[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06680830":3,"trial-entities:NCT06680830":1115,"trial-summary:NCT06680830":1119},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":24,"study_type":36,"primary_purpose":37,"phases":38,"enrollment_info":40,"interventions":43,"primary_outcomes":54,"secondary_outcomes":61,"sex":66,"minimum_age":67,"maximum_age":68,"healthy_volunteers":69,"eligibility_criteria":70,"std_ages":74,"locations":77,"central_contacts":1105,"overall_officials":1110,"references":1113,"see_also_links":1114},"NCT06680830","NEU-411-PD201","A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease","A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study and Open-Label Extension to Evaluate the Safety and Efficacy of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease (NEULARK)","RECRUITING","2028-06","2026-08","2026-08-28","2025-01-17","Neuron23 Inc.","INDUSTRY",true,"The goal of this Phase 2 clinical trial is to investigate the efficacy and safety of NEU-411 in men and women aged 40-80 years with early Parkinson's Disease (PD) who have predicted elevations in the activity of the \"leucine-rich repeat kinase 2\" (\"LRRK2\" for short) pathway based on their genetic profile. A DNA test will be used to identify the \"LRRK2-driven\" population with predicted elevation in the LRRK2 pathway.","NEU-411-PD201 is a Phase 2, randomized, placebo-controlled, proof-of-concept study and open-label extension (OLE) in participants with early Parkinson's Disease (PD) who have LRRK2-driven PD as measured by an investigational companion diagnostic genetic test (CDx). The study will evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of NEU-411, an orally-administered, potent, selective, bioavailable, highly permeable, brain penetrant, small molecule inhibitor of LRRK2 activity as compared to placebo.\n\nAfter participants are screened for inclusion in the randomized, placebo-controlled portion of the study, approximately 150 participants will be randomized in a 1:1 allocation to NEU-411 30 mg once per day or placebo for a 52-week treatment period with a safety follow-up visit within 2 weeks after the last treatment visit. Eligible participants may enroll in the OLE and receive treatment for an additional 26 weeks.",[19,20,21,22,23],"Parkinson Disease","Parkinson","Idiopathic Parkinson Disease","Early Parkinson Disease (Early PD)","Parkinson Disease, Idiopathic",[25,26,27,28,29,30,31,32,33,34,35],"Early PD","Parkinsons","Parkinsons Disease","Idiopathic Parkinsons Disease","leucine-rich repeat kinase 2","PD","NEULARK","LRRK2","PARK8","de novo Parkinsons disease","Parkinson's disease","INTERVENTIONAL","TREATMENT",[39],"PHASE2",{"count":41,"type":42},150,"ESTIMATED",[44,49],{"type":45,"name":46,"description":47,"armGroupLabels":48},"DRUG","NEU-411","NEU-411, a potent, selective, orally bioavailable, highly permeable, brain penetrant, small molecule inhibitor of LRRK2 activity",[46],{"type":50,"name":51,"description":52,"armGroupLabels":53},"OTHER","Placebo","Orally-administered matched placebo",[51],[55,58],{"measure":56,"timeFrame":57},"Change from baseline in the Roche digital biomarker score using the Roche Parkinson's Disease application (v3.0) compared to placebo","From enrollment to the end of treatment at 52 weeks",{"measure":59,"timeFrame":60},"Incidence of treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs) compared to