[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06617195":3,"trial-entities:NCT06617195":78,"trial-summary:NCT06617195":81},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":19,"study_type":20,"primary_purpose":21,"phases":22,"enrollment_info":23,"interventions":26,"primary_outcomes":33,"secondary_outcomes":38,"sex":39,"minimum_age":40,"maximum_age":41,"healthy_volunteers":42,"eligibility_criteria":43,"std_ages":47,"locations":50,"central_contacts":67,"overall_officials":74,"references":76,"see_also_links":77},"NCT06617195","24-003329","Mechanisms of Anabolic Resistance in Older Humans","RECRUITING","2030-09-16","2026-01","2026-01-21","2025-01-14","Mayo Clinic","OTHER",false,"The purpose of this research is to understand how chronic inflammation affects muscle function and responses to exercise in older adults.","Inflamed adipose tissue may contribute to blunted exercise response in skeletal muscle of older adults. The objective of this project is to evaluate a hypothesis that inflamed adipose secretes factors that activate inflammatory cascades in skeletal muscle, which may interfere with exercise-responsive molecular pathways and contribute to dysfunctional muscle phenotypes with aging. This project determine how adipose tissue influences skeletal muscle function and anabolic response to exercise in older adults. Young and older adults will complete studies to assess molecular response to acute exercise from protein synthesis rates, mRNA of exercise-responsive genes, and activation of signaling proteins in skeletal muscle. Adipose tissue will be assessed using a combination of non-invasive imaging and biopsy-based molecular phenotyping. The project will determine if acute exercise response is attenuated in older adults with inflamed adipose tissue phenotype.",[18],"Aging",[],"OBSERVATIONAL",null,[],{"count":24,"type":25},120,"ESTIMATED",[27],{"type":13,"name":28,"description":29,"armGroupLabels":30},"Exercise","Young and older adults will perform a single bout of unaccustomed resistance exercise to evaluate molecular and cellular response in skeletal muscle",[31,32],"Older","Young",[34],{"measure":35,"description":36,"timeFrame":37},"Anabolic response","Skeletal muscle protein synthesis rates will be measured from isotopic enrichment of muscle proteins","2 months",[],"ALL","21 Years","85 Years",true,{"inclusion":44,"exclusion":45,"raw_text":46},[],[],"Exclusion Criteria:\n\n1. Diabetes or fasting plasma glucose 126 mg\u002FdL\n2. Body mass index (BMI) 30 kg\u002Fm2\n3. Anemia (female subjects hemoglobin of \\<11 g\u002Fdl and male subjects hemoglobin \\<12 g\u002Fdl)\n4. Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment)\n5. Renal failure (serum creatinine \\> 1.5mg\u002Fdl)\n6. Chronic active liver disease (AST\\>144IU\u002FL or ALT\\>165IU\u002FL)\n7. Oral warfarin group medications or history of blood clotting disorders.\n8. Smoking\n9. Pregnancy or breastfeeding\n10. Alcohol consumption greater than 2 glasses\u002Fday or other substance abuse\n11. Untreated or uncontrolled hypothyroidism\n12. Debilitating chronic disease (at the discretion of the investigators)",[48,49],"ADULT","OLDER_ADULT",[51],{"facility":12,"status":7,"city":52,"state":53,"zip":54,"country":55,"contacts":56,"geoPoint":64},"Rochester","Minnesota","55905","United States",[57,62],{"name":58,"role":59,"phone":60,"email":61},"Ian R Lanza, PhD","CONTACT","507-255-8147","lanza.ian@mayo.edu",{"name":58,"role":63},"PRINCIPAL_INVESTIGATOR",{"lat":65,"lon":66},44.02163,-92.4699,[68,72],{"name":69,"role":59,"phone":70,"email":71},"Rachel Passehl","507-255-8112","passehl.rachel@mayo.edu",{"name":73,"role":59,"email":61},"Ian Lanza",[75],{"name":73,"affiliation":12,"role":63},[],[],{"nct_id":4,"conditions":79,"biomarkers":80},[18],[],{"nct_id":4,"found":42,"summary":82,"prompt_version":92},{"design":83,"status":84,"heading":85,"summary":86,"follow_up":87,"word_count":88,"commitments":89,"compensation":90,"drugs_mentioned":91},"This is an observational study involving 120 participants, including both young and older adults.","completed","Understanding Muscle Response to Exercise in Older Adults","This study aims to understand how aging and inflammation might affect how your muscles respond to exercise. Researchers are looking at young and older adults (ages 21-85) who will perform a single bout of resistance exercise. The main goal is to see how your body's muscle-building response (anabolic response) changes after exercise, measured over two months. You cannot participate if you have diabetes, a BMI over 30, anemia, or active heart disease. The study is currently observational, meaning researchers will observe participants without assigning specific treatments, and the recruitment status is unclear.","The main outcome, anabolic response, will be measured at 2 months after the exercise.",92,"Participants will perform a single session of unaccustomed resistance exercise. Researchers will assess muscle and fat tissue through biopsies and imaging.","Not stated in the trial record.",[28],"v2"]