[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06569394":3,"trial-entities:NCT06569394":88,"trial-summary:NCT06569394":91},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":21,"primary_purpose":14,"phases":22,"enrollment_info":24,"interventions":27,"primary_outcomes":37,"secondary_outcomes":50,"sex":51,"minimum_age":52,"maximum_age":53,"healthy_volunteers":15,"eligibility_criteria":54,"std_ages":58,"locations":60,"central_contacts":80,"overall_officials":83,"references":86,"see_also_links":87},"NCT06569394","23-0954","A Study of Cannabidiol in Young Adult Cannabis Users","A Randomized, Placebo Controlled Study of Cannabidiol in Young Adult Cannabis Users","RECRUITING","2028-06-30","2026-04","2026-05-01","2024-12-09","University of Colorado, Denver","OTHER",false,"The investigators will study the harm-reducing effect of hemp-derived CBD in non-treatment-seeking emerging adults who use cannabis regularly. The study will use a novel naturalistic cannabis administration approach, which examines ecologically valid cannabis use utilizing a mobile lab setting to assess the effects of the cannabis products the participants regularly use. The investigators will recruit a sample of emerging adults, half of whom primarily use flower products and half of whom primarily use concentrate products. Individuals will be randomly assigned to hemp-derived CBD or placebo.","Emerging adults have the highest prevalence of cannabis use and CUD of any age group. Despite high rates of use and CUD, treatment seeking is relatively uncommon among emerging adults. Those who use cannabis are less confident in their ability to abstain and show higher rates of ambivalence regarding the goal of abstinence than those who use other drugs. Thus, emerging adult cannabis users may be more receptive to non-abstinence or harm reduction approaches. The overarching aim of this proposal is to assess the effects of hemp-derived CBD in emerging adults on harms associated with cannabis use including subjective intoxication, affect and mood, psychotic experiences, and cognitive functioning, as well as to examine whether CBD supplementation reduces self-administration of THC and symptoms of CUD. The investigators propose a study design with high external validity and experimental controls to study the harm-reducing effect of hemp-derived CBD in non-treatment-seeking emerging adults who use cannabis regularly. The study will use a novel naturalistic cannabis administration approach, which examines ecologically valid cannabis use utilizing a mobile lab setting to assess the effects of the cannabis products the participants regularly use. The investigators will recruit a sample of emerging adults, half of whom primarily use flower products and half of whom primarily use concentrate products. Individuals will be randomly assigned to hemp-derived CBD or placebo, consistent with the preliminary studies that have approved US Food and Drug Administration (FDA) Investigation New Drug (IND 153535 and 157515).\n\nThe specific aims are to:\n\nAim 1: Test whether assignment to hemp-derived CBD, relative to placebo, over 8 weeks is associated with a) reduced self-administration of THC, b) a reduction in CUD symptoms, c) lower levels of anxiety, depression, d) better cognitive function, and e) higher anandamide (AEA) levels. Hypothesis: Compared to baseline, the CBD group will demonstrate reduced THC administration, fewer CUD symptoms, lower levels of anxiety and depression, and better cognitive functioning at 4 and 8 weeks compared to the placebo group. At 12 weeks (4 weeks post-trial), these effects will persist. Assignment to CBD will be correlated with higher AEA levels.\n\nAim 2: Test whether assignment to hemp-derived CBD, relative to placebo, reduces acute effects of cannabis administration on: a) subjective drug effects, b) cognitive function, and c) mood and psychotic symptoms. Hypothesis: Compared to cannabis self-administration at baseline (without CBD), the CBD group will demonstrate lower subjective drug effects (mood elevation, anxiety), fewer psychotic symptoms, and better cognitive functioning after cannabis self-administration at 4 and 8 weeks compared to the placebo group. At 12 weeks (4 weeks post-trial), these effects will persist.\n\nAim 3: Test whether cannabis product type (flower vs. concentrates) moderates the association between CBD assignment and a) cannabis use, b) mood and anxiety, and c) cognitive functioning in both longer-term (aim 1) and acute (aim 2) effects. Hypothesis: CBD effects will be greater among those who use concentrates compared to those who use flower products for both longer-term and acute effects.",[19],"Cannabis Use Disorder",[],"INTERVENTIONAL",[23],"PHASE2",{"count":25,"type":26},200,"ESTIMATED",[28,33],{"type":29,"name":30,"description":31,"armGroupLabels":32},"DRUG","Broad Spectrum Cannabidiol (bsCBD) 400 mg","Participants in this Arm will take 400 mg of bsCBD daily. Participants will take medication by mouth with food in the morning and evening.",[30],{"type":29,"name":34,"description":35,"armGroupLabels":36},"Placebo","Participants in this Arm will take a medically inert placebo. Participants will take medication by mouth with food in the morning and evening.",[34],[38,42,46],{"measure":39,"description":40,"timeFrame":41},"Difference in blood THC-COOH levels","THC-COOH levels in blood samples collected at baseline, Week 4, and Week 8 of medication ingestion.","8 weeks",{"measure":43,"description":44,"timeFrame":45},"Difference in blood THC levels","THC levels in blood samples collected before and after cannabis use at baseline, Week 4, and Week 8 of medication ingestion.","1 hour pre and post THC self-administration at baseline, 4 weeks, and 8 weeks",{"measure":47,"description":48,"timeFrame":49},"Difference in cannabis use","Total number of days of cannabis use during the 8-week medication period as reported on daily diaries.","8 Weeks",[],"ALL","18 Years","25 Years",{"inclusion":55,"exclusion":56,"raw_text":57},[],[],"Inclusion Criteria:\n\n1. Ages 18-25\n2. Must have used cannabis flower or concentrates at least five days per week for the past year.