placebo","From enrollment to the end of study at 54 weeks",[62],{"measure":63,"description":64,"timeFrame":65},"Movement Disorder Society's Unified Parkinson's Disease Rating Scale (MDS-UPDRS)","Change from baseline to Week 52 in motor function\u002Fnonmotor as measured by Movement Disorder Society's Unified Parkinson's Disease Rating Scale (MDS-UPDRS)","52 weeks","ALL","40 Years","80 Years",false,{"inclusion":71,"exclusion":72,"raw_text":73},[],[],"Inclusion Criteria:\n\n1. Aged 40-80 years at time of screening, inclusive\n2. Diagnosis of clinically established or clinically probable Parkinson's Disease (PD)\n3. LRRK2-driven PD using the investigational companion diagnostic genetic test (CDx)\n4. Modified Hoehn and Yahr (mH\\&Y) of 1 to 2.5\n\nExclusion Criteria:\n\n1. Secondary or atypical parkinsonian syndromes\n2. Uncontrolled diabetes mellitus with hemoglobin A1c (HbA1c) \\>8%\n3. Other significant medical conditions (as determined by medical history, examination, or clinical investigations at screening)\n\nAdditional inclusion and exclusion criteria for the RCP and OLE are outlined in the full study protocol.",[75,76],"ADULT","OLDER_ADULT",[78,96,111,127,141,155,168,182,196,210,226,240,254,268,283,297,312,327,342,357,372,387,403,418,433,448,463,476,487,501,516,531,546,561,576,591,606,622,636,646,661,676,691,706,721,736,750,764,778,792,807,821,835,849,863,874,889,903,916,930,945,959,973,983,997,1012,1025,1040,1051,1064,1079,1093],{"facility":79,"status":8,"city":80,"state":81,"zip":82,"country":83,"contacts":84,"geoPoint":93},"Banner Sun Health Research Institute","Sun City","Arizona","85351","United States",[85,90],{"name":86,"role":87,"phone":88,"email":89},"Serena Lowery","CONTACT","623-832-0080","Serena.Lowery@Bannerhealth.com",{"name":91,"role":92},"David Shprecher, 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Irvine","Irvine","92697",[132,136],{"name":133,"role":87,"phone":134,"email":135},"Rene Anguiano","949-824-6407","renea1@hs.uci.edu",{"name":137,"role":92},"Sanaz Attaripour Isfahani, MD",{"lat":139,"lon":140},33.66946,-117.82311,{"facility":142,"status":8,"city":143,"state":114,"zip":144,"country":83,"contacts":145,"geoPoint":152},"University of California, Los Angeles","Los Angeles","90095",[146,150],{"name":147,"role":87,"phone":148,"email":149},"Diane Yang","310-206-3356","DDYang@mednet.ucla.edu",{"name":151,"role":92},"Jeff Bronstein, MD, PhD",{"lat":153,"lon":154},34.05223,-118.24368,{"facility":156,"status":8,"city":157,"state":114,"zip":158,"country":83,"contacts":159,"geoPoint":165},"Esperanza Clinical","Murrieta","92562",[160,163],{"name":156,"role":87,"phone":161,"email":162},"951-417-4466","hello@esperanzaclinical.com",{"name":164,"role":92},"Michael Ropacki, PhD",{"lat":166,"lon":167},33.55391,-117.21392,{"facility":169,"status":8,"city":170,"state":114,"zip":171,"country":83,"contacts":172,"geoPoint":179},"Parkinson's Research Centers of America - Palo Alto","Palo Alto","94301",[173,177],{"name":174,"role":87,"phone":175,"email":176},"Leeana Bade","650-394-6690","Lbade@Parkinsonscenter.org",{"name":178,"role":92},"Salima Brillman, MD",{"lat":180,"lon":181},37.44188,-122.14302,{"facility":183,"status":8,"city":184,"state":114,"zip":185,"country":83,"contacts":186,"geoPoint":193},"Sutter Neuroscience Institute","Sacramento","95816",[187,191],{"name":188,"role":87,"phone":189,"email":190},"Sampreet