[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06693531":3,"trial-entities:NCT06693531":462,"trial-summary:NCT06693531":466},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":21,"primary_purpose":17,"phases":22,"enrollment_info":23,"interventions":26,"primary_outcomes":37,"secondary_outcomes":63,"sex":64,"minimum_age":65,"maximum_age":17,"healthy_volunteers":15,"eligibility_criteria":66,"std_ages":70,"locations":74,"central_contacts":451,"overall_officials":452,"references":456,"see_also_links":461},"NCT06693531","R668-EE-2328","A U.S. Registry of Eosinophilic Esophagitis Pediatric, Adolescent and Adult Patients Treated With DUPIXENT® As Standard of Care","A U.S. Registry of Eosinophilic Esophagitis Patients Treated With DUPIXENT® As Standard of Care","ACTIVE_NOT_RECRUITING","2030-05-22","2026-08","2026-08-12","2024-11-22","Regeneron Pharmaceuticals","INDUSTRY",false,"This observational research study is to better understand patients with eosinophilic esophagitis (EoE) who have recently been prescribed DUPIXENT® (dupilumab).\n\nThe purpose of this research study is to look at how DUPIXENT is used in normal care of patients with EoE.\n\nPossible benefits to others include a better understanding of EoE and helping to inform research and clinical trial design leading to treatment decisions in this patient population going forward.\n\nPatient questionnaires will measure the following:\n\n* How EoE makes one feel\n* EoE signs and\u002For symptoms, eg, how difficult it is to swallow\n* How EoE affects quality-of-life\n* How EoE impacts aspects of daily life\n* How EoE symptoms have changed throughout the study",null,[19],"Eosinophilic Esophagitis (EoE)",[],"OBSERVATIONAL",[],{"count":24,"type":25},368,"ACTUAL",[27],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":33},"DRUG","dupilumab","No investigational agents will be provided. Dupilumab will be prescribed as per usual clinical practice and will not be provided by the sponsor.",[32],"EoE Patients treated with DUPIXENT®",[34,35,36],"DUPIXENT®","REGN668","SAR231893",[38,41,43,45,47,49,51,53,55,58,61],{"measure":39,"timeFrame":40},"Demographic characteristic of participants who receive dupilumab for EoE: Age","Baseline and up to 3 years after treatment initiation",{"measure":42,"timeFrame":40},"Demographic characteristic of participants who receive dupilumab for EoE: Race",{"measure":44,"timeFrame":40},"Demographic characteristic of participants who receive dupilumab for EoE: Weight",{"measure":46,"timeFrame":40},"Demographic characteristic of participants who receive dupilumab for EoE: Height",{"measure":48,"timeFrame":40},"Disease characteristics of participants who receive dupilumab for EoE: Esophagogastroduodenoscopy (EGD)",{"measure":50,"timeFrame":40},"Disease characteristics of participants who receive dupilumab for EoE: Dilation\u002Fimpaction history",{"measure":52,"timeFrame":40},"Disease characteristics of participants who receive dupilumab for EoE: Dietary interventions",{"measure":54,"timeFrame":40},"Disease characteristics of participants who receive dupilumab for EoE: Medical history",{"measure":56,"timeFrame":57},"EoE medication history of participant","Previous 1 year and up to 3 years after treatment initiation",{"measure":59,"timeFrame":60},"Non-EoE medication history of participant","Previous 3 months and up to 3 years after treatment initiation",{"measure":62,"timeFrame":40},"Prior dupilumab exposure history of participant",[],"ALL","1 Year",{"inclusion":67,"exclusion":68,"raw_text":69},[],[],"Key Inclusion Criteria:\n\n1. Initiating treatment with DUPIXENT® for EoE according to the USPI\n2. Participants aged ≥12 years and caregivers or legal guardians of participants aged \\\u003C12 years must be able to understand and complete registry-related questionnaires\n\nKey Exclusion Criteria:\n\n1. Patients who have a contraindication to DUPIXENT® according to the USPI\n2. Treatment with DUPIXENT® within the 6 months prior to the screening assessment\n3. Participation in an ongoing interventional study on or within 6 months