\n3. Currently not seeking to cut down or stop cannabis use\n4. At least two symptoms of a DSM-5 cannabis use disorder\n\nExclusion Criteria:\n\n1. Use of any illicit substance besides alcohol, nicotine, or cannabis (e.g., cocaine, opiates, methamphetamine, MDMA, benzodiazepines, or barbiturates) in the past 60 days, as indicated by self-report and urine toxicology screening at the beginning of each study visit.\n2. Alcohol use on 3 or more days per week, and\u002For \\>3 drinks per drinking day in the past 60 days. Participants must also have a breath alcohol level of 0 at the beginning of each study visit.\n3. Daily nicotine use.\n4. Meets DSM-5 diagnostic criteria for a psychotic disorder (e.g., schizophrenia, schizophreniform disorder, schizoaffective disorder), bipolar disorder, major depression with suicidal ideation, or a history of treatment for these disorders.\n5. Current cardiovascular or respiratory disease (e.g., coronary artery disease, severe asthma, chronic obstructive pulmonary disease)\n6. Current use of any psychotropic (e.g., antidepressants, anxiogenics) or hepatotoxic medication.\n7. Current use of anti-epileptic medications (e.g., clobazam, sodium valproate) or medications known to have major interactions with Epidiolex (buprenorphine, leflunomide, levomethadyl acetate, lomitapide, mipomersen, pexidartinib, propoxyphene, sodium oxybate, and\u002For teriflunomide) or a history of seizures.\n8. Current use of strong or moderate CYP3A4 inhibitors or inducers (commonly used examples not captured by other exclusion criteria include protease inhibitors, macrolide antibiotics \\[e.g., erythromycin\\], azole antifungals \\[e.g., ketoconazole\\], verapamil, and grapefruit juice).\n9. Current use of strong or moderate CYP2C19 inhibitors or inducers (commonly used examples not captured by other exclusion criteria include proton pump inhibitors, prednisone, and norethisterone).\n10. Current or past hepatocellular disease, as indicated by medical history or alanine aminotransferase (ALT), aspartate aminotransferase (AST), or total bilirubin greater than two times the upper limit of the normal range at screening.\n11. For female participants, pregnancy or trying to become pregnant. A positive pregnancy test at the beginning of any study visit will result in exclusion from ongoing study participation.\n12. For female participants, currently lactating.\n13. For female patients of childbearing potential, not willing to use at least one approved method of birth control while taking the study medication, unless she is surgically sterile, partner is surgically sterile, or she is postmenopausal (one year).\n14. Current suicidality risk as indicated during the conduct of the C-SSRS with concurrence after a study physician's or PI evaluation if the response to C-SSRS questions 1 or 2 is \"yes\"",[59],"ADULT",[61],{"facility":62,"status":8,"city":63,"state":64,"zip":65,"country":66,"contacts":67,"geoPoint":77},"University of Colorado Anschutz Medical Campus","Aurora","Colorado","80045","United States",[68,73],{"name":69,"role":70,"phone":71,"email":72},"Christian J Hopfer, MD","CONTACT","303-724-3170","christian.hopfer@cuanschutz.edu",{"name":74,"role":70,"phone":75,"email":76},"Kristen M Raymond, BA","303-724-3196","kristen.raymond@cuanschutz.edu",{"lat":78,"lon":79},39.72943,-104.83192,[81,82],{"name":69,"role":70,"phone":71,"email":72},{"name":74,"role":70,"phone":75,"email":76},[84],{"name":69,"affiliation":13,"role":85},"PRINCIPAL_INVESTIGATOR",[],[],{"nct_id":4,"conditions":89,"biomarkers":90},[19],[],{"nct_id":4,"found":92,"summary":93,"prompt_version":102},true,{"design":94,"status":95,"heading":6,"summary":96,"follow_up":97,"word_count":98,"commitments":99,"compensation":100,"drugs_mentioned":101},"This is an interventional study with 200 planned participants. Participants will be randomly assigned to receive either Broad Spectrum Cannabidiol (bsCBD) or a placebo.","completed","This study is looking at how Broad Spectrum Cannabidiol (bsCBD) might help young adults (ages 18-25) who use cannabis regularly and have symptoms of cannabis use disorder (CUD). You could be eligible if you use cannabis frequently, are not trying to quit, and meet certain criteria for CUD. The study aims to see if taking 400 mg of bsCBD daily, compared to a placebo (an inactive substance), can reduce the harms linked to cannabis use. Researchers will measure differences in cannabis use and levels of cannabis-related substances in your blood over 8 weeks to see if bsCBD has a positive effect. The current recruitment status is unclear.","The primary endpoints are measured at 8 weeks, indicating a follow-up period of at least 8 weeks.",107,"Participants will take medication by mouth with food in the morning and evening. Blood samples will be taken at baseline, 4 weeks, and 8 weeks.","Not stated in the trial record.",[34],"v2"]