Moneski","916-887-4736","sampreet.moneski@sutterhealth.org",{"name":192,"role":92},"Nicklesh Thakur, DO",{"lat":194,"lon":195},38.58157,-121.4944,{"facility":197,"status":8,"city":198,"state":199,"zip":200,"country":83,"contacts":201,"geoPoint":207},"University of Colorado - Anschutz Medical 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Sperin","404-712-3529","brian.a.sperin@emory.edu",{"name":279,"role":92},"Stewart Factor, DO",{"lat":281,"lon":282},33.749,-84.38798,{"facility":284,"status":8,"city":285,"state":271,"zip":286,"country":83,"contacts":287,"geoPoint":294},"Augusta University","Augusta","30912",[288,292],{"name":289,"role":87,"phone":290,"email":291},"Buff Farrow","706-721-0619","BFARROW@augusta.edu",{"name":293,"role":92},"John Morgan, MD, PhD",{"lat":295,"lon":296},33.47097,-81.97484,{"facility":298,"status":8,"city":299,"state":300,"zip":301,"country":83,"contacts":302,"geoPoint":309},"Northwestern Medical Group, Department of Neurology","Chicago","Illinois","60611",[303,307],{"name":304,"role":87,"phone":305,"email":306},"Camryn Butze","312-503-6824","camryn.butze@northwestern.edu",{"name":308,"role":92},"Danielle N Larson, MD",{"lat":310,"lon":311},41.85003,-87.65005,{"facility":313,"status":8,"city":314,"state":315,"zip":316,"country":83,"contacts":317,"geoPoint":324},"University of Kansas Medical Center","Kansas City","Kansas","66160",[318,322],{"name":319,"role":87,"phone":320,"email":321},"Emily Jackson","913-588-0859","ejackson9@kumc.edu",{"name":323,"role":92},"Rajesh Pahwa, MD",{"lat":325,"lon":326},39.11417,-94.62746,{"facility":328,"status":8,"city":329,"state":330,"zip":331,"country":83,"contacts":332,"geoPoint":339},"University of Kentucky","Lexington","Kentucky","40536",[333,337],{"name":334,"role":87,"phone":335,"email":336},"Corisa Logan","859-218-5076","corisa.logan@uky.edu",{"name":338,"role":92},"John Slevin, MD, MBA",{"lat":340,"lon":341},37.98869,-84.47772,{"facility":343,"status":8,"city":344,"state":345,"zip":346,"country":83,"contacts":347,"geoPoint":354},"Ochsner Clinic Foundation","New Orleans","Louisiana","70121",[348,352],{"name":349,"role":87,"phone":350,"email":351},"Anna Leonard-Leumas","504-842-0148","anna.leonardleumas@ochsner.org",{"name":353,"role":92},"David Houghton, 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Hills","Michigan","48334",[393,398],{"name":394,"role":87,"phone":395,"phoneExt":396,"email":397},"Nancy Virdi","248-957-8944","1103","Nancy.Virdi@alcanzaclinical.com",{"name":399,"role":92},"Aaron Ellenbogen, DO, MPH",{"lat":401,"lon":402},42.48531,-83.37716,{"facility":404,"status":8,"city":405,"state":406,"zip":407,"country":83,"contacts":408,"geoPoint":415},"Struthers Parkinson Center","Golden Valley","Minnesota","55427",[409,413],{"name":410,"role":87,"phone":411,"email":412},"Carrie Weaver","952-993-5903","carrie.a.weaver@healthpartners.com",{"name":414,"role":92},"Sotirios Parashos, MD, PhD",{"lat":416,"lon":417},45.00969,-93.34912,{"facility":419,"status":8,"city":420,"state":421,"zip":422,"country":83,"contacts":423,"geoPoint":430},"Cleveland Clinic","Las Vegas","Nevada","89106",[424,428],{"name":425,"role":87,"phone":426,"email":427},"Liliana Dumitrescu","702-483-6000","DUMITRL@ccf.org",{"name":429,"role":92},"Zoltan Mari, MD",{"lat":431,"lon":432},36.17497,-115.13722,{"facility":434,"status":8,"city":435,"state":436,"zip":437,"country":83,"contacts":438,"geoPoint":445},"University