[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06475742":3,"trial-entities:NCT06475742":862,"trial-summary:NCT06475742":866},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":26,"primary_purpose":27,"phases":28,"enrollment_info":30,"interventions":33,"primary_outcomes":42,"secondary_outcomes":53,"sex":54,"minimum_age":55,"maximum_age":56,"healthy_volunteers":57,"eligibility_criteria":58,"std_ages":68,"locations":71,"central_contacts":855,"overall_officials":856,"references":860,"see_also_links":861},"NCT06475742","ID-064A303","Long-term Safety and Tolerability of Cenerimod in Adults With Systemic Lupus Erythematosus","A Phase 3, Multicenter, Open-label, Single-arm, Extension Study to Evaluate the Long-term Safety and Tolerability of Cenerimod in Adult Subjects With Moderate-to-Severe Systemic Lupus Erythematosus (SLE) on Top of Background Therapy","ENROLLING_BY_INVITATION","2028-05","2026-07","2026-07-28","2024-07-30","Viatris Innovation GmbH","INDUSTRY",true,"The goal of this clinical study is to learn about the long-term safety and tolerability of cenerimod in adult patients with moderate to severe symptoms of systemic lupus erythematosus.\n\nThe main questions it aims to answer are:\n\n* Whether cenerimod causes any adverse effects ('side effects') when given on top of drugs already being given for systemic lupus erythematosus.\n* How well cenerimod works to reduce symptoms of systemic lupus erythematosus when taken for up to 5 years.\n\nParticipants taking part in this study will have already taken part in another study, where they received either cenerimod or placebo (look-alike substance containing no active drug) for 1 year.\n\nIn this clinical study approximately 680 participants will receive cenerimod (on top of drugs already being given for systemic lupus erythematosus) for up to 5 years.","Participants who completed the 12-month double-blind treatment period (cenerimod 4 mg or placebo) in either of the parent studies, ID-064A301 or ID-064A302, are eligible to participate in this extension study.\n\nAll participants in this study will receive cenerimod 4 mg for up to a maximum of 60 months (5 years). All participants may additionally receive standard of care treatment for systemic lupus erythematosus, i.e., at least 1 of the following: oral corticosteroids, antimalarial drugs, or immunosuppressant drugs.\n\nThe safety follow-up period starts on the day after the last dose of study treatment and ends after 6 months with the final study visit. Thus, the maximum duration of participation is 5.5 years.\n\nData collected in this extension study will allow an assessment of whether the safety and tolerability profile of cenerimod established in the controlled parent studies remains the same after a longer period of treatment.",[19],"Lupus Erythematosus, Systemic",[21,22,23,24,25],"Skin and Connective Tissue Diseases","Connective Tissue Diseases","Immune System Diseases","Autoimmune Diseases","Musculoskeletal and connective tissue disorders","INTERVENTIONAL","TREATMENT",[29],"PHASE3",{"count":31,"type":32},680,"ESTIMATED",[34],{"type":35,"name":36,"description":37,"armGroupLabels":38,"otherNames":40},"DRUG","Cenerimod","Film-coated tablets at a dose of 4 mg.",[39],"Cenerimod 4 mg",[41],"ACT-334441",[43,47,50],{"measure":44,"description":45,"timeFrame":46},"Treatment-emergent adverse events","Occurrence of treatment-emergent adverse events up