of the baseline assessment. Once enrolled in registry, participation is allowed in other ongoing studies (at the discretion of the registry investigator)\n\nNOTE: Other protocol defined inclusion\u002Fexclusion criteria apply",[71,72,73],"CHILD","ADULT","OLDER_ADULT",[75,84,91,99,107,114,118,125,132,139,147,150,157,165,172,180,187,195,199,207,210,217,224,232,240,248,252,256,264,272,280,287,295,303,309,313,319,327,334,341,349,357,364,367,375,382,390,398,405,412,420,428,436,443],{"facility":76,"city":77,"state":78,"zip":79,"country":80,"geoPoint":81},"Phoenix Childrens Hospital","Phoenix","Arizona","85016","United States",{"lat":82,"lon":83},33.44838,-112.07404,{"facility":85,"city":86,"state":78,"zip":87,"country":80,"geoPoint":88},"Arizona Digestive Health\u002FGI Alliance","Sun City","85351",{"lat":89,"lon":90},33.59754,-112.27182,{"facility":92,"city":93,"state":94,"zip":95,"country":80,"geoPoint":96},"Arkansas Childrens Hospital","Little Rock","Arkansas","72202",{"lat":97,"lon":98},34.74648,-92.28959,{"facility":100,"city":101,"state":102,"zip":103,"country":80,"geoPoint":104},"Scripps Clinic","La Jolla","California","92037",{"lat":105,"lon":106},32.84727,-117.2742,{"facility":108,"city":109,"state":102,"zip":110,"country":80,"geoPoint":111},"University of California Los Angeles (UCLA)","Los Angeles","90024",{"lat":112,"lon":113},34.05223,-118.24368,{"facility":115,"city":109,"state":102,"zip":116,"country":80,"geoPoint":117},"University of Southern California Keck School of Medicine","90033",{"lat":112,"lon":113},{"facility":119,"city":120,"state":102,"zip":121,"country":80,"geoPoint":122},"University of California, San Francisco","Oakland","94609",{"lat":123,"lon":124},37.80437,-122.2708,{"facility":126,"city":127,"state":102,"zip":128,"country":80,"geoPoint":129},"Stanford University","Palo Alto","94304",{"lat":130,"lon":131},37.44188,-122.14302,{"facility":133,"city":134,"state":102,"zip":135,"country":80,"geoPoint":136},"University of California San Francisco (UCSF)","San Francisco","94115",{"lat":137,"lon":138},37.77493,-122.41942,{"facility":140,"city":141,"state":142,"zip":143,"country":80,"geoPoint":144},"Childrens Hospital Colorado","Aurora","Colorado","80045",{"lat":145,"lon":146},39.72943,-104.83192,{"facility":148,"city":141,"state":142,"zip":143,"country":80,"geoPoint":149},"University of Colorado Anschutz Medical Campus",{"lat":145,"lon":146},{"facility":151,"city":152,"state":142,"zip":153,"country":80,"geoPoint":154},"Rocky Mountain Gastroenterology","Littleton","80120",{"lat":155,"lon":156},39.61332,-105.01665,{"facility":158,"city":159,"state":160,"zip":161,"country":80,"geoPoint":162},"UConn Health - The Carole and Ray Neag Comprehensive Cancer Center","Farmington","Connecticut","06030",{"lat":163,"lon":164},41.71982,-72.83204,{"facility":166,"city":167,"state":160,"zip":168,"country":80,"geoPoint":169},"Yale School of Medicine","New Haven","06510",{"lat":170,"lon":171},41.30815,-72.92816,{"facility":173,"city":174,"state":175,"zip":176,"country":80,"geoPoint":177},"Gastroenterology of Greater Orlando","Orange City","Florida","32763",{"lat":178,"lon":179},28.94888,-81.29867,{"facility":181,"city":182,"state":175,"zip":183,"country":80,"geoPoint":184},"Orlando Health","Orlando","32806",{"lat":185,"lon":186},28.53834,-81.37924,{"facility":188,"city":189,"state":190,"zip":191,"country":80,"geoPoint":192},"Emory Healthcare, Emory Clinic","Atlanta","Georgia","30322",{"lat":193,"lon":194},33.749,-84.38798,{"facility":196,"city":189,"state":190,"zip":197,"country":80,"geoPoint":198},"GI Care for Kids LLC","30342",{"lat":193,"lon":194},{"facility":200,"city":201,"state":202,"zip":203,"country":80,"geoPoint":204},"Ann & Robert H. Lurie Children's Hospital of Chicago","Chicago","Illinois","60611",{"lat":205,"lon":206},41.85003,-87.65005,{"facility":208,"city":201,"state":202,"zip":203,"country":80,"geoPoint":209},"Northwestern University, Feinberg School of Medicine",{"lat":205,"lon":206},{"facility":211,"city":212,"state":202,"zip":213,"country":80,"geoPoint":214},"Comprehensive