoint":356},"CHU UCL Namur-Sainte-Elisabeth","Namur","B5000",{"lat":357,"lon":358},50.4669,4.86746,{"facility":360,"status":8,"city":361,"zip":362,"country":363,"geoPoint":364},"Fundação Sao Francisco Xavier","Ipatinga","35162-189","Brazil",{"lat":365,"lon":366},-19.46833,-42.53667,{"facility":368,"status":8,"city":369,"zip":370,"country":363,"geoPoint":371},"Hospital de Clínicas de Passo Fundo","Passo Fundo","99010-260",{"lat":372,"lon":373},-28.26278,-52.40667,{"facility":375,"status":8,"city":376,"zip":377,"country":363,"geoPoint":378},"Instituto de Pesquisa Clínica - Hospital Moinhos de Vento","Porto Alegre","90035-000",{"lat":379,"lon":380},-30.03283,-51.23019,{"facility":382,"status":8,"city":376,"zip":383,"country":363,"geoPoint":384},"Hospital de Clínicas de Porto Alegre","90035-903",{"lat":379,"lon":380},{"facility":386,"status":8,"city":376,"zip":387,"country":363,"geoPoint":388},"Irmandade da Santa Casa de Misericórdia de Porto Alegre","90050-170",{"lat":379,"lon":380},{"facility":390,"status":8,"city":376,"zip":391,"country":363,"geoPoint":392},"HPT São Lucas da PUCRS - UBEA","90610-000",{"lat":379,"lon":380},{"facility":394,"status":8,"city":395,"zip":396,"country":363,"geoPoint":397},"Fundação Faculdade Regional de Medicina de São José do Rio Petro","São José do Rio Preto","15090-000",{"lat":398,"lon":399},-20.81972,-49.37944,{"facility":401,"status":8,"city":402,"zip":403,"country":363,"geoPoint":404},"Hospital Sirio Libanês","São Paulo","01308-050",{"lat":405,"lon":406},-23.5475,-46.63611,{"facility":408,"status":8,"city":402,"zip":409,"country":363,"geoPoint":410},"Inst D'Or de Pesquisa E Ensino","01401-002",{"lat":405,"lon":406},{"facility":412,"status":8,"city":413,"zip":414,"country":415,"geoPoint":416},"Jewish General Hospital","Montreal","H3T 1E2","Canada",{"lat":417,"lon":418},45.50884,-73.58781,{"facility":420,"status":8,"city":421,"zip":422,"country":415,"geoPoint":423},"Health Sciences Centre","St. John's","A1V 3V6",{"lat":424,"lon":425},47.56494,-52.70931,{"facility":427,"status":8,"city":428,"zip":429,"country":415,"geoPoint":430},"Princess Margaret Cancer C","Toronto","M5G 2M9",{"lat":431,"lon":432},43.70643,-79.39864,{"facility":434,"status":8,"city":435,"state":436,"zip":437,"country":438,"geoPoint":439},"Anhui Provincial Hospital","Hefei","Anhui","230001","China",{"lat":440,"lon":441},31.86389,117.28083,{"facility":443,"status":8,"city":444,"state":445,"zip":446,"country":438,"geoPoint":447},"Beijing Cancer Hospital","Beijing","Beijing Municipality","100142",{"lat":448,"lon":449},39.9075,116.39723,{"facility":451,"status":8,"city":452,"state":453,"zip":454,"country":438,"geoPoint":455},"The Second Affiliated Hospital of Chongqing Medical University","Chongqing","Chongqing Municipality","400010",{"lat":456,"lon":457},29.56026,106.55771,{"facility":459,"status":8,"city":460,"state":461,"zip":462,"country":438,"geoPoint":463},"Fujian Provincial Cancer Hospital","Fuzhou","Fujian","350014",{"lat":464,"lon":465},26.06139,119.30611,{"facility":467,"status":8,"city":468,"state":461,"zip":469,"country":438,"geoPoint":470},"First Affiliated Hospital of Xiamen University","Xiamen","361003",{"lat":471,"lon":472},24.47979,118.08187,{"facility":474,"status":8,"city":475,"state":476,"zip":477,"country":438,"geoPoint":478},"Gansu Provincial Maternity and Child-care Hospital","Lanzhou","Gansu","730050",{"lat":479,"lon":480},36.05701,103.83987,{"facility":482,"status":8,"city":483,"state":484,"zip":485,"country":438,"geoPoint":486},"The