to the final study visit (maximum 5 years of study treatment plus 6-month safety follow-up period).","Day 1 (post dose) to a maximum of 5.5 years",{"measure":48,"description":49,"timeFrame":46},"Serious adverse events","Occurrence of serious adverse events up to the final study visit (maximum 5 years of study treatment plus 6-month safety follow-up period).",{"measure":51,"description":52,"timeFrame":46},"Adverse events of special interest","Occurrence of adverse events of special interest up to the final study visit (maximum 5 years of study treatment plus 6-month safety follow-up period).\n\nAdverse events of special interest include the anticipated risks of treatment with cenerimod, known class effects, and events that may be related to systemic lupus erythematosus comorbidities, i.e., adverse events related to:\n\n* Effects on heart rate and rhythm\n* Hypotension\n* Hypertension\n* Cardiovascular\n* Hepatobiliary disorders \u002F liver enzyme abnormalities\n* Pulmonary\n* Eye disorders\n* Infections\n* Skin malignancies\n* Non-skin malignancies",[],"ALL","18 Years","75 Years",false,{"inclusion":59,"exclusion":66,"raw_text":67},[60,61,62,63,64,65],"Completed the 12-month double-blind treatment period of either of the parent studies (ID-064A301, ID-064A302).","Did not meet any study treatment stopping criteria during the parent study.","Completed the last scheduled visit of the parent study. Participants who did not complete the last scheduled visit for reasons beyond their control may be eligible for this study upon approval by the sponsor. 3. Women of child-bearing potential:","Negative pregnancy test at Visit 1.","Agreement to undertake monthly urine pregnancy tests from Visit 2 up to 6 months after study treatment discontinuation.","Agreement to use a highly effective method of contraception from Visit 1 up to 6 months after study treatment discontinuation.",[],"Inclusion Criteria:\n\n1. Signed and dated informed consent form prior to any study-mandated procedure.\n2. Participants with a diagnosis of systemic lupus erythematosus who:\n\n   * Completed the 12-month double-blind treatment period of either of the parent studies (ID-064A301, ID-064A302).\n   * Did not meet any study treatment stopping criteria during the parent study.\n   * Completed the last scheduled visit of the parent study. Participants who did not complete the last scheduled visit for reasons beyond their control may be eligible for this study upon approval by the sponsor.\n3. Women of child-bearing potential:\n\n   * Negative pregnancy test at Visit 1.\n   * Agreement to undertake monthly urine pregnancy tests from Visit 2 up to 6 months after study treatment discontinuation.\n   * Agreement to use a highly effective method of contraception from Visit 1 up to 6 months after study treatment discontinuation.\n\nExclusion Criteria:\n\n1. Poor compliance with study-mandated procedures during the parent study (ID-064A301 or ID-064A302), e.g., took less than 80% of the planned doses of double-blind study treatment; or did not attend a majority of the site visits, unless there was a medically justified reason as judged by the investigator.\n2. Systemic lupus erythematosus driven renal disease, central nervous system lupus, or active severe or unstable neuropsychiatric systemic lupus erythematosus where, in the judgment of the investigator, protocol-specific systemic lupus erythematosus background therapy is insufficient, and the use of a more aggressive therapeutic approach or other treatments not permitted in the protocol is indicated.