of New Mexico","Albuquerque","New Mexico","87106",[439,443],{"name":440,"role":87,"phone":441,"email":442},"Anna Tingin","505-272-3342","atingin@salud.unm.edu",{"name":444,"role":92},"Sarah P Richardson, MD, FAAN",{"lat":446,"lon":447},35.08449,-106.65114,{"facility":449,"status":8,"city":450,"state":451,"zip":452,"country":83,"contacts":453,"geoPoint":460},"Northwell Health","Manhasset","New York","11030",[454,458],{"name":455,"role":87,"phone":456,"email":457},"Nicholas Zumba","516-472-5807","Neuroscienceresearch@northwell.edu",{"name":459,"role":92},"Ritesh Ramdhani, MD",{"lat":461,"lon":462},40.79788,-73.69957,{"facility":464,"status":8,"city":451,"state":451,"zip":465,"country":83,"contacts":466,"geoPoint":473},"Icahn School of Medicine at Mount Sinai\u002FMount Sinai West","10019",[467,471],{"name":468,"role":87,"phone":469,"email":470},"Ricardo Renvill","212-844-6055","ricardo.revill@mountsinai.org",{"name":472,"role":92},"Joohi Jimenez-Shahed, MD",{"lat":474,"lon":475},40.71427,-74.00597,{"facility":477,"status":8,"city":451,"state":451,"zip":478,"country":83,"contacts":479,"geoPoint":486},"Columbia University","10032",[480,484],{"name":481,"role":87,"phone":482,"email":483},"Columbia Movement Disorders Research","347-882-4315","mdresearch@cumc.columbia.edu",{"name":485,"role":92},"Sheng-Han Kuo, MD",{"lat":474,"lon":475},{"facility":488,"status":8,"city":489,"state":451,"zip":490,"country":83,"contacts":491,"geoPoint":498},"University of Rochester","Rochester","14618",[492,496],{"name":493,"role":87,"phone":494,"email":495},"Amy Chesire","585-341-7500","Amy_Chesire@URMC.Rochester.edu",{"name":497,"role":92},"Christopher Tarolli, MD",{"lat":499,"lon":500},43.15478,-77.61556,{"facility":502,"status":8,"city":503,"state":504,"zip":505,"country":83,"contacts":506,"geoPoint":513},"University of North Carolina - Chapel Hill","Chapel Hill","North Carolina","27599",[507,511],{"name":508,"role":87,"phone":509,"email":510},"Jessica Ferrall","919-962-8852","jferrall@neurology.unc.edu",{"name":512,"role":92},"Daniel Roque, MD",{"lat":514,"lon":515},35.9132,-79.05584,{"facility":517,"status":8,"city":518,"state":519,"zip":520,"country":83,"contacts":521,"geoPoint":528},"The Ohio State University","Columbus","Ohio","43210",[522,526],{"name":523,"role":87,"phone":524,"email":525},"Katherine Ambrogi","614-688-6685","katherine.ambrogi@osumc.edu",{"name":527,"role":92},"Ariane Park, MD, MPH",{"lat":529,"lon":530},39.96118,-82.99879,{"facility":532,"status":8,"city":533,"state":534,"zip":535,"country":83,"contacts":536,"geoPoint":543},"The Movement Disorder Clinic of 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PA","Dallas","Texas","75243",[612,617],{"name":613,"role":87,"phone":614,"phoneExt":615,"email":616},"Maya Manjane","214-750-9977","293","maya.manjane@carumresearch.com",{"name":618,"role":92},"Nirav Pavasia, MD",{"lat":620,"lon":621},32.78306,-96.80667,{"facility":623,"status":8,"city":624,"state":609,"zip":625,"country":83,"contacts":626,"geoPoint":633},"Baylor College of Medicine","Houston","77030",[627,631],{"name":628,"role":87,"phone":629,"email":630},"Aneesch Martin","713-798-2606","aneesch.martin@bcm.edu",{"name":632,"role":92},"Arjun Tarakad, MD",{"lat":634,"lon":635},29.76328,-95.36327,{"facility":637,"status":8,"city":624,"state":609,"zip":625,"country":83,"contacts":638,"geoPoint":645},"The University of Texas Health Science Center