First Affiliated Hospital of Sun Yat-sen University","Guangzhou","Guangdong","510080",{"lat":487,"lon":488},23.11667,113.25,{"facility":490,"status":8,"city":491,"state":484,"zip":492,"country":438,"geoPoint":493},"Cancer Hospital of Shantou University Medical College","Shantou","515063",{"lat":494,"lon":495},23.35489,116.67876,{"facility":497,"status":8,"city":498,"state":499,"zip":500,"country":438,"geoPoint":501},"Guangxi Medical University Affiliated Tumor Hospital","Nanning","Guangxi","530200",{"lat":502,"lon":503},22.81667,108.31667,{"facility":505,"status":8,"city":506,"state":507,"zip":508,"country":438,"geoPoint":509},"Harbin Medical University Cancer Hospital","Harbin","Heilongjiang","150091",{"lat":510,"lon":511},45.75,126.65,{"facility":513,"status":8,"city":514,"state":515,"zip":516,"country":438,"geoPoint":517},"The Second Affiliated Hospital of Zhengzhou University","Zhengzhou","Henan","450014",{"lat":518,"lon":519},34.75778,113.64861,{"facility":521,"status":8,"city":522,"state":523,"zip":524,"country":438,"geoPoint":525},"Hubei Cancer Hospital","Wuhan","Hubei","430079",{"lat":526,"lon":527},30.58333,114.26667,{"facility":529,"status":8,"city":530,"state":523,"zip":531,"country":438,"geoPoint":532},"Xiangyang Central Hospital","Xiangyang","441138",{"lat":533,"lon":534},32.0422,112.14479,{"facility":536,"status":8,"city":537,"state":538,"zip":539,"country":438,"geoPoint":540},"The Affiliated Hospital of Nanjing University Medical School","Nanjing","Jiangsu","210008",{"lat":541,"lon":542},32.06167,118.77778,{"facility":544,"status":8,"city":545,"state":546,"zip":547,"country":438,"geoPoint":548},"Jiangxi Maternal and Child Health Hospital","Nanchang","Jiangxi","330006",{"lat":549,"lon":550},28.68396,115.85306,{"facility":552,"status":8,"city":553,"state":554,"zip":555,"country":438,"geoPoint":556},"The First Hospital of Jilin University","Changchun","Jilin","130021",{"lat":557,"lon":558},43.88,125.32278,{"facility":560,"status":8,"city":561,"state":562,"zip":563,"country":438,"geoPoint":564},"The First Affiliated Hospital of Xian Jiaotong University","Xi'an","Shaanxi","710061",{"lat":565,"lon":566},34.25833,108.92861,{"facility":568,"status":8,"city":569,"state":570,"zip":571,"country":438,"geoPoint":572},"Cancer Hospital of Shandong First Medical University","Jinan","Shandong","250117",{"lat":573,"lon":574},36.66833,116.99722,{"facility":576,"status":8,"city":577,"state":570,"zip":578,"country":438,"geoPoint":579},"Affiliated Hospital of Jining Medical University","Jining","272029",{"lat":580,"lon":581},35.405,116.58139,{"facility":583,"status":8,"city":584,"state":570,"zip":585,"country":438,"geoPoint":586},"Linyi Cancer Hospital","Linyi","276001",{"lat":587,"lon":588},35.06306,118.34278,{"facility":590,"status":8,"city":591,"state":570,"zip":592,"country":438,"geoPoint":593},"Yantai Yuhuangding Hospital","Yantai","264000",{"lat":594,"lon":595},37.47649,121.44081,{"facility":597,"status":8,"city":598,"state":599,"zip":600,"country":438,"geoPoint":601},"Obstetrics & Gynecology Hospital of Fudan University","Shanghai","Shanghai Municipality","200011",{"lat":602,"lon":603},31.22222,121.45806,{"facility":605,"status":8,"city":598,"state":599,"zip":606,"country":438,"geoPoint":607},"Fudan University Shanghai Cancer Center","200032",{"lat":602,"lon":603},{"facility":609,"status":8,"city":610,"state":611,"zip":612,"country":438,"geoPoint":613},"Sichuan