\n3. Women of child-bearing potential planning to become pregnant up to the final study visit.\n4. Judged not eligible to participate by the investigator, for any other reason.\n5. Confirmed active or latent tuberculosis (applicable only if requested by local regulations).",[69,70],"ADULT","OLDER_ADULT",[72,81,89,96,103,107,110,114,121,129,137,145,152,159,166,174,178,182,189,196,203,210,214,222,229,237,244,252,256,260,267,274,281,289,296,303,310,317,324,331,339,346,354,362,369,372,375,378,382,385,389,393,397,400,408,415,423,427,434,441,445,449,457,465,472,479,486,494,501,508,515,522,529,537,544,551,558,565,569,576,580,587,594,602,609,616,620,627,631,638,646,653,660,667,674,682,689,697,705,708,711,715,722,730,737,744,751,759,767,774,781,788,796,800,804,811,819,822,829,837,844,848],{"facility":73,"city":74,"state":75,"zip":76,"country":77,"geoPoint":78},"University of Colorado Denver","Aurora","Colorado","80045","United States",{"lat":79,"lon":80},39.72943,-104.83192,{"facility":82,"city":83,"state":84,"zip":85,"country":77,"geoPoint":86},"Clinical Research of West Florida, Inc.","Clearwater","Florida","33765",{"lat":87,"lon":88},27.96585,-82.8001,{"facility":90,"city":91,"state":84,"zip":92,"country":77,"geoPoint":93},"Omega Research MetroWest, LLC","DeBary","32713",{"lat":94,"lon":95},28.88305,-81.30868,{"facility":97,"city":98,"state":84,"zip":99,"country":77,"geoPoint":100},"SouthCoast Research Center, Inc.","Miami","33136",{"lat":101,"lon":102},25.77427,-80.19366,{"facility":104,"city":98,"state":84,"zip":105,"country":77,"geoPoint":106},"Allied Biomedical Research Institute","33155",{"lat":101,"lon":102},{"facility":108,"city":98,"state":84,"zip":105,"country":77,"geoPoint":109},"D&H National Research Centers INC",{"lat":101,"lon":102},{"facility":111,"city":98,"state":84,"zip":112,"country":77,"geoPoint":113},"Professional research Center INC","33172",{"lat":101,"lon":102},{"facility":115,"city":116,"state":84,"zip":117,"country":77,"geoPoint":118},"San Marcus Res Clin Inc.","Miami Lakes","33014",{"lat":119,"lon":120},25.90871,-80.30866,{"facility":122,"city":123,"state":124,"zip":125,"country":77,"geoPoint":126},"Accurate Clinical Research Inc. - Lake Charles","Lake Charles","Louisiana","70605",{"lat":127,"lon":128},30.21309,-93.2044,{"facility":130,"city":131,"state":132,"zip":133,"country":77,"geoPoint":134},"RB Wellness Clinic","Las Vegas","Nevada","89102",{"lat":135,"lon":136},36.17497,-115.13722,{"facility":138,"city":139,"state":140,"zip":141,"country":77,"geoPoint":142},"Accurate Clinical Research Inc - (Najam)","Baytown","Texas","77521",{"lat":143,"lon":144},29.7355,-94.97743,{"facility":146,"city":147,"state":140,"zip":148,"country":77,"geoPoint":149},"Novel Research LLC","Bellaire","77401",{"lat":150,"lon":151},29.70579,-95.45883,{"facility":153,"city":154,"state":140,"zip":155,"country":77,"geoPoint":156},"Accurate Clinical Research Inc.","Houston","77089",{"lat":157,"lon":158},29.76328,-95.36327,{"facility":160,"city":161,"state":140,"zip":162,"country":77,"geoPoint":163},"Sun Research","San Antonio","78215",{"lat":164,"lon":165},29.42412,-98.49363,{"facility":167,"city":168,"zip":169,"country":170,"geoPoint":171},"Aprillus Asistencia e Investigacion","Buenos