Gastrointestinal Health, LLC","Libertyville","60048",{"lat":215,"lon":216},42.28308,-87.95313,{"facility":218,"city":219,"state":202,"zip":220,"country":80,"geoPoint":221},"Endeavor Health, Skokie Campus","Skokie","60077",{"lat":222,"lon":223},42.03336,-87.73339,{"facility":225,"city":226,"state":227,"zip":228,"country":80,"geoPoint":229},"Kansas Gastroenterology LLC","Wichita","Kansas","67226",{"lat":230,"lon":231},37.69224,-97.33754,{"facility":233,"city":234,"state":235,"zip":236,"country":80,"geoPoint":237},"Allergy & Asthma Specialists, P.S.C.","Owensboro","Kentucky","42301",{"lat":238,"lon":239},37.77422,-87.11333,{"facility":241,"city":242,"state":243,"zip":244,"country":80,"geoPoint":245},"Boston Specialists, Chinatown Office","Boston","Massachusetts","02111",{"lat":246,"lon":247},42.35843,-71.05977,{"facility":249,"city":242,"state":243,"zip":250,"country":80,"geoPoint":251},"Massachusetts General Hospital","02114",{"lat":246,"lon":247},{"facility":253,"city":242,"state":243,"zip":254,"country":80,"geoPoint":255},"Boston Childrens Hospital","02115",{"lat":246,"lon":247},{"facility":257,"city":258,"state":259,"zip":260,"country":80,"geoPoint":261},"Mayo Clinic","Rochester","Minnesota","55905",{"lat":262,"lon":263},44.02163,-92.4699,{"facility":265,"city":266,"state":267,"zip":268,"country":80,"geoPoint":269},"GI Associates and Endoscopy Center","Flowood","Mississippi","39232",{"lat":270,"lon":271},32.30959,-90.13898,{"facility":273,"city":274,"state":275,"zip":276,"country":80,"geoPoint":277},"Kansas City VA Medical Center","Kansas City","Missouri","64128",{"lat":278,"lon":279},39.09973,-94.57857,{"facility":281,"city":282,"state":275,"zip":283,"country":80,"geoPoint":284},"Washington University in Saint Louis","St Louis","63110",{"lat":285,"lon":286},38.62727,-90.19789,{"facility":288,"city":289,"state":290,"zip":291,"country":80,"geoPoint":292},"Allergy Partners of N.J., P.C.","Ocean City","New Jersey","07712",{"lat":293,"lon":294},39.27762,-74.5746,{"facility":296,"city":297,"state":298,"zip":299,"country":80,"geoPoint":300},"Steven And Alexandra Cohen Children's Medical Center Of New York","Lake Success","New York","11042",{"lat":301,"lon":302},40.77066,-73.71763,{"facility":304,"city":298,"state":298,"zip":305,"country":80,"geoPoint":306},"Weil Cornell Medicine NYP","10021",{"lat":307,"lon":308},40.71427,-74.00597,{"facility":310,"city":298,"state":298,"zip":311,"country":80,"geoPoint":312},"Icahn School of Medicine at Mount Sinai","10029",{"lat":307,"lon":308},{"facility":314,"city":258,"state":298,"zip":315,"country":80,"geoPoint":316},"Gastroenterology Group of Rochester LLP","14618",{"lat":317,"lon":318},43.15478,-77.61556,{"facility":320,"city":321,"state":322,"zip":323,"country":80,"geoPoint":324},"University of North Carolina at Chapel Hill","Chapel Hill","North Carolina","27599",{"lat":325,"lon":326},35.9132,-79.05584,{"facility":328,"city":329,"state":322,"zip":330,"country":80,"geoPoint":331},"Duke University","Durham","27710",{"lat":332,"lon":333},35.99403,-78.89862,{"facility":335,"city":336,"state":322,"zip":337,"country":80,"geoPoint":338},"Atrium Health \u002F Wake Forest University School of Medicine","Winston-Salem","27157",{"lat":339,"lon":340},36.09986,-80.24422,{"facility":342,"city":343,"state":344,"zip":345,"country":80,"geoPoint":346},"Great Lakes Gastroenterology Research, LLC","Mentor","Ohio","44060",{"lat":347,"lon":348},41.66616,-81.33955,{"facility":350,"city":351,"state":352,"zip":353,"country":80,"geoPoint":354},"Susquehanna Research Group","Camp Hill","Pennsylvania","17011",{"lat":355,"lon":356},40.23981,-76.91997,{"facility":358,"city":359,"state":352,"zip":360,"country":80,"geoPoint":361},"The Children's Hospital of Philadelphia","Philadelphia","19104",{"lat":362,"lon":363},39.95238,-75.16362,{"facility":365,"city":359,"state":352,"zip":360,"country":80,"geoPoint":366},"University of Pennsylvania",{"lat":362,"lon":363},{"facility":368,"city":369,"state":370,"zip":371,"country":80,"geoPoint":372},"Medical University of South Carolina","Charleston","South