Provincial People's Hospital","Chengdu","Sichuan","610072",{"lat":614,"lon":615},30.66667,104.06667,{"facility":617,"status":8,"city":618,"state":619,"zip":620,"country":438,"geoPoint":621},"Tianjin Medical University Cancer Institute & Hospital","Tianjin","Tianjin Municipality","300060",{"lat":622,"lon":623},39.14222,117.17667,{"facility":625,"status":8,"city":626,"state":627,"zip":628,"country":438,"geoPoint":629},"Zhejiang Cancer Hospital","Hangzhou","Zhejiang","310022",{"lat":630,"lon":631},30.29365,120.16142,{"facility":633,"status":8,"city":634,"state":627,"zip":635,"country":438,"geoPoint":636},"The First Affiliated Hospital of Wenzhou Medical University","Wenzhou","325015",{"lat":637,"lon":638},27.99942,120.66682,{"facility":640,"status":8,"city":641,"zip":642,"country":643,"geoPoint":644},"Gynekologicko-porodnická klinika, Fakultni nemocnice Brno","Brno","60200","Czechia",{"lat":645,"lon":646},49.19522,16.60796,{"facility":648,"status":8,"city":649,"zip":650,"country":643,"geoPoint":651},"University Hospital Olomouc - Onkologická klinika- Fakultni","Olomouc","77900",{"lat":652,"lon":653},49.59552,17.25175,{"facility":655,"status":8,"city":656,"zip":657,"country":643,"geoPoint":658},"Fakultní nemocnice Ostrava","Ostrava","01790",{"lat":659,"lon":660},49.83465,18.28204,{"facility":662,"status":8,"city":663,"zip":664,"country":643,"geoPoint":665},"Vseobecna fakultni nemocnice v Praze","Prague","12808",{"lat":666,"lon":667},50.08804,14.42076,{"facility":669,"status":8,"city":663,"zip":670,"country":643,"geoPoint":671},"Fakultní nemocnice Motol a Homolka","15000",{"lat":666,"lon":667},{"facility":673,"status":8,"city":663,"zip":674,"country":643,"geoPoint":675},"Fakultní nemocnice Bulovka","18081",{"lat":666,"lon":667},{"facility":677,"status":8,"city":678,"zip":335,"country":679,"geoPoint":680},"Aalborg Universit Hospital","Aalborg","Denmark",{"lat":681,"lon":682},57.048,9.9187,{"facility":684,"status":8,"city":685,"zip":686,"country":679,"geoPoint":687},"Rigshospitalet","Copenhagen","2100",{"lat":688,"lon":689},55.67594,12.56553,{"facility":691,"status":8,"city":692,"zip":693,"country":679,"geoPoint":694},"Herlev og Gentofte Hospital","Herlev","2730",{"lat":695,"lon":696},55.72366,12.43998,{"facility":698,"status":8,"city":699,"zip":259,"country":679,"geoPoint":700},"Odense University Hospital","Odense",{"lat":701,"lon":702},55.39594,10.38831,{"facility":704,"status":8,"city":705,"zip":706,"country":707,"geoPoint":708},"Kuopio University HPT","Kuopio","70210","Finland",{"lat":709,"lon":710},62.89238,27.67703,{"facility":712,"status":8,"city":713,"zip":714,"country":707,"geoPoint":715},"OYS Naisten poliklinikka","Oulu","90029",{"lat":716,"lon":717},65.01236,25.46816,{"facility":719,"status":8,"city":720,"zip":721,"country":707,"geoPoint":722},"Turun yliopistollinen keskussairaala","Turku","20521",{"lat":723,"lon":724},60.45148,22.26869,{"facility":726,"status":8,"city":727,"zip":728,"country":729,"geoPoint":730},"ICO - Site Paul Papin","Angers","49055","France",{"lat":731,"lon":732},47.47156,-0.55202,{"facility":734,"status":8,"city":735,"zip":736,"country":729,"geoPoint":737},"CHU Besançon Service Oncologie","Besançon","25000",{"lat":738,"lon":739},47.24878,6.01815,{"facility":741,"status":8,"city":742,"zip":743,"country":729,"geoPoint":744},"Centre François