Aires","1406","Argentina",{"lat":172,"lon":173},-34.61315,-58.37723,{"facility":175,"city":168,"zip":176,"country":170,"geoPoint":177},"Centro Médico Arsema","1416",{"lat":172,"lon":173},{"facility":179,"city":168,"zip":180,"country":170,"geoPoint":181},"Fundación Respirar","1426",{"lat":172,"lon":173},{"facility":183,"city":184,"zip":185,"country":170,"geoPoint":186},"IR Medical Center S.A.","Mendoza","5500",{"lat":187,"lon":188},-32.88946,-68.84582,{"facility":190,"city":191,"zip":192,"country":170,"geoPoint":193},"Instituto Medico CER","Quilmes","B1878DVB",{"lat":194,"lon":195},-34.72065,-58.25454,{"facility":197,"city":198,"zip":199,"country":170,"geoPoint":200},"Instituto CAICI SRL","Rosario","S2000PBJ",{"lat":201,"lon":202},-32.94682,-60.63932,{"facility":204,"city":205,"zip":206,"country":170,"geoPoint":207},"Centro de investigaciones medicas Tucuman","San Miguel de Tucumán","T4000AXL",{"lat":208,"lon":209},-26.81601,-65.21051,{"facility":211,"city":205,"zip":212,"country":170,"geoPoint":213},"ICT (Investigaciones Clínicas Tucumán)","T4000ICL",{"lat":208,"lon":209},{"facility":215,"city":216,"zip":217,"country":218,"geoPoint":219},"LMK Servicos Medico S\u002FS","Porto Alegre","90480000","Brazil",{"lat":220,"lon":221},-30.03283,-51.23019,{"facility":223,"city":224,"zip":225,"country":218,"geoPoint":226},"SER - Serviços Especializados em Reumatologia da Bahia","Salvador","40150-150",{"lat":227,"lon":228},-12.97563,-38.49096,{"facility":230,"city":231,"zip":232,"country":233,"geoPoint":234},"Outpatient Clinic for Specialized Outpatient Medical Care - Medical Center Kyuchuk Parizh Ltd.","Plovdiv","4004","Bulgaria",{"lat":235,"lon":236},42.15387,24.75001,{"facility":238,"city":239,"zip":240,"country":233,"geoPoint":241},"DCC Equita EOOD","Varna","9000",{"lat":242,"lon":243},43.21912,27.91024,{"facility":245,"city":246,"zip":247,"country":248,"geoPoint":249},"Enroll SpA","Providencia","7500588","Chile",{"lat":250,"lon":251},-33.43107,-70.60454,{"facility":253,"city":246,"zip":254,"country":248,"geoPoint":255},"Biomedica Research Group","7500710",{"lat":250,"lon":251},{"facility":257,"city":246,"zip":258,"country":248,"geoPoint":259},"Sociedad Médica del Aparato Locomotor S. A.","7510186",{"lat":250,"lon":251},{"facility":261,"city":262,"zip":263,"country":248,"geoPoint":264},"Centro de Especialidades Medicas Vanguardia","Temuco","4810345",{"lat":265,"lon":266},-38.73628,-72.59738,{"facility":268,"city":269,"zip":270,"country":248,"geoPoint":271},"Clinical Research Chile SpA","Valdivia","5110683",{"lat":272,"lon":273},-39.81422,-73.24589,{"facility":275,"city":276,"zip":277,"country":248,"geoPoint":278},"Hospital San José de Victoria","Victoria","4720000",{"lat":279,"lon":280},-38.23291,-72.33292,{"facility":282,"city":283,"zip":284,"country":285,"geoPoint":286},"Clínica de la costa S.A.S.","Barranquilla","080020","Colombia",{"lat":287,"lon":288},10.96854,-74.78132,{"facility":290,"city":291,"zip":292,"country":285,"geoPoint":293},"IDEARG (Instituto de Enfermedades Autoinmunes Renato Guzmán)","Bogotá","110221",{"lat":294,"lon":295},4.60971,-74.08175,{"facility":297,"city":298,"zip":299,"country":285,"geoPoint":300},"Servimed S.A.S","Bucaramanga","680003",{"lat":301,"lon":302},7.125,-73.11895,{"facility":304,"city":305,"zip":306,"country":285,"geoPoint":307},"Centro de Estudios de Reumatología y Dermatología","Cali","760042",{"lat":308,"lon":309},3.43054,-76.5199,{"facility":311,"city":312,"zip":313,"country":285,"geoPoint":314},"Preventive