Carolina","29425",{"lat":373,"lon":374},32.77632,-79.93275,{"facility":376,"city":377,"state":370,"zip":378,"country":80,"geoPoint":379},"Palmetto Gastroenterology Clinical Research","Summerville","29486",{"lat":380,"lon":381},33.0185,-80.17565,{"facility":383,"city":384,"state":385,"zip":386,"country":80,"geoPoint":387},"Vanderbilt University Medical Center","Nashville","Tennessee","37232",{"lat":388,"lon":389},36.16589,-86.78444,{"facility":391,"city":392,"state":393,"zip":394,"country":80,"geoPoint":395},"Brooke Army Medical Center","Fort Sam Houston","Texas","78234",{"lat":396,"lon":397},29.45303,-98.4417,{"facility":399,"city":400,"state":393,"zip":401,"country":80,"geoPoint":402},"Baylor College of Medicine","Houston","77030",{"lat":403,"lon":404},29.76328,-95.36327,{"facility":406,"city":407,"state":393,"zip":408,"country":80,"geoPoint":409},"GI Alliance","Southlake","76092",{"lat":410,"lon":411},32.94124,-97.13418,{"facility":413,"city":414,"state":415,"zip":416,"country":80,"geoPoint":417},"Tanner Clinic","Layton","Utah","84041",{"lat":418,"lon":419},41.06022,-111.97105,{"facility":421,"city":422,"state":423,"zip":424,"country":80,"geoPoint":425},"University of Virginia","Charlottesville","Virginia","22908",{"lat":426,"lon":427},38.02931,-78.47668,{"facility":429,"city":430,"state":431,"zip":432,"country":80,"geoPoint":433},"Seattle Children's Home Health Company","Seattle","Washington","98105",{"lat":434,"lon":435},47.60621,-122.33207,{"facility":437,"city":438,"state":431,"zip":439,"country":80,"geoPoint":440},"Washington Gastroenterology, GIA","Tacoma","98405",{"lat":441,"lon":442},47.25288,-122.44429,{"facility":444,"city":445,"state":446,"zip":447,"country":80,"geoPoint":448},"Medical College of Wisconsin","Milwaukee","Wisconsin","53226",{"lat":449,"lon":450},43.0389,-87.90647,[],[453],{"name":454,"affiliation":13,"role":455},"Clinical Trial Management","STUDY_DIRECTOR",[457],{"pmid":458,"type":459,"citation":460},"42100495","DERIVED","Dellon ES, Chehade M, McGowan EC, Jensen ET, Leung J, Eren D, Angello JT, Radwan A, Durrani SR, deMarchi S. Baseline characteristics, treatment patterns, and long-term outcomes in patients with eosinophilic esophagitis initiating dupilumab in routine clinical practice: study protocol of a phase IV, prospective, observational, multicenter registry (EDESIA). Ther Adv Gastroenterol. 2026 Apr 28;19:17562848261443887. doi: 10.1177\u002F17562848261443887. eCollection 2026.",[],{"nct_id":4,"conditions":463,"biomarkers":465},[464],"Eosinophilic Esophagitis",[],{"nct_id":4,"found":467,"summary":468,"prompt_version":478},true,{"design":469,"status":470,"heading":471,"summary":472,"follow_up":473,"word_count":474,"commitments":475,"compensation":476,"drugs_mentioned":477},"This is an observational study planning to include 350 participants. It does not involve new or experimental treatments; DUPIXENT® is prescribed as part of usual care.","completed","Understanding DUPIXENT® for Eosinophilic Esophagitis","This observational study is for people with Eosinophilic Esophagitis (EoE), a condition where a type of white blood cell (eosinophil) builds up in the esophagus, causing inflammation and difficulty swallowing. It aims to learn more about how DUPIXENT® (dupilumab) is used in regular medical care for EoE. You can join if you are starting DUPIXENT® for EoE and are at least 1 year old. The study will track information like your age, race, and weight, and you'll complete questionnaires about how EoE affects your feelings, symptoms (like swallowing difficulty), and daily life over three years. The goal is to better understand EoE and help improve future treatments.","Participants' demographic characteristics, such as age, race, and weight, will be measured at the start of the study and for up to 3 years after beginning DUPIXENT® treatment.",107,"You will complete questionnaires about your EoE symptoms and quality of life. The study will track your demographic information and weight for up to 3 years after starting DUPIXENT®.","Not stated in the trial record.",[29],"v2"]