Baclesse","Caen","14000",{"lat":745,"lon":746},49.18585,-0.35912,{"facility":748,"status":8,"city":749,"zip":750,"country":729,"geoPoint":751},"Clinique Victor Hugo - Centre Jean Bernard","Le Mans","72000",{"lat":752,"lon":753},48.0021,0.20251,{"facility":755,"status":8,"city":756,"zip":757,"country":729,"geoPoint":758},"Hôpital Nord Bâtiment Mistral","Marseille","13015",{"lat":759,"lon":760},43.29695,5.38107,{"facility":762,"status":8,"city":763,"zip":764,"country":729,"geoPoint":765},"Hôpital Saint Louis","Paris","75010",{"lat":766,"lon":767},48.85341,2.3488,{"facility":769,"status":8,"city":770,"zip":771,"country":729,"geoPoint":772},"ICO - Site René Gauducheau","Saint-Herblain","44800",{"lat":773,"lon":774},47.21154,-1.651,{"facility":776,"status":8,"city":777,"zip":778,"country":729,"geoPoint":779},"Institut de Cancérologie de Strasbourg Europe - ICANS","Strasbourg","67000",{"lat":780,"lon":781},48.58392,7.74553,{"facility":783,"status":8,"city":784,"zip":785,"country":786,"geoPoint":787},"Alexandra General Hospital of Athens","Athens","11528","Greece",{"lat":788,"lon":789},37.98376,23.72784,{"facility":791,"status":8,"city":784,"zip":785,"country":786,"geoPoint":792},"Aretaieio Hospital",{"lat":788,"lon":789},{"facility":794,"status":8,"city":795,"zip":796,"country":786,"geoPoint":797},"University General Hospital Attikon","Chaïdári","124 62",{"lat":798,"lon":799},38.01135,23.66597,{"facility":801,"status":8,"city":802,"zip":803,"country":786,"geoPoint":804},"General Hospital of Kalamata","Kalamata","24100",{"lat":805,"lon":806},37.03913,22.11265,{"facility":808,"status":8,"city":809,"zip":810,"country":786,"geoPoint":811},"IASO General Clinic","Marousi","151 23",{"lat":812,"lon":813},38.05,23.8,{"facility":815,"status":8,"city":816,"zip":817,"country":818,"geoPoint":819},"Semmelweis Egyetem","Budapest","1088","Hungary",{"lat":820,"lon":821},47.49835,19.04045,{"facility":823,"status":8,"city":824,"zip":825,"country":818,"geoPoint":826},"Debreceni Egyetem","Debrecen","4032",{"lat":827,"lon":828},47.53167,21.62444,{"facility":830,"status":8,"city":831,"zip":832,"country":818,"geoPoint":833},"Bács-Kiskun Vármegyei Oktatókórház","Kecskemét","6000",{"lat":834,"lon":835},46.90618,19.69128,{"facility":837,"status":8,"city":838,"zip":839,"country":840,"geoPoint":841},"Lady Davis Carmel Medical Center","Haifa","3436212","Israel",{"lat":842,"lon":843},32.81303,34.99928,{"facility":845,"status":8,"city":846,"zip":847,"country":840,"geoPoint":848},"Hadassah Ein Kerem Medical Center","Jerusalem","9112001",{"lat":849,"lon":850},31.76904,35.21633,{"facility":852,"status":8,"city":853,"zip":854,"country":840,"geoPoint":855},"Rabin Medical Center-Beilinson Campus","Petah Tikva","4941492",{"lat":856,"lon":857},32.08707,34.88747,{"facility":859,"status":8,"city":860,"zip":861,"country":840,"geoPoint":862},"Sheba Medical Center","Ramat Gan","5265601",{"lat":863,"lon":864},32.08227,34.81065,{"facility":866,"status":8,"city":867,"zip":868,"country":840,"geoPoint":869},"Sourasky Medical Centre","Tel Aviv","642390",{"lat":870,"lon":871},32.08088,34.78057,{"facility":873,"status":8,"city":874,"zip":875,"country":876,"geoPoint":877},"Istituto Tumori Giovanni Paolo II IRCCS Ospedale Oncologico Bari","Bari","70124","Italy",{"lat":878,"lon":879},41.12066,16.86982,{"facility":881,"status":8,"city":882,"zip":883,"country":876,"geoPoint":884},"Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS","Bologna","40138",{"lat":885,"lon":886},44.49381,11.33875,{"facility":888,"status":8,"city":889,"zip":890,"country":876,"geoPoint":891},"Azienda