Care SAS","Chía","250001",{"lat":315,"lon":316},4.85876,-74.05866,{"facility":318,"city":319,"zip":320,"country":285,"geoPoint":321},"Hospital Pablo Tobon Uribe","Medellín","050034",{"lat":322,"lon":323},6.245,-75.57151,{"facility":325,"city":326,"zip":327,"country":285,"geoPoint":328},"Healthy Medical Center SAS","Zipaquirá","250252",{"lat":329,"lon":330},5.02208,-74.00481,{"facility":332,"city":333,"zip":334,"country":335,"geoPoint":336},"iMedica s.r.o.","Brno","60200","Czechia",{"lat":337,"lon":338},49.19522,16.60796,{"facility":340,"city":341,"zip":342,"country":335,"geoPoint":343},"Institute of Rheumatology Prague","Prague","128 00",{"lat":344,"lon":345},50.08804,14.42076,{"facility":347,"city":348,"zip":349,"country":350,"geoPoint":351},"Centre Hospitalier Universitaire De La Reunion","Saint-Denis","97400","France",{"lat":352,"lon":353},48.93564,2.35387,{"facility":355,"city":356,"zip":357,"country":358,"geoPoint":359},"LTD \"New Plasma Clinic\"","Batumi","6010","Georgia",{"lat":360,"lon":361},41.64077,41.6306,{"facility":363,"city":364,"zip":365,"country":358,"geoPoint":366},"Institute of Clinical Cardiology, Ltd","Tbilisi","0159",{"lat":367,"lon":368},41.69143,44.83412,{"facility":370,"city":364,"zip":365,"country":358,"geoPoint":371},"LTD \"Tbilisi Central Hospital\"",{"lat":367,"lon":368},{"facility":373,"city":364,"zip":365,"country":358,"geoPoint":374},"National Institute of Endocrinology Ltd.",{"lat":367,"lon":368},{"facility":376,"city":364,"zip":365,"country":358,"geoPoint":377},"Tbilisi Heart and Vascular Clinic Ltd.",{"lat":367,"lon":368},{"facility":379,"city":364,"zip":380,"country":358,"geoPoint":381},"Aversi Clinic LTD","0160",{"lat":367,"lon":368},{"facility":383,"city":364,"zip":380,"country":358,"geoPoint":384},"Medi Club Georgia Ltd.",{"lat":367,"lon":368},{"facility":386,"city":364,"zip":387,"country":358,"geoPoint":388},"Ltd. Mtskheta Street Clinic","0179",{"lat":367,"lon":368},{"facility":390,"city":364,"zip":391,"country":358,"geoPoint":392},"The First Medical Center Ltd.","0180",{"lat":367,"lon":368},{"facility":394,"city":364,"zip":395,"country":358,"geoPoint":396},"LLC \"Innova\"","0186",{"lat":367,"lon":368},{"facility":398,"city":364,"zip":395,"country":358,"geoPoint":399},"LTD \"Tbilisi Heart Center\"",{"lat":367,"lon":368},{"facility":401,"city":402,"zip":403,"country":404,"geoPoint":405},"Universitatsklinikum Leipzig","Leipzig","4103","Germany",{"lat":406,"lon":407},51.33962,12.37129,{"facility":409,"city":410,"zip":411,"country":404,"geoPoint":412},"Klinik für Rheumatologie und Klinische Immunologie","Minden","32429",{"lat":413,"lon":414},52.28953,8.91455,{"facility":416,"city":417,"zip":418,"country":419,"geoPoint":420},"Naval Hospital of Athens","Athens","115 21","Greece",{"lat":421,"lon":422},37.98376,23.72784,{"facility":424,"city":417,"zip":425,"country":419,"geoPoint":426},"General Hospital of Athens \"Hippokration\"","115 27",{"lat":421,"lon":422},{"facility":428,"city":429,"zip":430,"country":419,"geoPoint":431},"University General Hospital Attikon General Hospital Of West Attica H Agia Varvara","Chaïdári","12462",{"lat":432,"lon":433},38.01135,23.66597,{"facility":435,"city":436,"zip":437,"country":419,"geoPoint":438},"Euromedica - Kyanos Stavros","Thessaloniki","546 36",{"lat":439,"lon":440},40.64072,22.93493,{"facility":442,"city":436,"zip":443,"country":419,"geoPoint":444},"General