at Houston",[639,643],{"name":640,"role":87,"phone":641,"email":642},"Brittany Duncan","713-486-3134","Brittany.J.Duncan@uth.tmc.edu",{"name":644,"role":92},"Raja Mehanna, 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Virginia","Charlottesville","Virginia","22903",[682,686],{"name":683,"role":87,"phone":684,"email":685},"Lauren Miller","434-982-6599","FDK5DN@UVAHealth.org",{"name":687,"role":92},"Binit Shah, MD, FAAN",{"lat":689,"lon":690},38.02931,-78.47668,{"facility":692,"status":8,"city":693,"state":694,"zip":695,"country":83,"contacts":696,"geoPoint":703},"EvergreenHealth","Kirkland","Washington","98034",[697,701],{"name":698,"role":87,"phone":699,"email":700},"Ryuma Barnes","425-899-5370","robarnes@evergreenhealthcare.org",{"name":702,"role":92},"Pinky Agarwal, MD, FAAN",{"lat":704,"lon":705},47.68149,-122.20874,{"facility":707,"status":8,"city":708,"state":694,"zip":709,"country":83,"contacts":710,"geoPoint":718},"Inland Northwest Research","Spokane","99202",[711,716],{"name":712,"role":87,"phone":713,"phoneExt":714,"email":715},"Michael Dauer","509-960-2818","6","mdauer@inwresearch.com",{"name":717,"role":92},"Jason Aldred, MD",{"lat":719,"lon":720},47.65966,-117.42908,{"facility":722,"status":8,"city":723,"state":724,"zip":725,"country":83,"contacts":726,"geoPoint":733},"Medical College of Wisconsin","Milwaukee","Wisconsin","53226",[727,731],{"name":728,"role":87,"phone":729,"email":730},"Shelby Schold","414-955-0698","sschold@mcw.edu",{"name":732,"role":92},"Karen Blindauer, MD",{"lat":734,"lon":735},43.0389,-87.90647,{"facility":737,"status":8,"city":738,"zip":739,"country":740,"contacts":741,"geoPoint":747},"Rambam Medical Center","Haifa","3109601","Israel",[742,746],{"name":743,"role":87,"phone":744,"email":745},"Ilana Schlesinger, MD, Prof","972-4-7771495","i_schles@rmc.gov.il",{"name":743,"role":92},{"lat":748,"lon":749},32.81303,34.99928,{"facility":751,"status":8,"city":752,"zip":753,"country":740,"contacts":754,"geoPoint":761},"Shaare Zedek Medical Center","Jerusalem","9103102",[755,759],{"name":756,"role":87,"phone":757,"email":758},"Yael Mimoun","972-5-43184600","yaelmi@szmc.org.il",{"name":760,"role":92},"Gilad Yahalom, MD, Prof",{"lat":762,"lon":763},31.76904,35.21633,{"facility":765,"status":8,"city":766,"zip":767,"country":740,"contacts":768,"geoPoint":775},"Sheba Medical Center","Ramat Gan","5262000",[769,773],{"name":770,"role":87,"phone":771,"email":772},"Adi Saar","972-3-5304931","adi.saar@sheba.health.gov.il",{"name":774,"role":92},"Sharon Hassin, MD, Prof",{"lat":776,"lon":777},32.08227,34.81065,{"facility":779,"status":8,"city":780,"zip":781,"country":740,"contacts":782,"geoPoint":789},"Tel Aviv Medical Center","Tel Aviv","6423906",[783,787],{"name":784,"role":87,"phone":785,"email":786},"Adi Ezra","972-3-6974912","adil@tlvmc.gov.il",{"name":788,"role":92},"Tanya Gurevich, MD, Prof",{"lat":790,"lon":791},32.08088,34.78057,{"facility":793,"status":8,"city":794,"zip":795,"country":796,"contacts":797,"geoPoint":804},"IRCCS Ospedale San Raffaele (HSR) - Dipartimento Di Neurologia","Milan","20132","Italy",[798,802],{"name":799,"role":87,"phone":800,"email":801},"Daniela Capilupo","+39 0226434815","capilupo.daniela@hsr.it",{"name":803,"role":92},"Massimo Filippi, MD, Prof",{"lat":805,"lon":806},42.78235,12.59836,{"facility":808,"status":8,"city":809,"zip":810,"country":796,"contacts":811,"geoPoint":818},"Universita