Ospedaliera Cannizzaro - Oncologia","Catania","95126",{"lat":892,"lon":893},37.49223,15.07041,{"facility":895,"status":8,"city":896,"zip":897,"country":876,"geoPoint":898},"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST)","Meldola","47014",{"lat":899,"lon":900},44.12775,12.0626,{"facility":902,"status":8,"city":903,"zip":904,"country":876,"geoPoint":905},"Ospedale San Raffaele","Milan","20132",{"lat":906,"lon":907},42.78235,12.59836,{"facility":909,"status":8,"city":903,"zip":910,"country":876,"geoPoint":911},"Istituto Nazionale dei Tumori","20133",{"lat":906,"lon":907},{"facility":913,"status":8,"city":903,"zip":914,"country":876,"geoPoint":915},"Istituto Europeo di Oncologia","20141",{"lat":906,"lon":907},{"facility":917,"status":8,"city":903,"zip":918,"country":876,"geoPoint":919},"Humanitas San Pio X","20159",{"lat":906,"lon":907},{"facility":921,"status":8,"city":922,"zip":923,"country":876,"geoPoint":924},"Istituto Nazionale Tumori Fondazione G. Pascale","Naples","80131",{"lat":925,"lon":926},40.85216,14.26811,{"facility":928,"status":8,"city":929,"zip":930,"country":876,"geoPoint":931},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","Roma","00168",{"lat":932,"lon":933},44.99364,11.10642,{"facility":935,"status":8,"city":936,"zip":937,"country":876,"geoPoint":938},"Azienda Ospedaliera Ordine Mauriziano Umberto I di Torino","Torino","10128",{"lat":939,"lon":940},44.88856,11.99138,{"facility":942,"status":8,"city":943,"zip":944,"country":945,"geoPoint":946},"Radboud UMC","Nijmegen","6525 GA","Netherlands",{"lat":947,"lon":948},51.8425,5.85278,{"facility":950,"status":8,"city":951,"zip":952,"country":945,"geoPoint":953},"Erasmus Medisch Centrum","Rotterdam","3015 AA",{"lat":954,"lon":955},51.9225,4.47917,{"facility":957,"status":8,"city":958,"zip":959,"country":960,"geoPoint":961},"Oslo University Hospital","Oslo","0379","Norway",{"lat":962,"lon":963},59.91273,10.74609,{"facility":965,"status":8,"city":966,"zip":967,"country":960,"geoPoint":968},"Stavanger University Hospital","Stavanger","4011",{"lat":969,"lon":970},58.97005,5.73332,{"facility":972,"status":8,"city":973,"zip":974,"country":975,"geoPoint":976},"Bialostockie Centrum Onkologii im. Marii Sklodowskiej-Curie","Bialystok","15-027","Poland",{"lat":977,"lon":978},53.13333,23.16433,{"facility":980,"status":8,"city":981,"zip":982,"country":975,"geoPoint":983},"Siedleckie Centrum Onkologii","Siedlce","08-110",{"lat":984,"lon":985},52.16772,22.29006,{"facility":987,"status":8,"city":988,"zip":989,"country":988,"geoPoint":990},"National Cancer Centre Singapore","Singapore","168583",{"lat":991,"lon":992},1.28967,103.85007,{"facility":994,"status":8,"city":995,"zip":996,"country":997,"geoPoint":998},"Samsung Changwon Hospital","Changwon","51353","South Korea",{"lat":999,"lon":1000},35.22806,128.68111,{"facility":1002,"status":8,"city":1003,"zip":1004,"country":997,"geoPoint":1005},"Keimyung Univty Dongsan Hospital","Daegu","42601",{"lat":1006,"lon":1007},35.87028,128.59111,{"facility":1009,"status":8,"city":1010,"zip":1011,"country":997,"geoPoint":1012},"National Cancer Center","Goyang","10408",{"lat":1013,"lon":1014},36.21689,127.19731,{"facility":1016,"status":8,"city":1017,"zip":1018,"country":997,"geoPoint":1019},"Seoul National University Bundang