Hospital of Thessaloniki \"Hippokration\"","546 42",{"lat":439,"lon":440},{"facility":446,"city":436,"zip":447,"country":419,"geoPoint":448},"424 General Military Hospital","564 29",{"lat":439,"lon":440},{"facility":450,"city":451,"zip":452,"country":453,"geoPoint":454},"Sarawak General Hospital","Kuching","93586","Malaysia",{"lat":455,"lon":456},1.55,110.33333,{"facility":458,"city":459,"zip":460,"country":461,"geoPoint":462},"Morales Vargas Centro de Investigación S.C.","León","37000","Mexico",{"lat":463,"lon":464},21.12183,-101.68253,{"facility":466,"city":467,"zip":468,"country":461,"geoPoint":469},"Unidad de Atención Médica e Investigación en Salud","Mérida","97070",{"lat":470,"lon":471},20.967,-89.62318,{"facility":473,"city":474,"zip":475,"country":461,"geoPoint":476},"Centro de Atención e Investigación Cardiovascular del Potosí, S.C.","San Luis Potosí City","78200",{"lat":477,"lon":478},22.15234,-100.97135,{"facility":480,"city":481,"zip":482,"country":461,"geoPoint":483},"Investigación Biomédica para el Desarrollo de Fármacos S.A. de C.V.","Zapopan","45070",{"lat":484,"lon":485},20.72111,-103.38742,{"facility":487,"city":488,"zip":489,"country":490,"geoPoint":491},"Centro de Investigación del Hospital Militar Central","Jesus Maria","15076","Peru",{"lat":492,"lon":493},-12.06982,-77.04495,{"facility":495,"city":496,"zip":497,"country":490,"geoPoint":498},"Hospital Nacional Cayetano Heredia","Lima","15102",{"lat":499,"lon":500},-12.04318,-77.02824,{"facility":502,"city":503,"zip":504,"country":490,"geoPoint":505},"Unidad de Investigación de la Clinica International","San Borja","15036",{"lat":506,"lon":507},-12.09841,-77.01107,{"facility":509,"city":510,"zip":511,"country":490,"geoPoint":512},"Instituto Peruano del Hueso y la Articulación S.A.C. (IPHAR)","San Isidro","15046",{"lat":513,"lon":514},-12.09655,-77.04258,{"facility":516,"city":517,"zip":518,"country":490,"geoPoint":519},"Unidad de Investigación en Reumatología e Inmunología CSJB","San Juan de Lurigancho","15431",{"lat":520,"lon":521},-12.0108,-77.00538,{"facility":523,"city":524,"zip":525,"country":490,"geoPoint":526},"Investigaciones Clinicas \u002F Instituto de Ginecologa y Reproduccion","Santiago de Surco","15023",{"lat":527,"lon":528},-12.13588,-77.00742,{"facility":530,"city":531,"zip":532,"country":533,"geoPoint":534},"Chong-Hua Hospital","Cebu City","6000","Philippines",{"lat":535,"lon":536},10.31672,123.89071,{"facility":538,"city":539,"zip":540,"country":533,"geoPoint":541},"Davao Doctors Hospital","Davao City","8000",{"lat":542,"lon":543},7.07306,125.61278,{"facility":545,"city":546,"zip":547,"country":533,"geoPoint":548},"Iloilo Doctors Hospital","Iloilo City","5000",{"lat":549,"lon":550},10.69694,122.56444,{"facility":552,"city":553,"zip":554,"country":533,"geoPoint":555},"Lipa Medix Medical Center","Lipa City","4217",{"lat":556,"lon":557},13.9411,121.1631,{"facility":559,"city":560,"zip":561,"country":533,"geoPoint":562},"Makati Medical Center","Makati","1229",{"lat":563,"lon":564},16.412,121.1226,{"facility":566,"city":560,"zip":567,"country":533,"geoPoint":568},"Ospital ng Makati","1642",{"lat":563,"lon":564},{"facility":570,"city":571,"zip":572,"country":533,"geoPoint":573},"St Lukes Medical Center","Quezon City","1102",{"lat":574,"lon":575},14.6488,121.0509,{"facility":577,"city":571,"zip":578,"country":533,"geoPoint":579},"Far Eastern