Degli Studi Della Campania \"Luigi Vanvitelli\" - Azienda Ospedaliera Universitaria","Naples","80138",[812,816],{"name":813,"role":87,"phone":814,"email":815},"Teresa Del Santo","+39 3494026479","delsantoteresa@gmail.com",{"name":817,"role":92},"Alessandro Tessitore, MD, PhD",{"lat":819,"lon":820},40.85216,14.26811,{"facility":822,"status":8,"city":823,"zip":824,"country":796,"contacts":825,"geoPoint":832},"Universita Degli Studi Di Padova - Azienda Ospedaliera Di Padova - Clinica Neurologica","Padua","35128",[826,830],{"name":827,"role":87,"phone":828,"email":829},"Angelo Antonini","+39 0498213607","angelo.antonini.pd@gmail.com",{"name":831,"role":92},"Angelo Antonini, MD, PhD, Prof",{"lat":833,"lon":834},45.40797,11.88586,{"facility":836,"status":8,"city":837,"zip":838,"country":796,"contacts":839,"geoPoint":846},"Azienda Ospedaliero Universitaria Pisana - Stabilimento Ospedaliero Di Santa Chiara","Pisa","56126",[840,844],{"name":841,"role":87,"phone":842,"email":843},"Pierangela Riani","+39 050992567","p.riani@ao-pisa.toscana.it",{"name":845,"role":92},"Roberta Ceravolo, MD, Prof",{"lat":847,"lon":848},43.70853,10.4036,{"facility":850,"status":8,"city":851,"zip":852,"country":796,"contacts":853,"geoPoint":860},"Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - San Raffaele Pisana","Rome","00166",[854,858],{"name":855,"role":87,"phone":856,"email":857},"Miriam Casali","+39 0652252311","miriam.casali@sanraffaele.it",{"name":859,"role":92},"Fabrizio Stocchi, MD, PhD",{"lat":861,"lon":862},41.89193,12.51133,{"facility":864,"status":8,"city":851,"zip":865,"country":796,"contacts":866,"geoPoint":873},"Fondazione Policilinico Universitario A Gemelli IRCCS","00168",[867,871],{"name":868,"role":87,"phone":869,"email":870},"Flavia Torlizzi","+39 0630155633","flavia.torlizzi@policlinicogemelli.it",{"name":872,"role":92},"Anna Rita Bentivoglio, MD, PhD",{"lat":861,"lon":862},{"facility":875,"status":8,"city":876,"zip":877,"country":878,"contacts":879,"geoPoint":886},"Centrum Medyczne Neuromed","Bydgoszcz","85-163","Poland",[880,884],{"name":881,"role":87,"phone":882,"email":883},"Beata Lisewska","+48 696268565","lisewskabeata@gmail.com",{"name":885,"role":92},"Pawel Lisewski, MD",{"lat":887,"lon":888},53.1235,18.00762,{"facility":890,"status":8,"city":891,"zip":892,"country":878,"contacts":893,"geoPoint":900},"NZOZ Wielospecjalistyczna Poradnia Lekarska Synapsis Lech Szczechowski","Katowice","32-600",[894,898],{"name":895,"role":87,"phone":896,"email":897},"Katarzyna Smilowska","+48 600282870","kasia.smilowska@gmail.com",{"name":899,"role":92},"Katarzyna Smilowska, MD, PhD",{"lat":901,"lon":902},50.2597,19.02173,{"facility":904,"status":8,"city":905,"zip":906,"country":878,"contacts":907,"geoPoint":913},"Pro Life Medica Sp. z o. o. ETA Lublin","Lublin","20-412",[908,912],{"name":909,"role":87,"phone":910,"email":911},"Dominika Tomaka, MD","+48 691485946","d.tomaka@etg-network.org",{"name":909,"role":92},{"lat":914,"lon":915},51.25058,22.57009,{"facility":917,"status":8,"city":918,"zip":919,"country":878,"contacts":920,"geoPoint":927},"Insula Badania Sp. Z o.o.","Warsaw","02-699",[921,925],{"name":922,"role":87,"phone":923,"email":924},"Marta Jethon","+48 501035250","jethon2@tlen.pl",{"name":926,"role":92},"Marta Jethon, MD",{"lat":928,"lon":929},52.22977,21.01178,{"facility":931,"status":8,"city":932,"state":933,"zip":934,"country":935,"contacts":936,"geoPoint":942},"Policlinica