Hospital","Seongnam","13620",{"lat":1020,"lon":1021},35.4421,126.46353,{"facility":1023,"status":8,"city":1024,"zip":1025,"country":997,"geoPoint":1026},"CHA Bundang Medical Center","Seongnam-si","13496",{"lat":1027,"lon":1028},37.43861,127.13778,{"facility":1030,"status":8,"city":1031,"zip":1032,"country":997,"geoPoint":1033},"Korea University Anam Hospital","Seoul","02841",{"lat":1034,"lon":1035},37.566,126.9784,{"facility":1037,"status":8,"city":1031,"zip":1038,"country":997,"geoPoint":1039},"Seoul National University Hospital","03080",{"lat":1034,"lon":1035},{"facility":1041,"status":8,"city":1031,"zip":1042,"country":997,"geoPoint":1043},"Severance Hospital, Yonsei University Health System","03722",{"lat":1034,"lon":1035},{"facility":1045,"status":8,"city":1031,"zip":1046,"country":997,"geoPoint":1047},"Asan Medical Center","05505",{"lat":1034,"lon":1035},{"facility":1049,"status":8,"city":1031,"zip":1050,"country":997,"geoPoint":1051},"Gangnam Severance Hospital, Yonsei University Health System","06273",{"lat":1034,"lon":1035},{"facility":1053,"status":8,"city":1031,"zip":1054,"country":997,"geoPoint":1055},"Samsung Medical Center","06351",{"lat":1034,"lon":1035},{"facility":1057,"status":8,"city":1031,"zip":1058,"country":997,"geoPoint":1059},"The Catholic University of Korea, Seoul St. Mary's Hospital","06591",{"lat":1034,"lon":1035},{"facility":1061,"status":8,"city":1031,"zip":1062,"country":997,"geoPoint":1063},"Ewha Womans University Seoul Hospital","07804",{"lat":1034,"lon":1035},{"facility":1065,"status":8,"city":1066,"zip":1067,"country":1068,"geoPoint":1069},"Hospital Universitari Vall, d'Hebron","Barcelona","08035","Spain",{"lat":1070,"lon":1071},41.38879,2.15899,{"facility":1073,"status":8,"city":1066,"zip":1074,"country":1068,"geoPoint":1075},"Hospital Clinic de Barcelona","08036",{"lat":1070,"lon":1071},{"facility":1077,"status":8,"city":1078,"zip":1079,"country":1068,"geoPoint":1080},"Hospital Universitario Reina Sofia","Córdoba","14004",{"lat":1081,"lon":1082},37.89155,-4.77275,{"facility":1084,"status":8,"city":1085,"zip":1086,"country":1068,"geoPoint":1087},"Hospital Universitar Donostia","Donostia \u002F San Sebastian","20014",{"lat":1088,"lon":1089},43.31283,-1.97499,{"facility":1091,"status":8,"city":1092,"zip":1093,"country":1068,"geoPoint":1094},"Institut Català d'Oncologia (ICO) Hospital Universitari de Girona Dr. Josep Trueta","Girona","17007",{"lat":1095,"lon":1096},41.98311,2.82493,{"facility":1098,"status":8,"city":1099,"zip":1100,"country":1068,"geoPoint":1101},"Hospital Universitario Ramón y Cajal","Madrid","28034",{"lat":1102,"lon":1103},40.4165,-3.70256,{"facility":1105,"status":8,"city":1099,"zip":1106,"country":1068,"geoPoint":1107},"Hospital Universitario 12 de Octubre","28041",{"lat":1102,"lon":1103},{"facility":1109,"status":8,"city":1099,"zip":1110,"country":1068,"geoPoint":1111},"Hospital Universitario La Paz","28046",{"lat":1102,"lon":1103},{"facility":1113,"status":8,"city":1114,"zip":1115,"country":1068,"geoPoint":1116},"Instituto Valenciano de Oncología - Valencia","Valencia","46009",{"lat":1117,"lon":1118},39.47391,-0.37966,{"facility":1120,"status":8,"city":1121,"zip":1122,"country":1123,"geoPoint":1124},"Skånes Universitetssjukhus Lund","Lund","222 42","Sweden",{"lat":1125,"lon":1126},55.70584,13.19321,{"facility":1128,"status":8,"city":1129,"zip":1130,"country":1123,"geoPoint":1131},"Karolinska University