University - Nicanor Reyes Medical Foundation","1118",{"lat":574,"lon":575},{"facility":581,"city":582,"zip":583,"country":533,"geoPoint":584},"St Luke's Medical Center Quezon City \u002F University of Santo Tomas Hospital","Sampaloc","1015",{"lat":585,"lon":586},14.5402,121.3602,{"facility":588,"city":589,"zip":590,"country":533,"geoPoint":591},"Jose R. Reyes Memorial Medical Center","Santa Cruz","1003\u002F1014",{"lat":592,"lon":593},14.6,120.98333,{"facility":595,"city":596,"zip":597,"country":598,"geoPoint":599},"Szpital Uniwersytecki nr 2 im. dr. Jana Biziela w Bydgoszczy","Bydgoszcz","85-168","Poland",{"lat":600,"lon":601},53.1235,18.00762,{"facility":603,"city":604,"zip":605,"country":598,"geoPoint":606},"Centrum Medyczne Pratia Częstochowa","Częstochowa","42-217",{"lat":607,"lon":608},50.79646,19.12409,{"facility":610,"city":611,"zip":612,"country":598,"geoPoint":613},"Centrum Medyczne Angelius Provita","Katowice","40-611",{"lat":614,"lon":615},50.2597,19.02173,{"facility":617,"city":611,"zip":618,"country":598,"geoPoint":619},"Vita Longa Sp. z o.o.","40-748",{"lat":614,"lon":615},{"facility":621,"city":622,"zip":623,"country":598,"geoPoint":624},"Medyczne Centrum Hetmanska","Poznan","60-218",{"lat":625,"lon":626},52.40692,16.92993,{"facility":628,"city":622,"zip":629,"country":598,"geoPoint":630},"Twoja Przychodnia Poznańskie Centrum Medyczne","60-324",{"lat":625,"lon":626},{"facility":632,"city":633,"zip":634,"country":598,"geoPoint":635},"Malwa-Med Iwona Chlebicka","Wroclaw","50-304",{"lat":636,"lon":637},51.10286,17.03006,{"facility":639,"city":640,"zip":641,"country":642,"geoPoint":643},"Hospital Prof. Doutor Fernando Fonseca","Amadora","2730-276","Portugal",{"lat":644,"lon":645},38.75382,-9.23083,{"facility":647,"city":648,"zip":649,"country":642,"geoPoint":650},"Centro Hospitalar Universitário do Algarve - Hospital de Faro","Faro","8000-386",{"lat":651,"lon":652},37.01869,-7.92716,{"facility":654,"city":655,"zip":656,"country":642,"geoPoint":657},"ULS Guarda","Guarda","6300-749",{"lat":658,"lon":659},40.53754,-7.26631,{"facility":661,"city":662,"zip":663,"country":642,"geoPoint":664},"Hospital Senhora Oliveira-Guimaraes","Guimarães","4835-044",{"lat":665,"lon":666},41.44443,-8.29619,{"facility":668,"city":669,"zip":670,"country":642,"geoPoint":671},"Centro Hospitalar de Vila Nova de Gaia\u002FEspinho, E.P.E.","Vila Nova de Gaia","4434-502",{"lat":672,"lon":673},41.12401,-8.61241,{"facility":675,"city":676,"zip":677,"country":678,"geoPoint":679},"Centro Reumatologico de Caguas","Caguas","00725","Puerto Rico",{"lat":680,"lon":681},18.23412,-66.0485,{"facility":683,"city":684,"zip":685,"country":678,"geoPoint":686},"GCM Medical Group, PSC","San Juan","00917",{"lat":687,"lon":688},18.46633,-66.10572,{"facility":690,"city":691,"zip":692,"country":693,"geoPoint":694},"Centrul Medical de Diagnostic si Tratament Ambulatoriu Neomed S.R.L","Brasov","500283","Romania",{"lat":695,"lon":696},45.64861,25.60613,{"facility":698,"city":699,"zip":700,"country":701,"geoPoint":702},"Institute for Rheumatology, Belgrade","Belgrade","11000","Serbia",{"lat":703,"lon":704},44.80401,20.46513,{"facility":706,"city":699,"zip":700,"country":701,"geoPoint":707},"Institute of Rheumatology, Belgrade",{"lat":703,"lon":704},{"facility":709,"city":699,"zip":700,"country":701,"geoPoint":710},"University Clinical Center of 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