Gipuzkoa - Centro de Investigacion Parkinson (CIP)","San Sebastián","Donostia","20014","Spain",[937,941],{"name":938,"role":87,"phone":939,"email":940},"Gurutz Linazasoro, MD","+34 943002812","glinazasoro@vivebiotech.com",{"name":938,"role":92},{"lat":943,"lon":944},43.56667,-5.9,{"facility":946,"status":8,"city":947,"zip":948,"country":935,"contacts":949,"geoPoint":956},"Instituto de Investigacion Sanitaria Biocruces Bizkaia - Hospital Universitario Cruces","Barakaldo","49003",[950,954],{"name":951,"role":87,"phone":952,"email":953},"Naiara Azcue","+34 944881576","azkue.naiara@gmail.com",{"name":955,"role":92},"Juan Carlos Gomez Esteban, MD, PhD",{"lat":957,"lon":958},43.29639,-2.98813,{"facility":960,"status":8,"city":961,"zip":962,"country":935,"contacts":963,"geoPoint":970},"Hospital Universitari Vall d'Hebron","Barcelona","08035",[964,969],{"name":965,"role":87,"phone":966,"phoneExt":967,"email":968},"Jorge Hernandez Vara, MD","+34 934893000","4884","jorge.hernandez@vallhebron.cat",{"name":965,"role":92},{"lat":971,"lon":972},41.38879,2.15899,{"facility":974,"status":8,"city":961,"zip":975,"country":935,"contacts":976,"geoPoint":982},"Hospital Clinic de Barcelona (Hospital Clinic i Provincial) - Barnaclinic S.A.","08036",[977,981],{"name":978,"role":87,"phone":979,"email":980},"Alicia Garrido, Pla","+34 932275785","agarridop@clinic.cat",{"name":978,"role":92},{"lat":971,"lon":972},{"facility":984,"status":8,"city":985,"zip":986,"country":935,"contacts":987,"geoPoint":994},"Universidad Autonoma de Madrid (UAM) - Hospital Universitario de La Princesa","Madrid","28006",[988,992],{"name":989,"role":87,"phone":990,"email":991},"Lydia Lopez Manzanares","+34 915202405","lydia.lopez@salud.madrid.org",{"name":993,"role":92},"Lydia Lopez Manzanares, MD",{"lat":995,"lon":996},40.4165,-3.70256,{"facility":998,"status":8,"city":999,"zip":1000,"country":935,"contacts":1001,"geoPoint":1009},"Hospital Universitario HM Puerta del Sur","Móstoles","28938",[1002,1007],{"name":1003,"role":87,"phone":1004,"phoneExt":1005,"email":1006},"Patricia Vicente","+34 912673100","7988","pvicentefernandez@hmhospitales.com",{"name":1008,"role":92},"Michele Matarazzo, MD",{"lat":1010,"lon":1011},40.32234,-3.86496,{"facility":1013,"status":8,"city":1014,"zip":1015,"country":935,"contacts":1016,"geoPoint":1022},"Hospital Universitario Virgen del Rocio (HUVR) - Instituto de Biomedicina de Sevilla (IBIS)","Seville","41013",[1017,1021],{"name":1018,"role":87,"phone":1019,"email":1020},"Pablo Mir, MD","+34 955923039","pmir@us.es",{"name":1018,"role":92},{"lat":1023,"lon":1024},37.38283,-5.97317,{"facility":1026,"status":8,"city":1027,"state":1028,"zip":1029,"country":1030,"contacts":1031,"geoPoint":1037},"St George's Hospital, University of London","London","England","SW17 0QT","United Kingdom",[1032,1036],{"name":1033,"role":87,"phone":1034,"email":1035},"Francesca Morgante, MD","+44 20 8725 5403","fmorgant@sgul.ac.uk",{"name":1033,"role":92},{"lat":1038,"lon":1039},51.50853,-0.12574,{"facility":1041,"status":8,"city":1027,"state":1028,"zip":1042,"country":1030,"contacts":1043,"geoPoint":1050},"University College London Hospitals NHS Foundation Trust","WC1N 3BG",[1044,1048],{"name":1045,"role":87,"phone":1046,"email":1047},"Olivia Burton","+44 20 3448 4531","olivia.burton7@NHS.net",{"name":1049,"role":92},"Huw