Hospital","Stockholm","17176",{"lat":1132,"lon":1133},59.32938,18.06871,{"facility":1135,"status":8,"city":1136,"zip":1137,"country":1123,"geoPoint":1138},"Akademiska Sjukhuset","Uppsala","75185",{"lat":1139,"lon":1140},59.85882,17.63889,{"facility":1142,"status":8,"city":1143,"zip":1144,"country":1145,"geoPoint":1146},"China Medical University Hospital","Taichung","40447","Taiwan",{"lat":1147,"lon":1148},24.1469,120.6839,{"facility":1150,"status":8,"city":1143,"zip":1151,"country":1145,"geoPoint":1152},"Taichung Veterans General Hospital","40705",{"lat":1147,"lon":1148},{"facility":1154,"status":8,"city":1143,"zip":1155,"country":1145,"geoPoint":1156},"Kuang Tien General Hospital","433004",{"lat":1147,"lon":1148},{"facility":1158,"status":8,"city":1159,"zip":1160,"country":1145,"geoPoint":1161},"National Cheng Kung University Hospital","Tainan","70457",{"lat":1162,"lon":1163},22.99083,120.21333,{"facility":1165,"status":8,"city":1166,"zip":1167,"country":1145,"geoPoint":1168},"MacKay Memorial Hospital_ Taipei Branch","Taipei","10449",{"lat":1169,"lon":1170},25.05306,121.52639,{"facility":1172,"status":8,"city":1166,"zip":1173,"country":1145,"geoPoint":1174},"Taipei Veterans General Hospital","11217",{"lat":1169,"lon":1170},{"facility":1176,"status":8,"city":1177,"zip":1178,"country":1179,"geoPoint":1180},"Baskent University Adana Application and Research Center","Adana","01120","Turkey (Türkiye)",{"lat":1181,"lon":1182},36.98615,35.32531,{"facility":1184,"status":8,"city":1185,"zip":1186,"country":1179,"geoPoint":1187},"Dr. Abdurrahman Yurtaslan Oncology Teaching and Research Hospital","Ankara","06200",{"lat":1188,"lon":1189},39.91987,32.85427,{"facility":1191,"status":8,"city":1185,"zip":1192,"country":1179,"geoPoint":1193},"Hacettepe University","06230",{"lat":1188,"lon":1189},{"facility":1195,"status":8,"city":1185,"zip":1196,"country":1179,"geoPoint":1197},"Baskent University Ankara Hospital","06490",{"lat":1188,"lon":1189},{"facility":1199,"status":8,"city":1200,"zip":1201,"country":1179,"geoPoint":1202},"İzmir City Hospital","Bayraklı","35540",{"lat":1203,"lon":1204},37.99375,41.18253,{"facility":1206,"status":8,"city":1207,"zip":1208,"country":1179,"geoPoint":1209},"Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi","Istanbul","34093",{"lat":1210,"lon":1211},41.01384,28.94966,{"facility":1213,"status":8,"city":1214,"zip":1215,"country":1216,"geoPoint":1217},"Royal Sussex County Hospital","Brighton","BN2 1ES","United Kingdom",{"lat":1218,"lon":1219},50.82838,-0.13947,{"facility":1221,"status":8,"city":1222,"zip":1223,"country":1216,"geoPoint":1224},"Bristol Haematology and Oncology Centre","Bristol","BS2 8ED",{"lat":1225,"lon":1226},51.45523,-2.59665,{"facility":1228,"status":8,"city":1229,"zip":1230,"country":1216,"geoPoint":1231},"Addenbrooke's Hospital","Cambridge","CB2 0QQ",{"lat":1232,"lon":1233},52.2,0.11667,{"facility":1235,"status":8,"city":1236,"zip":1237,"country":1216,"geoPoint":1238},"Castle Hill Hospital","Cottingham","HU165JQ",{"lat":1239,"lon":1240},52.50243,-0.7554,{"facility":1242,"status":8,"city":1243,"zip":1244,"country":1216,"geoPoint":1245},"Warwick Hospital","Coventry","CV2 2DX",{"lat":1246,"lon":1247},52.40656,-1.51217,{"facility":1249,"status":8,"city":1250,"zip":1251,"country":1216,"geoPoint":1252},"Western General Hospital","Edinburgh","EH4 2XU",{"lat":1253,"lon":1254},55.95206,-3.19648,{"facility":1256,"status":8,"city":1257,"zip":1258,"country":1216,"geoPoint":1259},"Royal Devon & Exeter HPT","Exeter","EX2 