[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06629077":3,"trial-entities:NCT06629077":117,"trial-summary:NCT06629077":121},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":21,"study_type":25,"primary_purpose":26,"phases":27,"enrollment_info":29,"interventions":32,"primary_outcomes":48,"secondary_outcomes":56,"sex":57,"minimum_age":58,"maximum_age":59,"healthy_volunteers":60,"eligibility_criteria":61,"std_ages":85,"locations":88,"central_contacts":107,"overall_officials":111,"references":115,"see_also_links":116},"NCT06629077","2024-0377","Brain Blood Vessel Responses to Changes in Blood Flow","Cerebrovascular Responses to Acute Hypoperfusion","RECRUITING","2027-01","2026-02","2026-03-02","2026-02-26","University of Wisconsin, Madison","OTHER",false,"Brain blood flow will be measured during a simulated postural change test and while breathing increased levels of carbon dioxide using magnetic resonance imaging.","Global cerebral blood flow (CBF) decreases with advancing age; however, some adults have accelerated declines in CBF, placing them at a greater risk of cognitive impairment. However, there is a lack of human studies that investigate the cause or consequence of altered blood flow regulation in the brain. This study will systematically address this gap in knowledge by examining cerebrovascular control in adults during acute physiological challenges (simulated postural change test and breathing increased carbon dioxide) that stimulate a change in CBF.",[19,20],"Magnetic Resonance Imaging","Cerebrovascular Circulation",[19,22,23,24],"Brain Blood Flow","Lower Body Negative Pressure","Carbon Dioxide","INTERVENTIONAL","BASIC_SCIENCE",[28],"PHASE2",{"count":30,"type":31},36,"ESTIMATED",[33,39,44],{"type":34,"name":35,"description":36,"armGroupLabels":37},"DEVICE","MRI","Participants will undergo an MRI scan while performing breathing and a simulated postural change task.",[38],"Middle-Aged Adults",{"type":40,"name":41,"description":42,"armGroupLabels":43},"DRUG","Prazosin","A dose of prazosin will be administered based on body weight.",[38],{"type":40,"name":45,"description":46,"armGroupLabels":47},"Placebo","Oral placebo",[38],[49,53],{"measure":50,"description":51,"timeFrame":52},"Change in blood flow","The change in intracranial blood flow during breathing and simulated postural change tasks will be measured with MRI","Two study visits, up to 240 minutes",{"measure":54,"description":55,"timeFrame":52},"Change in blood velocity","The change in blood velocity during breathing and simulated postural change tasks will be measured with MRI.",[],"ALL","55 Years","69 Years",true,{"inclusion":62,"exclusion":68,"raw_text":84},[63,64,65,66,67],"Between the ages of 55-69 years","Have a BMI less than or equal to 34.5 kg\u002Fm2","Nonsmoker","are less than 72 in (182.88 cm) height","Females must be postmenopausal",[69,70,71,72,73,74,75,76,77,78,79,80,81,82,83],"Diagnosis of Mild Cognitive Impairment (MCI) or Alzheimer's disease (AD)","History or evidence of hepatic disease, hematological disease, or peripheral vascular disease; severe kidney injury requiring hemodialysis","History of cardiovascular disease including: severe congestive heart failure, coronary artery disease, ischemic heart disease (stents, coronary artery bypass grafts) and tachycardia","Uncontrolled hypertension","History of clinically significant ischemic or hemorrhagic stroke, or significant cerebrovascular disease","Severe untreated obstructive sleep apnea","History of diabetes with HbA1c greater than 9.5%","Major neurologic disorders other than dementia (e.g., MS, ALS, brain surgery, etc.)","Current or recent (\\<1 year) major psychiatric condition (Axis I) or addictive disorders","Significant surgical history","Other significant medical conditions at investigators' discretion","Contraindications to MRI","Prescribed medications that interfere with prazosin","Lactose allergy","lower body will not fit in lower body negative pressure (LBNP) chamber (regardless of overall height and BMI).","Inclusion Criteria:\n\n* Between the ages of 55-69 years\n* Have a BMI less than or equal to 34.5 kg\u002Fm2\n* Nonsmoker\n* are less than 72 in (182.88 cm) height\n* Females must be postmenopausal\n\nExclusion Criteria:\n\n* Diagnosis of Mild Cognitive Impairment (MCI) or Alzheimer's disease (AD)\n* History or evidence of hepatic disease, hematological disease, or peripheral vascular disease; severe kidney injury requiring hemodialysis\n* History of cardiovascular disease including: severe congestive heart failure, coronary artery disease, ischemic heart disease (stents, coronary artery bypass grafts) and tachycardia\n* Uncontrolled hypertension\n* History of clinically significant ischemic or hemorrhagic stroke, or significant cerebrovascular disease\n* Severe untreated obstructive sleep apnea\n* History of diabetes with HbA1c greater than 9.5%\n* Major neurologic disorders other than dementia (e.g., MS, ALS, brain surgery, etc.)\n* Current or recent (\\<1 year) major psychiatric condition (Axis I) or addictive disorders\n* Significant surgical history\n* Other significant medical conditions at investigators' discretion\n* Contraindications to MRI\n* Prescribed medications that interfere with prazosin\n* Lactose allergy\n* lower body will not fit in lower body negative pressure (LBNP) chamber (regardless of overall height and BMI).",[86,87],"ADULT","OLDER_ADULT",[89],{"facility":90,"status":8,"city":91,"state":92,"zip":93,"country":94,"contacts":95,"geoPoint":104},"University of Wisconsin","Madison","Wisconsin","53705","United States",[96,101],{"name":97,"role":98,"phone":99,"email":100},"Anna J Howery, MS","CONTACT","608-262-9572","barneslab@education.wisc.edu",{"name":102,"role":103},"Jill N Barnes, PhD","PRINCIPAL_INVESTIGATOR",{"lat":105,"lon":106},43.07305,-89.40123,[108],{"name":109,"role":98,"phone":99,"email":110},"Anna Howery","ahowery@wisc.edu",[112],{"name":113,"affiliation":114,"role":103},"Jill Barnes, PhD","UW Madison",[],[],{"nct_id":4,"conditions":118,"biomarkers":120},[119],"Healthy",[],{"nct_id":4,"found":60,"summary":122,"prompt_version":132},{"design":123,"status":124,"heading":125,"summary":126,"follow_up":127,"word_count":128,"commitments":129,"compensation":130,"drugs_mentioned":131},"This is an interventional study planning to enroll 36 participants. It is not specified if it is randomized or blinded.","completed","Brain Blood Vessel Responses to Changes in Blood Flow Study","This study is looking at how blood vessels in the brain respond to changes in blood flow. Researchers will measure blood flow and blood velocity in the brain using MRI (magnetic resonance imaging) while participants perform breathing exercises and a simulated change in body position. You might receive either prazosin, a drug, or a placebo (an inactive substance). The study aims to understand why some older adults experience a faster decline in brain blood flow, which could increase their risk of memory problems. To join, you need to be between 55 and 69 years old, a non-smoker, and meet certain health and physical requirements. The study plans to enroll 36 participants, but its current recruitment status is unclear.","The primary endpoints are measured at two study visits, up to 240 minutes.",118,"You would undergo an MRI scan while performing breathing and a simulated postural change task. You would also receive a dose of prazosin or a placebo. These measurements will occur over two study visits, each lasting up to 240 minutes.","Not stated in the trial record.",[35,41,45],"v2"]