Morris, MD, PhD",{"lat":1038,"lon":1039},{"facility":1052,"status":8,"city":1053,"state":1028,"zip":1054,"country":1030,"contacts":1055,"geoPoint":1061},"Clinical Aging Research Unit, Newcastle University","Newcastle upon Tyne","NE4 5PL",[1056,1060],{"name":1057,"role":87,"phone":1058,"email":1059},"Nicola Pavese, MD, PhD, FRCP, FEAN","+44 0191 2081264","nicola.pavese@ncl.ac.uk",{"name":1057,"role":92},{"lat":1062,"lon":1063},54.97328,-1.61396,{"facility":1065,"status":8,"city":1066,"state":1067,"zip":1068,"country":1030,"contacts":1069,"geoPoint":1076},"Ninewells Hospital and Medical School - NHS Tayside","Dundee","Scotland","DD19SY",[1070,1074],{"name":1071,"role":87,"phone":1072,"email":1073},"Justine Hudson","+44 1382423086","justine.hudson2@nhs.scot",{"name":1075,"role":92},"Esther Sammler, MD",{"lat":1077,"lon":1078},56.46913,-2.97489,{"facility":1080,"status":1081,"city":1082,"zip":1083,"country":1030,"contacts":1084,"geoPoint":1090},"London North West University Healthcare NHS Trust - Northwick Park Hospital","NOT_YET_RECRUITING","Harrow","HA1 3UJ",[1085,1089],{"name":1086,"role":87,"phone":1087,"email":1088},"Tabish Saifee, MBBS, FRCP, PhD","+44 020 3448 4252","LNWH-tr.Research@nhs.net",{"name":1086,"role":92},{"lat":1091,"lon":1092},51.57835,-0.33208,{"facility":1094,"status":1081,"city":1027,"zip":1095,"country":1030,"contacts":1096,"geoPoint":1104},"Panthera Enfield","EN3 4GS",[1097,1101],{"name":1098,"role":87,"phone":1099,"email":1100},"Karen Faulkner","+44 785 020 8085","karen.faulkner@panthera-bio.com",{"name":1102,"role":1103},"Viquar Chamoun, MD","SUB_INVESTIGATOR",{"lat":1038,"lon":1039},[1106],{"name":1107,"role":87,"phone":1108,"email":1109},"Fatta B Nahab, MD, FAAN, FANA","650-228-2527","clinicaltrials@neuron23.com",[1111],{"name":1112,"affiliation":13,"role":92},"Fatta B Nahab, MD, FAAN FANA",[],[],{"nct_id":4,"conditions":1116,"biomarkers":1117},[19],[1118],"LRRK2 Gene",{"nct_id":4,"found":15,"summary":1120,"prompt_version":1130},{"design":1121,"status":1122,"heading":1123,"summary":1124,"follow_up":1125,"word_count":1126,"commitments":1127,"compensation":1128,"drugs_mentioned":1129},"This is a Phase 2, randomized, placebo-controlled study with an open-label extension, meaning some participants will receive NEU-411 and others a placebo, and then some may continue with NEU-411. Approximately 150 participants will be enrolled.","completed","Phase 2 Study of NEU-411 for Early Parkinson's Disease","This Phase 2 study is testing a drug called NEU-411 for people with early Parkinson's Disease (PD). NEU-411 is designed to block the activity of a protein called LRRK2, which is thought to play a role in some forms of PD. To join, you must be between 40 and 80 years old, have early PD, and a genetic test must show you have \"LRRK2-driven\" PD. Researchers will compare NEU-411 to a placebo (an inactive substance) to see if it improves symptoms measured by a special app and to check for any side effects. The study aims to enroll about 150 participants, but its current status is unclear.","Participants will be followed for safety for up to 54 weeks from enrollment, which includes a follow-up visit within two weeks after the last treatment.",107,"Participants will receive treatment for 52 weeks, followed by a safety check-up within two weeks. Eligible participants may then join an open-label extension for an additional 26 weeks of treatment.","Not stated in the trial record.",[46,51],"v2"]