5DW",{"lat":1260,"lon":1261},50.7236,-3.52751,{"facility":1263,"status":8,"city":1264,"zip":1265,"country":1216,"geoPoint":1266},"University College London Hospitals","London","NW1 2PG",{"lat":1267,"lon":1268},51.50853,-0.12574,{"facility":1270,"status":8,"city":1264,"zip":1271,"country":1216,"geoPoint":1272},"Guy's Hospital","SE1 9RT",{"lat":1267,"lon":1268},{"facility":1274,"status":8,"city":1275,"zip":1276,"country":1216,"geoPoint":1277},"Mount Vermont Cancer Center","Middlesex","HA6 2RN",{"lat":1278,"lon":1279},51.53174,-0.26856,{"facility":1281,"status":8,"city":1282,"zip":1283,"country":1216,"geoPoint":1284},"Nottingham University Hospitals NHS Trust","Nottingham","NG5 1PB",{"lat":1285,"lon":1286},52.9536,-1.15047,{"facility":1288,"status":8,"city":1289,"zip":1290,"country":1216,"geoPoint":1291},"Singleton Hospital","Swansea","SA2 8QA",{"lat":1292,"lon":1293},51.62079,-3.94323,{"facility":1295,"status":8,"city":1296,"zip":1297,"country":1216,"geoPoint":1298},"Royal Cornwall Hospital","Truro","TR1 3LJ",{"lat":1299,"lon":1300},50.26526,-5.05436,[1302],{"name":1303,"role":1304,"phone":1305,"phoneExt":1306,"email":1307},"BioNTech clinical trials patient information","CONTACT","+49 6131 9084","0","patients@biontech.de",[1309],{"name":1310,"affiliation":13,"role":1311},"BioNTech Responsible Person","STUDY_DIRECTOR",[1313],{"pmid":1314,"type":1315,"citation":1316},"40966692","DERIVED","Secord AA, Powell MA, McAlpine J. Molecular Characterization and Clinical Implications of Endometrial Cancer. Obstet Gynecol. 2025 Nov 1;146(5):660-671. doi: 10.1097\u002FAOG.0000000000006080. Epub 2025 Sep 18.",[],{"nct_id":4,"conditions":1319,"biomarkers":1321},[1320],"Endometrial Carcinoma",[1322],"ERBB2 Gene",{"nct_id":4,"found":15,"summary":1324,"prompt_version":1334},{"design":1325,"status":1326,"heading":1327,"summary":1328,"follow_up":1329,"word_count":1330,"commitments":1331,"compensation":1332,"drugs_mentioned":1333},"This is an open-label, randomized, multi-site Phase III study. Participants in Cohort 1 will be randomly assigned to receive either BNT323\u002FDB-1303 or chemotherapy, while Cohort 2 participants will receive BNT323\u002FDB-1303 alone. The study plans to enroll 480 participants.","completed","Clinical Study of BNT323\u002FDB-1303 or Chemotherapy for Recurring Uterine Cancer","This study is testing an investigational therapy called BNT323\u002FDB-1303, or standard chemotherapy (doxorubicin, paclitaxel, or docetaxel), for women with recurrent (returned) endometrial cancer (a type of uterine cancer). You could be eligible if you are an adult woman with endometrial cancer that has come back, and your tumor has specific levels of a biomarker (a measurable indicator) called HER2. The study is divided into two groups based on your HER2 levels. For some, success means the treatment slows down cancer growth (progression-free survival), while for others, it means the tumor shrinks or disappears (objective response rate). The study aims to enroll 480 participants, but its current recruitment status is unclear.","Participants will be followed for up to approximately 53 months to assess how well the treatment works.",110,"Participants will receive BNT323\u002FDB-1303 or chemotherapy through intravenous (IV) infusion or bolus until their disease progresses, they experience unacceptable side effects, or they withdraw consent.","Not stated in the trial record.",[41,49,54,58],"v2"]